iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052264

Ensembl Protein ID

ENSLOCP00000008940.1

UniProt Accession

W5MKN1; W5MKN1_LEPOC

Genbank Protein ID

ENSLOCP00000008940

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AHAT01016022

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000007370.1	ENSLOCT00000008951.1	ENSLOCP00000008940.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.50e-95	319.9	1	323

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
165	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m + + ew+ +esdPg+ft+l++ fg+k+  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          ++v+++ +++if
   Q: 1    MAGSAGEWCLMESDPGVFTELIKGFGCKGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SIVQDSRLDQIF 78
           667789************************.****************.*******************9.........8899******** PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaes.penkalalgnqqvlecihnslariesrseperqdedneqytkea 177
           fakqvi+N+Cat+A++svllnc++  ++lG+tl +++e++++++  ++k+lal+n++v++++hn +ar+++++ + + +++    +++a
   Q: 79   FAKQVINNACATQAIISVLLNCTHSDMHLGETLTEFREFSQSFDvIQMKGLALSNSEVIRQVHNGFARQQMFEFDAKSSAK----DEDA 163
           ******************************************962699***************************998777....79** PP
   S: 178  fhfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid....... 259
           fhfvsyv++ngrlyeldgl++ P+dlg  ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +       
   Q: 164  FHFVSYVPVNGRLYELDGLREGPIDLGT-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEHKIAELQNQlaeeepm 249
           ***************************9.78999*********..******************************97666556778888 PP
   S: 260  ..keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgv 334
              +  +Ll+ i+se++k++  +++e++k k++ki++irR++ny  fi++++k+la+ ++l  lve+    + ++++
   Q: 250  dtDQSSNLLSSIQSEIAKYQLLIEEENQKLKRYKIENIRRKHNYLPFIMELLKTLAEYQQLIPLVEKA---KEKQNA 323
           7755678**********************************************************993...333554 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MAGSAGEWCL MESDPGVFTE LIKGFGCKGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP 60
GEEPAGSIVQ DSRLDQIFFA KQVINNACAT QAIISVLLNC THSDMHLGET LTEFREFSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGGGA GCGCCGGAGA ATGGTGTCTA ATGGAGAGTG ATCCGGGAGT CTTCACAGAA 60
TTAATTAAAG GTTTTGGTGA GTTGGTGTAG CCTAATACAT TTCTTGAATA ATTATGTACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0031011--C:Ino80 complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	45.95	1.00e-81	296.00
IUUC-Aml-001866	Ailuropoda melanoleuca	90.76	2.00e-173	601.00
IUUC-Atr-002966	Amborella trichopoda	46.70	2.00e-79	289.00
IUUC-Apl-003306	Anas platyrhynchos	83.29	3.00e-172	597.00
IUUC-Aca-004763	Anolis carolinensis	92.97	1.00e-176	612.00
IUUC-Aly-005581	Arabidopsis lyrata	47.88	3.00e-77	281.00
IUUC-Ath-007283	Arabidopsis thaliana	47.58	3.00e-79	288.00
IUUC-Ago-007999	Ashbya gossypii	36.02	4.00e-31	128.00
IUUC-Acl-008231	Aspergillus clavatus	43.98	2.00e-51	196.00
IUUC-Afl-008557	Aspergillus flavus	38.24	2.00e-53	202.00
IUUC-Afu-008988	Aspergillus fumigatus	45.00	4.00e-53	201.00
IUUC-Ani-009420	Aspergillus nidulans	37.80	1.00e-52	199.00
IUUC-Ang-009859	Aspergillus niger	41.63	2.00e-48	185.00
IUUC-Aor-010145	Aspergillus oryzae	38.24	2.00e-53	202.00
IUUC-Ate-010347	Aspergillus terreus	41.73	2.00e-51	196.00
IUUC-Ame-010791	Astyanax mexicanus	93.33	0.00e+00	640.00
IUUC-Bgr-012298	Blumeria graminis	37.91	2.00e-48	185.00
IUUC-Bta-013251	Bos taurus	90.45	1.00e-171	595.00
IUUC-Bci-013786	Botrytis cinerea	37.06	4.00e-55	208.00
IUUC-Bdi-014132	Brachypodium distachyon	48.31	1.00e-78	286.00
IUUC-Bol-015611	Brassica oleracea	49.24	8.00e-82	296.00
IUUC-Bra-017769	Brassica rapa	49.24	8.00e-82	296.00
IUUC-Cel-018604	Caenorhabditis elegans	46.98	5.00e-80	290.00
IUUC-Cja-019768	Callithrix jacchus	82.16	2.00e-166	577.00
IUUC-Cfa-020207	Canis familiaris	90.76	2.00e-173	601.00
IUUC-Cpo-021925	Cavia porcellus	86.62	4.00e-164	570.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.94	1.00e-72	266.00
IUUC-Csa-023958	Chlorocebus sabaeus	89.81	4.00e-170	590.00
IUUC-Cho-024928	Choloepus hoffmanni	90.67	6.00e-39	154.00
IUUC-Cin-025771	Ciona intestinalis	54.32	9.00e-98	349.00
IUUC-Csv-026149	Ciona savignyi	56.56	4.00e-100	357.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	38.10	3.00e-51	194.00
IUUC-Cne-026955	Cryptococcus neoformans	36.28	2.00e-51	196.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.60	9.00e-48	183.00
IUUC-Dre-027409	Danio rerio	93.64	0.00e+00	637.00
IUUC-Dno-028921	Dasypus novemcinctus	90.45	8.00e-173	598.00
IUUC-Dse-031170	Dothistroma septosporum	37.85	1.00e-54	206.00
IUUC-Dme-031677	Drosophila melanogaster	60.75	2.00e-112	398.00
IUUC-Ete-032707	Echinops telfairi	63.44	1.00e-109	389.00
IUUC-Eca-033776	Equus caballus	91.00	3.00e-158	550.00
IUUC-Eeu-035305	Erinaceus europaeus	71.96	3.00e-76	278.00
IUUC-Fca-035846	Felis catus	83.58	3.00e-168	584.00
IUUC-Fal-037597	Ficedula albicollis	92.04	4.00e-154	536.00
IUUC-Fox-037670	Fusarium oxysporum	48.71	3.00e-52	198.00
IUUC-Fso-038243	Fusarium solani	48.71	9.00e-52	197.00
IUUC-Gmo-038499	Gadus morhua	88.54	4.00e-167	580.00
IUUC-Ggr-039975	Gaeumannomyces graminis	39.68	1.00e-45	176.00
IUUC-Gga-040904	Gallus gallus	91.87	0.00e+00	634.00
IUUC-Gac-042058	Gasterosteus aculeatus	93.95	1.00e-177	615.00
IUUC-Gma-043763	Glycine max	48.82	9.00e-84	303.00
IUUC-Ggo-044699	Gorilla gorilla	84.09	2.00e-155	541.00
IUUC-Hsa-046227	Homo sapiens	90.13	2.00e-172	597.00
IUUC-Hvu-047359	Hordeum vulgare	46.06	4.00e-80	291.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	82.61	5.00e-168	583.00
IUUC-Lch-049829	Latimeria chalumnae	92.04	5.00e-174	603.00
IUUC-Lpe-050899	Leersia perrieri	47.17	1.00e-75	276.00
IUUC-Lma-053110	Leptosphaeria maculans	37.29	2.00e-45	176.00
IUUC-Laf-053639	Loxodonta africana	90.76	2.00e-173	601.00
IUUC-Mcc-055506	Macaca mulatta	89.81	5.00e-170	590.00
IUUC-Mor-057001	Magnaporthe oryzae	43.93	1.00e-52	199.00
IUUC-Mpo-057608	Magnaporthe poae	40.96	2.00e-31	129.00
IUUC-Mtr-057731	Medicago truncatula	48.81	2.00e-83	302.00
IUUC-Mla-059016	Melampsora laricipopulina	43.07	2.00e-42	165.00
IUUC-Mga-060178	Meleagris gallopavo	92.13	4.00e-169	586.00
IUUC-Mvi-060353	Microbotryum violaceum	38.10	1.00e-52	199.00
IUUC-Mmr-060738	Microcebus murinus	90.45	6.00e-173	599.00
IUUC-Mdo-062266	Monodelphis domestica	91.22	1.00e-113	401.00
IUUC-Mmu-063619	Mus musculus	88.54	8.00e-170	589.00
IUUC-Mac-065301	Musa acuminata	50.31	3.00e-86	311.00
IUUC-Mpu-066058	Mustela putorius furo	91.08	6.00e-174	603.00
IUUC-Mlu-067292	Myotis lucifugus	89.49	3.00e-169	587.00
IUUC-Nfi-068275	Neosartorya fischeri	38.78	3.00e-54	205.00
IUUC-Ncr-068713	Neurospora crassa	37.62	9.00e-56	210.00
IUUC-Nle-069013	Nomascus leucogenys	89.49	2.00e-169	588.00
IUUC-Opr-070628	Ochotona princeps	79.18	7.00e-157	546.00
IUUC-Ont-072688	Oreochromis niloticus	93.04	6.00e-175	606.00
IUUC-Oan-073004	Ornithorhynchus anatinus	90.69	2.00e-134	471.00
IUUC-Ocu-074303	Oryctolagus cuniculus	91.08	3.00e-174	605.00
IUUC-Oba-075002	Oryza barthii	47.75	4.00e-80	291.00
IUUC-Obr-076392	Oryza brachyantha	48.43	9.00e-78	283.00
IUUC-Ogl-077271	Oryza glaberrima	47.75	4.00e-80	291.00
IUUC-Ogu-078493	Oryza glumaepatula	47.75	9.00e-81	293.00
IUUC-Oin-080084	Oryza indica	47.75	9.00e-81	293.00
IUUC-Olo-080803	Oryza longistaminata	47.45	2.00e-80	292.00
IUUC-Ome-081146	Oryza meridionalis	46.85	2.00e-79	288.00
IUUC-Oni-082146	Oryza nivara	47.75	9.00e-81	293.00
IUUC-Opu-083633	Oryza punctata	48.43	2.00e-76	278.00
IUUC-Oru-084789	Oryza rufipogon	47.75	9.00e-81	293.00
IUUC-Osa-086196	Oryza sativa	47.75	9.00e-81	293.00
IUUC-Ola-087126	Oryzias latipes	92.36	9.00e-170	588.00
IUUC-Olu-087665	Ostreococcus lucimarinus	40.14	3.00e-66	244.00
IUUC-Oga-089140	Otolemur garnettii	82.70	3.00e-167	580.00
IUUC-Oar-090296	Ovis aries	90.13	8.00e-172	595.00
IUUC-Ptr-090566	Pan troglodytes	90.13	2.00e-172	597.00
IUUC-Pan-092052	Papio anubis	89.81	4.00e-170	590.00
IUUC-Psi-093723	Pelodiscus sinensis	91.70	3.00e-160	557.00
IUUC-Pma-094568	Petromyzon marinus	61.94	5.00e-106	377.00
IUUC-Pno-095120	Phaeosphaeria nodorum	43.53	2.00e-46	179.00
IUUC-Ppa-095761	Physcomitrella patens	46.94	9.00e-83	300.00
IUUC-Pfo-096210	Poecilia formosa	93.63	3.00e-176	610.00
IUUC-Pab-098463	Pongo abelii	90.13	3.00e-172	597.00
IUUC-Pop-099423	Populus trichocarpa	48.52	7.00e-83	300.00
IUUC-Pca-100108	Procavia capensis	89.47	1.00e-132	465.00
IUUC-Ppe-101176	Prunus persica	49.85	8.00e-83	300.00
IUUC-Pva-102629	Pteropus vampyrus	87.83	7.00e-138	483.00
IUUC-Pgr-103419	Puccinia graminis	40.12	1.00e-54	206.00
IUUC-Pte-104207	Pyrenophora teres	41.18	4.00e-29	120.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	37.58	4.00e-53	201.00
IUUC-Rno-105579	Rattus norvegicus	79.32	1.00e-149	521.00
IUUC-Sha-106894	Sarcophilus harrisii	88.09	2.00e-146	511.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	39.86	2.00e-57	215.00
IUUC-Spo-108371	Schizosaccharomyces pombe	41.39	3.00e-59	221.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	37.55	2.00e-45	176.00
IUUC-Smo-109396	Selaginella moellendorffii	51.53	3.00e-87	315.00
IUUC-Sit-110630	Setaria italica	49.09	5.00e-84	304.00
IUUC-Sly-110972	Solanum lycopersicum	49.36	5.00e-79	287.00
IUUC-Stu-112185	Solanum tuberosum	49.85	4.00e-87	314.00
IUUC-Sar-113294	Sorex araneus	74.86	3.00e-151	527.00
IUUC-Sbi-113951	Sorghum bicolor	49.39	3.00e-84	305.00
IUUC-Ssc-115501	Sus scrofa	89.93	9.00e-162	562.00
IUUC-Tgu-117152	Taeniopygia guttata	91.70	4.00e-154	536.00
IUUC-Tru-118388	Takifugu rubripes	93.31	3.00e-177	613.00
IUUC-Tsy-119109	Tarsius syrichta	90.45	9.00e-173	598.00
IUUC-Tni-120048	Tetraodon nigroviridis	93.31	1.00e-177	615.00
IUUC-Tca-121750	Theobroma cacao	48.97	2.00e-86	312.00
IUUC-Tre-122130	Trichoderma reesei	39.53	4.00e-55	207.00
IUUC-Tvi-122284	Trichoderma virens	38.74	1.00e-50	193.00
IUUC-Tae-124082	Triticum aestivum	46.06	8.00e-80	290.00
IUUC-Tur-126366	Triticum urartu	43.15	3.00e-65	242.00
IUUC-Tme-127187	Tuber melanosporum	40.46	1.00e-57	216.00
IUUC-Tbe-127619	Tupaia belangeri	82.64	8.00e-133	466.00
IUUC-Ttr-128867	Tursiops truncatus	80.89	4.00e-115	407.00
IUUC-Vda-129912	Verticillium dahliae	37.04	4.00e-52	198.00
IUUC-Vpa-130552	Vicugna pacos	91.43	2.00e-117	415.00
IUUC-Vvi-130881	Vitis vinifera	49.70	1.00e-82	300.00
IUUC-Xtr-131934	Xenopus tropicalis	85.76	2.00e-172	597.00
IUUC-Xma-133312	Xiphophorus maculatus	93.31	6.00e-175	606.00
IUUC-Yli-134487	Yarrowia lipolytica	38.53	7.00e-45	174.00
IUUC-Zma-135462	Zea mays	42.94	3.00e-69	255.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence