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Tag Content
UUCD2 ID IUUC-Dre-028068
UUCD1 version UUC-DaR-01266
Ensembl Protein ID ENSDARP00000003173.8
UniProt Accession Q6TGU2; Q1LXR9; SEH1_DANRE
Genbank Protein ID AAQ97847.1; CAK10890.1
Protein Name Nucleoporin seh1; Nup107-160 subcomplex subunit seh1
Genbank Nucleotide ID AY398414; BX294130
Gene Name seh1l; sec13l; si:dkey-263o22.4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000004280.10 ENSDART00000013865.9 ENSDARP00000003173.8
ENSDARG00000004280.10 ENSDART00000151535.2 ENSDARP00000125785.1
ENSDARG00000004280.10 ENSDART00000151214.1 ENSDARP00000125892.1
ENSDARG00000004280.10 ENSDART00000168429.1 ENSDARP00000135312.1
ENSDARG00000004280.10 ENSDART00000163511.1 ENSDARP00000140663.1
ENSDARG00000004280.10 ENSDART00000052238.5 ENSDARP00000052237.4
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.70e-20 73.1 277 306
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWD 29
           H++ v+ +++  ++tll+s++dDg +++W 
   Q: 277  HNSQVWRVSWniTSTLLASSGDDGCVRLWK 306
           9**********977***************7 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (By similarity). Required for the regulation of the TORC1 pathway by amino acids (By similarity).
 Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (By similarity). Required for the regulation of the TORC1 pathway by amino acids (By similarity).
Protein Sequence
(Fasta)
MFVAKSIAAD HKDLIHDVSY DFHGRRMATC SSDQSVKVWD KGDDGEWHCT ASWKTHSGSV 60
WRVTWAHPEF GQVLASCSFD RTAAVWEEIV GESNDKQRGQ SHWIKRTTLV DSRTSVTDVK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-028068|E3,WD_repeat|Danio rerio
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Nucleotide Sequence
(Fasta)
AGGCTTGATA GGAGACTTGC AGTAACTCCG CTAGTGCAAT AGATGGCAGT AAACTGTGTT 60
CGACTGCAGT ATTAAAGCAG CGAACAACGA ATTCGAGTGA AGAAACATGG CACCGTAGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-028068|E3,WD_repeat|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0995--Kinetochore
KW-0498--Mitosis
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0031080--C:nuclear pore outer ring
GO:0051315--P:attachment of mitotic spindle microtubules to kinetochore
GO:0051301--P:cell division
GO:0007080--P:mitotic metaphase plate congression
GO:0051028--P:mRNA transport
GO:0006999--P:nuclear pore organization
GO:0015031--P:protein transport
KEGG dre:334749
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001926 Ailuropoda melanoleuca 87.50 9.00e-164 569.00
IUUC-Apl-003654 Anas platyrhynchos 86.69 2.00e-147 515.00
IUUC-Aca-004378 Anolis carolinensis 83.49 1.00e-151 529.00
IUUC-Ago-007816 Ashbya gossypii 35.21 6.00e-50 191.00
IUUC-Ame-011945 Astyanax mexicanus 92.62 0.00e+00 650.00
IUUC-Bta-013306 Bos taurus 88.44 4.00e-166 577.00
IUUC-Cel-018235 Caenorhabditis elegans 40.71 2.00e-71 262.00
IUUC-Cja-018849 Callithrix jacchus 88.16 5.00e-164 570.00
IUUC-Cfa-020841 Canis familiaris 87.46 2.00e-161 564.00
IUUC-Cpo-021379 Cavia porcellus 86.88 7.00e-164 569.00
IUUC-Csa-023900 Chlorocebus sabaeus 88.44 2.00e-165 575.00
IUUC-Cho-024660 Choloepus hoffmanni 85.48 7.00e-149 520.00
IUUC-Cin-025471 Ciona intestinalis 53.18 2.00e-101 362.00
IUUC-Csv-026242 Ciona savignyi 58.96 6.00e-89 320.00
IUUC-Dno-029981 Dasypus novemcinctus 82.04 7.00e-158 550.00
IUUC-Dme-031763 Drosophila melanogaster 56.00 7.00e-111 393.00
IUUC-Ete-032243 Echinops telfairi 53.33 5.00e-91 327.00
IUUC-Eca-033425 Equus caballus 87.28 1.00e-143 502.00
IUUC-Eeu-035119 Erinaceus europaeus 66.92 3.00e-99 355.00
IUUC-Fca-036520 Felis catus 87.88 5.00e-170 590.00
IUUC-Fal-037234 Ficedula albicollis 86.78 3.00e-151 530.00
IUUC-Gmo-039013 Gadus morhua 88.83 0.00e+00 634.00
IUUC-Gga-041059 Gallus gallus 87.58 8.00e-170 589.00
IUUC-Gac-041337 Gasterosteus aculeatus 90.77 4.00e-178 617.00
IUUC-Ggo-044944 Gorilla gorilla 83.24 8.00e-172 596.00
IUUC-Hsa-046038 Homo sapiens 83.24 5.00e-172 597.00
IUUC-Itr-048858 Ictidomys tridecemlineatus 87.63 4.00e-144 503.00
IUUC-Kpa-049201 Komagataella pastoris 36.22 4.00e-50 191.00
IUUC-Lch-050466 Latimeria chalumnae 72.35 9.00e-163 566.00
IUUC-Loc-052773 Lepisosteus oculatus 78.43 1.00e-173 602.00
IUUC-Laf-053409 Loxodonta africana 87.81 5.00e-165 573.00
IUUC-Meu-055958 Macropus eugenii 61.77 2.00e-102 365.00
IUUC-Mga-059348 Meleagris gallopavo 83.44 6.00e-149 520.00
IUUC-Mmr-060977 Microcebus murinus 90.95 3.00e-125 440.00
IUUC-Mdo-061806 Monodelphis domestica 87.88 7.00e-172 596.00
IUUC-Mmu-064328 Mus musculus 88.04 4.00e-178 617.00
IUUC-Mpu-066873 Mustela putorius furo 87.81 5.00e-164 570.00
IUUC-Mlu-067563 Myotis lucifugus 78.33 8.00e-158 549.00
IUUC-Nle-068977 Nomascus leucogenys 82.58 2.00e-157 548.00
IUUC-Opr-070773 Ochotona princeps 57.88 4.00e-77 281.00
IUUC-Ont-072644 Oreochromis niloticus 85.83 2.00e-180 625.00
IUUC-Oan-073098 Ornithorhynchus anatinus 86.90 9.00e-148 516.00
IUUC-Ocu-073911 Oryctolagus cuniculus 83.24 2.00e-171 595.00
IUUC-Ola-087096 Oryzias latipes 86.24 9.00e-175 606.00
IUUC-Oga-088798 Otolemur garnettii 88.18 7.00e-171 593.00
IUUC-Oar-090298 Ovis aries 87.02 9.00e-147 516.00
IUUC-Ptr-091074 Pan troglodytes 83.57 5.00e-173 600.00
IUUC-Pan-092013 Papio anubis 90.55 1.00e-130 458.00
IUUC-Psi-093508 Pelodiscus sinensis 80.50 7.00e-150 523.00
IUUC-Pma-094288 Petromyzon marinus 82.86 6.00e-104 369.00
IUUC-Ppa-095228 Physcomitrella patens 32.28 6.00e-36 144.00
IUUC-Pfo-096384 Poecilia formosa 85.56 1.00e-179 622.00
IUUC-Pab-098629 Pongo abelii 83.29 8.00e-173 599.00
IUUC-Pca-100322 Procavia capensis 62.19 4.00e-94 338.00
IUUC-Pva-102861 Pteropus vampyrus 88.12 4.00e-165 574.00
IUUC-Rno-104895 Rattus norvegicus 79.94 1.00e-161 565.00
IUUC-Sce-106420 Saccharomyces cerevisiae 34.94 2.00e-53 202.00
IUUC-Sha-106829 Sarcophilus harrisii 82.23 2.00e-157 548.00
IUUC-Sja-107923 Schizosaccharomyces japonicus 39.42 1.00e-63 236.00
IUUC-Spo-108184 Schizosaccharomyces pombe 39.88 5.00e-65 241.00
IUUC-Smo-109282 Selaginella moellendorffii 32.60 7.00e-37 147.00
IUUC-Sly-111125 Solanum lycopersicum 28.12 2.00e-32 133.00
IUUC-Sar-113279 Sorex araneus 87.63 6.00e-144 503.00
IUUC-Sbi-114110 Sorghum bicolor 29.19 3.00e-33 135.00
IUUC-Ssc-115589 Sus scrofa 85.20 8.00e-149 519.00
IUUC-Tgu-117523 Taeniopygia guttata 87.27 2.00e-169 588.00
IUUC-Tru-117985 Takifugu rubripes 71.08 3.00e-160 560.00
IUUC-Tsy-118913 Tarsius syrichta 81.91 1.00e-137 482.00
IUUC-Tni-120670 Tetraodon nigroviridis 89.97 3.00e-178 617.00
IUUC-Tae-122796 Triticum aestivum 28.16 3.00e-31 129.00
IUUC-Tme-126885 Tuber melanosporum 35.93 1.00e-53 203.00
IUUC-Tbe-127344 Tupaia belangeri 68.75 3.00e-118 418.00
IUUC-Ttr-128347 Tursiops truncatus 87.28 3.00e-143 501.00
IUUC-Vpa-130656 Vicugna pacos 87.28 4.00e-144 504.00
IUUC-Xtr-132736 Xenopus tropicalis 81.39 4.00e-169 587.00
IUUC-Xma-133678 Xiphophorus maculatus 86.59 2.00e-178 618.00
IUUC-Yli-134659 Yarrowia lipolytica 40.43 4.00e-62 231.00
Created Date 25-Jun-2017

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