iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aml-001409

Ensembl Protein ID

ENSAMEP00000009186.1

UniProt Accession

G1LQ56; G1LQ56_AILME

Genbank Protein ID

ENSAMEP00000009186

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

ACTA01056054

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000008730.1	ENSAMET00000009579.1	ENSAMEP00000009186.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	100.00	5.00e-155	544.00	IUUC-Hsa-046179
E3 activity/RING/RING	100.00	1.00e-154	543.00	IUUC-Mmu-063206
E3 activity/RING/RING	100.00	8.00e-155	543.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ailuropoda melanoleuca

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

ASRPAPPPPK PRRRLAKGRP PPQPGRQTPR GRGEPGMLTG AGEGRALVEP PRCQLDSGGA 60
GAPAQGGSAS PRPVSPQHHE LTSLFECPVC FDYVLPPILQ CQAGHLVCNQ CRQKLSCCPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGTCGCGTC CCGCCCCGCC CCCACCCAAG CCCCCGNNNN NNNNNNNNNN NNNNNNNNNN 60
NNNNNNNNNN NNNNNNNNGG CGACGCCTTG CCAAAGGGCG GCCCCCTCCT CAACCCGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011678	Astyanax mexicanus	92.09	5.00e-141	493.00
IUUC-Bta-012750	Bos taurus	99.61	5.00e-154	536.00
IUUC-Cja-019800	Callithrix jacchus	100.00	2.00e-154	537.00
IUUC-Cfa-020505	Canis familiaris	99.61	1.00e-153	535.00
IUUC-Cpo-021394	Cavia porcellus	99.22	8.00e-154	536.00
IUUC-Csa-023374	Chlorocebus sabaeus	100.00	2.00e-154	537.00
IUUC-Cho-024933	Choloepus hoffmanni	100.00	3.00e-154	537.00
IUUC-Dre-027711	Danio rerio	91.70	1.00e-140	492.00
IUUC-Dno-029260	Dasypus novemcinctus	92.73	4.00e-149	520.00
IUUC-Dor-030489	Dipodomys ordii	96.22	1.00e-107	381.00
IUUC-Ete-032946	Echinops telfairi	99.23	4.00e-156	543.00
IUUC-Eca-033546	Equus caballus	99.61	2.00e-156	544.00
IUUC-Eeu-034861	Erinaceus europaeus	96.14	8.00e-149	519.00
IUUC-Fal-037160	Ficedula albicollis	88.05	2.00e-132	464.00
IUUC-Gmo-039091	Gadus morhua	88.03	5.00e-139	486.00
IUUC-Gga-040252	Gallus gallus	97.67	2.00e-151	527.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.72	4.00e-139	487.00
IUUC-Ggo-044618	Gorilla gorilla	100.00	2.00e-154	537.00
IUUC-Hsa-046179	Homo sapiens	100.00	2.00e-154	537.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	98.45	1.00e-153	535.00
IUUC-Lch-049496	Latimeria chalumnae	95.72	2.00e-149	521.00
IUUC-Loc-052107	Lepisosteus oculatus	92.80	3.00e-141	493.00
IUUC-Laf-054257	Loxodonta africana	99.61	4.00e-154	536.00
IUUC-Mcc-055023	Macaca mulatta	100.00	2.00e-154	537.00
IUUC-Meu-055922	Macropus eugenii	97.25	3.00e-149	520.00
IUUC-Mga-060070	Meleagris gallopavo	96.11	1.00e-147	515.00
IUUC-Mmr-061494	Microcebus murinus	100.00	2.00e-154	537.00
IUUC-Mdo-061971	Monodelphis domestica	98.82	5.00e-153	533.00
IUUC-Mmu-063206	Mus musculus	100.00	8.00e-154	536.00
IUUC-Mpu-066597	Mustela putorius furo	100.00	2.00e-154	537.00
IUUC-Mlu-067199	Myotis lucifugus	99.61	1.00e-153	535.00
IUUC-Nle-069342	Nomascus leucogenys	100.00	2.00e-154	537.00
IUUC-Opr-070341	Ochotona princeps	56.86	6.00e-50	190.00
IUUC-Ont-071906	Oreochromis niloticus	90.12	5.00e-140	490.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	1.00e-49	189.00
IUUC-Ocu-073950	Oryctolagus cuniculus	99.61	2.00e-155	541.00
IUUC-Oga-089154	Otolemur garnettii	100.00	2.00e-154	537.00
IUUC-Oar-089446	Ovis aries	98.84	4.00e-155	540.00
IUUC-Ptr-091088	Pan troglodytes	100.00	2.00e-154	537.00
IUUC-Psi-093079	Pelodiscus sinensis	99.61	6.00e-156	542.00
IUUC-Pfo-097007	Poecilia formosa	85.38	1.00e-132	465.00
IUUC-Pab-098092	Pongo abelii	100.00	2.00e-154	537.00
IUUC-Pca-100328	Procavia capensis	96.86	2.00e-148	518.00
IUUC-Pva-102368	Pteropus vampyrus	100.00	4.00e-64	238.00
IUUC-Rno-105477	Rattus norvegicus	100.00	8.00e-154	536.00
IUUC-Sha-107630	Sarcophilus harrisii	99.23	1.00e-155	541.00
IUUC-Ssc-116441	Sus scrofa	99.61	6.00e-154	536.00
IUUC-Tru-118004	Takifugu rubripes	88.00	2.00e-134	471.00
IUUC-Tsy-119548	Tarsius syrichta	89.47	8.00e-68	249.00
IUUC-Tni-120846	Tetraodon nigroviridis	89.60	5.00e-137	479.00
IUUC-Vpa-130799	Vicugna pacos	99.42	1.00e-103	368.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence