iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003712

Ensembl Protein ID

ENSAPLP00000011037.1

UniProt Accession

U3IUW4; U3IUW4_ANAPL

Genbank Protein ID

ENSAPLP00000011037

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ADON01106505

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000011239.1	ENSAPLT00000011758.1	ENSAPLP00000011037.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.70e-56	189.6	281	808
UBD/Alpha-Helix/UBA	5.50e-19	67.4	675	711

Active Site

Position(s)	Description	Evidence
290	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
771	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG+kNlgN+CY+N+v+Q +++ipe+++++  + ++  +  +p +p++++ ++++kl + l                       k +++ 
   Q: 281  TGMKNLGNSCYLNAVMQIIFSIPEFQRAYVGNLPRIYDY-SPLDPTQDFNTQMAKLGHGLlsgqyskppmkselieqvmkeeHKPQHNG 368
           7******************************66666665.579****************98888888888877777665443377777* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++++c
   Q: 369  ISPRMFKAFISKGHPEFSSNRQQDAQEFFLHLINLVERNP-----------------------------VGSENPSDVFRFLVEERTQC 428
           ************************************9998.............................788899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++ ++e+   ++++  ++k+  +
   Q: 429  CQSRKVRYTERVDYIMQLPVAMEAATNKDeliayelkrreaeaarrappelvrakiPFSACLQAFSEPNNVED---FWSSALQAKSAGV 514
           *******99999999*****99998888799*****************************************7...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + + ++k++ +v++p+ Ld+++  ++                                        
   Q: 515  KTSRFASFPEYLVVQIKKFTFGLD-WIPKKLDVSVDMPDFLDINHLRATglqpgeeelpdiappiiipddpkdrtmnhfmdsldidess 602
           *********************997.*******************988878888888888888888888888888888888888887777 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 603  vmqlaemgfpleacrkavyytgnlgaevafnwiiahmeepdfaeplvvpafvgatssgatglgavgldnqppeemvaiiismgfqrnla 691
           77777777777777777777777777777777777777777777777777777777777777777766666666666666666666666 PP
   S: 268  ..........peekqke...............................................kkkYeLiavvvHsG.slssGHYvay 298
                           e                                               + +YeL++ ++H+G s+ sGHYv++
   Q: 692  iqalkatnnnL-----EralewifsrpeleeesepaldvmdlenhananilaetgsegprikdgPGRYELFGFISHMGtSTMSGHYVCH 775
           66655555550.....055555555555555666677777777777778888888888888899************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            k+ +g+W+ ++D +V ++  e+  +   +++Y++fY+r
   Q: 776  LKK-EGRWVIYNDLRVCAS--ERPPK---DQGYIYFYHR 808
           ***.9***********999..78888...99******97 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLld 40
           e++++ +++MGF r++a+qaL a+nnnle+A+e++++
   Q: 675  EEMVAIIISMGFQRNLAIQALKATNNNLERALEWIFS 711
           89*********************************96 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

DSEGGLYVCM NTFLGFGREH IERHYRKTGQ CVYLHLKRHV REKVPGASGG ALPKRRNAKL 60
FLADLETNSD LNGDDFEYED EAKLVLFPDH YEISLPNIEE LPALVTIACD ALLSAKSPYR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTCAGAAG GAGGTCTCTA TGTGTGCATG AACACGTTTC TGGGATTTGG AAGGGAACAC 60
ATTGAAAGGC ATTACCGGAA AACAGGACAG TGTGTATATT TGCACCTGAA GCGACATGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	83.46	0.00e+00	1322.00
IUUC-Aca-004634	Anolis carolinensis	87.79	0.00e+00	1409.00
IUUC-Ame-011470	Astyanax mexicanus	75.55	0.00e+00	1235.00
IUUC-Bta-013349	Bos taurus	83.23	0.00e+00	1342.00
IUUC-Cja-019021	Callithrix jacchus	83.35	0.00e+00	1320.00
IUUC-Cfa-020614	Canis familiaris	83.70	0.00e+00	1324.00
IUUC-Cpo-022484	Cavia porcellus	83.23	0.00e+00	1319.00
IUUC-Csa-024078	Chlorocebus sabaeus	83.72	0.00e+00	1325.00
IUUC-Cho-024522	Choloepus hoffmanni	69.17	0.00e+00	1063.00
IUUC-Cme-027335	Cyanidioschyzon merolae	28.09	1.00e-52	201.00
IUUC-Dre-027651	Danio rerio	75.33	0.00e+00	1279.00
IUUC-Dno-028975	Dasypus novemcinctus	83.39	0.00e+00	1315.00
IUUC-Dor-030130	Dipodomys ordii	61.90	0.00e+00	883.00
IUUC-Ete-032251	Echinops telfairi	71.15	0.00e+00	1105.00
IUUC-Eca-033568	Equus caballus	83.72	0.00e+00	1327.00
IUUC-Eeu-034612	Erinaceus europaeus	67.28	0.00e+00	1003.00
IUUC-Fca-036280	Felis catus	83.83	0.00e+00	1326.00
IUUC-Fal-036610	Ficedula albicollis	94.39	0.00e+00	1482.00
IUUC-Gmo-038906	Gadus morhua	72.58	0.00e+00	1181.00
IUUC-Gga-041215	Gallus gallus	94.58	0.00e+00	1499.00
IUUC-Gac-042441	Gasterosteus aculeatus	72.34	0.00e+00	1203.00
IUUC-Ggo-044446	Gorilla gorilla	83.85	0.00e+00	1327.00
IUUC-Hsa-046546	Homo sapiens	83.60	0.00e+00	1321.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	79.14	0.00e+00	1253.00
IUUC-Lch-050425	Latimeria chalumnae	79.71	0.00e+00	1317.00
IUUC-Loc-052072	Lepisosteus oculatus	76.82	0.00e+00	1249.00
IUUC-Laf-053909	Loxodonta africana	81.82	0.00e+00	1308.00
IUUC-Mcc-054686	Macaca mulatta	83.85	0.00e+00	1326.00
IUUC-Meu-056361	Macropus eugenii	76.79	0.00e+00	1197.00
IUUC-Mga-059972	Meleagris gallopavo	89.90	0.00e+00	1430.00
IUUC-Mmr-060916	Microcebus murinus	83.83	0.00e+00	1323.00
IUUC-Mdo-062302	Monodelphis domestica	85.80	0.00e+00	1403.00
IUUC-Mmu-063639	Mus musculus	82.74	0.00e+00	1352.00
IUUC-Mpu-066533	Mustela putorius furo	83.70	0.00e+00	1325.00
IUUC-Mlu-067786	Myotis lucifugus	78.22	0.00e+00	1249.00
IUUC-Nle-069997	Nomascus leucogenys	83.67	0.00e+00	1311.00
IUUC-Ont-071859	Oreochromis niloticus	71.83	0.00e+00	1203.00
IUUC-Oan-072959	Ornithorhynchus anatinus	85.77	2.00e-126	444.00
IUUC-Ocu-074265	Oryctolagus cuniculus	83.35	0.00e+00	1318.00
IUUC-Ola-087344	Oryzias latipes	72.01	0.00e+00	1220.00
IUUC-Oga-088734	Otolemur garnettii	83.48	0.00e+00	1325.00
IUUC-Oar-089636	Ovis aries	82.86	0.00e+00	1340.00
IUUC-Ptr-090982	Pan troglodytes	83.72	0.00e+00	1326.00
IUUC-Pan-091991	Papio anubis	83.85	0.00e+00	1326.00
IUUC-Psi-093509	Pelodiscus sinensis	90.51	0.00e+00	1473.00
IUUC-Pfo-096029	Poecilia formosa	74.40	0.00e+00	1253.00
IUUC-Pab-098672	Pongo abelii	79.53	0.00e+00	1229.00
IUUC-Pca-100860	Procavia capensis	65.03	0.00e+00	877.00
IUUC-Ppe-101315	Prunus persica	43.78	0.00e+00	639.00
IUUC-Pva-102545	Pteropus vampyrus	77.19	0.00e+00	1202.00
IUUC-Rno-105210	Rattus norvegicus	82.24	0.00e+00	1330.00
IUUC-Sar-113733	Sorex araneus	82.96	0.00e+00	704.00
IUUC-Tgu-116591	Taeniopygia guttata	94.08	0.00e+00	1501.00
IUUC-Tru-118627	Takifugu rubripes	71.33	0.00e+00	1223.00
IUUC-Tsy-119278	Tarsius syrichta	76.54	0.00e+00	1189.00
IUUC-Tni-120804	Tetraodon nigroviridis	73.43	0.00e+00	1242.00
IUUC-Tbe-127699	Tupaia belangeri	69.45	0.00e+00	760.00
IUUC-Ttr-128295	Tursiops truncatus	75.99	0.00e+00	1179.00
IUUC-Vpa-130170	Vicugna pacos	73.49	0.00e+00	1146.00
IUUC-Xtr-132809	Xenopus tropicalis	74.23	0.00e+00	1199.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence