iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118327

UUCD1 version

UUC-TaR-00344

Ensembl Protein ID

ENSTRUP00000017319.1

UniProt Accession

H2SY31; H2SY31_TAKRU

Protein Name

Uncharacterized protein

Gene Name

si:dkey-42p8.3; TLE2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000007051.1	ENSTRUT00000017390.1	ENSTRUP00000017316.1
ENSTRUG00000007051.1	ENSTRUT00000017391.1	ENSTRUP00000017317.1
ENSTRUG00000007051.1	ENSTRUT00000017392.1	ENSTRUP00000017318.1
ENSTRUG00000007051.1	ENSTRUT00000017393.1	ENSTRUP00000017319.1
ENSTRUG00000007051.1	ENSTRUT00000017394.1	ENSTRUP00000017320.1
ENSTRUG00000007051.1	ENSTRUT00000017395.1	ENSTRUP00000017321.1
ENSTRUG00000007051.1	ENSTRUT00000017396.1	ENSTRUP00000017322.1
ENSTRUG00000007051.1	ENSTRUT00000017397.1	ENSTRUP00000017323.1
ENSTRUG00000007051.1	ENSTRUT00000017398.1	ENSTRUP00000017324.1
ENSTRUG00000007051.1	ENSTRUT00000017399.1	ENSTRUP00000017325.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.00e-23	81.2	636	674
UBD/Beta-Prp	1.40e-40	140.6	505	673

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t+++WDlr+g++l+
   Q: 636  GHTDGASCIDIsNDgTKLWTGGLDNTVRCWDLREGRQLQ 674
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 51   heaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.tl 133
           h + v av++s ++   v ++  + +kvwd+s   t +++  l   + +++++s+++ p+g +l++G++ +t+ +wdl t +   +  l
   Q: 505  HGEVVCAVTISASAR-HVYTGGKGCVKVWDISqpgTKSPMAQLDclNRDNYIRSCKILPDGRTLIVGGEASTLSIWDLATPTPRIKaEL 592
           555688899999985.555555579*******776555555555779*********************************998776588 PP
   S: 134  sghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecv 215
           +    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ +
   Q: 593  TSSAPACYALAISPDNKVCFSCCSDGNIVVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRCWDLREGRQL 673
           8888888899*********************************9.********************************99754 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

IKVSGDQLAD THHPVPLQPG QSFKFTVLET LDRIKEEFQF LQAQYHSLKL ECEKLASEKT 60
EMQRHYIMYY EMSYGLNIEM HKQAEIVKRL SAICAQIIPF LSQEHQQQVV QAVERAKQVT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTACCCTC AGGGCAGGCA TCCGGTAAGT ACCTCTCCGT GTCTTTGCGA CCGTCCATGA 60
CTGTCCATCA GGTCCAGTGT CTCTTTTTTA CACCACCATG TCTCCTTGAC AGTGTCCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0006355--P:regulation of transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001746	Ailuropoda melanoleuca	65.72	0.00e+00	892.00
IUUC-Ame-010996	Astyanax mexicanus	85.38	0.00e+00	1178.00
IUUC-Dre-028144	Danio rerio	84.52	0.00e+00	1149.00
IUUC-Gac-041949	Gasterosteus aculeatus	83.65	0.00e+00	1070.00
IUUC-Ont-072426	Oreochromis niloticus	92.41	0.00e+00	1280.00
IUUC-Ola-087404	Oryzias latipes	88.29	0.00e+00	992.00
IUUC-Pfo-096589	Poecilia formosa	85.03	0.00e+00	1146.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence