iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000013516.3	ENSXETT00000029616.3	ENSXETP00000029616.3
ENSXETG00000013516.3	ENSXETT00000064851.1	ENSXETP00000058711.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UFD/MUB	28.73	3.00e-15	80.50	IUUC-Ath-007357

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xenopus tropicalis

Functional Description
(View)

Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).

Protein Sequence
(Fasta)

MDETSPLVSP DRDQTDYSYQ SQCSPGVPVC LSPNGRFSAV PGVVVRIPGS ATSPIRGSAA 60
SGPSPPGSPC DRERQPLLER SQTRGAAAQA ERERNKFPDD PEFAEVVKKA EKAIVRDILP 120

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Nucleotide Sequence
(Fasta)

ATGGATGAAA CCAGCCCGTT AGTATCTCCA GACCGGGACC AGACTGATTA CTCTTACCAG 60
TCTCAGTGCT CTCCTGGAGT CCCTGTTTGC CTTAGTCCCA ATGGGCGCTT CTCAGCTGTA 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
KW-0771--Synaptosome
KW-0808--Transferase

Interpro

IPR000403--PI3/4_kinase_cat_dom

Pfam

PF00454--PI3_PI4_kinase

Gene Ontology

GO:0030054--C:cell junction
GO:0031410--C:cytoplasmic vesicle
GO:0030425--C:dendrite
GO:0005768--C:endosome
GO:0035838--C:growing cell tip
GO:0044231--C:host cell presynaptic membrane
GO:0005887--C:integral component of plasma membrane
GO:0031224--C:intrinsic component of membrane
GO:0005765--C:lysosomal membrane
GO:0045121--C:membrane raft
GO:0005739--C:mitochondrion
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0042734--C:presynaptic membrane
GO:0005802--C:trans-Golgi network
GO:0004430--F:1-phosphatidylinositol 4-kinase activity
GO:0035651--F:AP-3 adaptor complex binding
GO:0005524--F:ATP binding
GO:0007032--P:endosome organization
GO:0007030--P:Golgi organization
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0046854--P:phosphatidylinositol phosphorylation

KEGG

xtr:594904

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002849	Amborella trichopoda	27.24	1.00e-12	68.20
IUUC-Aly-005869	Arabidopsis lyrata	27.99	4.00e-15	76.30
IUUC-Ath-007357	Arabidopsis thaliana	28.73	4.00e-16	79.70
IUUC-Acl-008056	Aspergillus clavatus	34.73	3.00e-64	239.00
IUUC-Afl-008443	Aspergillus flavus	32.74	7.00e-59	221.00
IUUC-Aor-010129	Aspergillus oryzae	32.74	8.00e-59	221.00
IUUC-Ame-011505	Astyanax mexicanus	69.47	0.00e+00	638.00
IUUC-Bra-016840	Brassica rapa	30.22	9.00e-18	85.10
IUUC-Cel-018333	Caenorhabditis elegans	38.83	5.00e-69	254.00
IUUC-Dre-027593	Danio rerio	77.33	0.00e+00	717.00
IUUC-Dme-032030	Drosophila melanogaster	68.84	5.00e-87	315.00
IUUC-Ete-032358	Echinops telfairi	70.53	3.00e-145	508.00
IUUC-Fox-037982	Fusarium oxysporum	34.61	9.00e-63	234.00
IUUC-Gmo-039406	Gadus morhua	71.43	0.00e+00	687.00
IUUC-Gga-040459	Gallus gallus	78.09	0.00e+00	732.00
IUUC-Gac-041454	Gasterosteus aculeatus	77.28	0.00e+00	715.00
IUUC-Lpe-051162	Leersia perrieri	26.64	1.00e-13	71.60
IUUC-Loc-051878	Lepisosteus oculatus	78.81	0.00e+00	718.00
IUUC-Mla-059000	Melampsora laricipopulina	38.69	2.00e-53	204.00
IUUC-Mvi-060280	Microbotryum violaceum	42.13	1.00e-35	145.00
IUUC-Ont-072217	Oreochromis niloticus	77.75	0.00e+00	716.00
IUUC-Ogl-077697	Oryza glaberrima	26.77	8.00e-12	65.50
IUUC-Ssl-108516	Sclerotinia sclerotiorum	34.08	4.00e-65	242.00
IUUC-Stu-112084	Solanum tuberosum	26.49	8.00e-13	68.60
IUUC-Ssc-115853	Sus scrofa	76.41	0.00e+00	728.00
IUUC-Tni-120604	Tetraodon nigroviridis	77.33	0.00e+00	716.00
IUUC-Tre-122021	Trichoderma reesei	34.07	3.00e-63	236.00
IUUC-Tur-126000	Triticum urartu	24.93	2.00e-12	67.40
IUUC-Vvi-131161	Vitis vinifera	25.14	3.00e-14	73.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence