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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Ath-007504
Ensembl Protein ID AT5G44740.2
UniProt Accession Q8H2D5; A4ZYA7; A4ZYA8; O48586; Q8H1C5; Q9C5F5; POLH_ARATH
Genbank Protein ID CAC94893.1; ABP49608.1; ABP49609.1; AAN39011.1; BAB08827.1; AAC79146.1; AED95154.1; AED95155.1; AAK25993.1; AAM44927.1
Protein Name DNA polymerase eta; Radiation-sensitive protein 30; Y-family DNA polymerase H
Genbank Nucleotide ID AJ416380; EF495196; EF495197; AY151396; AB016874; AC002342; CP002688; CP002688; AF360283; AY113879
Gene Name POLH; RAD30; At5g44740; K23L20.8; T19K24.15
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT5G44740 AT5G44740.2 AT5G44740.2
AT5G44740 AT5G44740.1 AT5G44740.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexPINAHINTMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/ZnF/UBZ 41.24 3.00e-92 337.00 IUUC-Hsa-046608
UBD/ZnF/UBZ 25.75 2.00e-20 95.50 IUUC-Sce-106137
UBD/Alpha-Helix/UBM 30.96 5.00e-31 133.00 IUUC-Xtr-132975
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     Error-free DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis (TLS), where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers and confers resistance to ultraviolet light. Depending on the context, it inserts the correct base, but may cause base transitions and transversions. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Exhibits cyclobutane dimer nonmutagenic bypass activity in vitro.
 Error-free DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis (TLS), where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers and confers resistance to ultraviolet light. Depending on the context, it inserts the correct base, but may cause base transitions and transversions. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Exhibits cyclobutane dimer nonmutagenic bypass activity in vitro.
Protein Sequence
(Fasta)
MPVARPEASD ARVIAHVDMD CFYVQVEQRK QPELRGLPSA VVQYNEWQGG GLIAVSYEAR 60
KCGVKRSMRG DEAKAACPQI QLVQVPVARG KADLNLYRSA GSEVVSILAK SGKCERASID 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ath-007504|UBD,UBZ;UBD,UBM|Arabidopsis thaliana
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Nucleotide Sequence
(Fasta)
TATTTTCGCG CGCTATTCAT CAGTCATCAT CCCCAAGAAA CCCCTCTTTC GGTGGTAAAA 60
ACTCTCTCTC TCTCTCTCTC TCTCCCTCTG ATTTCTGCGG AGATTTCTGA AATAGAAATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ath-007504|UBD,UBZ;UBD,UBM|Arabidopsis thaliana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0237--DNA synthesis
KW-0238--DNA-binding
KW-0239--DNA-directed DNA polymerase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0515--Mutator protein
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0704--Schiff base
KW-0808--Transferase
Interpro

IPR017061--DNA_pol_eta/kappa
IPR017961--DNA_pol_Y-fam_little_finger
IPR001126--UmuC
PROSITE

PS50173--UMUC
Pfam

PF00817--IMS
PF11799--IMS_C
Gene Ontology

GO:0005634--C:nucleus
GO:0003684--F:damaged DNA binding
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0046872--F:metal ion binding
GO:0006260--P:DNA replication
GO:0042276--P:error-prone translesion synthesis
GO:0010224--P:response to UV-B
GO:0009650--P:UV protection
KEGG ath:AT5G44740
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000901 Aegilops tauschii 72.59 7.00e-136 476.00
IUUC-Aml-001521 Ailuropoda melanoleuca 41.35 1.00e-92 333.00
IUUC-Atr-002484 Amborella trichopoda 70.93 0.00e+00 687.00
IUUC-Apl-003696 Anas platyrhynchos 35.89 4.00e-49 189.00
IUUC-Aca-005058 Anolis carolinensis 42.46 2.00e-88 319.00
IUUC-Aly-006400 Arabidopsis lyrata 92.71 0.00e+00 1269.00
IUUC-Ago-007927 Ashbya gossypii 26.93 3.00e-18 86.30
IUUC-Acl-008115 Aspergillus clavatus 30.07 1.00e-42 167.00
IUUC-Afl-008392 Aspergillus flavus 30.62 8.00e-43 167.00
IUUC-Afu-008955 Aspergillus fumigatus 30.81 4.00e-41 162.00
IUUC-Ani-009140 Aspergillus nidulans 31.71 1.00e-40 160.00
IUUC-Ang-009579 Aspergillus niger 31.37 5.00e-42 165.00
IUUC-Aor-010144 Aspergillus oryzae 29.53 2.00e-42 166.00
IUUC-Ate-010589 Aspergillus terreus 31.39 2.00e-41 164.00
IUUC-Ame-010824 Astyanax mexicanus 42.83 4.00e-97 348.00
IUUC-Bgr-012128 Blumeria graminis 32.90 4.00e-44 172.00
IUUC-Bta-013570 Bos taurus 39.87 4.00e-78 285.00
IUUC-Bci-013638 Botrytis cinerea 29.15 2.00e-42 166.00
IUUC-Bdi-014945 Brachypodium distachyon 52.65 0.00e+00 642.00
IUUC-Bol-016267 Brassica oleracea 83.98 0.00e+00 1138.00
IUUC-Bra-017812 Brassica rapa 81.73 0.00e+00 1141.00
IUUC-Cel-018475 Caenorhabditis elegans 34.82 1.00e-61 230.00
IUUC-Cja-019783 Callithrix jacchus 36.26 3.00e-60 226.00
IUUC-Cfa-021182 Canis familiaris 45.27 1.00e-87 316.00
IUUC-Cpo-021579 Cavia porcellus 41.63 3.00e-83 302.00
IUUC-Cre-022939 Chlamydomonas reinhardtii 31.74 3.00e-26 113.00
IUUC-Csa-023918 Chlorocebus sabaeus 41.21 4.00e-86 311.00
IUUC-Cho-024661 Choloepus hoffmanni 44.28 1.00e-84 306.00
IUUC-Cin-025717 Ciona intestinalis 44.60 2.00e-66 245.00
IUUC-Csv-026134 Ciona savignyi 62.90 1.00e-43 168.00
IUUC-Cgl-026574 Colletotrichum gloeosporioides 29.93 1.00e-40 160.00
IUUC-Cne-026787 Cryptococcus neoformans 29.50 5.00e-31 129.00
IUUC-Cme-027172 Cyanidioschyzon merolae 28.42 3.00e-41 162.00
IUUC-Dre-028594 Danio rerio 43.70 9.00e-92 330.00
IUUC-Dno-029221 Dasypus novemcinctus 41.84 9.00e-87 313.00
IUUC-Dor-030818 Dipodomys ordii 44.91 5.00e-45 175.00
IUUC-Dse-031223 Dothistroma septosporum 32.43 3.00e-42 165.00
IUUC-Dme-031727 Drosophila melanogaster 38.34 7.00e-86 311.00
IUUC-Ete-033036 Echinops telfairi 40.93 1.00e-83 303.00
IUUC-Eca-034307 Equus caballus 41.14 6.00e-86 311.00
IUUC-Eeu-035197 Erinaceus europaeus 55.28 7.00e-32 131.00
IUUC-Fca-035449 Felis catus 40.89 6.00e-85 307.00
IUUC-Fal-036901 Ficedula albicollis 46.05 1.00e-42 167.00
IUUC-Fox-037911 Fusarium oxysporum 32.39 1.00e-42 167.00
IUUC-Fso-038351 Fusarium solani 30.77 3.00e-39 156.00
IUUC-Gmo-039408 Gadus morhua 40.77 2.00e-95 342.00
IUUC-Ggr-039856 Gaeumannomyces graminis 29.27 2.00e-36 147.00
IUUC-Gga-040686 Gallus gallus 45.89 6.00e-85 308.00
IUUC-Gac-042191 Gasterosteus aculeatus 40.86 1.00e-92 333.00
IUUC-Gma-043642 Glycine max 57.91 0.00e+00 766.00
IUUC-Ggo-045651 Gorilla gorilla 29.26 1.00e-35 144.00
IUUC-Hsa-046608 Homo sapiens 44.44 3.00e-85 308.00
IUUC-Hvu-047627 Hordeum vulgare 53.83 0.00e+00 647.00
IUUC-Itr-048689 Ictidomys tridecemlineatus 40.25 7.00e-83 301.00
IUUC-Kpa-049113 Komagataella pastoris 27.59 1.00e-25 110.00
IUUC-Lch-049987 Latimeria chalumnae 46.98 2.00e-46 180.00
IUUC-Lpe-051542 Leersia perrieri 55.17 0.00e+00 661.00
IUUC-Loc-052036 Lepisosteus oculatus 37.44 3.00e-73 269.00
IUUC-Lma-053317 Leptosphaeria maculans 32.21 3.00e-40 159.00
IUUC-Laf-053792 Loxodonta africana 42.11 9.00e-87 313.00
IUUC-Mcc-055144 Macaca mulatta 44.58 5.00e-85 307.00
IUUC-Meu-056553 Macropus eugenii 36.84 4.00e-49 187.00
IUUC-Mor-057207 Magnaporthe oryzae 30.17 1.00e-41 164.00
IUUC-Mpo-057497 Magnaporthe poae 29.11 6.00e-40 158.00
IUUC-Mtr-058741 Medicago truncatula 59.14 0.00e+00 773.00
IUUC-Mla-059160 Melampsora laricipopulina 29.59 7.00e-41 161.00
IUUC-Mga-059487 Meleagris gallopavo 46.85 2.00e-46 179.00
IUUC-Mvi-060508 Microbotryum violaceum 30.58 3.00e-40 159.00
IUUC-Mmr-061610 Microcebus murinus 40.71 7.00e-85 307.00
IUUC-Mdo-061810 Monodelphis domestica 43.53 1.00e-81 296.00
IUUC-Mmu-063400 Mus musculus 40.72 9.00e-84 303.00
IUUC-Mac-064894 Musa acuminata 55.54 0.00e+00 705.00
IUUC-Mpu-066225 Mustela putorius furo 38.82 9.00e-68 250.00
IUUC-Mlu-067052 Myotis lucifugus 41.05 3.00e-84 305.00
IUUC-Nfi-068296 Neosartorya fischeri 28.03 7.00e-41 161.00
IUUC-Ncr-068957 Neurospora crassa 33.42 3.00e-45 176.00
IUUC-Nle-069730 Nomascus leucogenys 38.92 7.00e-68 251.00
IUUC-Opr-070411 Ochotona princeps 37.46 7.00e-43 168.00
IUUC-Ont-071788 Oreochromis niloticus 41.52 2.00e-94 339.00
IUUC-Oan-073017 Ornithorhynchus anatinus 43.42 4.00e-83 301.00
IUUC-Ocu-074059 Oryctolagus cuniculus 44.09 4.00e-81 295.00
IUUC-Oba-075708 Oryza barthii 56.95 0.00e+00 660.00
IUUC-Obr-076475 Oryza brachyantha 53.79 0.00e+00 659.00
IUUC-Ogl-077868 Oryza glaberrima 56.37 0.00e+00 667.00
IUUC-Ogu-078157 Oryza glumaepatula 56.95 0.00e+00 659.00
IUUC-Oin-079707 Oryza indica 71.75 3.00e-142 498.00
IUUC-Olo-080763 Oryza longistaminata 63.73 3.00e-169 587.00
IUUC-Oni-082290 Oryza nivara 55.62 0.00e+00 654.00
IUUC-Opu-083795 Oryza punctata 56.12 0.00e+00 672.00
IUUC-Oru-085178 Oryza rufipogon 57.10 0.00e+00 662.00
IUUC-Osa-086176 Oryza sativa 56.37 0.00e+00 666.00
IUUC-Ola-087517 Oryzias latipes 41.70 7.00e-95 340.00
IUUC-Olu-087640 Ostreococcus lucimarinus 38.70 3.00e-83 301.00
IUUC-Oga-088142 Otolemur garnettii 41.63 1.00e-86 313.00
IUUC-Oar-089974 Ovis aries 39.41 2.00e-78 286.00
IUUC-Ptr-090591 Pan troglodytes 44.44 3.00e-85 308.00
IUUC-Pan-091688 Papio anubis 41.21 4.00e-86 311.00
IUUC-Psi-092952 Pelodiscus sinensis 35.29 5.00e-54 204.00
IUUC-Pma-094381 Petromyzon marinus 27.39 1.00e-18 87.80
IUUC-Pno-094892 Phaeosphaeria nodorum 33.72 4.00e-38 152.00
IUUC-Ppa-095504 Physcomitrella patens 53.77 2.00e-139 488.00
IUUC-Pfo-096999 Poecilia formosa 41.92 2.00e-94 340.00
IUUC-Pab-098195 Pongo abelii 36.63 2.00e-33 136.00
IUUC-Pop-099023 Populus trichocarpa 72.45 0.00e+00 739.00
IUUC-Pca-100689 Procavia capensis 35.48 7.00e-64 238.00
IUUC-Ppe-101947 Prunus persica 62.74 0.00e+00 823.00
IUUC-Pva-102392 Pteropus vampyrus 41.48 3.00e-84 305.00
IUUC-Pgr-103588 Puccinia graminis 29.72 2.00e-41 163.00
IUUC-Ptt-103860 Puccinia triticina 32.99 2.00e-39 156.00
IUUC-Pte-104326 Pyrenophora teres 31.46 5.00e-40 158.00
IUUC-Pyt-104573 Pyrenophora triticirepentis 31.97 3.00e-39 156.00
IUUC-Rno-105209 Rattus norvegicus 42.27 4.00e-85 308.00
IUUC-Sce-106137 Saccharomyces cerevisiae 25.82 5.00e-21 95.50
IUUC-Sha-106467 Sarcophilus harrisii 43.64 4.00e-85 308.00
IUUC-Sja-107701 Schizosaccharomyces japonicus 29.95 2.00e-32 134.00
IUUC-Spo-108204 Schizosaccharomyces pombe 29.55 3.00e-41 163.00
IUUC-Ssl-108431 Sclerotinia sclerotiorum 29.78 2.00e-32 133.00
IUUC-Smo-109141 Selaginella moellendorffii 61.31 9.00e-149 519.00
IUUC-Sit-110280 Setaria italica 56.09 0.00e+00 702.00
IUUC-Sly-111756 Solanum lycopersicum 56.73 0.00e+00 743.00
IUUC-Stu-112504 Solanum tuberosum 71.56 7.00e-134 469.00
IUUC-Sar-113088 Sorex araneus 36.82 2.00e-64 239.00
IUUC-Sbi-114731 Sorghum bicolor 55.38 0.00e+00 693.00
IUUC-Sre-115144 Sporisorium reilianum 39.06 5.00e-20 92.80
IUUC-Ssc-115300 Sus scrofa 39.83 2.00e-82 299.00
IUUC-Tgu-117128 Taeniopygia guttata 47.03 6.00e-43 166.00
IUUC-Tru-118550 Takifugu rubripes 42.58 2.00e-93 336.00
IUUC-Tsy-119086 Tarsius syrichta 30.97 2.00e-33 137.00
IUUC-Tni-120908 Tetraodon nigroviridis 41.08 2.00e-92 333.00
IUUC-Tca-121449 Theobroma cacao 59.86 0.00e+00 813.00
IUUC-Tre-122135 Trichoderma reesei 28.82 2.00e-38 153.00
IUUC-Tvi-122467 Trichoderma virens 30.83 9.00e-42 164.00
IUUC-Tae-125677 Triticum aestivum 53.09 0.00e+00 639.00
IUUC-Tur-126600 Triticum urartu 67.91 1.00e-166 579.00
IUUC-Tme-126967 Tuber melanosporum 34.18 8.00e-47 181.00
IUUC-Tbe-127444 Tupaia belangeri 41.25 2.00e-83 302.00
IUUC-Ttr-128797 Tursiops truncatus 39.26 9.00e-78 284.00
IUUC-Uma-129609 Ustilago maydis 34.59 3.00e-19 90.10
IUUC-Vda-130004 Verticillium dahliae 31.35 1.00e-42 167.00
IUUC-Vpa-130029 Vicugna pacos 36.22 3.00e-47 182.00
IUUC-Vvi-131117 Vitis vinifera 60.92 0.00e+00 743.00
IUUC-Xtr-132975 Xenopus tropicalis 30.96 2.00e-32 133.00
IUUC-Xma-133279 Xiphophorus maculatus 42.83 5.00e-96 344.00
IUUC-Yli-134477 Yarrowia lipolytica 29.32 4.00e-29 122.00
IUUC-Zma-135837 Zea mays 54.70 0.00e+00 691.00
Created Date 25-Jun-2017

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