iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027571

Ensembl Protein ID

ENSDARP00000086448.4

UniProt Accession

Q08BB3; DCA12_DANRE

Genbank Protein ID

AAI24797.1

Protein Name

DDB1- and CUL4-associated factor 12; WD repeat-containing protein 40A

Genbank Nucleotide ID

BC124796

Gene Name

dcaf12; wdr40a; zgc:154031

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000063155.5	ENSDART00000092015.4	ENSDARP00000086448.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.60e-22	77.2	211	247

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlrtgvll 36
           gH+d+++++a+ sdt+ vsGs+Dg++ +W+++++vl 
   Q: 211  GHNDWIFSIAWiSDTMAVSGSRDGSMGLWEISEDVLS 247
           8*****************************9988876 PP

Organism

Danio rerio

Functional Description
(View)

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Protein Sequence
(Fasta)

MARKTVSRKR KAEEPKEQQF DWCQSAFKRP RVSSSVRHAQ HWWQSRRSVV CSVRGREFRP 60
QQQHEWSFQR SLRGFAAGRI PGILREREFS LGRLNKVFAS QWLNHRQVVC GTKCNTLFVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAATCCTG TGTGCCTCCA TTTTACCTCA TATTGGATTA GTCTGTTTGC TCAGACAAAA 60
GATACACGAT TCCTCCCCTG ATGAATGCAG GAAACTGAGG ATATCCTTAC TGATTAACCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

SMART

SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005815--C:microtubule organizing center
GO:0016567--P:protein ubiquitination

KEGG

dre:570671

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002102	Ailuropoda melanoleuca	70.35	0.00e+00	674.00
IUUC-Apl-003794	Anas platyrhynchos	71.67	0.00e+00	664.00
IUUC-Aca-004264	Anolis carolinensis	77.19	7.00e-180	623.00
IUUC-Ame-011254	Astyanax mexicanus	90.04	0.00e+00	885.00
IUUC-Bta-012923	Bos taurus	70.35	0.00e+00	677.00
IUUC-Cja-019590	Callithrix jacchus	76.50	2.00e-162	565.00
IUUC-Cfa-021123	Canis familiaris	70.35	0.00e+00	675.00
IUUC-Cpo-022378	Cavia porcellus	59.13	6.00e-136	477.00
IUUC-Csa-023339	Chlorocebus sabaeus	70.14	0.00e+00	674.00
IUUC-Cho-024837	Choloepus hoffmanni	59.02	4.00e-115	408.00
IUUC-Dno-029106	Dasypus novemcinctus	70.76	0.00e+00	675.00
IUUC-Dor-030162	Dipodomys ordii	56.64	3.00e-122	431.00
IUUC-Dme-031774	Drosophila melanogaster	41.10	4.00e-74	271.00
IUUC-Ete-033140	Echinops telfairi	49.54	2.00e-73	268.00
IUUC-Eca-034316	Equus caballus	69.94	0.00e+00	674.00
IUUC-Eeu-034641	Erinaceus europaeus	70.49	4.00e-147	514.00
IUUC-Fca-036150	Felis catus	71.77	0.00e+00	662.00
IUUC-Fal-036636	Ficedula albicollis	70.06	0.00e+00	676.00
IUUC-Gmo-038736	Gadus morhua	82.61	0.00e+00	786.00
IUUC-Gga-040896	Gallus gallus	77.81	0.00e+00	631.00
IUUC-Gac-042623	Gasterosteus aculeatus	80.54	0.00e+00	799.00
IUUC-Ggo-044968	Gorilla gorilla	77.05	1.00e-163	568.00
IUUC-Hsa-046020	Homo sapiens	70.55	0.00e+00	676.00
IUUC-Itr-048766	Ictidomys tridecemlineatus	70.14	0.00e+00	674.00
IUUC-Kpa-049170	Komagataella pastoris	28.69	2.00e-06	47.40
IUUC-Lch-050244	Latimeria chalumnae	69.06	0.00e+00	685.00
IUUC-Loc-052777	Lepisosteus oculatus	76.29	0.00e+00	712.00
IUUC-Laf-054505	Loxodonta africana	69.33	0.00e+00	664.00
IUUC-Mcc-055187	Macaca mulatta	71.34	0.00e+00	657.00
IUUC-Meu-056026	Macropus eugenii	68.25	4.00e-177	614.00
IUUC-Mga-059618	Meleagris gallopavo	43.55	4.00e-89	322.00
IUUC-Mmr-061121	Microcebus murinus	64.77	2.00e-170	592.00
IUUC-Mdo-062823	Monodelphis domestica	71.17	0.00e+00	672.00
IUUC-Mmu-064332	Mus musculus	70.76	0.00e+00	679.00
IUUC-Mpu-066157	Mustela putorius furo	70.55	0.00e+00	676.00
IUUC-Mlu-067146	Myotis lucifugus	69.94	0.00e+00	672.00
IUUC-Nle-069179	Nomascus leucogenys	68.51	0.00e+00	644.00
IUUC-Opr-070970	Ochotona princeps	74.59	1.00e-156	546.00
IUUC-Ont-072013	Oreochromis niloticus	80.95	0.00e+00	752.00
IUUC-Oan-072810	Ornithorhynchus anatinus	72.18	9.00e-51	192.00
IUUC-Ocu-074646	Oryctolagus cuniculus	69.73	0.00e+00	676.00
IUUC-Ola-087062	Oryzias latipes	77.71	0.00e+00	761.00
IUUC-Olu-087756	Ostreococcus lucimarinus	27.68	1.00e-14	73.90
IUUC-Oga-089071	Otolemur garnettii	70.55	0.00e+00	677.00
IUUC-Oar-089522	Ovis aries	70.14	0.00e+00	675.00
IUUC-Ptr-091042	Pan troglodytes	66.87	0.00e+00	629.00
IUUC-Pan-092832	Papio anubis	70.35	0.00e+00	676.00
IUUC-Psi-093131	Pelodiscus sinensis	71.89	0.00e+00	664.00
IUUC-Pma-094151	Petromyzon marinus	63.35	2.00e-54	205.00
IUUC-Pfo-096970	Poecilia formosa	80.75	0.00e+00	800.00
IUUC-Pab-098019	Pongo abelii	70.55	0.00e+00	676.00
IUUC-Pca-100731	Procavia capensis	54.16	2.00e-126	445.00
IUUC-Pva-103128	Pteropus vampyrus	70.35	0.00e+00	674.00
IUUC-Rno-105945	Rattus norvegicus	60.94	9.00e-156	543.00
IUUC-Sha-107518	Sarcophilus harrisii	76.84	3.00e-162	564.00
IUUC-Smo-108742	Selaginella moellendorffii	32.20	2.00e-46	179.00
IUUC-Sar-113026	Sorex araneus	70.47	2.00e-152	531.00
IUUC-Ssc-115446	Sus scrofa	73.70	0.00e+00	647.00
IUUC-Tgu-117240	Taeniopygia guttata	69.59	5.00e-161	560.00
IUUC-Tru-118560	Takifugu rubripes	80.17	0.00e+00	794.00
IUUC-Tsy-119344	Tarsius syrichta	75.71	0.00e+00	652.00
IUUC-Tni-119714	Tetraodon nigroviridis	78.89	0.00e+00	782.00
IUUC-Tbe-127634	Tupaia belangeri	82.14	3.00e-75	276.00
IUUC-Ttr-128503	Tursiops truncatus	70.76	0.00e+00	679.00
IUUC-Vpa-130126	Vicugna pacos	64.09	8.00e-113	400.00
IUUC-Xtr-132744	Xenopus tropicalis	52.38	3.00e-63	236.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence