iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003252

Ensembl Protein ID

ENSAPLP00000003035.1

UniProt Accession

U3I714; U3I714_ANAPL

Genbank Protein ID

ENSAPLP00000003035

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01115513

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000003524.1	ENSAPLT00000003630.1	ENSAPLP00000003035.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.80e-07	29.8	20	86
E3 activity/RING/RING	8.60e-08	32.3	24	66

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggk...tcPvtrqplteedlvPnltlrrliqa 67
           + + CpI l++ ++Pv +++ + + r ++ k l++++k   +cP++++++t+++l+ n   ++li+ 
   Q: 20   KNLECPICLDVVKEPVSTKCDHIFCRFCMYKLLSKKKKgvvQCPLCKTEVTKRSLTENSRFKQLIEG 86
           5688****************************9999999**************************86 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+  k+ p+++ C H+f++ C +k+  l++++++  +CPlC+
   Q: 24   CPICLDVVKE-PVSTKCDHIFCRFCMYKL--LSKKKKGVVQCPLCK 66
           ********99.**************9666..666799999*****7 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MDLAVVAAGE VQNVLLAMQK NLECPICLDV VKEPVSTKCD HIFCRFCMYK LLSKKKKGVV 60
QCPLCKTEVT KRSLTENSRF KQLIEGLLEA IHAFELDTGV KFLNSHRLPK SSTEATAAKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACCTGG CCGTGGTTGC CGCTGGAGAG GTGCAGAATG TGCTCTTGGC TATGCAGAAG 60
AACTTGGAGT GCCCCATTTG GTACGGCCGG GGATCAGCGC TGGGGCTCGG TCTTTTATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007059--P:chromosome segregation
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000225	Aegilops tauschii	34.23	2.00e-17	84.70
IUUC-Aml-002388	Ailuropoda melanoleuca	39.85	1.00e-117	418.00
IUUC-Aca-004526	Anolis carolinensis	60.43	3.00e-85	309.00
IUUC-Ame-011720	Astyanax mexicanus	52.71	6.00e-61	229.00
IUUC-Bta-013433	Bos taurus	40.15	5.00e-119	422.00
IUUC-Bdi-014760	Brachypodium distachyon	32.43	8.00e-18	85.90
IUUC-Bol-016476	Brassica oleracea	28.38	8.00e-19	89.00
IUUC-Bra-017176	Brassica rapa	28.57	7.00e-20	92.40
IUUC-Cel-018208	Caenorhabditis elegans	32.61	4.00e-11	62.80
IUUC-Cja-019149	Callithrix jacchus	33.71	0.00e+00	711.00
IUUC-Cfa-020322	Canis familiaris	38.98	2.00e-115	411.00
IUUC-Cpo-021583	Cavia porcellus	37.88	2.00e-92	334.00
IUUC-Cre-022597	Chlamydomonas reinhardtii	32.53	9.00e-10	57.80
IUUC-Csa-024227	Chlorocebus sabaeus	41.06	8.00e-58	218.00
IUUC-Cho-024530	Choloepus hoffmanni	53.30	4.00e-67	250.00
IUUC-Cin-025364	Ciona intestinalis	41.56	3.00e-14	72.00
IUUC-Dno-029247	Dasypus novemcinctus	29.53	2.00e-98	354.00
IUUC-Ete-032472	Echinops telfairi	49.62	4.00e-69	257.00
IUUC-Eca-033446	Equus caballus	35.24	2.00e-124	440.00
IUUC-Eeu-034858	Erinaceus europaeus	53.37	3.00e-51	197.00
IUUC-Fca-035991	Felis catus	35.82	1.00e-118	421.00
IUUC-Fal-036803	Ficedula albicollis	56.92	0.00e+00	1731.00
IUUC-Gmo-038782	Gadus morhua	47.92	2.00e-47	184.00
IUUC-Gga-040969	Gallus gallus	62.81	0.00e+00	1525.00
IUUC-Gac-042296	Gasterosteus aculeatus	48.40	8.00e-58	219.00
IUUC-Ggo-044740	Gorilla gorilla	34.79	1.00e-115	411.00
IUUC-Hsa-046086	Homo sapiens	35.78	2.00e-120	427.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	35.71	3.00e-121	430.00
IUUC-Kpa-049242	Komagataella pastoris	36.51	2.00e-08	52.00
IUUC-Lch-049789	Latimeria chalumnae	40.49	4.00e-112	400.00
IUUC-Loc-051952	Lepisosteus oculatus	63.33	2.00e-81	297.00
IUUC-Laf-053648	Loxodonta africana	32.01	2.00e-85	311.00
IUUC-Mcc-055210	Macaca mulatta	35.32	7.00e-127	449.00
IUUC-Meu-056342	Macropus eugenii	51.23	2.00e-43	171.00
IUUC-Mga-060163	Meleagris gallopavo	60.62	0.00e+00	1930.00
IUUC-Mmr-061402	Microcebus murinus	30.28	7.00e-43	168.00
IUUC-Mdo-062209	Monodelphis domestica	39.06	2.00e-126	447.00
IUUC-Mmu-064003	Mus musculus	30.54	2.00e-100	361.00
IUUC-Mpu-065825	Mustela putorius furo	45.40	1.00e-101	363.00
IUUC-Mlu-068176	Myotis lucifugus	38.00	2.00e-104	374.00
IUUC-Nle-069178	Nomascus leucogenys	35.99	6.00e-123	436.00
IUUC-Opr-070574	Ochotona princeps	36.52	1.00e-91	331.00
IUUC-Ont-072380	Oreochromis niloticus	51.14	9.00e-63	235.00
IUUC-Oan-073243	Ornithorhynchus anatinus	65.12	7.00e-29	119.00
IUUC-Ocu-074424	Oryctolagus cuniculus	39.21	3.00e-103	370.00
IUUC-Ola-086863	Oryzias latipes	46.81	1.00e-57	218.00
IUUC-Oar-089938	Ovis aries	36.84	3.00e-123	437.00
IUUC-Ptr-090960	Pan troglodytes	34.55	0.00e+00	689.00
IUUC-Pan-092609	Papio anubis	32.28	1.00e-70	262.00
IUUC-Psi-093889	Pelodiscus sinensis	41.02	2.00e-131	462.00
IUUC-Pfo-096328	Poecilia formosa	50.23	5.00e-61	229.00
IUUC-Pab-097982	Pongo abelii	34.33	0.00e+00	717.00
IUUC-Pca-100698	Procavia capensis	44.93	2.00e-90	327.00
IUUC-Pva-102631	Pteropus vampyrus	38.94	2.00e-105	377.00
IUUC-Ptt-103843	Puccinia triticina	35.48	2.00e-06	46.60
IUUC-Rno-105879	Rattus norvegicus	52.88	4.00e-64	240.00
IUUC-Sha-106701	Sarcophilus harrisii	33.33	1.00e-70	261.00
IUUC-Sit-110609	Setaria italica	26.67	5.00e-18	86.30
IUUC-Sar-113047	Sorex araneus	61.46	2.00e-32	135.00
IUUC-Ssc-115846	Sus scrofa	35.45	1.00e-113	405.00
IUUC-Tgu-116785	Taeniopygia guttata	55.10	0.00e+00	1219.00
IUUC-Tru-117895	Takifugu rubripes	50.97	4.00e-60	226.00
IUUC-Tsy-118885	Tarsius syrichta	50.94	2.00e-38	154.00
IUUC-Tni-119654	Tetraodon nigroviridis	43.48	2.00e-51	197.00
IUUC-Tbe-127421	Tupaia belangeri	36.06	4.00e-59	224.00
IUUC-Ttr-128685	Tursiops truncatus	38.95	1.00e-101	365.00
IUUC-Vpa-130216	Vicugna pacos	55.88	2.00e-84	307.00
IUUC-Vvi-131586	Vitis vinifera	32.61	1.00e-10	62.40
IUUC-Xtr-132398	Xenopus tropicalis	62.15	6.00e-74	273.00
IUUC-Xma-133651	Xiphophorus maculatus	51.12	3.00e-48	187.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence