iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	5.30e-69	233.4	4	321

Active Site

Position(s)	Description	Evidence
83	Nucleophile	ECO:0000250}
158	Proton donor	ECO:0000250}

Domain Profile

DUB/UCH

   S: 5    vkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAll 105
           + +w+ +esdPg+ft++++ fgv++  qveelysLd +    + +p +gl++lFk+ +  e+             +  d  ++iffa+q+i+N+Cat+Al+
   Q: 4    AGSWCLIESDPGVFTEMLRGFGVDGL-QVEELYSLDDDK--AMTRPTYGLIFLFKWRQGDETTG-----------IPSDK-QNIFFAHQTIQNACATQALI 89
           568***********************.********9988..677**************999998...........22333.578***************** PP
   S: 106  svllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldlgkk 206
             l n ed  + lG+ l++ ke+    +p+ ++ +l+n+++++ +hns+ r+  ++++++ +e      ++++hfv+yv+i++++yeldgl++ Pl+ ++ 
   Q: 90   NLLMNVEDTDVKLGNILNQYKEFAIDLDPNTRGHCLSNSEEIRTVHNSFSRQTLFELDIKGGES-----EDNYHFVTYVPIGNKVYELDGLRELPLEVAEF 185
           ***********************************************************99776.....79****************************** PP
   S: 207  keteelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkidkeLlkL..lkdieseeekieaqlddekekrkkfkiddirRtenydefi 305
           ++++++ +++k v+   +r+++++++ei fnl+a+v++r+ +       +++ ++L++    +++e +++  ++ ++de+ k  ++  ++ rR++ny  f+
   Q: 186  QKEQDWIEAIKPVI--QQRMQKYSEGEITFNLMALVPNRKQKL------QEMMENLIQAneNNELEEQIADLNKAIADEDYKMEMYRKENNRRRHNYTPFV 278
           **************..**********************99543......33333333331147888999999***************************** PP
   S: 306  cifikdlaregilrklveetisevre...fgvnegrlakqrkq 345
           ++++k la+eg l  lv++     +e    +  + +l  +rkq
   Q: 279  IELMKILAKEGKLVGLVDNAYQAAKEkskLNTDITKLELKRKQ 321
           ******************9998888876677777777766665 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity).

Protein Sequence
(Fasta)

MTDAGSWCLI ESDPGVFTEM LRGFGVDGLQ VEELYSLDDD KAMTRPTYGL IFLFKWRQGD 60
ETTGIPSDKQ NIFFAHQTIQ NACATQALIN LLMNVEDTDV KLGNILNQYK EFAIDLDPNT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGCGCTC CACTGCAACA AAGCTGACTA TATTTTTTGA ATCCAGGTTT TTTTTCGAAA 60
CATTTATTTT GCACAATAAA TCTCTTTTCG GTTAGAGTTC ACTTTCTATT TAAAAGTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cel:CELE_C08B11.7

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	41.85	2.00e-67	248.00
IUUC-Aml-001866	Ailuropoda melanoleuca	47.27	6.00e-81	292.00
IUUC-Atr-002966	Amborella trichopoda	39.59	3.00e-58	218.00
IUUC-Apl-003306	Anas platyrhynchos	41.81	2.00e-74	271.00
IUUC-Aca-004763	Anolis carolinensis	47.27	8.00e-82	295.00
IUUC-Aly-005581	Arabidopsis lyrata	39.39	8.00e-59	219.00
IUUC-Ath-007283	Arabidopsis thaliana	38.18	6.00e-62	229.00
IUUC-Ago-007999	Ashbya gossypii	30.74	1.00e-32	132.00
IUUC-Acl-008231	Aspergillus clavatus	40.65	6.00e-49	186.00
IUUC-Afl-008557	Aspergillus flavus	36.70	1.00e-48	184.00
IUUC-Afu-008988	Aspergillus fumigatus	37.35	5.00e-50	189.00
IUUC-Ani-009420	Aspergillus nidulans	36.33	7.00e-47	179.00
IUUC-Ang-009859	Aspergillus niger	38.34	3.00e-45	174.00
IUUC-Aor-010145	Aspergillus oryzae	36.70	1.00e-48	184.00
IUUC-Ate-010347	Aspergillus terreus	32.94	3.00e-45	174.00
IUUC-Ame-010791	Astyanax mexicanus	46.89	9.00e-82	295.00
IUUC-Bgr-012298	Blumeria graminis	37.33	2.00e-42	164.00
IUUC-Bta-013251	Bos taurus	47.42	1.00e-81	294.00
IUUC-Bci-013786	Botrytis cinerea	37.97	3.00e-48	184.00
IUUC-Bdi-014132	Brachypodium distachyon	42.99	8.00e-66	242.00
IUUC-Bol-015611	Brassica oleracea	41.03	4.00e-61	226.00
IUUC-Bra-017769	Brassica rapa	40.73	9.00e-61	225.00
IUUC-Cja-019768	Callithrix jacchus	42.77	4.00e-75	273.00
IUUC-Cfa-020207	Canis familiaris	47.27	6.00e-81	292.00
IUUC-Cpo-021925	Cavia porcellus	46.95	2.00e-78	284.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	41.27	5.00e-64	236.00
IUUC-Csa-023958	Chlorocebus sabaeus	47.42	6.00e-81	293.00
IUUC-Cho-024928	Choloepus hoffmanni	49.33	7.00e-17	79.70
IUUC-Cin-025771	Ciona intestinalis	45.17	2.00e-73	267.00
IUUC-Csv-026149	Ciona savignyi	44.44	5.00e-75	273.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	34.22	4.00e-41	160.00
IUUC-Cne-026955	Cryptococcus neoformans	36.76	3.00e-54	204.00
IUUC-Cme-027104	Cyanidioschyzon merolae	34.14	5.00e-49	186.00
IUUC-Dre-027409	Danio rerio	46.89	3.00e-81	293.00
IUUC-Dno-028921	Dasypus novemcinctus	47.27	6.00e-81	292.00
IUUC-Dor-030891	Dipodomys ordii	32.18	4.00e-25	108.00
IUUC-Dse-031170	Dothistroma septosporum	33.23	9.00e-46	176.00
IUUC-Dme-031677	Drosophila melanogaster	50.64	7.00e-91	325.00
IUUC-Ete-032707	Echinops telfairi	34.77	1.00e-47	182.00
IUUC-Eca-033776	Equus caballus	45.33	2.00e-68	251.00
IUUC-Eeu-035305	Erinaceus europaeus	41.94	7.00e-40	156.00
IUUC-Fca-035846	Felis catus	43.49	2.00e-76	277.00
IUUC-Fal-037597	Ficedula albicollis	44.29	1.00e-68	251.00
IUUC-Fox-037670	Fusarium oxysporum	37.74	1.00e-47	182.00
IUUC-Fso-038243	Fusarium solani	37.99	1.00e-46	178.00
IUUC-Gmo-038499	Gadus morhua	43.55	2.00e-72	264.00
IUUC-Ggr-039975	Gaeumannomyces graminis	34.73	1.00e-40	158.00
IUUC-Gga-040904	Gallus gallus	46.67	6.00e-84	302.00
IUUC-Gac-042058	Gasterosteus aculeatus	46.13	3.00e-79	286.00
IUUC-Gma-043030	Glycine max	43.16	1.00e-65	241.00
IUUC-Ggo-044699	Gorilla gorilla	47.69	1.00e-70	258.00
IUUC-Hsa-046227	Homo sapiens	47.27	7.00e-81	292.00
IUUC-Hvu-047359	Hordeum vulgare	41.54	3.00e-66	244.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	42.69	7.00e-76	276.00
IUUC-Lch-049829	Latimeria chalumnae	47.59	2.00e-83	300.00
IUUC-Lpe-050899	Leersia perrieri	42.90	1.00e-63	235.00
IUUC-Loc-052264	Lepisosteus oculatus	47.12	2.00e-79	287.00
IUUC-Lma-053110	Leptosphaeria maculans	37.50	5.00e-44	170.00
IUUC-Laf-053639	Loxodonta africana	47.27	6.00e-81	292.00
IUUC-Mcc-055506	Macaca mulatta	47.42	5.00e-81	293.00
IUUC-Meu-056267	Macropus eugenii	35.27	2.00e-39	155.00
IUUC-Mor-057001	Magnaporthe oryzae	37.85	1.00e-44	172.00
IUUC-Mpo-057608	Magnaporthe poae	41.30	6.00e-30	122.00
IUUC-Mtr-057731	Medicago truncatula	40.73	3.00e-66	243.00
IUUC-Mla-059016	Melampsora laricipopulina	47.21	2.00e-44	170.00
IUUC-Mga-060178	Meleagris gallopavo	44.86	3.00e-71	260.00
IUUC-Mvi-060353	Microbotryum violaceum	35.99	2.00e-47	181.00
IUUC-Mmr-060738	Microcebus murinus	47.27	6.00e-81	292.00
IUUC-Mdo-062266	Monodelphis domestica	51.96	2.00e-60	224.00
IUUC-Mmu-063619	Mus musculus	46.79	7.00e-81	292.00
IUUC-Mac-065301	Musa acuminata	44.34	5.00e-71	259.00
IUUC-Mpu-066058	Mustela putorius furo	47.27	3.00e-81	293.00
IUUC-Mlu-067292	Myotis lucifugus	47.27	4.00e-81	293.00
IUUC-Nfi-068275	Neosartorya fischeri	37.05	6.00e-52	196.00
IUUC-Ncr-068713	Neurospora crassa	38.41	5.00e-52	196.00
IUUC-Nle-069013	Nomascus leucogenys	47.42	3.00e-81	293.00
IUUC-Opr-070628	Ochotona princeps	40.18	6.00e-67	246.00
IUUC-Ont-072688	Oreochromis niloticus	46.79	7.00e-79	285.00
IUUC-Oan-073004	Ornithorhynchus anatinus	49.55	5.00e-59	219.00
IUUC-Ocu-074303	Oryctolagus cuniculus	47.27	2.00e-81	295.00
IUUC-Oba-075002	Oryza barthii	42.68	1.00e-64	238.00
IUUC-Obr-076392	Oryza brachyantha	41.64	1.00e-64	238.00
IUUC-Ogl-077271	Oryza glaberrima	42.68	1.00e-64	238.00
IUUC-Ogu-078493	Oryza glumaepatula	42.68	4.00e-65	240.00
IUUC-Oin-080084	Oryza indica	42.68	4.00e-65	240.00
IUUC-Olo-080803	Oryza longistaminata	42.99	1.00e-65	242.00
IUUC-Ome-081146	Oryza meridionalis	42.06	7.00e-65	239.00
IUUC-Oni-082146	Oryza nivara	42.68	4.00e-65	240.00
IUUC-Opu-083633	Oryza punctata	41.32	5.00e-64	236.00
IUUC-Oru-084789	Oryza rufipogon	42.68	4.00e-65	240.00
IUUC-Osa-086196	Oryza sativa	42.68	4.00e-65	240.00
IUUC-Ola-087126	Oryzias latipes	46.45	2.00e-79	287.00
IUUC-Olu-087665	Ostreococcus lucimarinus	41.45	2.00e-60	224.00
IUUC-Oga-089140	Otolemur garnettii	43.20	6.00e-76	276.00
IUUC-Oar-090296	Ovis aries	46.95	6.00e-80	289.00
IUUC-Ptr-090566	Pan troglodytes	47.27	7.00e-81	292.00
IUUC-Pan-092052	Papio anubis	47.42	6.00e-81	293.00
IUUC-Psi-093723	Pelodiscus sinensis	45.33	4.00e-70	256.00
IUUC-Pma-094568	Petromyzon marinus	40.14	9.00e-59	218.00
IUUC-Pno-095120	Phaeosphaeria nodorum	37.34	3.00e-46	177.00
IUUC-Ppa-095761	Physcomitrella patens	40.94	3.00e-62	230.00
IUUC-Pfo-096210	Poecilia formosa	47.74	6.00e-81	292.00
IUUC-Pab-098463	Pongo abelii	47.27	7.00e-81	292.00
IUUC-Pop-099109	Populus trichocarpa	40.79	7.00e-66	242.00
IUUC-Pca-100108	Procavia capensis	50.21	3.00e-67	247.00
IUUC-Ppe-101176	Prunus persica	41.39	6.00e-63	233.00
IUUC-Pva-102629	Pteropus vampyrus	51.45	3.00e-71	260.00
IUUC-Pgr-103419	Puccinia graminis	39.63	1.00e-55	208.00
IUUC-Pte-104207	Pyrenophora teres	43.71	1.00e-30	124.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	38.26	3.00e-49	187.00
IUUC-Rno-105579	Rattus norvegicus	40.56	2.00e-63	234.00
IUUC-Sha-106894	Sarcophilus harrisii	46.84	2.00e-67	248.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	37.11	2.00e-48	184.00
IUUC-Spo-108371	Schizosaccharomyces pombe	42.07	3.00e-53	200.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	36.90	5.00e-39	153.00
IUUC-Smo-109396	Selaginella moellendorffii	43.65	8.00e-66	242.00
IUUC-Sit-110630	Setaria italica	44.38	3.00e-68	250.00
IUUC-Sly-110972	Solanum lycopersicum	41.10	3.00e-61	227.00
IUUC-Stu-112185	Solanum tuberosum	42.55	2.00e-70	257.00
IUUC-Sar-113294	Sorex araneus	40.59	3.00e-67	247.00
IUUC-Sbi-113951	Sorghum bicolor	44.38	7.00e-69	252.00
IUUC-Ssc-115501	Sus scrofa	45.30	5.00e-72	263.00
IUUC-Tgu-117152	Taeniopygia guttata	44.29	1.00e-68	251.00
IUUC-Tru-118388	Takifugu rubripes	46.77	4.00e-80	290.00
IUUC-Tsy-119109	Tarsius syrichta	47.27	8.00e-81	292.00
IUUC-Tni-120048	Tetraodon nigroviridis	46.77	2.00e-80	291.00
IUUC-Tca-121750	Theobroma cacao	43.03	3.00e-72	263.00
IUUC-Tre-122130	Trichoderma reesei	36.81	6.00e-46	176.00
IUUC-Tvi-122284	Trichoderma virens	39.02	1.00e-42	165.00
IUUC-Tae-124082	Triticum aestivum	41.23	6.00e-67	246.00
IUUC-Tur-126366	Triticum urartu	37.70	9.00e-50	189.00
IUUC-Tme-127187	Tuber melanosporum	39.87	7.00e-54	202.00
IUUC-Tbe-127619	Tupaia belangeri	40.35	1.00e-50	191.00
IUUC-Ttr-128867	Tursiops truncatus	43.80	2.00e-52	197.00
IUUC-Vda-129912	Verticillium dahliae	39.16	5.00e-49	186.00
IUUC-Vpa-130552	Vicugna pacos	50.72	3.00e-60	224.00
IUUC-Vvi-130881	Vitis vinifera	43.16	3.00e-65	240.00
IUUC-Xtr-131934	Xenopus tropicalis	47.60	2.00e-81	294.00
IUUC-Xma-133312	Xiphophorus maculatus	47.74	4.00e-81	293.00
IUUC-Yli-134487	Yarrowia lipolytica	36.11	1.00e-48	185.00
IUUC-Zma-135462	Zea mays	38.34	2.00e-54	204.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence