iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-024078

Ensembl Protein ID

ENSCSAP00000009269.1

UniProt Accession

A0A0D9RKY0; A0A0D9RKY0_CHLSB

Genbank Protein ID

ENSCSAP00000009269

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AQIB01119119

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000013094.1	ENSCSAT00000011188.1	ENSCSAP00000009269.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.70e-57	193.3	336	860
UBD/Alpha-Helix/UBA	1.40e-20	72.7	730	767

Active Site

Position(s)	Description	Evidence
345	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
823	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 336  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeHKPQQNG 423
           7******************************788777765.79*****************8888888888888877765543388888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 424  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 483
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             +  cL++f+++e++++   ++++  ++k+  +
   Q: 484  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaeanrrplpelvrakiPFGACLQAFSEPENVDD---FWSSALQAKSAGV 569
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 570  KTSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRARglqpgeeelpdisppivipddskdrlmnqlidpsdidess 657
           *********************997.*******************999889999999999999999998888888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 658  vmqlaemgfpleacrkavyftgnmgaevafnwiivhmeepdfaepltmpgyggaasagasvfgatgldnqppeeivaiitsmgfqrnqa 746
           77777777777777777777777777777777777777777777777777777777777777777777666666666666666666666 PP
   S: 268  ...........peekqke...........................................kkkYeLiavvvHsG.slssGHYvayvkn 301
                      +     +                                           + +YeL+a ++H+G s+ sGHY++++k+
   Q: 747  iqalratnnnlE-----RaldwifshpefeedsdfviemennananiiseakpegprvkdgSGTYELFAFISHMGtSTMSGHYICHIKK 830
           666665555550.....05555555555555555666666666677788888888888888**************************** PP
   S: 302  ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 831  -EGRWVIYNDHKVCAS--ERPPK---DLGYMYFYHR 860
           .9***********999..78888...89******97 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaLra+nnnle+A+++++++
   Q: 730  EEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSH 767
           899*********************************97 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MQRRGALFGM PGGSGGRKMA AGDIGELLVP HMPTIRVPRS GDRVYKNECA FSYDSPNSEG 60
GLYVCMNTFL AFGREHVERH FRKTGQSVYM HLKRHVREKV RGASGGALPK RRNSKIFLDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGCGCGCT CCGGCTCCGG CTCGGCTCGC TCGGCTCCGG TGCGTGCCGA GGCCATGCAG 60
CGCCGGGGCG CCCTGTTCGG CATGCCGGGC GGCAGCGGAG GCCGGAAGAT GGCTGCAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

csab:103221201

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	40.07	6.00e-169	588.00
IUUC-Aml-001356	Ailuropoda melanoleuca	98.49	0.00e+00	1617.00
IUUC-Atr-002580	Amborella trichopoda	42.35	0.00e+00	653.00
IUUC-Apl-003712	Anas platyrhynchos	83.85	0.00e+00	1358.00
IUUC-Aca-004634	Anolis carolinensis	83.31	0.00e+00	1400.00
IUUC-Aly-005727	Arabidopsis lyrata	43.46	0.00e+00	654.00
IUUC-Acl-008057	Aspergillus clavatus	33.73	2.00e-116	413.00
IUUC-Ate-010531	Aspergillus terreus	30.63	6.00e-96	345.00
IUUC-Ame-011470	Astyanax mexicanus	74.45	0.00e+00	1284.00
IUUC-Bta-013349	Bos taurus	98.03	0.00e+00	1652.00
IUUC-Cja-019021	Callithrix jacchus	97.33	0.00e+00	1596.00
IUUC-Cfa-020614	Canis familiaris	98.72	0.00e+00	1628.00
IUUC-Cpo-022484	Cavia porcellus	98.03	0.00e+00	1510.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	38.38	7.00e-101	361.00
IUUC-Cho-024522	Choloepus hoffmanni	81.41	0.00e+00	1181.00
IUUC-Csv-026347	Ciona savignyi	43.15	0.00e+00	700.00
IUUC-Cme-027335	Cyanidioschyzon merolae	25.58	3.00e-53	204.00
IUUC-Dre-027651	Danio rerio	74.83	0.00e+00	1348.00
IUUC-Dno-028975	Dasypus novemcinctus	98.27	0.00e+00	1620.00
IUUC-Dor-030130	Dipodomys ordii	73.77	0.00e+00	1069.00
IUUC-Ete-032251	Echinops telfairi	82.78	0.00e+00	1282.00
IUUC-Eca-033568	Equus caballus	98.88	0.00e+00	1510.00
IUUC-Eeu-034612	Erinaceus europaeus	79.68	0.00e+00	1150.00
IUUC-Fca-036280	Felis catus	99.01	0.00e+00	1513.00
IUUC-Fal-036610	Ficedula albicollis	84.77	0.00e+00	1336.00
IUUC-Gmo-038906	Gadus morhua	72.64	0.00e+00	1251.00
IUUC-Gga-041215	Gallus gallus	83.35	0.00e+00	1434.00
IUUC-Gac-042441	Gasterosteus aculeatus	72.60	0.00e+00	1273.00
IUUC-Gma-043614	Glycine max	42.92	0.00e+00	639.00
IUUC-Ggo-044446	Gorilla gorilla	99.30	0.00e+00	1634.00
IUUC-Hsa-046546	Homo sapiens	99.54	0.00e+00	1635.00
IUUC-Hvu-047563	Hordeum vulgare	44.59	3.00e-162	565.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	89.67	0.00e+00	1433.00
IUUC-Lch-050425	Latimeria chalumnae	77.97	0.00e+00	1359.00
IUUC-Loc-052072	Lepisosteus oculatus	77.48	0.00e+00	1309.00
IUUC-Laf-053909	Loxodonta africana	96.54	0.00e+00	1610.00
IUUC-Mcc-054686	Macaca mulatta	99.77	0.00e+00	1639.00
IUUC-Meu-056361	Macropus eugenii	80.68	0.00e+00	1312.00
IUUC-Mtr-058680	Medicago truncatula	44.58	0.00e+00	667.00
IUUC-Mga-059972	Meleagris gallopavo	79.23	0.00e+00	1300.00
IUUC-Mvi-060476	Microbotryum violaceum	32.05	2.00e-106	380.00
IUUC-Mmr-060916	Microcebus murinus	97.68	0.00e+00	1614.00
IUUC-Mdo-062302	Monodelphis domestica	89.52	0.00e+00	1516.00
IUUC-Mmu-063639	Mus musculus	95.48	0.00e+00	1604.00
IUUC-Mac-065634	Musa acuminata	40.02	1.00e-178	620.00
IUUC-Mpu-066533	Mustela putorius furo	98.84	0.00e+00	1629.00
IUUC-Mlu-067786	Myotis lucifugus	91.67	0.00e+00	1469.00
IUUC-Nle-069997	Nomascus leucogenys	99.37	0.00e+00	1503.00
IUUC-Ont-071859	Oreochromis niloticus	72.81	0.00e+00	1276.00
IUUC-Oan-072959	Ornithorhynchus anatinus	89.12	4.00e-129	453.00
IUUC-Ocu-074265	Oryctolagus cuniculus	98.02	0.00e+00	1600.00
IUUC-Oba-075109	Oryza barthii	42.06	0.00e+00	638.00
IUUC-Obr-076292	Oryza brachyantha	42.57	0.00e+00	634.00
IUUC-Ogu-078776	Oryza glumaepatula	41.94	0.00e+00	655.00
IUUC-Olo-080711	Oryza longistaminata	40.44	1.00e-167	583.00
IUUC-Ome-081506	Oryza meridionalis	41.54	7.00e-171	593.00
IUUC-Oni-082320	Oryza nivara	41.18	0.00e+00	632.00
IUUC-Opu-083801	Oryza punctata	41.82	0.00e+00	630.00
IUUC-Ola-087344	Oryzias latipes	71.72	0.00e+00	1280.00
IUUC-Oga-088734	Otolemur garnettii	98.56	0.00e+00	1561.00
IUUC-Oar-089636	Ovis aries	98.02	0.00e+00	1572.00
IUUC-Ptr-090982	Pan troglodytes	99.54	0.00e+00	1638.00
IUUC-Pan-091991	Papio anubis	99.88	0.00e+00	1641.00
IUUC-Psi-093509	Pelodiscus sinensis	86.49	0.00e+00	1464.00
IUUC-Pfo-096029	Poecilia formosa	74.28	0.00e+00	1320.00
IUUC-Pab-098672	Pongo abelii	95.25	0.00e+00	1536.00
IUUC-Pop-098943	Populus trichocarpa	43.53	0.00e+00	650.00
IUUC-Pca-100860	Procavia capensis	74.07	0.00e+00	1040.00
IUUC-Ppe-101315	Prunus persica	44.12	0.00e+00	662.00
IUUC-Pva-102545	Pteropus vampyrus	90.15	0.00e+00	1475.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	31.58	2.00e-95	343.00
IUUC-Rno-105210	Rattus norvegicus	94.67	0.00e+00	1580.00
IUUC-Spo-108144	Schizosaccharomyces pombe	30.63	2.00e-104	373.00
IUUC-Sly-111523	Solanum lycopersicum	42.54	0.00e+00	687.00
IUUC-Sar-113733	Sorex araneus	96.53	0.00e+00	776.00
IUUC-Tgu-116591	Taeniopygia guttata	84.61	0.00e+00	1434.00
IUUC-Tru-118627	Takifugu rubripes	71.17	0.00e+00	1286.00
IUUC-Tsy-119278	Tarsius syrichta	89.96	0.00e+00	1356.00
IUUC-Tni-120804	Tetraodon nigroviridis	74.25	0.00e+00	1316.00
IUUC-Tae-125686	Triticum aestivum	42.32	0.00e+00	647.00
IUUC-Tur-126732	Triticum urartu	39.93	3.00e-175	608.00
IUUC-Tbe-127699	Tupaia belangeri	79.03	0.00e+00	872.00
IUUC-Ttr-128295	Tursiops truncatus	89.81	0.00e+00	1472.00
IUUC-Vpa-130170	Vicugna pacos	87.11	0.00e+00	1331.00
IUUC-Xtr-132809	Xenopus tropicalis	74.13	0.00e+00	1276.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence