iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-067754

Ensembl Protein ID

ENSMLUP00000018963.1

UniProt Accession

G1Q5I0; G1Q5I0_MYOLU

Genbank Protein ID

ENSMLUP00000018963

Protein Name

Inhibitor of growth protein

Genbank Nucleotide ID

AAPE02007005

Gene Name

ING4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000029523.1	ENSMLUT00000029181.1	ENSMLUP00000018963.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	7.30e-10	38.9	200	247

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C++ + +e  ++ C++  C+ ewfH+aC++l+   ++p+ + w+Cp+C++
   Q: 200  TYC-LCHQVSYGE--MIGCDNpdCSiEWFHFACVGLT---TKPRGK-WFCPRCSQ 247
           69*.*******99..********999***********...899996.******97 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM SSARNLSSEE 60
KLALLKQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGCGG GGATGTATTT GGAACATTAT CTGGACAGTA AGAGCAGTCT GGAGGAGGGG 60
GTCAGGGGTC ACAGCGTGGT GGGGCGGGGG CGGGCTGAGG AGATCTAAGG CCCCGAGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028647--ING4
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007050--P:cell cycle arrest
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006260--P:DNA replication
GO:0043966--P:histone H3 acetylation
GO:0043983--P:histone H4-K12 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001338	Ailuropoda melanoleuca	91.27	1.00e-115	409.00
IUUC-Apl-004097	Anas platyrhynchos	86.06	2.00e-109	388.00
IUUC-Aca-004593	Anolis carolinensis	89.29	5.00e-115	406.00
IUUC-Ame-011133	Astyanax mexicanus	76.86	2.00e-111	394.00
IUUC-Bta-012699	Bos taurus	87.30	1.00e-115	408.00
IUUC-Bdi-014508	Brachypodium distachyon	33.33	2.00e-31	129.00
IUUC-Bol-015245	Brassica oleracea	29.08	3.00e-29	121.00
IUUC-Cja-019988	Callithrix jacchus	91.67	1.00e-111	395.00
IUUC-Cfa-021282	Canis familiaris	91.67	1.00e-111	395.00
IUUC-Cpo-022011	Cavia porcellus	91.27	4.00e-121	426.00
IUUC-Cre-022920	Chlamydomonas reinhardtii	30.04	3.00e-27	115.00
IUUC-Csa-023203	Chlorocebus sabaeus	91.67	1.00e-111	395.00
IUUC-Cin-025479	Ciona intestinalis	60.49	2.00e-79	288.00
IUUC-Dre-028264	Danio rerio	76.47	3.00e-110	390.00
IUUC-Dno-029766	Dasypus novemcinctus	88.45	1.00e-104	372.00
IUUC-Dor-031136	Dipodomys ordii	77.82	9.00e-91	326.00
IUUC-Dme-032200	Drosophila melanogaster	84.00	4.00e-40	158.00
IUUC-Eca-033565	Equus caballus	92.06	5.00e-122	429.00
IUUC-Eeu-034948	Erinaceus europaeus	78.40	4.00e-98	350.00
IUUC-Fca-036368	Felis catus	91.67	9.00e-112	395.00
IUUC-Fal-037120	Ficedula albicollis	85.66	4.00e-108	383.00
IUUC-Gmo-038982	Gadus morhua	78.26	2.00e-109	388.00
IUUC-Gga-040771	Gallus gallus	89.29	5.00e-115	406.00
IUUC-Gac-042184	Gasterosteus aculeatus	77.02	1.00e-107	382.00
IUUC-Ggo-045559	Gorilla gorilla	91.67	1.00e-111	395.00
IUUC-Hsa-046852	Homo sapiens	91.67	1.00e-111	395.00
IUUC-Hvu-047046	Hordeum vulgare	34.51	1.00e-36	146.00
IUUC-Itr-047978	Ictidomys tridecemlineatus	91.67	1.00e-121	429.00
IUUC-Kpa-049229	Komagataella pastoris	59.18	2.00e-16	79.00
IUUC-Lpe-051512	Leersia perrieri	33.73	2.00e-31	129.00
IUUC-Laf-054057	Loxodonta africana	91.67	9.00e-112	395.00
IUUC-Mcc-055212	Macaca mulatta	87.01	2.00e-105	374.00
IUUC-Meu-056511	Macropus eugenii	90.38	3.00e-112	397.00
IUUC-Mtr-058288	Medicago truncatula	33.33	5.00e-32	131.00
IUUC-Mga-059967	Meleagris gallopavo	86.80	5.00e-109	386.00
IUUC-Mmr-060843	Microcebus murinus	90.08	7.00e-116	409.00
IUUC-Mdo-062357	Monodelphis domestica	90.87	5.00e-121	426.00
IUUC-Mmu-064093	Mus musculus	91.27	4.00e-121	426.00
IUUC-Mpu-066923	Mustela putorius furo	80.16	6.00e-89	320.00
IUUC-Nle-069062	Nomascus leucogenys	91.67	1.00e-111	395.00
IUUC-Opr-070207	Ochotona princeps	84.10	2.00e-102	364.00
IUUC-Ont-072446	Oreochromis niloticus	78.17	3.00e-110	390.00
IUUC-Ocu-074235	Oryctolagus cuniculus	91.67	8.00e-112	395.00
IUUC-Ome-081291	Oryza meridionalis	34.35	2.00e-35	142.00
IUUC-Osa-085563	Oryza sativa	34.35	2.00e-35	142.00
IUUC-Ola-086429	Oryzias latipes	73.41	3.00e-101	360.00
IUUC-Olu-087851	Ostreococcus lucimarinus	33.94	2.00e-20	92.00
IUUC-Oga-089123	Otolemur garnettii	91.67	9.00e-112	395.00
IUUC-Oar-089524	Ovis aries	87.30	1.00e-115	408.00
IUUC-Ptr-090908	Pan troglodytes	91.67	6.00e-112	396.00
IUUC-Pan-092837	Papio anubis	91.27	2.00e-115	408.00
IUUC-Psi-093828	Pelodiscus sinensis	88.56	1.00e-104	372.00
IUUC-Pfo-096617	Poecilia formosa	77.78	4.00e-111	393.00
IUUC-Pab-097978	Pongo abelii	90.79	6.00e-101	359.00
IUUC-Pop-099415	Populus trichocarpa	73.68	3.00e-26	111.00
IUUC-Pca-100475	Procavia capensis	61.90	9.00e-81	292.00
IUUC-Pva-102325	Pteropus vampyrus	92.06	5.00e-122	429.00
IUUC-Rno-105178	Rattus norvegicus	86.51	3.00e-125	440.00
IUUC-Sha-106773	Sarcophilus harrisii	90.87	8.00e-121	426.00
IUUC-Sit-110189	Setaria italica	33.21	2.00e-33	135.00
IUUC-Sly-111209	Solanum lycopersicum	35.27	2.00e-33	135.00
IUUC-Stu-112762	Solanum tuberosum	34.88	4.00e-33	134.00
IUUC-Sre-115124	Sporisorium reilianum	58.21	4.00e-22	100.00
IUUC-Ssc-115797	Sus scrofa	85.14	1.00e-97	348.00
IUUC-Tgu-117270	Taeniopygia guttata	89.29	5.00e-115	406.00
IUUC-Tru-118253	Takifugu rubripes	77.87	2.00e-109	388.00
IUUC-Tbe-127558	Tupaia belangeri	91.27	1.00e-115	409.00
IUUC-Ttr-128300	Tursiops truncatus	86.73	2.00e-56	212.00
IUUC-Uma-129581	Ustilago maydis	57.63	6.00e-21	95.90
IUUC-Yli-134326	Yarrowia lipolytica	28.12	2.00e-24	105.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence