iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.00e-14	52.7	188	242

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v++ ++++ +n+deL+  kGd+++v     +++gW++g  +l+g+ G fP+n+v++++
   Q: 188  IVKARFNFKQTNEDELSVCKGDIIYVT--RVEEGGWWEG--TLNGRTGWFPSNYVREIK 242
           68999*********************7..999*******..8**************996 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MQSRMWLSPH SCPESCSERT RASVMNPEER VVTWLISLGV LESPKKTICD PEEFLKSSLK 60
NGVVLCKLIS RLLPGSVEKY CQEPQTEADC IDNINDFLKG CATLQVEVFE PDDLYSGANF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTTCAAG TTTCGAAAAA GAACCGGTGA TGTTCTCCCA GGAGTTTGTC CATTCCTTAT 60
CATTCCTTTC CATATCTTTA GGTATGATCT CTGTGGTTTA GAAATCCCAC GTTCCACTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035556--P:intracellular signal transduction
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001631	Ailuropoda melanoleuca	84.13	0.00e+00	1122.00
IUUC-Apl-003960	Anas platyrhynchos	73.52	0.00e+00	1092.00
IUUC-Aca-004988	Anolis carolinensis	69.15	0.00e+00	1021.00
IUUC-Aly-005591	Arabidopsis lyrata	38.71	8.00e-09	54.70
IUUC-Ame-011546	Astyanax mexicanus	63.91	0.00e+00	944.00
IUUC-Bta-013527	Bos taurus	91.23	0.00e+00	1348.00
IUUC-Bdi-014394	Brachypodium distachyon	37.93	3.00e-08	52.80
IUUC-Cja-018935	Callithrix jacchus	90.84	0.00e+00	1328.00
IUUC-Cfa-021269	Canis familiaris	90.19	0.00e+00	1322.00
IUUC-Cpo-021620	Cavia porcellus	86.54	0.00e+00	1268.00
IUUC-Csa-023415	Chlorocebus sabaeus	91.23	0.00e+00	1335.00
IUUC-Dre-028580	Danio rerio	62.96	0.00e+00	962.00
IUUC-Dno-029201	Dasypus novemcinctus	84.83	0.00e+00	1318.00
IUUC-Dor-030868	Dipodomys ordii	74.19	0.00e+00	1006.00
IUUC-Eca-033500	Equus caballus	91.48	0.00e+00	1331.00
IUUC-Eeu-035269	Erinaceus europaeus	79.60	2.00e-158	553.00
IUUC-Fca-035683	Felis catus	89.55	0.00e+00	1304.00
IUUC-Fal-037611	Ficedula albicollis	73.45	0.00e+00	1093.00
IUUC-Gmo-038980	Gadus morhua	60.63	0.00e+00	906.00
IUUC-Gga-040940	Gallus gallus	73.42	0.00e+00	1101.00
IUUC-Gac-042203	Gasterosteus aculeatus	60.53	0.00e+00	937.00
IUUC-Ggo-044755	Gorilla gorilla	91.74	0.00e+00	1341.00
IUUC-Hsa-046210	Homo sapiens	91.48	0.00e+00	1340.00
IUUC-Lch-049517	Latimeria chalumnae	68.90	0.00e+00	1013.00
IUUC-Loc-052393	Lepisosteus oculatus	64.75	0.00e+00	1020.00
IUUC-Laf-054196	Loxodonta africana	88.81	0.00e+00	1320.00
IUUC-Mcc-055716	Macaca mulatta	91.23	0.00e+00	1335.00
IUUC-Meu-056285	Macropus eugenii	72.51	0.00e+00	674.00
IUUC-Mtr-058576	Medicago truncatula	44.44	6.00e-11	61.60
IUUC-Mga-060029	Meleagris gallopavo	73.78	0.00e+00	1103.00
IUUC-Mmr-060803	Microcebus murinus	91.48	0.00e+00	1338.00
IUUC-Mdo-062654	Monodelphis domestica	79.31	0.00e+00	1190.00
IUUC-Mmu-063479	Mus musculus	97.24	0.00e+00	1454.00
IUUC-Mpu-066065	Mustela putorius furo	90.19	0.00e+00	1305.00
IUUC-Mlu-068222	Myotis lucifugus	89.43	0.00e+00	1288.00
IUUC-Nle-069379	Nomascus leucogenys	91.74	0.00e+00	1341.00
IUUC-Opr-070687	Ochotona princeps	71.51	0.00e+00	806.00
IUUC-Oan-073067	Ornithorhynchus anatinus	79.12	0.00e+00	1199.00
IUUC-Ocu-074852	Oryctolagus cuniculus	90.84	0.00e+00	1319.00
IUUC-Oga-089048	Otolemur garnettii	84.74	0.00e+00	1141.00
IUUC-Oar-089339	Ovis aries	90.11	0.00e+00	1370.00
IUUC-Pan-092666	Papio anubis	88.93	0.00e+00	1286.00
IUUC-Psi-093116	Pelodiscus sinensis	73.84	0.00e+00	1122.00
IUUC-Pfo-097394	Poecilia formosa	60.95	0.00e+00	922.00
IUUC-Pab-098567	Pongo abelii	91.74	0.00e+00	1342.00
IUUC-Pca-100997	Procavia capensis	77.30	0.00e+00	1068.00
IUUC-Pva-102500	Pteropus vampyrus	89.16	0.00e+00	1271.00
IUUC-Sar-113420	Sorex araneus	85.94	0.00e+00	1232.00
IUUC-Ssc-115679	Sus scrofa	91.17	0.00e+00	1174.00
IUUC-Tgu-117069	Taeniopygia guttata	72.79	0.00e+00	1078.00
IUUC-Tru-118488	Takifugu rubripes	56.21	0.00e+00	829.00
IUUC-Tsy-119243	Tarsius syrichta	83.63	0.00e+00	915.00
IUUC-Tni-120584	Tetraodon nigroviridis	60.15	0.00e+00	905.00
IUUC-Tbe-127994	Tupaia belangeri	75.35	0.00e+00	1077.00
IUUC-Ttr-128839	Tursiops truncatus	90.06	0.00e+00	1288.00
IUUC-Vpa-130144	Vicugna pacos	91.43	0.00e+00	733.00
IUUC-Xtr-132624	Xenopus tropicalis	68.57	0.00e+00	1040.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence