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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018445
Ensembl Protein ID F45H11.2
UniProt Accession Q93725; NEDD8_CAEEL
Genbank Protein ID CAB01708.1
Protein Name NEDD8; Neddylin; Protein NED-8; Ubiquitin-like protein Nedd8
Genbank Nucleotide ID Z78420
Gene Name ned-8; F45H11.2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00003587 F45H11.2 F45H11.2
Annotation
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UBL/NEDD8 2.60e-42 143.2 1 76
ULD/UDP/UBQ/UBQ_PIM 5.90e-22 77.7 1 71
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UBL/NEDD8
   S: 1    mlikvktLtgkeieieieesdtierikerveekeGiPPsqqrliyaGkqleddktaadynlekgsvLhLvLaLrGG 76
           mlikvktLtgkeie++ie+ d++erike+veekeGiPP qqrli+aGkq++ddktaady++ +gsvLhLvLaLrGG
   Q: 1    MLIKVKTLTGKEIELDIEPNDRVERIKEKVEEKEGIPPPQQRLIFAGKQMNDDKTAADYKVLGGSVLHLVLALRGG 76
           89*************************************************************************9 PP
   

   ULD/UDP/UBQ/UBQ_PIM
   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvv 71
           m ++vktl+gke+el+++++d ve+ Kek++++ g+pp qq+LI+aGk+++Dd+t  ++++  gsv+hlv+
   Q: 1    MLIKVKTLTGKEIELDIEPNDRVERIKEKVEEKEGIPPPQQRLIFAGKQMNDDKTAADYKVLGGSVLHLVL 71
           789******************************************************************97 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
 Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
Protein Sequence
(Fasta)
MLIKVKTLTG KEIELDIEPN DRVERIKEKV EEKEGIPPPQ QRLIFAGKQM NDDKTAADYK 60
VLGGSVLHLV LALRGGF 77
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018445|ULD,NEDD8;ULD,UBQ_PIM|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGTACTTCA TTCGCTTTTC TTTCGTCTTG ACGAACGGTG AGCAATTTTC TATCTCATTT 60
CTTGAATTTT TCTTCTTCTT TTCTCAATAA TATATTTCAT AGCTATGAGA ACTTTTAATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018445|ULD,NEDD8;ULD,UBQ_PIM|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
Pfam

PF00240--ubiquitin
PRINTS

PR00348--UBIQUITIN
SMART

SM00213--UBQ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0007275--P:multicellular organism development
GO:0043066--P:negative regulation of apoptotic process
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0010629--P:negative regulation of gene expression
GO:0043065--P:positive regulation of apoptotic process
KEGG cel:CELE_F45H11.2
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001930 Ailuropoda melanoleuca 83.33 1.00e-18 82.40
IUUC-Atr-003172 Amborella trichopoda 78.95 4.00e-32 127.00
IUUC-Ago-008002 Ashbya gossypii 64.47 1.00e-24 102.00
IUUC-Acl-008037 Aspergillus clavatus 80.26 5.00e-31 123.00
IUUC-Afu-008979 Aspergillus fumigatus 75.00 2.00e-29 118.00
IUUC-Ani-009466 Aspergillus nidulans 80.26 5.00e-31 123.00
IUUC-Ang-009839 Aspergillus niger 78.95 1.00e-30 122.00
IUUC-Ame-011045 Astyanax mexicanus 86.84 2.00e-27 112.00
IUUC-Bgr-011975 Blumeria graminis 75.00 5.00e-28 113.00
IUUC-Bta-013565 Bos taurus 81.25 6.00e-20 87.00
IUUC-Bci-013689 Botrytis cinerea 71.43 2.00e-20 88.60
IUUC-Cja-019714 Callithrix jacchus 86.15 1.00e-21 92.40
IUUC-Cfa-020576 Canis familiaris 83.33 1.00e-18 82.40
IUUC-Cpo-022447 Cavia porcellus 80.00 1.00e-19 86.30
IUUC-Csa-023443 Chlorocebus sabaeus 84.21 3.00e-34 134.00
IUUC-Cho-024788 Choloepus hoffmanni 88.16 6.00e-28 113.00
IUUC-Cin-025290 Ciona intestinalis 89.47 4.00e-29 117.00
IUUC-Cgl-026712 Colletotrichum gloeosporioides 73.68 8.00e-28 112.00
IUUC-Cme-027142 Cyanidioschyzon merolae 75.00 1.00e-24 103.00
IUUC-Dre-028273 Danio rerio 86.84 2.00e-27 111.00
IUUC-Dor-030213 Dipodomys ordii 88.16 4.00e-28 114.00
IUUC-Dse-031407 Dothistroma septosporum 76.32 1.00e-29 119.00
IUUC-Dme-031610 Drosophila melanogaster 89.47 1.00e-35 139.00
IUUC-Ete-032442 Echinops telfairi 88.16 8.00e-28 113.00
IUUC-Eca-033619 Equus caballus 86.15 1.00e-21 92.40
IUUC-Eeu-035250 Erinaceus europaeus 86.15 1.00e-21 92.40
IUUC-Fca-036565 Felis catus 81.97 8.00e-19 83.20
IUUC-Fal-036836 Ficedula albicollis 77.27 9.00e-19 83.20
IUUC-Fox-037878 Fusarium oxysporum 76.32 8.00e-29 116.00
IUUC-Fso-038359 Fusarium solani 76.32 8.00e-29 116.00
IUUC-Gmo-038699 Gadus morhua 84.62 8.00e-21 89.70
IUUC-Ggr-039872 Gaeumannomyces graminis 78.95 7.00e-30 120.00
IUUC-Gga-041132 Gallus gallus 86.30 2.00e-25 106.00
IUUC-Gac-042098 Gasterosteus aculeatus 86.84 3.00e-27 111.00
IUUC-Ggo-044777 Gorilla gorilla 84.75 2.00e-18 82.00
IUUC-Hsa-045911 Homo sapiens 86.15 1.00e-21 92.40
IUUC-Hvu-047076 Hordeum vulgare 78.95 2.00e-23 98.20
IUUC-Itr-048900 Ictidomys tridecemlineatus 88.16 4.00e-28 114.00
IUUC-Lch-050564 Latimeria chalumnae 86.84 2.00e-27 111.00
IUUC-Lma-053069 Leptosphaeria maculans 77.63 3.00e-30 121.00
IUUC-Laf-053906 Loxodonta africana 84.21 5.00e-26 107.00
IUUC-Mcc-054619 Macaca mulatta 72.13 4.00e-21 90.90
IUUC-Meu-056784 Macropus eugenii 84.62 7.00e-21 90.10
IUUC-Mor-057128 Magnaporthe oryzae 81.58 6.00e-31 123.00
IUUC-Mpo-057329 Magnaporthe poae 80.26 3.00e-30 121.00
IUUC-Mla-058992 Melampsora laricipopulina 72.37 8.00e-22 93.20
IUUC-Mvi-060369 Microbotryum violaceum 73.68 1.00e-27 112.00
IUUC-Mdo-062773 Monodelphis domestica 81.67 7.00e-18 80.10
IUUC-Mmu-063552 Mus musculus 86.36 4.00e-22 94.40
IUUC-Mpu-065984 Mustela putorius furo 85.92 5.00e-25 103.00
IUUC-Nfi-068282 Neosartorya fischeri 75.00 2.00e-29 118.00
IUUC-Ncr-068922 Neurospora crassa 78.95 5.00e-30 120.00
IUUC-Nle-069841 Nomascus leucogenys 85.48 4.00e-19 86.70
IUUC-Ocu-074716 Oryctolagus cuniculus 86.15 1.00e-21 92.40
IUUC-Opu-083943 Oryza punctata 59.46 9.00e-22 92.80
IUUC-Olu-087844 Ostreococcus lucimarinus 82.67 6.00e-23 97.10
IUUC-Oar-089805 Ovis aries 83.33 1.00e-18 82.40
IUUC-Pan-092763 Papio anubis 86.15 1.00e-21 92.40
IUUC-Pno-095039 Phaeosphaeria nodorum 77.92 6.00e-31 123.00
IUUC-Pfo-096478 Poecilia formosa 86.84 1.00e-27 112.00
IUUC-Pab-098633 Pongo abelii 84.62 6.00e-21 90.10
IUUC-Pca-100180 Procavia capensis 86.15 1.00e-21 92.40
IUUC-Pva-102640 Pteropus vampyrus 86.15 1.00e-21 92.40
IUUC-Pgr-103621 Puccinia graminis 68.42 6.00e-27 110.00
IUUC-Pte-104313 Pyrenophora teres 77.92 1.00e-31 125.00
IUUC-Pyt-104549 Pyrenophora triticirepentis 76.62 4.00e-31 124.00
IUUC-Rno-105633 Rattus norvegicus 86.36 4.00e-22 94.40
IUUC-Sha-107504 Sarcophilus harrisii 80.26 4.00e-25 104.00
IUUC-Sja-107751 Schizosaccharomyces japonicus 82.89 1.00e-32 129.00
IUUC-Spo-108180 Schizosaccharomyces pombe 82.89 2.00e-32 128.00
IUUC-Smo-108916 Selaginella moellendorffii 72.22 7.00e-24 100.00
IUUC-Sar-113327 Sorex araneus 86.15 1.00e-21 92.40
IUUC-Sre-114970 Sporisorium reilianum 81.58 9.00e-32 126.00
IUUC-Ssc-115698 Sus scrofa 79.69 5.00e-19 84.00
IUUC-Tru-118771 Takifugu rubripes 86.84 1.00e-27 112.00
IUUC-Tsy-118907 Tarsius syrichta 86.15 1.00e-21 92.40
IUUC-Tni-120371 Tetraodon nigroviridis 86.84 2.00e-27 111.00
IUUC-Tre-122155 Trichoderma reesei 76.32 1.00e-28 115.00
IUUC-Tvi-122440 Trichoderma virens 76.32 5.00e-29 117.00
IUUC-Tme-126933 Tuber melanosporum 75.00 3.00e-29 117.00
IUUC-Ttr-128587 Tursiops truncatus 82.61 1.00e-20 89.40
IUUC-Uma-129335 Ustilago maydis 79.22 2.00e-31 124.00
IUUC-Vda-129767 Verticillium dahliae 75.00 4.00e-28 114.00
IUUC-Vpa-130121 Vicugna pacos 84.62 1.00e-20 89.00
IUUC-Xtr-132345 Xenopus tropicalis 86.84 2.00e-27 111.00
IUUC-Xma-134074 Xiphophorus maculatus 84.51 2.00e-24 101.00
IUUC-Yli-134497 Yarrowia lipolytica 64.47 3.00e-25 104.00
Created Date 25-Jun-2017

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