iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033805

UUCD1 version

UUC-EqC-01013

Ensembl Protein ID

ENSECAP00000018429.1

UniProt Accession

F6TYN2; F6TYN2_HORSE

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Gene Name

BAP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000020681.1	ENSECAT00000022311.1	ENSECAP00000018429.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	4.80e-170	565.7	3	726

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk++++++d++v+d+di++++ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q+++++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSNV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSY 173
           ******************99..******************************************************************* PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid......... 259
           v+i+grl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr+++++rl+vlk++         
   Q: 174  VPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRIKYEARLHVLKVNrqtvlealq 260
           *************************************..************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qlirvtqpeliqthksqesqlpeeskpasgkspmaleagrasaasesthtdgveevagscpqapthsppskpklvvkppgsslngvppt 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  ptpivqrlpafldnhnyakspmqeeedlaagvgrsrvpvrppqqysddeddyeddedddvqntnsairykrkgpgkpgplsssgdgqls 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  vlqpntinvlaeklkesqkdlsiplsiktssgagspavampthsqpsptpsnestdtaseigsafnsplrspirsanptrpsspvtshi 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  skvlfgeedsllrvdcirynravrdlgpvistgllhlaedgvlsplalteggkgsspsirpsqgssspeekevleavdgrekpglvrpg 616
           ***************************************************************************************** PP
   S: 260  ..........keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvnegr 338
                     keLl+Llk++e+e++++ea+l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l++lve++is++r++gv++gr
   Q: 617  eplsgekyspKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGR 705
           ***************************************************************************************** PP
   S: 339  lakqrkqgrekkirplkrkrk 359
           l+kqrk++r+k++rp+k+kr+
   Q: 706  LHKQRKPDRRKRSRPYKAKRQ 726
           *******************97 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSNVDLGP TLSRMKDFTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCACGGGG CCCGTTGTCT GTGTGTGGGC CTAGGGGCCC CGGGGGCAGC GGGGGCTCCC 60
GGCGGGGGCG GCTGTGGGTC GGGAGGGCCT GGACATGGCG CTGAGGGGCC GCCCCGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ecb:100051934

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	93.89	0.00e+00	1217.00
IUUC-Apl-003405	Anas platyrhynchos	70.36	0.00e+00	635.00
IUUC-Aca-004836	Anolis carolinensis	80.36	0.00e+00	1148.00
IUUC-Ago-007999	Ashbya gossypii	37.07	5.00e-28	118.00
IUUC-Ang-009859	Aspergillus niger	41.37	9.00e-43	167.00
IUUC-Ame-011946	Astyanax mexicanus	63.65	0.00e+00	887.00
IUUC-Bta-013131	Bos taurus	91.69	0.00e+00	1082.00
IUUC-Cja-019599	Callithrix jacchus	96.16	0.00e+00	1331.00
IUUC-Cfa-021003	Canis familiaris	96.43	0.00e+00	1225.00
IUUC-Cpo-022143	Cavia porcellus	95.75	0.00e+00	1306.00
IUUC-Csa-023477	Chlorocebus sabaeus	95.88	0.00e+00	1296.00
IUUC-Cho-024734	Choloepus hoffmanni	82.42	0.00e+00	755.00
IUUC-Csv-025842	Ciona savignyi	57.88	5.00e-94	337.00
IUUC-Dre-027793	Danio rerio	65.62	0.00e+00	914.00
IUUC-Dno-029253	Dasypus novemcinctus	94.88	0.00e+00	1284.00
IUUC-Dor-030891	Dipodomys ordii	89.16	0.00e+00	1214.00
IUUC-Dme-031796	Drosophila melanogaster	61.19	2.00e-92	332.00
IUUC-Ete-032646	Echinops telfairi	86.79	4.00e-173	601.00
IUUC-Eeu-035216	Erinaceus europaeus	93.54	8.00e-151	526.00
IUUC-Fca-035611	Felis catus	95.82	0.00e+00	1166.00
IUUC-Fal-037186	Ficedula albicollis	80.18	0.00e+00	1001.00
IUUC-Gmo-038824	Gadus morhua	69.44	2.00e-180	625.00
IUUC-Gga-040875	Gallus gallus	82.67	0.00e+00	1127.00
IUUC-Gac-042226	Gasterosteus aculeatus	67.89	0.00e+00	939.00
IUUC-Ggo-045122	Gorilla gorilla	95.34	0.00e+00	1328.00
IUUC-Hsa-045882	Homo sapiens	95.34	0.00e+00	1328.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	96.43	0.00e+00	1313.00
IUUC-Lch-049960	Latimeria chalumnae	72.90	0.00e+00	1007.00
IUUC-Loc-052408	Lepisosteus oculatus	75.53	0.00e+00	659.00
IUUC-Laf-054187	Loxodonta africana	95.34	0.00e+00	1252.00
IUUC-Mcc-055273	Macaca mulatta	94.79	0.00e+00	1292.00
IUUC-Meu-056267	Macropus eugenii	83.20	0.00e+00	1176.00
IUUC-Mga-059958	Meleagris gallopavo	88.56	3.00e-155	540.00
IUUC-Mmr-061280	Microcebus murinus	95.75	0.00e+00	1278.00
IUUC-Mdo-062625	Monodelphis domestica	89.85	0.00e+00	1278.00
IUUC-Mmu-063853	Mus musculus	93.00	0.00e+00	1275.00
IUUC-Mlu-067771	Myotis lucifugus	94.24	0.00e+00	1245.00
IUUC-Opr-070741	Ochotona princeps	92.87	0.00e+00	1281.00
IUUC-Ont-072172	Oreochromis niloticus	66.36	0.00e+00	947.00
IUUC-Oan-073167	Ornithorhynchus anatinus	79.84	0.00e+00	1135.00
IUUC-Ocu-074176	Oryctolagus cuniculus	94.64	0.00e+00	1235.00
IUUC-Ola-087203	Oryzias latipes	85.23	5.00e-135	473.00
IUUC-Oga-089153	Otolemur garnettii	95.15	0.00e+00	1287.00
IUUC-Oar-090008	Ovis aries	92.59	0.00e+00	1246.00
IUUC-Ptr-091234	Pan troglodytes	95.61	0.00e+00	1333.00
IUUC-Pan-092005	Papio anubis	96.16	0.00e+00	1322.00
IUUC-Psi-093995	Pelodiscus sinensis	84.20	0.00e+00	659.00
IUUC-Pma-094110	Petromyzon marinus	88.19	6.00e-65	241.00
IUUC-Pfo-097418	Poecilia formosa	65.39	0.00e+00	931.00
IUUC-Pab-098267	Pongo abelii	95.47	0.00e+00	1306.00
IUUC-Pca-101084	Procavia capensis	93.14	0.00e+00	1210.00
IUUC-Pva-102292	Pteropus vampyrus	97.09	0.00e+00	922.00
IUUC-Rno-105251	Rattus norvegicus	90.97	0.00e+00	1249.00
IUUC-Sha-107100	Sarcophilus harrisii	88.19	0.00e+00	1268.00
IUUC-Sar-113559	Sorex araneus	88.06	0.00e+00	1088.00
IUUC-Ssc-115688	Sus scrofa	95.75	0.00e+00	1304.00
IUUC-Tgu-117424	Taeniopygia guttata	81.11	0.00e+00	1125.00
IUUC-Tru-118585	Takifugu rubripes	67.84	0.00e+00	929.00
IUUC-Tsy-119299	Tarsius syrichta	83.66	0.00e+00	964.00
IUUC-Tni-120808	Tetraodon nigroviridis	67.47	0.00e+00	926.00
IUUC-Tbe-127705	Tupaia belangeri	95.43	0.00e+00	632.00
IUUC-Ttr-128225	Tursiops truncatus	94.38	0.00e+00	1248.00
IUUC-Vpa-130193	Vicugna pacos	92.78	4.00e-131	461.00
IUUC-Xtr-132449	Xenopus tropicalis	71.43	0.00e+00	946.00
IUUC-Xma-133232	Xiphophorus maculatus	64.61	0.00e+00	922.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence