iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098018

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01166382

Gene Name

WSB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000008076.2	ENSPPYT00000009452.2	ENSPPYP00000009082.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	5.30e-17	61.5	375	420
E3 adaptor/Cullin RING/DCX/DWD	2.10e-32	109.8	169	203
UBD/Beta-Prp	2.90e-47	161.4	135	378

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           +++w ++++++SLqhLCR++Irr +++q++   ++LP+P++L ++L+y+
   Q: 375  VYFWATPRQVPSLQHLCRMSIRRVMPTQEV---QELPIPSKLLEFLSYR 420
           689************************999...**************97 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           Ht+ v++l f +d   +lvs+s+D+t++vWDl+++
   Q: 169  HTEVVRDLTFaPDgsLILVSASRDKTLRVWDLKDD 203
           9**********8865668*************9987 PP

UBD/Beta-Prp

   S: 17   kfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfs 103
            f +d+ llatg  +g+ik+wdv tgkll  l +h++ v++++f pdg+ ilv++s+D+t++vwdl+ +g ++ +l+gh++ v+s++fs
   Q: 135  RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLKdDGNMMKVLRGHQNWVYSCAFS 223
           5678999***********************************************************9799******************* PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tgght 180
           p+++ l s ++ + + +w++++++ ++  l+gh++ v    ++pdg ll+++s+D+ v +Wd  +g++l ++             g+++
   Q: 224  PDSSMLCSVGASKAVFLWNMDKYTMIR-KLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFghlfppptpifaGGAND 311
           ***************************.9******************************************************9888** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           + v+s+sf+++g +++s ++d+ v++w + +      + +  +n ++ +fs ++  l+ g++Dgs+++W
   Q: 312  RWVRSVSFSHDGLHVASLADDKMVRFWRIDED--YPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
           *****************************888..68899****************************** PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MASFPPRVNE KEIVRSRTIG ELLAPAAPFD KKCGRENWTV AFAPHGAYFA WFQRHRTFHL 60
VPWSRCAPNF LLHGTKNVTN SSSLRLPRQN SDGGQKNKPR EHIIDCGDIV WSLAFGSSVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCCGCGG GCTGTGACGT CACGTGGCCG CGCCCCTGCT GCCCAGATAT CTCCTGCGCC 60
GCCCGCCATT TTGACTCCAG TGTCTTGTTT GCAGTCGGCG CGTTAAGGGA ACTGTGTTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001635	Ailuropoda melanoleuca	96.20	0.00e+00	820.00
IUUC-Apl-003903	Anas platyrhynchos	88.70	0.00e+00	763.00
IUUC-Aca-005214	Anolis carolinensis	76.76	0.00e+00	681.00
IUUC-Ame-011740	Astyanax mexicanus	73.87	0.00e+00	665.00
IUUC-Bta-013475	Bos taurus	96.20	0.00e+00	820.00
IUUC-Cja-019053	Callithrix jacchus	97.37	0.00e+00	848.00
IUUC-Cfa-020103	Canis familiaris	97.15	0.00e+00	826.00
IUUC-Cpo-022438	Cavia porcellus	94.06	0.00e+00	828.00
IUUC-Csa-024062	Chlorocebus sabaeus	97.39	0.00e+00	854.00
IUUC-Cho-024334	Choloepus hoffmanni	83.14	0.00e+00	689.00
IUUC-Cin-025590	Ciona intestinalis	38.38	2.00e-75	276.00
IUUC-Csv-026023	Ciona savignyi	38.37	1.00e-75	276.00
IUUC-Dre-028089	Danio rerio	73.63	0.00e+00	667.00
IUUC-Dno-029436	Dasypus novemcinctus	91.74	0.00e+00	671.00
IUUC-Dor-031107	Dipodomys ordii	88.60	0.00e+00	738.00
IUUC-Ete-032326	Echinops telfairi	91.89	0.00e+00	769.00
IUUC-Eca-033401	Equus caballus	95.72	0.00e+00	815.00
IUUC-Eeu-034520	Erinaceus europaeus	92.87	0.00e+00	822.00
IUUC-Fca-036386	Felis catus	96.20	0.00e+00	821.00
IUUC-Fal-036616	Ficedula albicollis	84.77	0.00e+00	732.00
IUUC-Gmo-039335	Gadus morhua	71.25	7.00e-176	609.00
IUUC-Gga-040856	Gallus gallus	86.70	0.00e+00	771.00
IUUC-Gac-042140	Gasterosteus aculeatus	73.00	0.00e+00	656.00
IUUC-Ggo-044619	Gorilla gorilla	97.15	0.00e+00	850.00
IUUC-Hsa-046300	Homo sapiens	97.62	0.00e+00	853.00
IUUC-Itr-048830	Ictidomys tridecemlineatus	95.72	0.00e+00	841.00
IUUC-Lch-049550	Latimeria chalumnae	80.06	3.00e-170	590.00
IUUC-Loc-051769	Lepisosteus oculatus	76.25	0.00e+00	676.00
IUUC-Laf-054576	Loxodonta africana	94.54	0.00e+00	813.00
IUUC-Mcc-054666	Macaca mulatta	99.24	7.00e-156	542.00
IUUC-Meu-055989	Macropus eugenii	88.57	0.00e+00	644.00
IUUC-Mga-059722	Meleagris gallopavo	86.27	0.00e+00	764.00
IUUC-Mmr-060970	Microcebus murinus	95.72	0.00e+00	817.00
IUUC-Mdo-062249	Monodelphis domestica	77.91	0.00e+00	639.00
IUUC-Mmu-063742	Mus musculus	91.43	0.00e+00	807.00
IUUC-Mpu-066518	Mustela putorius furo	95.49	0.00e+00	840.00
IUUC-Mlu-068063	Myotis lucifugus	93.82	0.00e+00	805.00
IUUC-Nle-069561	Nomascus leucogenys	97.39	0.00e+00	853.00
IUUC-Opr-071158	Ochotona princeps	90.48	0.00e+00	793.00
IUUC-Ont-072542	Oreochromis niloticus	72.07	0.00e+00	649.00
IUUC-Oan-073217	Ornithorhynchus anatinus	89.79	0.00e+00	790.00
IUUC-Ocu-074251	Oryctolagus cuniculus	94.87	0.00e+00	793.00
IUUC-Ola-086549	Oryzias latipes	71.13	0.00e+00	649.00
IUUC-Oga-088382	Otolemur garnettii	96.20	0.00e+00	823.00
IUUC-Oar-090263	Ovis aries	94.30	0.00e+00	822.00
IUUC-Ptr-090922	Pan troglodytes	97.39	0.00e+00	853.00
IUUC-Pan-092518	Papio anubis	97.39	0.00e+00	854.00
IUUC-Psi-093512	Pelodiscus sinensis	87.89	0.00e+00	778.00
IUUC-Pma-094324	Petromyzon marinus	57.64	2.00e-132	465.00
IUUC-Pfo-096264	Poecilia formosa	71.83	0.00e+00	652.00
IUUC-Pca-101034	Procavia capensis	92.38	0.00e+00	751.00
IUUC-Pva-102862	Pteropus vampyrus	91.45	0.00e+00	751.00
IUUC-Rno-106116	Rattus norvegicus	91.69	0.00e+00	809.00
IUUC-Sha-106952	Sarcophilus harrisii	88.54	0.00e+00	740.00
IUUC-Sar-113211	Sorex araneus	82.39	2.00e-145	508.00
IUUC-Ssc-116440	Sus scrofa	96.67	0.00e+00	822.00
IUUC-Tgu-116675	Taeniopygia guttata	85.50	0.00e+00	736.00
IUUC-Tru-118295	Takifugu rubripes	71.13	0.00e+00	629.00
IUUC-Tsy-118916	Tarsius syrichta	83.37	0.00e+00	691.00
IUUC-Tni-120302	Tetraodon nigroviridis	70.19	2.00e-179	621.00
IUUC-Tbe-127416	Tupaia belangeri	81.82	0.00e+00	660.00
IUUC-Ttr-128185	Tursiops truncatus	96.44	0.00e+00	822.00
IUUC-Xtr-132465	Xenopus tropicalis	81.67	0.00e+00	728.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence