iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000105339.10	ENST00000518347.5	ENSP00000430695.1
ENSG00000105339.10	ENST00000518198.1	ENSP00000428641.1
ENSG00000105339.10	ENST00000519811.5	ENSP00000428714.1
ENSG00000105339.10	ENST00000520986.5	ENSP00000429780.1
ENSG00000105339.10	ENST00000523058.5	ENSP00000430786.1
ENSG00000105339.10	ENST00000518668.5	ENSP00000428276.1
ENSG00000105339.10	ENST00000518249.5	ENSP00000428155.1
ENSG00000105339.10	ENST00000517985.5	ENSP00000429533.1
ENSG00000105339.10	ENST00000520725.5	ENSP00000429725.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
HINT	InWeb_IM
Disease-associated Variation
ClinVar	GWASdb
Post-translational Modifications (PTMs)
CPLM	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.70e-06	28.4	1065	1101

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf......sdtllvsGsdDgtikvWDlrtg 33
           H +svt+l        +   + s+s Dg + vW+++t 
   Q: 1065 HCSSVTDLIVqdgqeaP-SNVYSCSMDGMVLVWNVSTL 1101
           89999999667665543.348*************9875 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAEAASPHLS LPSGLLELCA LLGAPRDSLR SLEQVAYKKG VKHLSALLDP EVLSIFVPPF 60
ISKEDSQMAG ANCGTLGKTR MRSLRKKREK PRPEQWKGLP GPPRAPEPED VAVPGGVDLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTCCTGG TGGCGCCGTG AAGATCTGTG TGTGTAGTTC TTGGAAAGAT TCCAGGTGCT 60
TGAAAACGAC GTCTCAGTGG GTCAAGGGTG AGTGGGGAAT CAGAGGTGAC CCATGTCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005112--dDENN_dom
IPR001194--DENN_dom
IPR005113--uDENN_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50947--DDENN
PS50211--DENN
PS50946--UDENN
PS00678--WD_REPEATS_1
PS50294--WD_REPEATS_REGION

Pfam

PF02141--DENN

SMART

SM00801--dDENN
SM00799--DENN
SM00320--WD40

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002428	Ailuropoda melanoleuca	78.10	0.00e+00	1892.00
IUUC-Ame-011614	Astyanax mexicanus	52.30	0.00e+00	1311.00
IUUC-Cfa-021105	Canis familiaris	78.61	0.00e+00	1904.00
IUUC-Csv-025827	Ciona savignyi	24.14	2.00e-06	48.90
IUUC-Dor-030471	Dipodomys ordii	79.00	0.00e+00	1002.00
IUUC-Gmo-039067	Gadus morhua	52.25	6.00e-107	382.00
IUUC-Gac-041903	Gasterosteus aculeatus	50.54	0.00e+00	1201.00
IUUC-Loc-052634	Lepisosteus oculatus	55.30	0.00e+00	1417.00
IUUC-Mcc-055358	Macaca mulatta	90.51	0.00e+00	2220.00
IUUC-Mmr-060775	Microcebus murinus	80.87	0.00e+00	2087.00
IUUC-Mmu-063704	Mus musculus	78.32	0.00e+00	1972.00
IUUC-Ont-072676	Oreochromis niloticus	50.12	0.00e+00	1229.00
IUUC-Oni-082213	Oryza nivara	26.18	1.00e-20	95.90
IUUC-Olu-087744	Ostreococcus lucimarinus	24.73	8.00e-10	60.10
IUUC-Oga-088682	Otolemur garnettii	80.86	0.00e+00	2063.00
IUUC-Ptr-090684	Pan troglodytes	97.50	0.00e+00	2269.00
IUUC-Pan-092645	Papio anubis	90.75	0.00e+00	2234.00
IUUC-Pfo-096475	Poecilia formosa	51.48	0.00e+00	1214.00
IUUC-Ppe-101883	Prunus persica	22.91	4.00e-20	94.00
IUUC-Rno-105167	Rattus norvegicus	77.46	0.00e+00	1929.00
IUUC-Ssc-115459	Sus scrofa	74.60	5.00e-107	380.00
IUUC-Tru-118373	Takifugu rubripes	23.12	1.00e-14	76.30
IUUC-Tni-119750	Tetraodon nigroviridis	23.56	2.00e-14	75.50

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence