iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.30e-06	26.4	1067	1103

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.....sdtllvsGsdDgtikvWDlrtgv 34
           H + vt+la      +   + s+s Dgt+  W+++t +
   Q: 1067 HRSAVTGLAVpsgkkP-SAVYSCSLDGTVLAWNVSTLR 1103
           999******9754332.449*************98876 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAEPSARHLS LPSGLLELCA LLGASQDSLR GLEQIAQKRG VNGASSLVPE VLSVFVPPFT 60
TKEDGQVVGA SCTLSKGRRR SFRKKREKPR MESWKSHPGD SKGPDSEDVT IPGGVDLLAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCAAGTCCG GCTAGACACG CCTCCACAGA AGTCCTGCCC CTGCCAAATC ACAGACCAGG 60
CTCCTTCGTG TTGTACAGGC CTCCTAGGTC CCGCCCACAC CAGACCCCCC ACAGACCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005112--dDENN_dom
IPR001194--DENN_dom
IPR005113--uDENN_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50947--DDENN
PS50211--DENN
PS50946--UDENN
PS00678--WD_REPEATS_1
PS50294--WD_REPEATS_REGION

Pfam

PF02141--DENN

SMART

SM00801--dDENN
SM00799--DENN
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0017112--F:Rab guanyl-nucleotide exchange factor activity
GO:0044257--P:cellular protein catabolic process
GO:0008333--P:endosome to lysosome transport

KEGG

rno:315055

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002428	Ailuropoda melanoleuca	78.98	0.00e+00	1951.00
IUUC-Ame-011614	Astyanax mexicanus	53.93	0.00e+00	1377.00
IUUC-Cfa-021105	Canis familiaris	78.51	0.00e+00	1949.00
IUUC-Dor-030471	Dipodomys ordii	83.26	0.00e+00	1112.00
IUUC-Gmo-039067	Gadus morhua	48.81	2.00e-102	367.00
IUUC-Gac-041903	Gasterosteus aculeatus	51.35	0.00e+00	1275.00
IUUC-Hsa-046572	Homo sapiens	77.47	0.00e+00	1877.00
IUUC-Loc-052634	Lepisosteus oculatus	56.25	0.00e+00	1493.00
IUUC-Mcc-055358	Macaca mulatta	78.13	0.00e+00	1949.00
IUUC-Mmr-060775	Microcebus murinus	79.07	0.00e+00	2089.00
IUUC-Mmu-063704	Mus musculus	92.80	0.00e+00	2389.00
IUUC-Ont-072676	Oreochromis niloticus	51.55	0.00e+00	1312.00
IUUC-Oni-082213	Oryza nivara	26.18	4.00e-19	90.90
IUUC-Olu-087744	Ostreococcus lucimarinus	27.65	4.00e-12	67.80
IUUC-Oga-088682	Otolemur garnettii	79.44	0.00e+00	2056.00
IUUC-Ptr-090684	Pan troglodytes	77.79	0.00e+00	1812.00
IUUC-Pan-092645	Papio anubis	78.38	0.00e+00	1965.00
IUUC-Pfo-096475	Poecilia formosa	51.71	0.00e+00	1286.00
IUUC-Ppe-101883	Prunus persica	21.24	9.00e-20	92.80
IUUC-Ssc-115459	Sus scrofa	68.29	7.00e-100	356.00
IUUC-Tru-118373	Takifugu rubripes	23.95	3.00e-16	81.30
IUUC-Tni-119750	Tetraodon nigroviridis	23.62	1.00e-15	79.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence