iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120770

UUCD1 version

UUC-TeN-00757

Ensembl Protein ID

ENSTNIP00000001785.1

UniProt Accession

H3C0L9; H3C0L9_TETNG

Protein Name

Uncharacterized protein

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000010295.1	ENSTNIT00000000742.1	ENSTNIP00000002909.1
ENSTNIG00000010295.1	ENSTNIT00000013390.1	ENSTNIP00000013198.1
ENSTNIG00000010295.1	ENSTNIT00000000546.1	ENSTNIP00000001785.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.80e-51	174.7	700	1020

Active Site

Position(s)	Description	Evidence
985	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           +++k+l v f+++  + +    ++f+  ++ +l +p+ g+f+y+e+++  ++p + +     ++ +++ ++G+l+g+a ++++++ l
   Q: 700  AFRKKLLVIFTDNRKVTN-VNISDFFLHVFGHLIDPKSGMFMYNEDETLAWFPPKPK-----KKARIYFLFGVLCGLAFFHQNMVHL 780
           567889999999887777.57789****************************99877.....467777789**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN.keeYvkl 176
           p++ +++k+ll++k sl+dl e+dp +++sl +++e   s  e ++ld tf+v++      +++eL p+ +  pVt +N ++++v +
   Q: 781  PFPLVLFKKLLRVKPSLDDLREFDPVRAESLRYLLED-CSPEEVESLDATFTVET---WGGETVELDPSESGKPVTASNsRQQFVAA 863
           ***********************************98.45666667999999666...5555666*************95679**** PP
   S: 177  vveyrlkegikeqveafr.eGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
            v++ ++ ++++ +e+f+ +G + +++l++    + + ++l +++  +i +e++k +t y++ y +++p i +Fwe++ ++s+ee+k
   Q: 864  FVNHAFNASVESVFEEFKhKGSHHLLSLKIKV--QSSKIQL-TSK--QIISEHIK-NTVYEEPYDANHPNIVTFWEAFDRLSAEEKK 944
           *****************748*****9998432..3333333.333..46666665.5****************************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYss.....keilkekLlyAieetkgFe 334
            fL F+Tgs+r+PlgG++++k  + ++ + a++  lP+s TC+++L LP Y+s      + ++++Ll Ai +++gF 
   Q: 945  HFLWFLTGSERVPLGGMKSIKMAVATLAN-ATELALPESLTCYHLLMLPVYDSdspdsISLMQSRLLQAIYNKSGFR 1020
           *********************66555555.999******************8622222579*************996 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

LYCWGDSSSG QFGPRTATRP VSWTVPRTVI DISCGDRHIL FLTEDGCVLS CGNNSDGQLG 60
RKKKHKNKAP GCVEGLGHVV QISCGCNHSL AVDASGHVFS WGAAEDGQLG LNPNPLSGRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGCTGT ACTGTTGGGG GGACAGCTCC AGTGGACAGT TCGGTCCACG GACAGCGACG 60
CGTCCCGTTT CATGGACTGT CCCGCGGACC GTGATCGACA TCAGCTGTGG GGATCGACAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011023	Astyanax mexicanus	39.85	0.00e+00	711.00
IUUC-Gmo-038792	Gadus morhua	43.03	0.00e+00	686.00
IUUC-Gac-041342	Gasterosteus aculeatus	53.14	0.00e+00	946.00
IUUC-Loc-052736	Lepisosteus oculatus	40.32	0.00e+00	658.00
IUUC-Ont-071328	Oreochromis niloticus	54.46	0.00e+00	1063.00
IUUC-Pfo-096202	Poecilia formosa	51.98	0.00e+00	944.00
IUUC-Tru-117816	Takifugu rubripes	60.15	0.00e+00	1104.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence