iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000001392.1	ENSONIT00000001756.1	ENSONIP00000001757.1
ENSONIG00000001392.1	ENSONIT00000001757.1	ENSONIP00000001758.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-96	323.7	90	731

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkg..............ellkslqklfeelwkskkkavsprellk 75
           GlkN+gNtC+mN++LQcLsn++ ++e+l   ++k + ++e++++  +              e++++l  l+++lw+ + +    r++++
   Q: 90   GLKNHGNTCFMNAILQCLSNTELFAEYLVLeHYKGEEEDEEQPK--TngvhlqkkgplakgEVTEQLSGLVRALWTFEYTPQHSRDFKN 176
           9**************************98833333333333322..223666666666677**************************** PP
   S: 76   alkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvss 164
           +++k a +f+g++q+DaqEfl +lld+++e+l+  + +++   +   +++ ++++  +++ +  s++++lFq q++s+++c++c+++s+
   Q: 177  VVSKNATQFKGNAQHDAQEFLLWLLDRVHEDLNTVNPNSRPAIKPPIEEDDQSIEGPSPPLSAGSFVQELFQAQYRSSLTCPHCQKQSN 265
           ********************************998888888888888889999999********************************* PP
   S: 165  reepfldlslpvpgkeetkke.................................................................... 185
           +++pfl +slp+p  +++ ++                                                                    
   Q: 266  TFDPFLCISLPIPLPHTR-PLyvtvvyqgkyshcmrigvavplnstvyrlrdavsretkipmdqfvltemyydgfhrsfcdddddldii 353
           *************87755.34689***************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 354  qesdsifafetpetfrlenirtkrgsllanlnhnnlkygteigrtpsfmqgavtpvtaspnknlgpekvillvcnractghqgkrfglp 442
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 443  fvlylertvtwdalqkeilekmrhllrpgvyiqvgpfslrvvgvvgityllpqderplchptveraykscgqggpphvkivvewdketk 531
           ***************************************************************************************** PP
   S: 186  ...............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeq 243
                                          +l +c++ +tkee+l  ++++ c++ck++q+ + kl+l++lP+vLilhLkRf  ++e+
   Q: 532  dylfghteeeyipdaesvylhreqhhqpqacTLAQCFQLYTKEEQLAPDDAWRCPHCKQLQQGRIKLSLWTLPDVLILHLKRF--RQEG 618
           ***********************************************************************************..99** PP
   S: 244  ksrekinkkvefple.Ldlspfctspeekqke...................kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdD 311
           ++r k+++ v fpl+ +d++p+++++++++ +                   ++ Y+L+av++H+G++++GHY+ay+kn  +g+W++fdD
   Q: 619  DRRVKMQNMVRFPLMgMDMAPHVVKRSQSSWSlpshwspwrrsyglgrnpdDYLYDLYAVCNHHGNMHGGHYTAYCKNsIDGQWYCFDD 707
           ************************977666559999999999999999999***************************66888****** PP
   S: 312  skVtevkeeevleetgstaYvlfYkrr 338
           s+Vt++  ++v++   +taY+lfY+rr
   Q: 708  SEVTAIADDDVCQ---QTAYILFYQRR 731
           *************...*********96 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MSCKAATKDK KSSFSKKLFR RGSVRSVGSF MSKLLRTLTA LSHFGSEVQT EDDKDDGGFS 60
TFKSGSKDVP MEDGDLGGFL SRERVPGVSG LKNHGNTCFM NAILQCLSNT ELFAEYLVLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAAGAAGT AAACGACAAG CTACTTGGTA GCTTAGCCCG AATGTGCCTC TGAATGTGCT 60
AGAAGATGTG AGGTTTAACT GGATTTCGTA CACTCTCTGC TTAGAGCGTA ATTGCCTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003186	Anas platyrhynchos	62.50	0.00e+00	1043.00
IUUC-Ame-010968	Astyanax mexicanus	74.26	0.00e+00	1534.00
IUUC-Dre-027372	Danio rerio	75.49	0.00e+00	1402.00
IUUC-Dor-030448	Dipodomys ordii	63.75	2.00e-166	579.00
IUUC-Gmo-039479	Gadus morhua	79.52	0.00e+00	1825.00
IUUC-Gac-041778	Gasterosteus aculeatus	85.44	0.00e+00	1965.00
IUUC-Lch-050332	Latimeria chalumnae	59.29	0.00e+00	1184.00
IUUC-Loc-051953	Lepisosteus oculatus	68.84	0.00e+00	1423.00
IUUC-Meu-056822	Macropus eugenii	52.24	0.00e+00	879.00
IUUC-Mdo-062700	Monodelphis domestica	58.20	0.00e+00	1176.00
IUUC-Ola-086745	Oryzias latipes	86.68	0.00e+00	1866.00
IUUC-Psi-093881	Pelodiscus sinensis	59.54	0.00e+00	994.00
IUUC-Pfo-097171	Poecilia formosa	89.10	0.00e+00	1986.00
IUUC-Sha-107041	Sarcophilus harrisii	58.55	0.00e+00	1043.00
IUUC-Tgu-116889	Taeniopygia guttata	62.16	0.00e+00	1041.00
IUUC-Tru-117929	Takifugu rubripes	84.41	0.00e+00	1870.00
IUUC-Tni-120236	Tetraodon nigroviridis	81.34	0.00e+00	1820.00
IUUC-Tbe-127491	Tupaia belangeri	78.26	3.00e-64	240.00
IUUC-Xtr-132509	Xenopus tropicalis	57.76	0.00e+00	1076.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence