iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-063048

UUCD1 version

UUC-MoD-01117

Ensembl Protein ID

ENSMODP00000008574.2

UniProt Accession

F6PSB4; F6PSB4_MONDO

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000006916.3	ENSMODT00000008744.3	ENSMODP00000008574.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-112	376.2	147	680

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w k++ ++v p++l + +k ++++f+gy+
   Q: 147  TGLKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 230
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqD+qEfl++l+dql+eelk+        +++++ ee++e d+s ++de                                        
   Q: 231  QQDTQEFLRCLMDQLHEELKEpvaadvrdSDSSDSEEKREGDRSPSEDEflscdsssdrgegdgqgrgvgmgntlaetelliqdeagrg 319
           *******************997777777666666666666666666666**************************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 320  isekermkdrkfswghqrtsseqvdedadvdtsmtaiddrptealpsprstspcrtpepdndaymrcssrpcspvhqethsklsssppr 408
           ***************************************************************************************** PP
   S: 130  ....................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke............. 185
                                ++kk+ +++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+             
   Q: 409  sspvrvgpsyvlkkaqvlaaGKKKKELRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhsaiyqsvpakpg 497
           *******************999999**********************************************99888************* PP
   S: 186  ....................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfs 238
                                               +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ +lPe+L++hLkRf 
   Q: 498  acgdsytsqgwiafimeyirrfvvscipswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRF- 585
           ****************************************************************************************. PP
   S: 239  fseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevlee 325
            ++e + + kin++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+e+ v++ 
   Q: 586  -RHEVMYSFKINSHVSFPLEgLDLQPFLAKECVSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVHETVVQN- 670
           .9999*************************99888..9**************************78999*******************. PP
   S: 326  tgstaYvlfYkr 337
             ++aYvlfY++
   Q: 671  --AEAYVLFYRK 680
           ..********98 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

RMGDSREICS HLDSIGEVTK EDLLLKSKGT CQSCGAGGPN LWACLQVACP YVGCGESFAD 60
HSTIHAQAKK HNLTVNLTTF RVWCYACEKE VFLDQRLAAH PPSPPSKFSE QETTLPSHPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCTTTGGT ATGATCCTGA TCAGCTTCTT CCATAAGAGA TGAAGCAGTG AGTCATCTAC 60
AGGACAATGC TTACAGCTGC CCAGTGGAGT CACTTGGAGG TATGGCAAAC CAGAACCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005813--C:centrosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	87.16	0.00e+00	1557.00
IUUC-Apl-003351	Anas platyrhynchos	90.48	0.00e+00	1655.00
IUUC-Aca-005077	Anolis carolinensis	76.35	0.00e+00	1116.00
IUUC-Ame-011777	Astyanax mexicanus	76.91	0.00e+00	1352.00
IUUC-Bta-013063	Bos taurus	86.15	0.00e+00	1537.00
IUUC-Cja-019868	Callithrix jacchus	88.24	0.00e+00	1588.00
IUUC-Cfa-020761	Canis familiaris	87.91	0.00e+00	1583.00
IUUC-Cpo-022267	Cavia porcellus	81.50	0.00e+00	1467.00
IUUC-Csa-024251	Chlorocebus sabaeus	88.77	0.00e+00	1595.00
IUUC-Cho-024483	Choloepus hoffmanni	92.92	1.00e-120	427.00
IUUC-Csv-025889	Ciona savignyi	42.07	8.00e-36	142.00
IUUC-Dre-028061	Danio rerio	75.68	0.00e+00	1216.00
IUUC-Dno-029423	Dasypus novemcinctus	88.11	0.00e+00	1584.00
IUUC-Dor-030877	Dipodomys ordii	84.83	0.00e+00	1018.00
IUUC-Dme-031837	Drosophila melanogaster	50.11	3.00e-140	493.00
IUUC-Ete-032802	Echinops telfairi	77.78	2.00e-135	476.00
IUUC-Eca-034283	Equus caballus	87.70	0.00e+00	1575.00
IUUC-Eeu-034620	Erinaceus europaeus	85.01	0.00e+00	1081.00
IUUC-Fca-036357	Felis catus	87.36	0.00e+00	1541.00
IUUC-Fal-037411	Ficedula albicollis	90.35	0.00e+00	1640.00
IUUC-Gmo-038944	Gadus morhua	59.29	0.00e+00	1038.00
IUUC-Gga-041101	Gallus gallus	89.02	0.00e+00	1627.00
IUUC-Gac-041315	Gasterosteus aculeatus	75.13	0.00e+00	1321.00
IUUC-Ggo-045600	Gorilla gorilla	86.57	0.00e+00	1540.00
IUUC-Hsa-045825	Homo sapiens	88.00	0.00e+00	1558.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	76.31	0.00e+00	1296.00
IUUC-Lch-050002	Latimeria chalumnae	77.52	0.00e+00	1354.00
IUUC-Loc-052574	Lepisosteus oculatus	78.43	0.00e+00	1414.00
IUUC-Laf-054428	Loxodonta africana	88.36	0.00e+00	1581.00
IUUC-Mcc-055736	Macaca mulatta	88.66	0.00e+00	1595.00
IUUC-Meu-056645	Macropus eugenii	53.34	0.00e+00	889.00
IUUC-Mga-059781	Meleagris gallopavo	88.89	0.00e+00	1630.00
IUUC-Mmr-061241	Microcebus murinus	58.46	0.00e+00	1058.00
IUUC-Mmu-064079	Mus musculus	84.87	0.00e+00	1534.00
IUUC-Mpu-066616	Mustela putorius furo	86.74	0.00e+00	1598.00
IUUC-Mlu-067294	Myotis lucifugus	85.29	0.00e+00	1480.00
IUUC-Nle-070015	Nomascus leucogenys	87.79	0.00e+00	1548.00
IUUC-Opr-070328	Ochotona princeps	87.69	0.00e+00	1564.00
IUUC-Ont-071464	Oreochromis niloticus	77.38	0.00e+00	1321.00
IUUC-Oan-073259	Ornithorhynchus anatinus	84.51	0.00e+00	1414.00
IUUC-Ocu-074630	Oryctolagus cuniculus	85.31	0.00e+00	1501.00
IUUC-Ola-087240	Oryzias latipes	76.34	0.00e+00	1304.00
IUUC-Oga-088761	Otolemur garnettii	86.79	0.00e+00	1567.00
IUUC-Oar-089490	Ovis aries	82.00	0.00e+00	1405.00
IUUC-Ptr-091662	Pan troglodytes	88.00	0.00e+00	1556.00
IUUC-Pan-092199	Papio anubis	87.70	0.00e+00	1583.00
IUUC-Psi-093726	Pelodiscus sinensis	91.65	0.00e+00	1677.00
IUUC-Pma-094389	Petromyzon marinus	65.19	2.00e-100	358.00
IUUC-Pfo-097415	Poecilia formosa	61.70	0.00e+00	1082.00
IUUC-Pab-098632	Pongo abelii	87.68	0.00e+00	1546.00
IUUC-Pca-100614	Procavia capensis	81.84	0.00e+00	1209.00
IUUC-Pva-102820	Pteropus vampyrus	57.71	0.00e+00	902.00
IUUC-Rno-105215	Rattus norvegicus	84.86	0.00e+00	1533.00
IUUC-Sce-106176	Saccharomyces cerevisiae	30.50	2.00e-25	111.00
IUUC-Sha-106601	Sarcophilus harrisii	94.88	0.00e+00	1624.00
IUUC-Sar-113665	Sorex araneus	59.17	0.00e+00	1092.00
IUUC-Ssc-115533	Sus scrofa	85.65	0.00e+00	1533.00
IUUC-Tgu-117364	Taeniopygia guttata	90.54	0.00e+00	1602.00
IUUC-Tru-117770	Takifugu rubripes	74.62	0.00e+00	1301.00
IUUC-Tsy-119598	Tarsius syrichta	53.28	0.00e+00	898.00
IUUC-Tni-120001	Tetraodon nigroviridis	74.78	0.00e+00	1272.00
IUUC-Tbe-128125	Tupaia belangeri	59.77	9.00e-66	245.00
IUUC-Ttr-128732	Tursiops truncatus	87.15	0.00e+00	1554.00
IUUC-Vpa-130598	Vicugna pacos	58.66	0.00e+00	1066.00
IUUC-Xtr-132157	Xenopus tropicalis	77.78	0.00e+00	1374.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence