iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098672

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ABGA01144758

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000014322.2	ENSPPYT00000016660.2	ENSPPYP00000016018.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.80e-43	147.0	377	828
UBD/Alpha-Helix/UBA	1.40e-20	72.9	698	735

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 56   lfeelw...kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknksl 141
           l+e+++   k +++ +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++ 
   Q: 377  LLEQVMkeeKPQQNGISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSEN 436
           44444555588899**************************************998.............................68889 PP
   S: 142  isdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelege 203
            sd+F++ ++++i+c + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++e++++ 
   Q: 437  PSDVFRFLVEERIQCCQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaeanrrplpelvrakiPFSACLQAFSEPENVDD- 524
           9********************9999999999999999998887799****************************************97. PP
   S: 204  nkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts......................... 267
             ++++  ++k+  + + ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                         
   Q: 525  --FWSSALQAKSAGVITSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRARglqpgeeelpdisppivipddskdr 610
           ..**********************************997.*******************999889999999999999999998888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 611  lmnqlidpsdidessvmqlaemgfpleacrkavyftgnmgaevafnwiivhmeepdfaepltmpgyggaasagasvfgasgldnqppee 699
           88888888888888887777777777777777777777777777777777777777777777777777777777777777777666666 PP
   S: 268  ..........................peekqke...........................................kkkYeLiavvvHs 287
                                     +     +                                           + +YeL+a ++H+
   Q: 700  ivaiitsmgfqrnqaiqalratnnnlE-----RaldwifshpefeedsdfviemennananiiseakpegprvkdgSGTYELFAFISHM 783
           666666666666666666665555550.....05555555555555555666666666677788888888888888************* PP
   S: 288  G.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           G s+ sGHY++++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 784  GtSTMSGHYICHIKK-EGRWVIYNDHKVCAS--ERPPK---DLGYMYFYRR 828
           ***************.9***********999..78888...99******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaLra+nnnle+A+++++++
   Q: 698  EEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSH 735
           899*********************************97 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MQRRGALFGM PGGSGGRKMA AGDIGELLVP HMPTIRVPRS GDRVYKNECA FSYDSPNSEG 60
GLYVCMNTFL AFGREHVERH FRKTGQSVYM HLKRHVREKV RGASGGALPK RRNSKIFLDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNAGCCCG CTCGGGCTCC CGCGCCGACG 60
CCTCAAGGGC TCGCCCTCCG CCCCCCGCCG CCGAGCCCGG CCCGCGCGCC GGGCCCCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	39.60	2.00e-160	559.00
IUUC-Aml-001356	Ailuropoda melanoleuca	93.95	0.00e+00	1512.00
IUUC-Apl-003712	Anas platyrhynchos	79.65	0.00e+00	1260.00
IUUC-Aca-004634	Anolis carolinensis	79.84	0.00e+00	1313.00
IUUC-Ame-011470	Astyanax mexicanus	70.95	0.00e+00	1199.00
IUUC-Bta-013349	Bos taurus	93.74	0.00e+00	1555.00
IUUC-Cja-019021	Callithrix jacchus	93.16	0.00e+00	1500.00
IUUC-Cfa-020614	Canis familiaris	94.20	0.00e+00	1524.00
IUUC-Cpo-022484	Cavia porcellus	93.49	0.00e+00	1412.00
IUUC-Csa-024078	Chlorocebus sabaeus	95.25	0.00e+00	1538.00
IUUC-Cho-024522	Choloepus hoffmanni	84.02	0.00e+00	1178.00
IUUC-Cme-027335	Cyanidioschyzon merolae	30.30	8.00e-29	122.00
IUUC-Dre-027651	Danio rerio	71.21	0.00e+00	1261.00
IUUC-Dno-028975	Dasypus novemcinctus	94.10	0.00e+00	1524.00
IUUC-Dor-030130	Dipodomys ordii	71.57	0.00e+00	1018.00
IUUC-Ete-032251	Echinops telfairi	78.44	0.00e+00	1187.00
IUUC-Eca-033568	Equus caballus	94.30	0.00e+00	1414.00
IUUC-Eeu-034612	Erinaceus europaeus	75.34	0.00e+00	1054.00
IUUC-Fca-036280	Felis catus	94.17	0.00e+00	1410.00
IUUC-Fal-036610	Ficedula albicollis	80.27	0.00e+00	1234.00
IUUC-Gmo-038906	Gadus morhua	69.36	0.00e+00	1167.00
IUUC-Gga-041215	Gallus gallus	79.31	0.00e+00	1333.00
IUUC-Gac-042441	Gasterosteus aculeatus	69.09	0.00e+00	1186.00
IUUC-Ggo-044446	Gorilla gorilla	95.25	0.00e+00	1537.00
IUUC-Hsa-046546	Homo sapiens	95.48	0.00e+00	1538.00
IUUC-Hvu-047563	Hordeum vulgare	41.67	3.00e-144	505.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	85.92	0.00e+00	1350.00
IUUC-Lch-050425	Latimeria chalumnae	74.28	0.00e+00	1266.00
IUUC-Lpe-051523	Leersia perrieri	41.41	6.00e-173	600.00
IUUC-Loc-052072	Lepisosteus oculatus	74.21	0.00e+00	1224.00
IUUC-Laf-053909	Loxodonta africana	92.15	0.00e+00	1509.00
IUUC-Mcc-054686	Macaca mulatta	95.25	0.00e+00	1537.00
IUUC-Meu-056361	Macropus eugenii	76.68	0.00e+00	1216.00
IUUC-Mga-059972	Meleagris gallopavo	75.03	0.00e+00	1200.00
IUUC-Mmr-060916	Microcebus murinus	93.63	0.00e+00	1516.00
IUUC-Mdo-062302	Monodelphis domestica	85.51	0.00e+00	1420.00
IUUC-Mmu-063639	Mus musculus	91.19	0.00e+00	1504.00
IUUC-Mpu-066533	Mustela putorius furo	94.32	0.00e+00	1525.00
IUUC-Mlu-067786	Myotis lucifugus	87.44	0.00e+00	1373.00
IUUC-Nle-069997	Nomascus leucogenys	94.99	0.00e+00	1403.00
IUUC-Ont-071859	Oreochromis niloticus	69.36	0.00e+00	1191.00
IUUC-Oan-072959	Ornithorhynchus anatinus	75.53	2.00e-103	367.00
IUUC-Ocu-074265	Oryctolagus cuniculus	93.83	0.00e+00	1506.00
IUUC-Oba-075109	Oryza barthii	41.40	5.00e-175	608.00
IUUC-Ogu-078776	Oryza glumaepatula	41.28	5.00e-180	624.00
IUUC-Olo-080711	Oryza longistaminata	39.85	2.00e-158	552.00
IUUC-Ome-081506	Oryza meridionalis	40.97	9.00e-162	563.00
IUUC-Oni-082320	Oryza nivara	40.52	3.00e-173	602.00
IUUC-Opu-083801	Oryza punctata	41.16	7.00e-173	600.00
IUUC-Oru-085139	Oryza rufipogon	40.40	1.00e-171	596.00
IUUC-Ola-087344	Oryzias latipes	68.16	0.00e+00	1187.00
IUUC-Oga-088734	Otolemur garnettii	93.87	0.00e+00	1456.00
IUUC-Oar-089636	Ovis aries	93.43	0.00e+00	1473.00
IUUC-Ptr-090982	Pan troglodytes	95.48	0.00e+00	1541.00
IUUC-Pan-091991	Papio anubis	95.37	0.00e+00	1539.00
IUUC-Psi-093509	Pelodiscus sinensis	82.45	0.00e+00	1363.00
IUUC-Pfo-096029	Poecilia formosa	70.68	0.00e+00	1233.00
IUUC-Pop-098943	Populus trichocarpa	41.11	3.00e-169	588.00
IUUC-Pca-100860	Procavia capensis	69.55	0.00e+00	946.00
IUUC-Ppe-101315	Prunus persica	41.88	6.00e-172	597.00
IUUC-Pva-102545	Pteropus vampyrus	85.86	0.00e+00	1377.00
IUUC-Ptt-103928	Puccinia triticina	27.78	2.00e-84	306.00
IUUC-Rno-105210	Rattus norvegicus	90.38	0.00e+00	1483.00
IUUC-Sar-113733	Sorex araneus	87.38	0.00e+00	676.00
IUUC-Tgu-116591	Taeniopygia guttata	80.56	0.00e+00	1334.00
IUUC-Tru-118627	Takifugu rubripes	67.65	0.00e+00	1197.00
IUUC-Tsy-119278	Tarsius syrichta	85.87	0.00e+00	1261.00
IUUC-Tni-120804	Tetraodon nigroviridis	70.53	0.00e+00	1222.00
IUUC-Tur-126732	Triticum urartu	39.47	1.00e-166	580.00
IUUC-Tbe-127699	Tupaia belangeri	73.61	0.00e+00	788.00
IUUC-Ttr-128295	Tursiops truncatus	85.76	0.00e+00	1378.00
IUUC-Vpa-130170	Vicugna pacos	82.53	0.00e+00	1234.00
IUUC-Xtr-132809	Xenopus tropicalis	70.42	0.00e+00	1185.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence