iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011196

Ensembl Protein ID

ENSAMXP00000003551.1

UniProt Accession

W5K7J0; W5K7J0_ASTMX

Genbank Protein ID

ENSAMXP00000003551

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

APWO01087442

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000003480.1	ENSAMXT00000003551.1	ENSAMXP00000003551.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	81.25	6.00e-126	447.00	IUUC-Dme-031700
E3 activity/RING/RING	88.34	1.00e-169	593.00	IUUC-Hsa-046357
E3 activity/RING/RING	97.52	2.00e-166	582.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Astyanax mexicanus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSPTVRLQPV YSWKGVLKLF TCIAARTASK PKEVHTFQEK KIALLGNHMD EEMSRQTATA 60
LPTGTSKCAP SQRVPTLSGT TASNSDLASL FECPVCFDYV LPPILQCQSG HLVCSNCRPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGCCCA CTGTTAGGCT GCAGCCCGTC TACTCATGGA AGGGGGTGCT CAAGCTCTTC 60
ACATGCATAG CTGCCCGAAC GGCCAGCAAG CCTAAAGGTA ACACAAGCCC ACCGCTGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	37.32	9.00e-46	177.00
IUUC-Aml-001186	Ailuropoda melanoleuca	88.00	3.00e-170	590.00
IUUC-Atr-002857	Amborella trichopoda	36.43	7.00e-45	174.00
IUUC-Apl-003813	Anas platyrhynchos	97.16	9.00e-168	582.00
IUUC-Aca-005014	Anolis carolinensis	94.24	5.00e-169	586.00
IUUC-Aly-006522	Arabidopsis lyrata	37.96	1.00e-41	163.00
IUUC-Ath-007049	Arabidopsis thaliana	33.45	5.00e-42	164.00
IUUC-Bta-012887	Bos taurus	88.31	5.00e-171	593.00
IUUC-Bdi-014200	Brachypodium distachyon	37.55	2.00e-46	179.00
IUUC-Bol-015523	Brassica oleracea	35.95	2.00e-41	162.00
IUUC-Bra-017336	Brassica rapa	34.38	1.00e-41	163.00
IUUC-Cel-018320	Caenorhabditis elegans	63.17	5.00e-117	414.00
IUUC-Cja-019796	Callithrix jacchus	88.31	9.00e-171	592.00
IUUC-Cfa-020642	Canis familiaris	96.83	3.00e-169	587.00
IUUC-Cpo-022348	Cavia porcellus	97.16	2.00e-167	581.00
IUUC-Csa-023974	Chlorocebus sabaeus	88.34	5.00e-171	593.00
IUUC-Cin-025674	Ciona intestinalis	78.37	3.00e-135	473.00
IUUC-Csv-026233	Ciona savignyi	84.65	1.00e-132	465.00
IUUC-Dre-028041	Danio rerio	97.60	0.00e+00	681.00
IUUC-Dno-029764	Dasypus novemcinctus	97.17	3.00e-168	583.00
IUUC-Dme-031700	Drosophila melanogaster	83.47	6.00e-120	423.00
IUUC-Ete-032423	Echinops telfairi	96.63	2.00e-157	548.00
IUUC-Eca-033536	Equus caballus	97.16	9.00e-168	582.00
IUUC-Eeu-035314	Erinaceus europaeus	96.63	1.00e-157	548.00
IUUC-Fca-035362	Felis catus	87.69	2.00e-170	591.00
IUUC-Fal-037487	Ficedula albicollis	87.65	8.00e-169	585.00
IUUC-Gga-040269	Gallus gallus	97.16	9.00e-168	582.00
IUUC-Gac-042282	Gasterosteus aculeatus	98.94	2.00e-169	587.00
IUUC-Gma-042926	Glycine max	34.44	8.00e-41	160.00
IUUC-Ggo-045444	Gorilla gorilla	88.34	5.00e-171	593.00
IUUC-Hsa-046357	Homo sapiens	88.34	5.00e-171	593.00
IUUC-Hvu-047574	Hordeum vulgare	36.96	1.00e-45	176.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	97.16	2.00e-167	581.00
IUUC-Lch-049504	Latimeria chalumnae	96.81	3.00e-167	580.00
IUUC-Lpe-050879	Leersia perrieri	40.25	6.00e-43	167.00
IUUC-Loc-052191	Lepisosteus oculatus	96.69	5.00e-178	616.00
IUUC-Laf-053668	Loxodonta africana	97.16	9.00e-168	582.00
IUUC-Mcc-054640	Macaca mulatta	88.34	5.00e-171	593.00
IUUC-Mtr-058747	Medicago truncatula	34.81	3.00e-42	165.00
IUUC-Mga-059503	Meleagris gallopavo	97.17	2.00e-168	584.00
IUUC-Mmr-060794	Microcebus murinus	97.16	2.00e-167	581.00
IUUC-Mmu-064129	Mus musculus	97.52	6.00e-168	582.00
IUUC-Mac-065014	Musa acuminata	35.05	4.00e-43	168.00
IUUC-Mpu-066488	Mustela putorius furo	88.00	2.00e-170	590.00
IUUC-Mlu-067207	Myotis lucifugus	97.17	8.00e-169	585.00
IUUC-Nle-069706	Nomascus leucogenys	88.31	9.00e-171	592.00
IUUC-Ont-071849	Oreochromis niloticus	98.94	6.00e-170	589.00
IUUC-Ocu-074876	Oryctolagus cuniculus	88.00	7.00e-170	589.00
IUUC-Oba-075454	Oryza barthii	40.66	3.00e-43	168.00
IUUC-Obr-076037	Oryza brachyantha	35.43	1.00e-40	160.00
IUUC-Ogl-077712	Oryza glaberrima	40.66	3.00e-43	168.00
IUUC-Ogu-078910	Oryza glumaepatula	40.66	5.00e-43	168.00
IUUC-Oin-079749	Oryza indica	40.66	3.00e-43	168.00
IUUC-Olo-080244	Oryza longistaminata	34.83	1.00e-40	160.00
IUUC-Ome-081318	Oryza meridionalis	40.66	3.00e-43	168.00
IUUC-Oni-083109	Oryza nivara	40.66	3.00e-43	168.00
IUUC-Opu-084065	Oryza punctata	41.08	2.00e-43	169.00
IUUC-Oru-084785	Oryza rufipogon	40.66	3.00e-43	168.00
IUUC-Osa-085610	Oryza sativa	40.66	3.00e-43	168.00
IUUC-Ola-086814	Oryzias latipes	98.94	2.00e-169	587.00
IUUC-Oga-088399	Otolemur garnettii	97.16	2.00e-167	581.00
IUUC-Oar-089323	Ovis aries	88.24	9.00e-170	588.00
IUUC-Ptr-090692	Pan troglodytes	97.17	3.00e-168	583.00
IUUC-Pan-092012	Papio anubis	88.34	5.00e-171	593.00
IUUC-Psi-093687	Pelodiscus sinensis	85.63	8.00e-171	592.00
IUUC-Pma-094387	Petromyzon marinus	92.61	3.00e-159	553.00
IUUC-Ppa-095212	Physcomitrella patens	35.82	9.00e-41	160.00
IUUC-Pfo-097134	Poecilia formosa	98.94	2.00e-169	587.00
IUUC-Pab-097555	Pongo abelii	88.34	5.00e-171	593.00
IUUC-Pop-099970	Populus trichocarpa	35.29	8.00e-45	173.00
IUUC-Ppe-101760	Prunus persica	36.10	9.00e-44	170.00
IUUC-Rno-104866	Rattus norvegicus	97.52	6.00e-168	582.00
IUUC-Sha-106547	Sarcophilus harrisii	87.50	5.00e-170	590.00
IUUC-Smo-109412	Selaginella moellendorffii	35.18	5.00e-39	154.00
IUUC-Sit-110595	Setaria italica	37.11	2.00e-42	166.00
IUUC-Sly-111259	Solanum lycopersicum	36.76	1.00e-41	163.00
IUUC-Stu-112474	Solanum tuberosum	32.68	3.00e-43	168.00
IUUC-Sbi-114090	Sorghum bicolor	37.50	3.00e-43	168.00
IUUC-Tgu-116579	Taeniopygia guttata	97.16	9.00e-168	582.00
IUUC-Tru-118250	Takifugu rubripes	93.97	4.00e-160	556.00
IUUC-Tni-120488	Tetraodon nigroviridis	97.87	6.00e-165	572.00
IUUC-Tca-121228	Theobroma cacao	34.01	9.00e-42	163.00
IUUC-Tae-123647	Triticum aestivum	37.32	9.00e-46	177.00
IUUC-Tur-126259	Triticum urartu	35.11	1.00e-39	156.00
IUUC-Ttr-129166	Tursiops truncatus	96.68	4.00e-141	494.00
IUUC-Vvi-131451	Vitis vinifera	37.86	5.00e-42	164.00
IUUC-Xtr-132553	Xenopus tropicalis	97.16	2.00e-167	580.00
IUUC-Xma-133670	Xiphophorus maculatus	98.94	2.00e-169	587.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence