iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059814

UUCD1 version

UUC-MeG-00863

Ensembl Protein ID

ENSMGAP00000012009.2

UniProt Accession

G1NG28; G1NG28_MELGA

Protein Name

Uncharacterized protein

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000011465.2	ENSMGAT00000012895.2	ENSMGAP00000012009.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-68	230.3	344	960

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L++i++++++ll+   + ++++  k p ++l++ +++l+++    + + k+   +++++a++++ae+fsgy
   Q: 344  QGFSNLGNTCYMNAILQSLFSIQSFANDLLK---QGIPWK--KIPLNALIRRFAHLLAKKDvsSPEVKKELLKKVKSAISATAERFSGY 427
           69*****************************...*****9..689************99876677788888999*************** PP
   S: 88   eqqDaqEflaflldqleeelkk.eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
           +q+Da+Efl+++ldql+e+++k +k+++ e   ++d+s    + + + +k +++++  +++++++++i+c++c+++ +++e+f+dls++
   Q: 428  MQNDAHEFLSQCLDQLKEDMEKlNKTWKSEPVPNDDSSPGRASDDLSATKVYTCPVISNLEFEVQHSIICKTCGETVTKREQFNDLSID 516
           ********************7744555555555666666666688899999************************************** PP
   S: 176  vpgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +p++++  ++ s+qd+L+ f+++ee+e    y+cekc++k+ a+ ++k+++lP+vLilhLkR+sf+ + + ++k+ ++v +p+ L+l +
   Q: 517  LPRRKKLFPSrSIQDSLDLFFRAEEIE----YSCEKCNGKS-AVVTHKFNRLPRVLILHLKRYSFNVALSLNHKVGQQVVIPRYLTLLS 600
           **9999876569**************9....********99.9********************************************** PP
   S: 264  fcts..................................................................................... 267
           +ct+                                                                                     
   Q: 601  HCTEstrlpltlgwsahsavsrplkasqmvnsctiststpcrkytfkskssaslcvdsdsddeplkrsvansqrlcniqsrdqqqlqee 689
           ******************************************************99999999999999999999999999999999999 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 690  peksskrskmegdkpelgnagfdgmsedellaavleiskreaslslshdedkptsspdtgfgddeiqelpenletmetekpkaplesgp 778
           88888888888888888888888888888888888888888888888888888888888888777777777777777777777777777 PP
   S: 268  ...........................................peekqke....................................... 274
                                                      +     +                                       
   Q: 779  anfteitkdfdenkenktpegsqgevdwlqqydmerereeqelQ-----Qalaqslqeqeareqkedddlkratelslqefnsslldsv 862
           77777777777666666666666666666666666555555550.....0555555555555566666666777777777777777777 PP
   S: 275  ......................................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevl 323
                                                 +     +++++    ++   HY+++v++ k++ W++++D +V+ + e++v+
   Q: 863  gsdedsgnedvldmeyseaeaeelkrnaetkktlwsraH-----VSICSEVRvTALLCHYISDVYDIKKQsWFTYNDLEVSRTLETTVQ 946
           777777777777777777777778888877655443320.....333333334556679*******99889****************** PP
   S: 324  eetgstaYvlfYkr 337
            ++++++Y++fY++
   Q: 947  CDRDRSGYIFFYMH 960
           ************98 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MAPLKVHGPV RMRSMQTGIT KWKEGSFEIV EKDNKVSLVV HYNVGGIPKT FQLSHNIKSV 60
TLRPNGRKLC CLMLTLKDTS FLTIDKVPLK DANEMRMYLD AVHQDRLHTA GKPSQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCCCGC TGAAAGTGCA CGGCCCCGTG CGGATGCGCA GCATGCAGAC CGGCATCACC 60
AAGTGGAAGG AGGGCAGCTT CGAGATCGTG GAGAAGGACA ACAAAGTCAG CCTGGTGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	76.08	0.00e+00	1367.00
IUUC-Apl-004033	Anas platyrhynchos	93.33	0.00e+00	1746.00
IUUC-Aca-005370	Anolis carolinensis	72.14	0.00e+00	1322.00
IUUC-Ame-011884	Astyanax mexicanus	56.65	0.00e+00	948.00
IUUC-Bta-012725	Bos taurus	75.43	0.00e+00	1343.00
IUUC-Cja-019939	Callithrix jacchus	75.86	0.00e+00	1320.00
IUUC-Cfa-020835	Canis familiaris	76.06	0.00e+00	1399.00
IUUC-Cpo-022067	Cavia porcellus	76.32	0.00e+00	1245.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.37	5.00e-24	105.00
IUUC-Csa-023085	Chlorocebus sabaeus	76.01	0.00e+00	1361.00
IUUC-Cho-024390	Choloepus hoffmanni	66.76	1.00e-127	450.00
IUUC-Cin-025496	Ciona intestinalis	37.07	6.00e-41	161.00
IUUC-Csv-025812	Ciona savignyi	35.09	7.00e-38	151.00
IUUC-Dre-028255	Danio rerio	55.99	0.00e+00	901.00
IUUC-Dno-028986	Dasypus novemcinctus	76.08	0.00e+00	1347.00
IUUC-Dor-031062	Dipodomys ordii	67.75	0.00e+00	718.00
IUUC-Ete-032359	Echinops telfairi	68.07	0.00e+00	645.00
IUUC-Eca-033964	Equus caballus	76.21	0.00e+00	1371.00
IUUC-Eeu-034492	Erinaceus europaeus	69.53	0.00e+00	647.00
IUUC-Fca-036359	Felis catus	75.96	0.00e+00	1375.00
IUUC-Fal-037640	Ficedula albicollis	92.62	0.00e+00	1741.00
IUUC-Gmo-039600	Gadus morhua	54.63	0.00e+00	897.00
IUUC-Gga-040126	Gallus gallus	96.36	0.00e+00	1764.00
IUUC-Gac-041557	Gasterosteus aculeatus	53.99	0.00e+00	859.00
IUUC-Ggo-045571	Gorilla gorilla	71.61	0.00e+00	1189.00
IUUC-Hsa-046043	Homo sapiens	75.35	0.00e+00	1340.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	75.30	0.00e+00	1329.00
IUUC-Lch-050357	Latimeria chalumnae	65.43	0.00e+00	1025.00
IUUC-Loc-052849	Lepisosteus oculatus	61.12	0.00e+00	995.00
IUUC-Laf-054570	Loxodonta africana	75.63	0.00e+00	1323.00
IUUC-Mcc-054989	Macaca mulatta	77.04	0.00e+00	1252.00
IUUC-Meu-056273	Macropus eugenii	60.12	3.00e-159	555.00
IUUC-Mmr-061726	Microcebus murinus	75.20	0.00e+00	1343.00
IUUC-Mdo-062974	Monodelphis domestica	79.39	0.00e+00	1461.00
IUUC-Mmu-064069	Mus musculus	73.79	0.00e+00	1283.00
IUUC-Mpu-066008	Mustela putorius furo	75.45	0.00e+00	1337.00
IUUC-Mlu-068224	Myotis lucifugus	37.51	2.00e-140	492.00
IUUC-Nle-069259	Nomascus leucogenys	75.71	0.00e+00	1335.00
IUUC-Opr-070882	Ochotona princeps	66.17	4.00e-106	379.00
IUUC-Ont-072441	Oreochromis niloticus	54.66	0.00e+00	886.00
IUUC-Oan-073151	Ornithorhynchus anatinus	81.67	1.00e-112	399.00
IUUC-Ocu-074879	Oryctolagus cuniculus	74.49	0.00e+00	1323.00
IUUC-Ola-087007	Oryzias latipes	53.36	0.00e+00	827.00
IUUC-Oga-088385	Otolemur garnettii	74.40	0.00e+00	1333.00
IUUC-Oar-090305	Ovis aries	75.61	0.00e+00	1368.00
IUUC-Ptr-091299	Pan troglodytes	75.71	0.00e+00	1338.00
IUUC-Pan-091996	Papio anubis	75.99	0.00e+00	1320.00
IUUC-Psi-093176	Pelodiscus sinensis	87.99	0.00e+00	1635.00
IUUC-Pma-094331	Petromyzon marinus	47.25	0.00e+00	703.00
IUUC-Ppa-095732	Physcomitrella patens	28.17	2.00e-21	97.10
IUUC-Pfo-096503	Poecilia formosa	54.16	0.00e+00	851.00
IUUC-Pab-098543	Pongo abelii	76.07	0.00e+00	732.00
IUUC-Pca-101099	Procavia capensis	70.89	0.00e+00	1037.00
IUUC-Pva-103163	Pteropus vampyrus	71.05	0.00e+00	1263.00
IUUC-Rno-105766	Rattus norvegicus	74.39	0.00e+00	1295.00
IUUC-Sha-106610	Sarcophilus harrisii	74.55	0.00e+00	1345.00
IUUC-Sar-113256	Sorex araneus	66.38	2.00e-87	317.00
IUUC-Ssc-116353	Sus scrofa	75.96	0.00e+00	1323.00
IUUC-Tgu-116971	Taeniopygia guttata	92.21	0.00e+00	1707.00
IUUC-Tru-117932	Takifugu rubripes	46.99	5.00e-133	468.00
IUUC-Tsy-119185	Tarsius syrichta	72.55	0.00e+00	880.00
IUUC-Tni-119842	Tetraodon nigroviridis	62.66	5.00e-110	391.00
IUUC-Tbe-127281	Tupaia belangeri	65.81	2.00e-151	529.00
IUUC-Ttr-128177	Tursiops truncatus	78.23	0.00e+00	1061.00
IUUC-Vpa-130031	Vicugna pacos	75.91	0.00e+00	1381.00
IUUC-Xtr-132949	Xenopus tropicalis	66.67	0.00e+00	1166.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence