iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132427

Ensembl Protein ID

ENSXETP00000021911.2

UniProt Accession

F6USI5; F6USI5_XENTR

Genbank Protein ID

ENSXETP00000021911

Protein Name

Vav guanine nucleotide exchange factor 3

Genbank Nucleotide ID

AAMC01009384

Gene Name

vav3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000009944.3	ENSXETT00000021911.2	ENSXETP00000021911.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.30e-12	45.1	798	849

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l k dvv++   ++  +gW++g  e +gk G fP+ +ve+
   Q: 798  IARYDFCARDMRELSLFKEDVVKIY-TKSGTNGWWRG--ESNGKVGWFPSTYVEE 849
           688*********************9.999********..9*************86 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MEPWRQCAQW LIRCKVLPPN HRVTLDTAQV FDLAQTLRDG VLLCQLLKNL QGNSINLKEI 60
NLRPQMSQIM CYKNVRTIIA SCCNNFGYRL IQAFITYSLF IPKCFAKVIE TLSKLSHTTI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCCTT GGAGGCAGTG TGCCCAGTGG CTGATCAGAT GTAAGGTGCT CCCCCCCAAT 60
CACAGGGTGA CATTGGACAC AGCACAGGTG TTTGACCTGG CCCAGACTCT CCGGGATGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035556--P:intracellular signal transduction
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	72.50	0.00e+00	1175.00
IUUC-Apl-003734	Anas platyrhynchos	71.52	0.00e+00	1078.00
IUUC-Aca-004477	Anolis carolinensis	68.26	0.00e+00	1114.00
IUUC-Ame-011279	Astyanax mexicanus	57.11	0.00e+00	930.00
IUUC-Bta-012722	Bos taurus	72.50	0.00e+00	1179.00
IUUC-Cja-018941	Callithrix jacchus	72.24	0.00e+00	1150.00
IUUC-Cfa-020266	Canis familiaris	72.08	0.00e+00	1029.00
IUUC-Cpo-021966	Cavia porcellus	72.96	0.00e+00	1024.00
IUUC-Csa-023892	Chlorocebus sabaeus	71.25	0.00e+00	1053.00
IUUC-Dre-028199	Danio rerio	60.14	0.00e+00	992.00
IUUC-Dno-029474	Dasypus novemcinctus	72.27	0.00e+00	1174.00
IUUC-Eca-033961	Equus caballus	72.08	0.00e+00	1054.00
IUUC-Eeu-034719	Erinaceus europaeus	61.40	3.00e-177	615.00
IUUC-Fca-036572	Felis catus	71.96	0.00e+00	1138.00
IUUC-Fal-036802	Ficedula albicollis	71.10	0.00e+00	1196.00
IUUC-Gmo-039409	Gadus morhua	61.99	0.00e+00	1003.00
IUUC-Gga-040884	Gallus gallus	72.27	0.00e+00	1190.00
IUUC-Gac-041395	Gasterosteus aculeatus	64.80	0.00e+00	1091.00
IUUC-Ggo-044460	Gorilla gorilla	71.88	0.00e+00	1006.00
IUUC-Hsa-046099	Homo sapiens	70.42	0.00e+00	1155.00
IUUC-Itr-048144	Ictidomys tridecemlineatus	70.58	0.00e+00	1027.00
IUUC-Lch-049650	Latimeria chalumnae	78.40	1.00e-102	364.00
IUUC-Loc-052487	Lepisosteus oculatus	65.11	0.00e+00	1094.00
IUUC-Laf-054564	Loxodonta africana	71.68	0.00e+00	1165.00
IUUC-Mcc-054622	Macaca mulatta	70.19	0.00e+00	1152.00
IUUC-Meu-056680	Macropus eugenii	66.51	0.00e+00	1062.00
IUUC-Mga-060013	Meleagris gallopavo	70.71	0.00e+00	1145.00
IUUC-Mmr-061251	Microcebus murinus	68.71	0.00e+00	1165.00
IUUC-Mdo-061875	Monodelphis domestica	72.27	0.00e+00	1180.00
IUUC-Mmu-063735	Mus musculus	72.15	0.00e+00	1198.00
IUUC-Mpu-065856	Mustela putorius furo	72.86	0.00e+00	1180.00
IUUC-Mlu-068108	Myotis lucifugus	69.62	0.00e+00	1118.00
IUUC-Nle-069863	Nomascus leucogenys	69.76	0.00e+00	1130.00
IUUC-Opr-070372	Ochotona princeps	62.93	0.00e+00	752.00
IUUC-Ont-072286	Oreochromis niloticus	65.29	0.00e+00	1078.00
IUUC-Ocu-074194	Oryctolagus cuniculus	72.74	0.00e+00	1187.00
IUUC-Ola-086336	Oryzias latipes	64.05	0.00e+00	1070.00
IUUC-Oar-089272	Ovis aries	72.62	0.00e+00	1219.00
IUUC-Ptr-090652	Pan troglodytes	70.46	0.00e+00	1153.00
IUUC-Pan-092550	Papio anubis	69.66	0.00e+00	1006.00
IUUC-Psi-093784	Pelodiscus sinensis	67.28	0.00e+00	999.00
IUUC-Pfo-097308	Poecilia formosa	63.34	0.00e+00	1075.00
IUUC-Pab-098698	Pongo abelii	70.27	0.00e+00	1150.00
IUUC-Pva-102262	Pteropus vampyrus	72.55	0.00e+00	1129.00
IUUC-Rno-105421	Rattus norvegicus	71.92	0.00e+00	1200.00
IUUC-Sha-107325	Sarcophilus harrisii	72.50	0.00e+00	1196.00
IUUC-Sar-113456	Sorex araneus	69.68	0.00e+00	1147.00
IUUC-Tgu-116595	Taeniopygia guttata	70.44	0.00e+00	1130.00
IUUC-Tru-117884	Takifugu rubripes	59.02	0.00e+00	1011.00
IUUC-Tsy-119429	Tarsius syrichta	65.90	0.00e+00	955.00
IUUC-Tni-119951	Tetraodon nigroviridis	63.13	0.00e+00	1020.00
IUUC-Tur-126441	Triticum urartu	25.44	2.70e-01	29.60
IUUC-Ttr-128281	Tursiops truncatus	72.39	0.00e+00	1175.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence