iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000010883.1	ENSPSIT00000012197.1	ENSPSIP00000012139.1
ENSPSIG00000010883.1	ENSPSIT00000012199.1	ENSPSIP00000012141.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.60e-152	507.2	2	688

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 14   dPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCaty 102
            Pglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk+++++++++v+d+di++++ffa+q+i+NsCat+
   Q: 2    PPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDETSVIDDDIVNNMFFAHQLIPNSCATH 85
           69***************.************....******************************************************* PP
   S: 103  AllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrly 191
           Allsvllnc+++  dlG+tlsr+k++t ++spe+k++a+gn+++l+++hns+ar+e+r++pe+q++ ++++t+eafhfvsyv+i+grl+
   Q: 86   ALLSVLLNCSSV--DLGPTLSRMKDFTRGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGISAVRTMEAFHFVSYVPIKGRLF 172
           ************..*************************************************************************** PP
   S: 192  eldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid................. 259
           eldglk++P+d+g++ e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr+++++rl+vlk++                 
   Q: 173  ELDGLKVYPIDHGPWAEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRMKYEARLHVLKMNrqtvlealqqlirvtqp 259
           *****************************..********************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 260  eliqtqksqesqaaeqprpagskacaapetsraqptpdstgqghpasaqslphrskvgakapgsclngapanpnpivqrlpafldnhny 348
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 349  akspmqeeedlaagvgrsrvpvhqhysddeddyddeeeevcsaaaaisreraarlslphdahpaggesplpprpasmthgssragprvl 437
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 438  agskrqpwwpggwrkklhsfqpcspapcrasaqgparrggspraarkapenlairaasksllpppakspvvlagtgrlrpggwgapnsp 526
           ***************************************************************************************** PP
   S: 260  ........................................................keLlkLlkdies......eeekieaqlddekek 286
                                                                   +e ++L +  +       e+ ++ea+l++e+ek
   Q: 527  eprgrssirwwkglassapwtllegwvvvppswtxggealaavradekeasepgdsREKVALCRPSDHpcgaagEIVNYEACLKEEVEK 615
           ********************************************************999999986653233333999************ PP
   S: 287  rkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvnegrlakqrkqgrekkirplkrkrk 359
           rkkfkidd+rRt+nydefic+fi++la+eg+l+ lve++is++r++gv++grl+kqrk++r+k++rp+k+kr+
   Q: 616  RKKFKIDDQRRTHNYDEFICTFISMLAQEGMLASLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ 688
           ***********************************************************************97 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

SPPGLFTLLV EDFGVKGVQV EEIYDLQSKC QGPVYGFIFL FKWIEERRSR RKVSTLVDET 60
SVIDDDIVNN MFFAHQLIPN SCATHALLSV LLNCSSVDLG PTLSRMKDFT RGFSPESKGY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCCTCCAG GTCTCTTCAC CCTGTTGGTA GAAGATTTTG GTGAGTACAG GAGCCATTCT 60
GCAGGGTTGG TTTAGTCTCA GACGCGGACG CTGGCCGCCG TCAGCTGGTC TTGTCTCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	84.46	2.00e-173	602.00
IUUC-Apl-003405	Anas platyrhynchos	50.74	1.00e-103	369.00
IUUC-Aca-004836	Anolis carolinensis	63.57	0.00e+00	847.00
IUUC-Ame-011946	Astyanax mexicanus	73.40	5.00e-161	561.00
IUUC-Bta-013131	Bos taurus	80.31	3.00e-159	555.00
IUUC-Cja-019599	Callithrix jacchus	62.83	0.00e+00	775.00
IUUC-Cfa-021003	Canis familiaris	63.17	0.00e+00	761.00
IUUC-Cpo-022143	Cavia porcellus	62.30	0.00e+00	776.00
IUUC-Csa-023477	Chlorocebus sabaeus	62.20	0.00e+00	774.00
IUUC-Cho-024734	Choloepus hoffmanni	67.84	4.00e-64	239.00
IUUC-Csv-025842	Ciona savignyi	61.15	8.00e-90	323.00
IUUC-Dre-027793	Danio rerio	74.94	2.00e-165	575.00
IUUC-Dno-029253	Dasypus novemcinctus	62.20	0.00e+00	766.00
IUUC-Dor-030891	Dipodomys ordii	58.50	0.00e+00	700.00
IUUC-Dme-031796	Drosophila melanogaster	59.16	6.00e-86	311.00
IUUC-Ete-032646	Echinops telfairi	94.26	3.00e-129	455.00
IUUC-Eca-033805	Equus caballus	84.20	3.00e-175	608.00
IUUC-Eeu-035216	Erinaceus europaeus	71.36	4.00e-74	271.00
IUUC-Fca-035611	Felis catus	83.59	2.00e-169	589.00
IUUC-Fal-037186	Ficedula albicollis	63.75	0.00e+00	709.00
IUUC-Gmo-038824	Gadus morhua	79.29	9.00e-170	590.00
IUUC-Gga-040875	Gallus gallus	67.94	0.00e+00	808.00
IUUC-Gac-042226	Gasterosteus aculeatus	58.69	0.00e+00	712.00
IUUC-Ggo-045122	Gorilla gorilla	63.04	0.00e+00	773.00
IUUC-Hsa-045882	Homo sapiens	83.68	1.00e-175	610.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	62.97	0.00e+00	763.00
IUUC-Lch-049960	Latimeria chalumnae	71.36	2.00e-159	555.00
IUUC-Loc-052408	Lepisosteus oculatus	74.60	4.00e-172	597.00
IUUC-Laf-054187	Loxodonta africana	63.57	0.00e+00	809.00
IUUC-Mcc-055273	Macaca mulatta	60.83	0.00e+00	750.00
IUUC-Meu-056267	Macropus eugenii	59.45	0.00e+00	739.00
IUUC-Mga-059958	Meleagris gallopavo	89.54	3.00e-158	550.00
IUUC-Mmr-061280	Microcebus murinus	63.76	0.00e+00	759.00
IUUC-Mdo-062625	Monodelphis domestica	63.98	0.00e+00	838.00
IUUC-Mmu-063853	Mus musculus	62.25	0.00e+00	768.00
IUUC-Mlu-067771	Myotis lucifugus	83.16	8.00e-174	603.00
IUUC-Opr-070741	Ochotona princeps	63.37	0.00e+00	796.00
IUUC-Ont-072172	Oreochromis niloticus	77.33	5.00e-170	591.00
IUUC-Oan-073167	Ornithorhynchus anatinus	86.13	0.00e+00	672.00
IUUC-Ocu-074176	Oryctolagus cuniculus	62.87	0.00e+00	757.00
IUUC-Ola-087203	Oryzias latipes	84.71	6.00e-128	449.00
IUUC-Oga-089153	Otolemur garnettii	62.50	0.00e+00	761.00
IUUC-Oar-090008	Ovis aries	85.53	7.00e-178	617.00
IUUC-Ptr-091234	Pan troglodytes	83.68	2.00e-176	612.00
IUUC-Pan-092005	Papio anubis	61.37	0.00e+00	777.00
IUUC-Pma-094110	Petromyzon marinus	55.26	3.00e-67	249.00
IUUC-Pfo-097418	Poecilia formosa	76.90	2.00e-167	582.00
IUUC-Pab-098267	Pongo abelii	83.68	2.00e-176	612.00
IUUC-Pca-101084	Procavia capensis	60.23	0.00e+00	717.00
IUUC-Pva-102292	Pteropus vampyrus	84.72	1.00e-175	609.00
IUUC-Rno-105251	Rattus norvegicus	78.67	7.00e-172	597.00
IUUC-Sha-107100	Sarcophilus harrisii	63.33	0.00e+00	838.00
IUUC-Sar-113559	Sorex araneus	95.45	1.00e-118	419.00
IUUC-Ssc-115688	Sus scrofa	61.63	0.00e+00	769.00
IUUC-Tgu-117424	Taeniopygia guttata	64.92	0.00e+00	822.00
IUUC-Tru-118585	Takifugu rubripes	58.38	0.00e+00	721.00
IUUC-Tsy-119299	Tarsius syrichta	50.60	4.00e-139	488.00
IUUC-Tni-120808	Tetraodon nigroviridis	74.13	2.00e-162	566.00
IUUC-Tbe-127705	Tupaia belangeri	82.64	5.00e-153	533.00
IUUC-Ttr-128225	Tursiops truncatus	61.36	0.00e+00	747.00
IUUC-Vpa-130193	Vicugna pacos	77.78	3.00e-98	352.00
IUUC-Xtr-132449	Xenopus tropicalis	78.31	1.00e-171	595.00
IUUC-Xma-133232	Xiphophorus maculatus	76.09	1.00e-164	573.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence