iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088708

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03075730

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000011667.2	ENSOGAT00000011671.2	ENSOGAP00000010443.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.00e-39	136.1	93	262
UBD/ZnF/ZnF_A20	2.40e-24	85.0	750	783

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepeakg 77
           ++lkt+gDGnCL++Avsq+l+g+ d+d+ l++al+++L+e+ ++++    q es + +ef+e++        +de++++ k++++++ g
   Q: 93   VALKTNGDGNCLMHAVSQYLWGIPDTDLvLRKALFSTLKETDTQNFkfrwQLESLRSQEFVETGlcydtrnwNDEWDNLIKMASTDTPG 181
           789********************************************9*99***********************************554 PP
   S: 78   ..........eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
                     eeihif+L++iL+rpiiv+++++l+s          ++ggi+lpl++p+++ +++pivL+Y+s H+ +Lv+
   Q: 182  aqgglqynslEEIHIFVLCNILRRPIIVISDKMLRSlesgsnfaplRLGGIYLPLHWPAQEcYRYPIVLGYDSQHFVPLVT 262
           4558***************************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           p+k++C++ +C+++Gn+++ngyC++C++++++++
   Q: 750  PPKQRCRApACDHFGNAKCNGYCNECFQFKQMYG 783
           9*******************************96 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MAEQLLPQAL YLSNMRKAVK IRERTPEDVF KPTNGIIHHF RTMHRYTLEM FRTCQFCPQF 60
REIIHKALID RNIQASLESQ KKLNWCREVR KLVALKTNGD GNCLMHAVSQ YLWGIPDTDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGAAC AACTCCTTCC CCAGGCCTTG TATTTGAGCA ATATGCGGAA AGCTGTGAAG 60
ATAAGAGAGA GAACTCCAGA AGATGTTTTT AAACCTACCA ATGGGATCAT TCATCATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	87.59	0.00e+00	1442.00
IUUC-Apl-003501	Anas platyrhynchos	65.91	0.00e+00	1040.00
IUUC-Aca-004245	Anolis carolinensis	62.70	0.00e+00	1038.00
IUUC-Ame-011789	Astyanax mexicanus	46.44	0.00e+00	679.00
IUUC-Bta-012664	Bos taurus	83.54	0.00e+00	1351.00
IUUC-Cja-019895	Callithrix jacchus	88.99	0.00e+00	1451.00
IUUC-Cfa-020754	Canis familiaris	86.84	0.00e+00	1431.00
IUUC-Cpo-021780	Cavia porcellus	87.22	0.00e+00	1415.00
IUUC-Csa-023568	Chlorocebus sabaeus	89.62	0.00e+00	1477.00
IUUC-Cho-024300	Choloepus hoffmanni	87.46	0.00e+00	639.00
IUUC-Dre-028577	Danio rerio	49.00	0.00e+00	677.00
IUUC-Dno-029382	Dasypus novemcinctus	81.90	0.00e+00	1320.00
IUUC-Dor-030874	Dipodomys ordii	83.80	0.00e+00	1347.00
IUUC-Ete-032721	Echinops telfairi	88.76	0.00e+00	786.00
IUUC-Eca-033596	Equus caballus	84.54	0.00e+00	1381.00
IUUC-Eeu-035159	Erinaceus europaeus	84.08	0.00e+00	1080.00
IUUC-Fca-035847	Felis catus	87.47	0.00e+00	1432.00
IUUC-Fal-036681	Ficedula albicollis	64.84	0.00e+00	1058.00
IUUC-Gmo-038521	Gadus morhua	58.23	7.00e-145	507.00
IUUC-Gga-040975	Gallus gallus	63.86	0.00e+00	1051.00
IUUC-Gac-042216	Gasterosteus aculeatus	60.29	2.00e-151	529.00
IUUC-Ggo-045258	Gorilla gorilla	88.86	0.00e+00	1465.00
IUUC-Hsa-046071	Homo sapiens	89.11	0.00e+00	1466.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	87.85	0.00e+00	1425.00
IUUC-Lch-050326	Latimeria chalumnae	57.20	0.00e+00	907.00
IUUC-Loc-051945	Lepisosteus oculatus	46.15	2.00e-175	609.00
IUUC-Laf-053722	Loxodonta africana	85.70	0.00e+00	1394.00
IUUC-Mcc-055503	Macaca mulatta	89.87	0.00e+00	1477.00
IUUC-Meu-056481	Macropus eugenii	72.38	0.00e+00	1134.00
IUUC-Mga-059690	Meleagris gallopavo	62.17	0.00e+00	968.00
IUUC-Mmr-061233	Microcebus murinus	90.78	0.00e+00	1464.00
IUUC-Mdo-062446	Monodelphis domestica	77.42	0.00e+00	1255.00
IUUC-Mmu-063436	Mus musculus	84.81	0.00e+00	1350.00
IUUC-Mpu-066808	Mustela putorius furo	87.22	0.00e+00	1432.00
IUUC-Mlu-067339	Myotis lucifugus	87.91	0.00e+00	1428.00
IUUC-Nle-069888	Nomascus leucogenys	89.24	0.00e+00	1472.00
IUUC-Opr-070303	Ochotona princeps	84.99	0.00e+00	1392.00
IUUC-Ont-072283	Oreochromis niloticus	56.64	1.00e-145	510.00
IUUC-Oan-072925	Ornithorhynchus anatinus	73.18	0.00e+00	1189.00
IUUC-Ocu-073889	Oryctolagus cuniculus	86.22	0.00e+00	1380.00
IUUC-Ola-087417	Oryzias latipes	58.11	1.00e-145	510.00
IUUC-Oar-089271	Ovis aries	83.54	0.00e+00	1362.00
IUUC-Ptr-091296	Pan troglodytes	89.11	0.00e+00	1465.00
IUUC-Pan-092474	Papio anubis	89.87	0.00e+00	1479.00
IUUC-Psi-093447	Pelodiscus sinensis	68.34	0.00e+00	1118.00
IUUC-Pfo-096511	Poecilia formosa	44.97	0.00e+00	654.00
IUUC-Pab-098700	Pongo abelii	89.24	0.00e+00	1469.00
IUUC-Pca-100246	Procavia capensis	74.30	0.00e+00	1169.00
IUUC-Pva-102606	Pteropus vampyrus	77.16	5.00e-177	614.00
IUUC-Rno-105818	Rattus norvegicus	84.96	0.00e+00	1382.00
IUUC-Sha-106559	Sarcophilus harrisii	76.66	0.00e+00	1236.00
IUUC-Sar-113454	Sorex araneus	91.16	0.00e+00	636.00
IUUC-Ssc-116064	Sus scrofa	85.82	0.00e+00	1380.00
IUUC-Tgu-117212	Taeniopygia guttata	64.51	0.00e+00	1050.00
IUUC-Tru-118230	Takifugu rubripes	58.60	2.00e-149	523.00
IUUC-Tsy-119066	Tarsius syrichta	85.19	0.00e+00	1394.00
IUUC-Tni-119825	Tetraodon nigroviridis	46.13	0.00e+00	665.00
IUUC-Tur-126383	Triticum urartu	50.00	6.00e-03	32.00
IUUC-Tbe-127601	Tupaia belangeri	93.60	0.00e+00	657.00
IUUC-Ttr-128930	Tursiops truncatus	83.80	0.00e+00	1372.00
IUUC-Vpa-130450	Vicugna pacos	90.77	0.00e+00	775.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence