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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018271
UUCD1 version UUC-CaE-00326
Ensembl Protein ID T10F2.4
UniProt Accession Q10051; PRP19_CAEEL
Genbank Protein ID CCD72869.1
Protein Name Pre-mRNA-processing factor 19; PRP19/PSO4 homolog; RING-type E3 ubiquitin transferase PRP19
Genbank Nucleotide ID FO081619
Gene Name prp-19; T10F2.4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00020423 T10F2.4 T10F2.4
Annotation
mRNA Expression
GEO
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 5.30e-11 42.7 2 54
E3 adaptor/Cullin RING/DCX/DWD 2.40e-31 106.7 378 416
UBD/Beta-Prp 1.50e-52 178.9 214 438
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 5    eflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvP 57
            f+C Is+el +dPvv++ sG+ +dr+ I k++a++g+ +P+ + +l+e++lv 
   Q: 2    SFVCGISGELTEDPVVSQvSGHIFDRRLIVKFIAENGT-DPISHGELSEDQLVS 54
           59***********************************9.************986 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllk 37
           gHt+ v+++af  ++ +l++Gs Dg +k+WDlr+ + lk
   Q: 378  GHTAAVRSIAFseNGYYLATGSEDGEVKLWDLRKLKNLK 416
           8**********976699***************9987766 PP
   

   UBD/Beta-Prp
   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGs 113
           it++++  +++l +tg+ d+t+ ++d+++++++++++gh+++++av ++pd  + +++s D +i+vw+  +++   ++  h++ v+++s+++sgd+++s+s
   Q: 214  ITALDI--KGNLSLTGGIDKTVVLYDYEKEQVMQTFKGHNKKINAVVLHPDNITAISASADSHIRVWSATDSSSKAIIDVHQAPVTDISLNASGDYILSAS 312
           788888..99*****************************************99************************************************ PP
   S: 114  hdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtg 212
           +d++    d+++g+ l +  ++ g + +v ++++hpdg ++ +G++D +v++Wdlk++++   + g ht +v+s++f++ng +l++gs+dg vklwdl++ 
   Q: 313  DDSYWAFSDIRSGKSLCKvsVEPGSQIAVHSIEFHPDGLIFGTGAADAVVKIWDLKNQTVAAAFPG-HTAAVRSIAFSENGYYLATGSEDGEVKLWDLRKL 412
           **************999888*********************************************9.********************************** PP
   S: 213  ecvrtlng.htdnvksvrfspnderl 237
           + ++t+ +  +++++s+ f+  +++l
   Q: 413  KNLKTFANeEKQPINSLSFDMTGTFL 438
           99***988466889999998777776 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs.
 Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs.
Protein Sequence
(Fasta)
MSFVCGISGE LTEDPVVSQV SGHIFDRRLI VKFIAENGTD PISHGELSED QLVSLKSGGT 60
GSAPRNVSGT SIPSLLKMLQ DEWDTVMLNS FSLRQQLQIA RQELSHSLYQ HDAACRVISR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018271|E3,U-box;E3,WD_repeat;UBD,Beta-Prp|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGATGTCTT TCGTGTGCGG AATCAGTGGT GAACTGACCG AAGACCCAGT CGTCTCTCAA 60
GTCTCAGGGC ACATCTTTGA TCGTCGGCTG ATCGTTAAAT TCATTGCCGA AAACGGAACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018271|E3,U-box;E3,WD_repeat;UBD,Beta-Prp|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00504--Ubox
SM00320--WD40
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000974--C:Prp19 complex
GO:0071006--C:U2-type catalytic step 1 spliceosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030154--P:cell differentiation
GO:0006281--P:DNA repair
GO:0000349--P:generation of catalytic spliceosome for first transesterification step
GO:0007275--P:multicellular organism development
GO:0070534--P:protein K63-linked ubiquitination
KEGG cel:CELE_T10F2.4
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000488 Aegilops tauschii 37.55 1.00e-88 320.00
IUUC-Aml-001230 Ailuropoda melanoleuca 50.30 6.00e-138 483.00
IUUC-Atr-002594 Amborella trichopoda 38.45 2.00e-99 355.00
IUUC-Apl-003686 Anas platyrhynchos 48.01 1.00e-103 368.00
IUUC-Aca-005272 Anolis carolinensis 52.17 3.00e-147 513.00
IUUC-Aly-005586 Arabidopsis lyrata 38.95 2.00e-101 361.00
IUUC-Ath-007696 Arabidopsis thaliana 39.53 7.00e-103 366.00
IUUC-Acl-008335 Aspergillus clavatus 32.70 8.00e-58 216.00
IUUC-Afl-008527 Aspergillus flavus 33.06 4.00e-62 230.00
IUUC-Afu-008957 Aspergillus fumigatus 35.28 3.00e-71 261.00
IUUC-Ani-009280 Aspergillus nidulans 33.73 7.00e-60 223.00
IUUC-Ang-009746 Aspergillus niger 35.57 6.00e-64 236.00
IUUC-Aor-009905 Aspergillus oryzae 34.21 1.00e-65 242.00
IUUC-Ate-010412 Aspergillus terreus 35.73 1.00e-59 222.00
IUUC-Ame-011561 Astyanax mexicanus 52.50 2.00e-60 224.00
IUUC-Bgr-012283 Blumeria graminis 31.47 1.00e-51 195.00
IUUC-Bta-013242 Bos taurus 51.58 3.00e-147 513.00
IUUC-Bci-013901 Botrytis cinerea 31.11 6.00e-60 223.00
IUUC-Bdi-014896 Brachypodium distachyon 40.15 3.00e-107 380.00
IUUC-Bol-016207 Brassica oleracea 40.12 2.00e-104 371.00
IUUC-Bra-017650 Brassica rapa 39.92 1.00e-102 365.00
IUUC-Cja-019879 Callithrix jacchus 51.58 2.00e-148 517.00
IUUC-Cfa-020175 Canis familiaris 51.58 3.00e-147 513.00
IUUC-Cpo-022379 Cavia porcellus 51.78 1.00e-147 514.00
IUUC-Cre-022993 Chlamydomonas reinhardtii 37.62 2.00e-91 328.00
IUUC-Csa-023500 Chlorocebus sabaeus 51.58 4.00e-147 513.00
IUUC-Cho-025065 Choloepus hoffmanni 45.02 2.00e-64 237.00
IUUC-Cin-025699 Ciona intestinalis 51.98 5.00e-118 416.00
IUUC-Csv-026128 Ciona savignyi 48.35 1.00e-134 471.00
IUUC-Cgl-026507 Colletotrichum gloeosporioides 33.20 2.00e-58 218.00
IUUC-Cne-026860 Cryptococcus neoformans 37.10 1.00e-90 325.00
IUUC-Dre-028187 Danio rerio 52.27 4.00e-147 513.00
IUUC-Dno-029453 Dasypus novemcinctus 51.58 5.00e-147 513.00
IUUC-Dor-030150 Dipodomys ordii 50.00 2.00e-57 215.00
IUUC-Dse-031220 Dothistroma septosporum 32.40 2.00e-56 211.00
IUUC-Dme-031906 Drosophila melanogaster 45.67 6.00e-130 456.00
IUUC-Ete-033035 Echinops telfairi 50.44 3.00e-67 248.00
IUUC-Eca-033478 Equus caballus 51.58 5.00e-147 513.00
IUUC-Eeu-034974 Erinaceus europaeus 50.30 3.00e-98 350.00
IUUC-Fca-036194 Felis catus 51.40 3.00e-144 503.00
IUUC-Fal-037417 Ficedula albicollis 51.19 5.00e-147 513.00
IUUC-Fox-037922 Fusarium oxysporum 32.60 8.00e-57 213.00
IUUC-Fso-038256 Fusarium solani 33.06 4.00e-62 230.00
IUUC-Gmo-038713 Gadus morhua 53.45 2.00e-151 527.00
IUUC-Ggr-039854 Gaeumannomyces graminis 29.54 2.00e-44 172.00
IUUC-Gga-041143 Gallus gallus 51.68 3.00e-147 513.00
IUUC-Gac-042129 Gasterosteus aculeatus 52.27 1.00e-148 518.00
IUUC-Gma-044273 Glycine max 40.62 2.00e-104 371.00
IUUC-Ggo-045262 Gorilla gorilla 51.58 4.00e-147 513.00
IUUC-Hsa-046036 Homo sapiens 51.58 4.00e-147 513.00
IUUC-Hvu-047442 Hordeum vulgare 37.70 1.00e-57 214.00
IUUC-Itr-048169 Ictidomys tridecemlineatus 51.68 8.00e-146 509.00
IUUC-Lch-050105 Latimeria chalumnae 51.67 1.00e-144 504.00
IUUC-Lpe-050976 Leersia perrieri 39.38 5.00e-106 377.00
IUUC-Loc-052042 Lepisosteus oculatus 46.06 7.00e-103 366.00
IUUC-Lma-053143 Leptosphaeria maculans 32.73 1.00e-59 223.00
IUUC-Laf-053451 Loxodonta africana 50.10 3.00e-144 503.00
IUUC-Mcc-055786 Macaca mulatta 51.58 4.00e-147 513.00
IUUC-Meu-056161 Macropus eugenii 50.43 4.00e-65 241.00
IUUC-Mor-057215 Magnaporthe oryzae 29.12 9.00e-46 176.00
IUUC-Mpo-057419 Magnaporthe poae 27.74 6.00e-39 154.00
IUUC-Mtr-057756 Medicago truncatula 39.81 1.00e-100 358.00
IUUC-Mla-059085 Melampsora laricipopulina 34.36 3.00e-76 277.00
IUUC-Mga-060158 Meleagris gallopavo 49.90 4.00e-129 453.00
IUUC-Mvi-060441 Microbotryum violaceum 32.56 1.00e-66 246.00
IUUC-Mmr-061085 Microcebus murinus 51.58 4.00e-147 513.00
IUUC-Mdo-061804 Monodelphis domestica 51.78 2.00e-147 514.00
IUUC-Mmu-063608 Mus musculus 49.71 1.00e-143 501.00
IUUC-Mac-064972 Musa acuminata 39.88 7.00e-104 369.00
IUUC-Mpu-065700 Mustela putorius furo 51.58 3.00e-147 513.00
IUUC-Mlu-068223 Myotis lucifugus 50.67 3.00e-144 503.00
IUUC-Nfi-068504 Neosartorya fischeri 34.68 7.00e-71 259.00
IUUC-Ncr-068729 Neurospora crassa 33.80 5.00e-60 223.00
IUUC-Nle-069754 Nomascus leucogenys 51.58 4.00e-147 513.00
IUUC-Opr-070621 Ochotona princeps 49.70 8.00e-136 475.00
IUUC-Ont-071377 Oreochromis niloticus 52.66 2.00e-149 521.00
IUUC-Oan-073498 Ornithorhynchus anatinus 39.32 6.00e-54 202.00
IUUC-Ocu-074182 Oryctolagus cuniculus 49.53 3.00e-143 500.00
IUUC-Oba-075509 Oryza barthii 39.96 1.00e-107 382.00
IUUC-Obr-076480 Oryza brachyantha 39.58 1.00e-106 379.00
IUUC-Ogl-077052 Oryza glaberrima 39.96 1.00e-107 382.00
IUUC-Ogu-078919 Oryza glumaepatula 39.96 2.00e-107 381.00
IUUC-Oin-079357 Oryza indica 39.42 2.00e-102 364.00
IUUC-Olo-080376 Oryza longistaminata 39.59 1.00e-95 342.00
IUUC-Ome-081973 Oryza meridionalis 39.38 4.00e-96 343.00
IUUC-Oni-082849 Oryza nivara 39.96 1.00e-107 382.00
IUUC-Opu-083243 Oryza punctata 39.77 2.00e-107 381.00
IUUC-Oru-084613 Oryza rufipogon 39.96 1.00e-107 382.00
IUUC-Osa-085407 Oryza sativa 40.12 1.00e-107 382.00
IUUC-Ola-086566 Oryzias latipes 52.25 3.00e-147 513.00
IUUC-Olu-087757 Ostreococcus lucimarinus 37.60 3.00e-82 297.00
IUUC-Oga-089010 Otolemur garnettii 50.10 2.00e-137 480.00
IUUC-Oar-089638 Ovis aries 51.58 3.00e-147 513.00
IUUC-Ptr-091141 Pan troglodytes 51.58 4.00e-147 513.00
IUUC-Pan-092662 Papio anubis 51.58 4.00e-147 513.00
IUUC-Psi-093777 Pelodiscus sinensis 50.24 2.00e-116 411.00
IUUC-Pno-095115 Phaeosphaeria nodorum 32.19 7.00e-63 233.00
IUUC-Ppa-095841 Physcomitrella patens 39.50 2.00e-105 374.00
IUUC-Pfo-096390 Poecilia formosa 52.86 6.00e-150 522.00
IUUC-Pab-098250 Pongo abelii 52.19 5.00e-139 486.00
IUUC-Pop-099854 Populus trichocarpa 40.77 2.00e-103 368.00
IUUC-Pca-100553 Procavia capensis 51.58 6.00e-145 506.00
IUUC-Ppe-101383 Prunus persica 40.62 5.00e-100 357.00
IUUC-Pva-102189 Pteropus vampyrus 51.58 3.00e-147 513.00
IUUC-Pgr-103304 Puccinia graminis 35.17 5.00e-78 283.00
IUUC-Ptt-103984 Puccinia triticina 34.41 2.00e-78 285.00
IUUC-Pte-104385 Pyrenophora teres 31.65 1.00e-61 229.00
IUUC-Pyt-104697 Pyrenophora triticirepentis 31.45 2.00e-60 225.00
IUUC-Rno-105581 Rattus norvegicus 51.58 3.00e-147 513.00
IUUC-Sha-107071 Sarcophilus harrisii 49.81 3.00e-144 503.00
IUUC-Sja-107697 Schizosaccharomyces japonicus 30.75 1.00e-36 146.00
IUUC-Spo-108315 Schizosaccharomyces pombe 29.00 5.00e-39 154.00
IUUC-Ssl-108628 Sclerotinia sclerotiorum 32.03 1.00e-59 222.00
IUUC-Smo-109648 Selaginella moellendorffii 38.52 7.00e-99 353.00
IUUC-Sit-109873 Setaria italica 39.69 5.00e-107 380.00
IUUC-Sly-111673 Solanum lycopersicum 39.65 2.00e-98 351.00
IUUC-Stu-112125 Solanum tuberosum 39.85 4.00e-99 353.00
IUUC-Sbi-114696 Sorghum bicolor 37.33 2.00e-95 341.00
IUUC-Sre-115134 Sporisorium reilianum 31.81 4.00e-68 251.00
IUUC-Ssc-116260 Sus scrofa 51.58 3.00e-147 513.00
IUUC-Tgu-116533 Taeniopygia guttata 51.19 7.00e-147 512.00
IUUC-Tru-117800 Takifugu rubripes 52.47 4.00e-149 520.00
IUUC-Tsy-118980 Tarsius syrichta 48.98 7.00e-131 459.00
IUUC-Tni-120334 Tetraodon nigroviridis 46.87 2.00e-126 444.00
IUUC-Tca-121807 Theobroma cacao 41.35 6.00e-109 386.00
IUUC-Tre-121920 Trichoderma reesei 31.10 2.00e-56 211.00
IUUC-Tvi-122294 Trichoderma virens 29.71 5.00e-51 193.00
IUUC-Tae-125713 Triticum aestivum 39.96 2.00e-107 381.00
IUUC-Tur-126664 Triticum urartu 36.22 5.00e-98 350.00
IUUC-Tme-127026 Tuber melanosporum 34.48 3.00e-63 234.00
IUUC-Tbe-127582 Tupaia belangeri 50.30 4.00e-98 350.00
IUUC-Ttr-128313 Tursiops truncatus 51.68 1.00e-145 508.00
IUUC-Uma-129626 Ustilago maydis 32.46 1.00e-68 253.00
IUUC-Vda-129699 Verticillium dahliae 32.39 5.00e-58 217.00
IUUC-Vpa-130593 Vicugna pacos 52.64 3.00e-131 460.00
IUUC-Vvi-131668 Vitis vinifera 40.08 2.00e-103 368.00
IUUC-Xtr-132186 Xenopus tropicalis 54.82 1.00e-130 458.00
IUUC-Xma-133212 Xiphophorus maculatus 52.86 5.00e-150 523.00
IUUC-Yli-134607 Yarrowia lipolytica 49.24 5.00e-31 125.00
IUUC-Zma-135662 Zea mays 39.58 3.00e-107 380.00
Created Date 25-Jun-2017

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