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Tag Content
iUUCD ID IUUC-Mcc-054695
Ensembl Protein ID ENSMMUP00000004277.2
UniProt Accession Q0GBW6; Q0GBW6_MACMU
Genbank Protein ID ABI33114.1; AFH29361.1; AFJ71053.1
Protein Name Interferon-induced helicase C domain-containing protein 1; Melanoma differentiation associated protein-5
Genbank Nucleotide ID JSUE03008994; JU472557; JV635713
Gene Name IFIH1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000003202.3 ENSMMUT00000004537.3 ENSMMUP00000004277.2
ENSMMUG00000003202.3 ENSMMUT00000058655.1 ENSMMUP00000060886.1
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/CARD 1.40e-55 186.9 7 80
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/CARD
   S: 1    tdeeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLktL...vqkegWfrefl 73
           tde++r+l+s++++rv+++++v++vld yl+ fl++e+ke+i+++++t+gnmqa+elLL+tL   v+++gW+ref+
   Q: 7    TDENFRYLISCFRARVKMYIQVEPVLD-YLT-FLPAEVKEQIQRTVATSGNMQAVELLLSTLekgVWHLGWTREFV 80
           69*************************.***.*******************************************6 PP
   
Organism Macaca mulatta
Protein Sequence
(Fasta)
MSNGYSTDEN FRYLISCFRA RVKMYIQVEP VLDYLTFLPA EVKEQIQRTV ATSGNMQAVE 60
LLLSTLEKGV WHLGWTREFV EALRRAGSPL AARYMNPELT DLPSPSFENA HDECLQLLNL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-054695|UBD,CARD|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCGAATG GGTATTCCAC AGACGAGAAT TTCCGCTATC TCATCTCGTG CTTCAGGGCC 60
AGGGTGAAAA TGTACATCCA GGTGGAGCCT GTGCTGGACT ACCTGACCTT TCTGCCTGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-054695|UBD,CARD|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0862--Zinc
Interpro

IPR031964--CARD_dom
IPR011029--DEATH-like_dom
IPR006935--Helicase/UvrB_N
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR021673--RLR_CTR
PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51789--RLR_CTR
Pfam

PF16739--CARD_2
PF00271--Helicase_C
PF04851--ResIII
PF11648--RIG-I_C-RD
SMART

SM00487--DEXDc
SM00490--HELICc
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0003725--F:double-stranded RNA binding
GO:0004386--F:helicase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0003727--F:single-stranded RNA binding
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0039530--P:MDA-5 signaling pathway
GO:0032727--P:positive regulation of interferon-alpha production
GO:0032728--P:positive regulation of interferon-beta production
GO:0016925--P:protein sumoylation
KEGG mcc:702024
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001336 Ailuropoda melanoleuca 84.92 0.00e+00 1637.00
IUUC-Apl-003900 Anas platyrhynchos 61.83 0.00e+00 1208.00
IUUC-Aca-005329 Anolis carolinensis 59.48 0.00e+00 1029.00
IUUC-Aly-005838 Arabidopsis lyrata 31.46 2.10e-01 28.10
IUUC-Ame-011305 Astyanax mexicanus 48.02 0.00e+00 878.00
IUUC-Bta-012361 Bos taurus 84.49 0.00e+00 1597.00
IUUC-Cja-018760 Callithrix jacchus 93.37 0.00e+00 1758.00
IUUC-Cfa-020321 Canis familiaris 83.68 0.00e+00 1576.00
IUUC-Cpo-022450 Cavia porcellus 81.01 0.00e+00 1596.00
IUUC-Cre-022916 Chlamydomonas reinhardtii 33.33 2.00e-12 68.60
IUUC-Csa-024194 Chlorocebus sabaeus 99.61 0.00e+00 1830.00
IUUC-Cho-024364 Choloepus hoffmanni 77.42 0.00e+00 1055.00
IUUC-Dre-028305 Danio rerio 54.58 0.00e+00 717.00
IUUC-Dno-029831 Dasypus novemcinctus 87.41 0.00e+00 1682.00
IUUC-Dor-030410 Dipodomys ordii 78.72 0.00e+00 1271.00
IUUC-Ete-032950 Echinops telfairi 68.25 0.00e+00 781.00
IUUC-Eca-034279 Equus caballus 88.69 0.00e+00 1677.00
IUUC-Eeu-034678 Erinaceus europaeus 80.80 0.00e+00 1580.00
IUUC-Fca-035618 Felis catus 88.75 0.00e+00 993.00
IUUC-Fal-037106 Ficedula albicollis 59.48 0.00e+00 1106.00
IUUC-Gmo-038598 Gadus morhua 49.37 0.00e+00 674.00
IUUC-Gga-040467 Gallus gallus 61.31 0.00e+00 1186.00
IUUC-Gac-042316 Gasterosteus aculeatus 47.61 0.00e+00 840.00
IUUC-Ggo-045461 Gorilla gorilla 98.34 0.00e+00 1807.00
IUUC-Hsa-045771 Homo sapiens 98.44 0.00e+00 1807.00
IUUC-Itr-048762 Ictidomys tridecemlineatus 86.44 0.00e+00 1631.00
IUUC-Lch-049913 Latimeria chalumnae 66.26 0.00e+00 931.00
IUUC-Lpe-051697 Leersia perrieri 29.81 4.80e+00 26.90
IUUC-Loc-052768 Lepisosteus oculatus 53.68 0.00e+00 991.00
IUUC-Laf-053933 Loxodonta africana 85.41 0.00e+00 1625.00
IUUC-Meu-056829 Macropus eugenii 74.29 0.00e+00 1125.00
IUUC-Mga-059205 Meleagris gallopavo 62.02 0.00e+00 1187.00
IUUC-Mmr-060703 Microcebus murinus 89.32 0.00e+00 1653.00
IUUC-Mdo-063079 Monodelphis domestica 72.01 0.00e+00 1445.00
IUUC-Mmu-064066 Mus musculus 80.41 0.00e+00 1637.00
IUUC-Mpu-066261 Mustela putorius furo 84.50 0.00e+00 1597.00
IUUC-Mlu-068196 Myotis lucifugus 83.72 0.00e+00 1576.00
IUUC-Nle-069479 Nomascus leucogenys 93.95 0.00e+00 1733.00
IUUC-Opr-070717 Ochotona princeps 77.21 0.00e+00 1183.00
IUUC-Ont-071702 Oreochromis niloticus 47.70 0.00e+00 858.00
IUUC-Oan-073639 Ornithorhynchus anatinus 66.67 0.00e+00 1202.00
IUUC-Ocu-074521 Oryctolagus cuniculus 87.32 0.00e+00 1695.00
IUUC-Ola-086351 Oryzias latipes 46.47 0.00e+00 821.00
IUUC-Oga-088539 Otolemur garnettii 86.34 0.00e+00 1625.00
IUUC-Oar-090186 Ovis aries 84.39 0.00e+00 1583.00
IUUC-Ptr-090575 Pan troglodytes 93.76 0.00e+00 1725.00
IUUC-Pan-092371 Papio anubis 99.51 0.00e+00 1831.00
IUUC-Psi-093072 Pelodiscus sinensis 64.56 0.00e+00 1269.00
IUUC-Pma-094345 Petromyzon marinus 43.58 9.00e-97 347.00
IUUC-Pfo-096401 Poecilia formosa 51.94 0.00e+00 674.00
IUUC-Pab-097623 Pongo abelii 96.59 0.00e+00 1823.00
IUUC-Pca-100993 Procavia capensis 78.82 0.00e+00 1316.00
IUUC-Pva-102227 Pteropus vampyrus 80.70 0.00e+00 1496.00
IUUC-Rno-105198 Rattus norvegicus 80.33 0.00e+00 1630.00
IUUC-Sha-107622 Sarcophilus harrisii 73.38 0.00e+00 1432.00
IUUC-Sar-113625 Sorex araneus 70.58 0.00e+00 748.00
IUUC-Tgu-117486 Taeniopygia guttata 60.62 0.00e+00 1146.00
IUUC-Tru-118445 Takifugu rubripes 45.37 0.00e+00 822.00
IUUC-Tsy-119512 Tarsius syrichta 88.10 0.00e+00 1599.00
IUUC-Tni-120711 Tetraodon nigroviridis 45.76 0.00e+00 858.00
IUUC-Tbe-127644 Tupaia belangeri 76.59 0.00e+00 1416.00
IUUC-Ttr-128989 Tursiops truncatus 80.88 0.00e+00 1590.00
IUUC-Vpa-130587 Vicugna pacos 79.86 0.00e+00 1263.00
IUUC-Xtr-132127 Xenopus tropicalis 53.99 0.00e+00 1022.00
Created Date 25-Jun-2017

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