iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/CUE	CUE	25796185

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/CUE	4.80e-07	30.0	241	280

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLLe 41
           +eta+e++++iFP+l+ys+   +++ +   +e++++   +
   Q: 241  VETAQERNEPIFPALIYSSGVIYPYVLVTAVENTTDPREP 280
           89*********************************98765 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function.

Protein Sequence
(Fasta)

MPSTRRQQEG GGADAETHTV YGTNLITNRN SQEDENVVEE AELKYGASHV IHLFVPVSLC 60
MALVVFTMNT ITFYSQNNGR HLLYTPFVRE TDSIVEKGLM SLGNALVMLC VVVLMTVLLI 120

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Nucleotide Sequence
(Fasta)

ATGCCTTCCA CAAGGAGACA ACAGGAGGGC GGAGGTGCAG ATGCGGAAAC ACATGTAAGT 60
TATTTAGACA TTTTATTTTT CTCAAGAACT AAATTGTTAA AATTGCTACA ATGCATTGTT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001686--Pept_A22A_Ceel
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01075--PRESENILNSEL

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0070765--C:gamma-secretase complex
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0045176--P:apical protein localization
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0001708--P:cell fate specification
GO:0016048--P:detection of temperature stimulus
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007399--P:nervous system development
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0018991--P:oviposition
GO:0045747--P:positive regulation of Notch signaling pathway
GO:0048563--P:post-embryonic animal organ morphogenesis
GO:0016485--P:protein processing
GO:0017015--P:regulation of transforming growth factor beta receptor signaling pathway

KEGG

cel:CELE_F35H12.3

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	29.89	4.00e-31	129.00
IUUC-Aml-002356	Ailuropoda melanoleuca	50.00	3.00e-56	211.00
IUUC-Atr-003039	Amborella trichopoda	29.21	2.00e-41	162.00
IUUC-Apl-003727	Anas platyrhynchos	52.74	6.00e-87	313.00
IUUC-Aca-004582	Anolis carolinensis	53.23	4.00e-90	323.00
IUUC-Aly-005455	Arabidopsis lyrata	40.52	8.00e-26	110.00
IUUC-Ath-006730	Arabidopsis thaliana	38.99	3.00e-25	108.00
IUUC-Ago-007845	Ashbya gossypii	24.68	9.10e-01	27.30
IUUC-Ani-009130	Aspergillus nidulans	41.03	2.90e-02	32.30
IUUC-Ame-010686	Astyanax mexicanus	51.12	2.00e-92	331.00
IUUC-Bta-013026	Bos taurus	52.87	7.00e-93	333.00
IUUC-Bdi-014196	Brachypodium distachyon	31.72	6.00e-37	147.00
IUUC-Bol-015841	Brassica oleracea	30.75	9.00e-38	149.00
IUUC-Bra-017580	Brassica rapa	48.00	2.00e-25	108.00
IUUC-Cja-019994	Callithrix jacchus	52.62	1.00e-86	311.00
IUUC-Cfa-020074	Canis familiaris	53.69	6.00e-88	316.00
IUUC-Cpo-022237	Cavia porcellus	51.82	3.00e-87	313.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.64	7.00e-27	114.00
IUUC-Csa-023537	Chlorocebus sabaeus	52.37	1.00e-87	315.00
IUUC-Cho-024735	Choloepus hoffmanni	46.68	1.00e-79	288.00
IUUC-Cin-025780	Ciona intestinalis	48.76	2.00e-90	324.00
IUUC-Csv-025967	Ciona savignyi	50.25	1.00e-94	338.00
IUUC-Dre-028689	Danio rerio	50.88	7.00e-85	306.00
IUUC-Dno-029758	Dasypus novemcinctus	52.57	3.00e-88	317.00
IUUC-Dor-031127	Dipodomys ordii	52.54	3.00e-69	254.00
IUUC-Dme-031929	Drosophila melanogaster	50.58	7.00e-99	353.00
IUUC-Ete-032487	Echinops telfairi	46.61	2.00e-30	125.00
IUUC-Eca-034387	Equus caballus	51.74	6.00e-73	266.00
IUUC-Eeu-035134	Erinaceus europaeus	54.04	8.00e-69	252.00
IUUC-Fca-036243	Felis catus	51.87	1.00e-87	315.00
IUUC-Fal-036600	Ficedula albicollis	53.38	6.00e-88	316.00
IUUC-Gmo-039665	Gadus morhua	51.12	3.00e-76	277.00
IUUC-Gga-040993	Gallus gallus	53.87	3.00e-89	320.00
IUUC-Gac-042511	Gasterosteus aculeatus	50.61	9.00e-85	306.00
IUUC-Gma-043822	Glycine max	36.27	7.00e-27	113.00
IUUC-Ggo-045338	Gorilla gorilla	50.64	2.00e-75	275.00
IUUC-Hsa-046822	Homo sapiens	52.37	1.00e-87	315.00
IUUC-Hvu-047141	Hordeum vulgare	29.80	1.00e-31	129.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	50.32	5.00e-75	273.00
IUUC-Lch-049946	Latimeria chalumnae	56.59	3.00e-69	254.00
IUUC-Lpe-051132	Leersia perrieri	42.75	1.00e-23	103.00
IUUC-Loc-052427	Lepisosteus oculatus	48.97	2.00e-91	328.00
IUUC-Laf-053758	Loxodonta africana	48.16	1.00e-89	322.00
IUUC-Mcc-055682	Macaca mulatta	52.37	1.00e-87	315.00
IUUC-Meu-056004	Macropus eugenii	49.81	5.00e-63	233.00
IUUC-Mtr-058392	Medicago truncatula	29.55	7.00e-34	136.00
IUUC-Mga-059466	Meleagris gallopavo	52.96	3.00e-89	320.00
IUUC-Mvi-060239	Microbotryum violaceum	27.66	5.20e-02	30.40
IUUC-Mmr-060890	Microcebus murinus	50.48	3.00e-76	277.00
IUUC-Mdo-062122	Monodelphis domestica	52.76	9.00e-90	322.00
IUUC-Mmu-063176	Mus musculus	51.82	4.00e-87	313.00
IUUC-Mac-064858	Musa acuminata	34.08	1.00e-23	102.00
IUUC-Mpu-065927	Mustela putorius furo	53.27	3.00e-87	314.00
IUUC-Mlu-067079	Myotis lucifugus	51.97	3.00e-94	337.00
IUUC-Nle-070180	Nomascus leucogenys	52.37	1.00e-87	315.00
IUUC-Opr-070847	Ochotona princeps	52.37	7.00e-88	316.00
IUUC-Ont-071846	Oreochromis niloticus	52.00	8.00e-91	326.00
IUUC-Oan-073378	Ornithorhynchus anatinus	52.38	3.00e-86	310.00
IUUC-Ocu-074527	Oryctolagus cuniculus	52.62	8.00e-90	323.00
IUUC-Oba-075256	Oryza barthii	56.52	2.00e-24	105.00
IUUC-Obr-076302	Oryza brachyantha	30.71	4.00e-35	141.00
IUUC-Ogl-077097	Oryza glaberrima	56.52	4.00e-24	104.00
IUUC-Ogu-078570	Oryza glumaepatula	56.52	3.00e-24	104.00
IUUC-Oin-079244	Oryza indica	56.52	4.00e-24	104.00
IUUC-Olo-080484	Oryza longistaminata	56.52	2.00e-24	104.00
IUUC-Ome-081814	Oryza meridionalis	31.58	2.00e-32	132.00
IUUC-Oni-082057	Oryza nivara	56.52	3.00e-24	104.00
IUUC-Opu-084176	Oryza punctata	30.24	3.00e-32	131.00
IUUC-Oru-084618	Oryza rufipogon	56.52	3.00e-24	104.00
IUUC-Osa-085602	Oryza sativa	56.52	3.00e-24	104.00
IUUC-Ola-086707	Oryzias latipes	59.72	3.00e-71	260.00
IUUC-Olu-087811	Ostreococcus lucimarinus	31.50	2.00e-38	151.00
IUUC-Oga-088560	Otolemur garnettii	61.78	7.00e-74	270.00
IUUC-Oar-090348	Ovis aries	53.20	2.00e-90	325.00
IUUC-Ptr-091060	Pan troglodytes	52.37	1.00e-87	315.00
IUUC-Pan-091742	Papio anubis	50.32	3.00e-75	274.00
IUUC-Psi-093505	Pelodiscus sinensis	53.23	2.00e-87	314.00
IUUC-Pma-094612	Petromyzon marinus	49.75	1.00e-78	285.00
IUUC-Ppa-095431	Physcomitrella patens	30.29	7.00e-45	173.00
IUUC-Pfo-097396	Poecilia formosa	51.35	3.00e-98	350.00
IUUC-Pab-098591	Pongo abelii	52.37	1.00e-87	315.00
IUUC-Pop-099661	Populus trichocarpa	31.75	5.00e-35	140.00
IUUC-Pca-101029	Procavia capensis	51.86	2.00e-77	281.00
IUUC-Ppe-101495	Prunus persica	29.70	7.00e-41	160.00
IUUC-Pva-102244	Pteropus vampyrus	50.74	3.00e-86	311.00
IUUC-Ptt-103917	Puccinia triticina	37.14	8.00e-04	33.50
IUUC-Rno-105861	Rattus norvegicus	52.99	2.00e-88	318.00
IUUC-Sha-107045	Sarcophilus harrisii	52.74	4.00e-90	323.00
IUUC-Smo-109325	Selaginella moellendorffii	36.00	2.00e-31	128.00
IUUC-Sit-110624	Setaria italica	29.97	1.00e-31	129.00
IUUC-Sly-110865	Solanum lycopersicum	52.17	8.00e-15	70.90
IUUC-Stu-112433	Solanum tuberosum	32.94	2.00e-38	151.00
IUUC-Sar-113169	Sorex araneus	50.84	7.00e-70	256.00
IUUC-Sbi-114305	Sorghum bicolor	33.64	4.00e-32	131.00
IUUC-Ssc-115766	Sus scrofa	52.96	1.00e-88	318.00
IUUC-Tgu-117280	Taeniopygia guttata	52.59	6.00e-82	296.00
IUUC-Tru-117732	Takifugu rubripes	53.71	6.00e-95	339.00
IUUC-Tsy-119624	Tarsius syrichta	49.62	8.00e-80	289.00
IUUC-Tni-119852	Tetraodon nigroviridis	49.00	7.00e-87	313.00
IUUC-Tca-121865	Theobroma cacao	32.07	6.00e-41	160.00
IUUC-Tae-125925	Triticum aestivum	32.16	2.00e-33	135.00
IUUC-Tur-126237	Triticum urartu	33.87	2.00e-31	128.00
IUUC-Tbe-127632	Tupaia belangeri	50.16	2.00e-74	271.00
IUUC-Ttr-128793	Tursiops truncatus	53.20	9.00e-84	302.00
IUUC-Vda-129703	Verticillium dahliae	32.47	2.30e-02	33.90
IUUC-Vpa-130625	Vicugna pacos	45.32	5.00e-68	250.00
IUUC-Vvi-131312	Vitis vinifera	31.92	9.00e-41	159.00
IUUC-Xtr-132756	Xenopus tropicalis	48.43	2.00e-94	338.00
IUUC-Xma-133377	Xiphophorus maculatus	52.88	5.00e-96	343.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence