iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062510

UUCD1 version

UUC-MoD-00836

Ensembl Protein ID

ENSMODP00000010357.1

UniProt Accession

F7F2Z5; F7F2Z5_MONDO

Protein Name

Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39

Gene Name

CIAO1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000008332.1	ENSMODT00000010557.1	ENSMODP00000010357.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.30e-44	145.7	192	222
UBD/Beta-Prp	2.00e-61	207.9	13	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH++ v++l+f ++  +l+s+sdD t+++W+
   Q: 192  GHESTVWSLSFdPSgQRLASCSDDRTVRIWR 222
           8***********6669**************8 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvtt.gkl.lrsl.sgheaevtavkfspdgkilvtgseDrtikvw..dlstgkcvhtl 90
           +h++s++  +++ p ++lla+ + d++i++w  +  g++  + l +gh+ +v+ v +sp g++l+++s D+t ++w  + ++++cv tl
   Q: 13   AHPDSRCWFLAWNPTGTLLASCGGDRSIRIWGKEGdGWVcKSVLaEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVTTL 101
           688999999999*******************88751444255559*******************************99999******** PP
   S: 91   kghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk..llrtl 175
           +ghe++v s+++ psg+ l++ s+d+ + vw+++++ ++e   +l+ h++ v +v +hp++ ll+s+s+D tv+l++ + ++  +  tl
   Q: 102  EGHENEVKSVAWAPSGSLLATCSRDKSVWVWEVDEEDEYECvsVLNSHTQDVKHVIWHPSQELLASASYDDTVKLYREEEDDwvCYATL 190
           *********************************9987776566*********************************99777544999** PP
   S: 176  tgghtdsvyslsfdsngkelvsgsldgtvklw 207
           +g h++ v slsfd++g++l+s+s+d+tv++w
   Q: 191  EG-HESTVWSLSFDPSGQRLASCSDDRTVRIW 221
           99.***************************** PP

Organism

Monodelphis domestica

Functional Description
(View)

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Protein Sequence
(Fasta)

MKDSLILLAR VPAHPDSRCW FLAWNPTGTL LASCGGDRSI RIWGKEGDGW VCKSVLAEGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGSLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCACCACA ATGAAGGACT CCCTAATACT CCTGGCCCGC GTGCCGGCCC ACCCAGACTC 60
CCGCTGCTGG TTCCTGGCCT GGAACCCTAC GGGGACCCTG CTGGCCTCGT GCGGCGGCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR028608--CIAO1/Cia1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097361--C:CIA complex
GO:0071817--C:MMXD complex
GO:0007059--P:chromosome segregation
GO:0016226--P:iron-sulfur cluster assembly

KEGG

mdo:100030912

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000874	Aegilops tauschii	43.22	4.00e-68	252.00
IUUC-Aml-001317	Ailuropoda melanoleuca	92.33	9.00e-178	615.00
IUUC-Atr-003029	Amborella trichopoda	51.90	2.00e-94	338.00
IUUC-Apl-004042	Anas platyrhynchos	76.52	3.00e-56	209.00
IUUC-Aly-006458	Arabidopsis lyrata	47.83	4.00e-85	308.00
IUUC-Ath-006671	Arabidopsis thaliana	47.67	4.00e-85	307.00
IUUC-Ago-007820	Ashbya gossypii	41.18	1.00e-59	223.00
IUUC-Acl-008042	Aspergillus clavatus	32.49	6.00e-51	194.00
IUUC-Afl-008639	Aspergillus flavus	32.62	3.00e-53	202.00
IUUC-Afu-008899	Aspergillus fumigatus	35.23	1.00e-48	187.00
IUUC-Ani-009453	Aspergillus nidulans	32.14	3.00e-50	192.00
IUUC-Ang-009758	Aspergillus niger	34.84	7.00e-52	197.00
IUUC-Aor-010212	Aspergillus oryzae	32.62	3.00e-53	202.00
IUUC-Ate-010314	Aspergillus terreus	33.33	6.00e-53	201.00
IUUC-Ame-010676	Astyanax mexicanus	77.54	7.00e-159	553.00
IUUC-Bgr-012095	Blumeria graminis	30.95	1.00e-37	150.00
IUUC-Bta-012884	Bos taurus	90.27	5.00e-174	603.00
IUUC-Bci-013622	Botrytis cinerea	32.87	1.00e-38	154.00
IUUC-Bdi-014614	Brachypodium distachyon	49.11	7.00e-87	313.00
IUUC-Bol-016439	Brassica oleracea	47.94	8.00e-84	303.00
IUUC-Bra-016830	Brassica rapa	47.20	1.00e-82	300.00
IUUC-Cel-018709	Caenorhabditis elegans	39.51	3.00e-62	231.00
IUUC-Cja-019822	Callithrix jacchus	92.04	4.00e-177	613.00
IUUC-Cfa-020823	Canis familiaris	93.22	4.00e-179	620.00
IUUC-Cre-022811	Chlamydomonas reinhardtii	49.11	4.00e-81	295.00
IUUC-Csa-023754	Chlorocebus sabaeus	92.92	7.00e-179	619.00
IUUC-Cin-025395	Ciona intestinalis	59.10	5.00e-119	420.00
IUUC-Csv-025943	Ciona savignyi	57.36	3.00e-115	408.00
IUUC-Cgl-026435	Colletotrichum gloeosporioides	31.81	7.00e-37	148.00
IUUC-Cne-026939	Cryptococcus neoformans	32.51	4.00e-49	189.00
IUUC-Cme-027239	Cyanidioschyzon merolae	39.66	2.00e-43	169.00
IUUC-Dre-028172	Danio rerio	75.45	4.00e-156	543.00
IUUC-Dno-029472	Dasypus novemcinctus	93.86	3.00e-151	527.00
IUUC-Dor-031134	Dipodomys ordii	81.42	2.00e-148	518.00
IUUC-Dse-031535	Dothistroma septosporum	30.09	2.00e-45	176.00
IUUC-Dme-032020	Drosophila melanogaster	58.48	1.00e-116	412.00
IUUC-Eca-033700	Equus caballus	93.22	4.00e-179	620.00
IUUC-Eeu-035010	Erinaceus europaeus	91.45	8.00e-175	605.00
IUUC-Fca-036309	Felis catus	85.29	3.00e-169	587.00
IUUC-Fal-037243	Ficedula albicollis	72.09	1.00e-84	305.00
IUUC-Fox-038058	Fusarium oxysporum	33.16	5.00e-45	175.00
IUUC-Fso-038459	Fusarium solani	33.80	2.00e-39	156.00
IUUC-Gmo-039375	Gadus morhua	74.93	6.00e-141	493.00
IUUC-Ggr-040002	Gaeumannomyces graminis	34.27	1.00e-39	157.00
IUUC-Gga-040294	Gallus gallus	81.82	2.00e-129	454.00
IUUC-Gac-042499	Gasterosteus aculeatus	73.29	5.00e-138	483.00
IUUC-Gma-043543	Glycine max	48.67	2.00e-87	315.00
IUUC-Ggo-045181	Gorilla gorilla	92.92	7.00e-179	619.00
IUUC-Hsa-046528	Homo sapiens	92.92	7.00e-179	619.00
IUUC-Hvu-047341	Hordeum vulgare	57.98	9.00e-57	213.00
IUUC-Itr-048790	Ictidomys tridecemlineatus	93.51	5.00e-179	620.00
IUUC-Kpa-049353	Komagataella pastoris	35.88	1.00e-55	210.00
IUUC-Lch-049763	Latimeria chalumnae	80.84	9.00e-163	565.00
IUUC-Lpe-051500	Leersia perrieri	44.47	8.00e-82	297.00
IUUC-Loc-052021	Lepisosteus oculatus	81.74	6.00e-157	546.00
IUUC-Lma-053331	Leptosphaeria maculans	35.50	6.00e-55	209.00
IUUC-Laf-054558	Loxodonta africana	90.27	2.00e-173	601.00
IUUC-Mcc-055374	Macaca mulatta	92.63	6.00e-178	616.00
IUUC-Meu-056042	Macropus eugenii	80.69	1.00e-116	412.00
IUUC-Mor-057187	Magnaporthe oryzae	34.90	6.00e-39	155.00
IUUC-Mtr-058072	Medicago truncatula	48.82	3.00e-86	311.00
IUUC-Mla-059108	Melampsora laricipopulina	31.67	1.00e-51	197.00
IUUC-Mga-059370	Meleagris gallopavo	64.04	1.00e-100	359.00
IUUC-Mvi-060495	Microbotryum violaceum	37.43	1.00e-57	217.00
IUUC-Mmr-060902	Microcebus murinus	92.92	3.00e-178	617.00
IUUC-Mmu-063575	Mus musculus	90.56	3.00e-174	603.00
IUUC-Mac-065322	Musa acuminata	51.49	3.00e-92	331.00
IUUC-Mpu-065925	Mustela putorius furo	93.22	5.00e-180	623.00
IUUC-Mlu-067755	Myotis lucifugus	92.92	2.00e-178	618.00
IUUC-Nfi-068327	Neosartorya fischeri	34.83	1.00e-48	187.00
IUUC-Ncr-068845	Neurospora crassa	32.30	1.00e-30	127.00
IUUC-Nle-069406	Nomascus leucogenys	91.74	3.00e-174	603.00
IUUC-Opr-070416	Ochotona princeps	72.86	8.00e-130	456.00
IUUC-Ont-071936	Oreochromis niloticus	74.78	7.00e-142	496.00
IUUC-Oan-073452	Ornithorhynchus anatinus	90.30	7.00e-74	269.00
IUUC-Ocu-074791	Oryctolagus cuniculus	91.74	6.00e-176	609.00
IUUC-Oba-075636	Oryza barthii	49.85	7.00e-90	323.00
IUUC-Obr-076742	Oryza brachyantha	50.00	7.00e-78	283.00
IUUC-Ogl-077766	Oryza glaberrima	49.85	7.00e-90	323.00
IUUC-Ogu-079039	Oryza glumaepatula	49.85	2.00e-90	325.00
IUUC-Oin-079315	Oryza indica	49.66	3.00e-78	285.00
IUUC-Olo-080669	Oryza longistaminata	44.27	4.00e-82	298.00
IUUC-Ome-081490	Oryza meridionalis	49.85	3.00e-90	325.00
IUUC-Oni-082572	Oryza nivara	49.85	7.00e-90	323.00
IUUC-Opu-083732	Oryza punctata	49.70	7.00e-90	323.00
IUUC-Oru-084763	Oryza rufipogon	49.85	7.00e-90	323.00
IUUC-Osa-085372	Oryza sativa	49.85	7.00e-90	323.00
IUUC-Ola-087379	Oryzias latipes	72.65	6.00e-138	483.00
IUUC-Olu-087801	Ostreococcus lucimarinus	37.93	1.00e-43	169.00
IUUC-Oga-089076	Otolemur garnettii	92.63	2.00e-178	618.00
IUUC-Oar-090022	Ovis aries	91.15	4.00e-175	607.00
IUUC-Ptr-090809	Pan troglodytes	92.92	7.00e-179	619.00
IUUC-Pan-091685	Papio anubis	92.92	2.00e-180	625.00
IUUC-Psi-093046	Pelodiscus sinensis	88.72	8.00e-171	592.00
IUUC-Pma-094181	Petromyzon marinus	64.69	2.00e-134	472.00
IUUC-Pno-094882	Phaeosphaeria nodorum	34.95	4.00e-55	208.00
IUUC-Ppa-095172	Physcomitrella patens	47.97	6.00e-86	310.00
IUUC-Pfo-096396	Poecilia formosa	70.92	1.00e-137	482.00
IUUC-Pab-098427	Pongo abelii	92.92	2.00e-177	614.00
IUUC-Pop-100016	Populus trichocarpa	50.74	2.00e-90	325.00
IUUC-Pca-101048	Procavia capensis	90.56	6.00e-174	603.00
IUUC-Ppe-102050	Prunus persica	47.43	4.00e-86	311.00
IUUC-Pva-103117	Pteropus vampyrus	91.45	2.00e-176	611.00
IUUC-Pgr-103307	Puccinia graminis	33.87	1.00e-55	210.00
IUUC-Ptt-103938	Puccinia triticina	37.20	1.00e-48	187.00
IUUC-Pte-104315	Pyrenophora teres	33.33	9.00e-55	207.00
IUUC-Pyt-104825	Pyrenophora triticirepentis	32.85	2.00e-54	206.00
IUUC-Rno-105523	Rattus norvegicus	90.27	4.00e-174	603.00
IUUC-Sce-106297	Saccharomyces cerevisiae	42.59	3.00e-63	235.00
IUUC-Sha-106981	Sarcophilus harrisii	98.63	9.00e-151	525.00
IUUC-Sja-107715	Schizosaccharomyces japonicus	38.84	1.00e-55	211.00
IUUC-Spo-108214	Schizosaccharomyces pombe	41.76	2.00e-56	213.00
IUUC-Smo-109034	Selaginella moellendorffii	44.38	1.00e-81	296.00
IUUC-Sit-110663	Setaria italica	50.44	1.00e-90	326.00
IUUC-Sly-110898	Solanum lycopersicum	47.67	2.00e-83	301.00
IUUC-Stu-112647	Solanum tuberosum	51.50	7.00e-71	260.00
IUUC-Sbi-114288	Sorghum bicolor	48.39	6.00e-87	314.00
IUUC-Sre-115065	Sporisorium reilianum	44.56	2.00e-77	283.00
IUUC-Ssc-115960	Sus scrofa	86.94	1.00e-176	612.00
IUUC-Tru-118382	Takifugu rubripes	70.33	3.00e-145	507.00
IUUC-Tsy-119585	Tarsius syrichta	85.84	2.00e-157	548.00
IUUC-Tni-120133	Tetraodon nigroviridis	73.33	2.00e-140	491.00
IUUC-Tca-121167	Theobroma cacao	49.85	7.00e-82	297.00
IUUC-Tre-122119	Trichoderma reesei	29.68	3.00e-41	162.00
IUUC-Tvi-122407	Trichoderma virens	29.83	4.00e-41	162.00
IUUC-Tae-125748	Triticum aestivum	48.37	2.00e-83	301.00
IUUC-Tur-126682	Triticum urartu	48.89	2.00e-67	249.00
IUUC-Tme-127095	Tuber melanosporum	35.42	2.00e-59	223.00
IUUC-Tbe-128004	Tupaia belangeri	92.04	8.00e-177	612.00
IUUC-Ttr-129284	Tursiops truncatus	88.30	6.00e-169	586.00
IUUC-Uma-129527	Ustilago maydis	44.65	5.00e-77	281.00
IUUC-Vda-129854	Verticillium dahliae	30.82	2.00e-38	153.00
IUUC-Vpa-130681	Vicugna pacos	93.97	1.00e-48	186.00
IUUC-Vvi-131004	Vitis vinifera	53.75	4.00e-88	317.00
IUUC-Xtr-131928	Xenopus tropicalis	82.49	1.00e-157	548.00
IUUC-Xma-134290	Xiphophorus maculatus	70.03	2.00e-134	471.00
IUUC-Yli-134364	Yarrowia lipolytica	42.57	3.00e-65	241.00
IUUC-Zma-135658	Zea mays	49.85	1.00e-87	316.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence