iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089432

Ensembl Protein ID

ENSOARP00000009735.1

UniProt Accession

W5PH18; W5PH18_SHEEP

Genbank Protein ID

ENSOARP00000009735

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01110786

Gene Name

RNF139

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000009072.1	ENSOART00000009877.1	ENSOARP00000009735.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.40e-08	35.3	507	545

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+ +f +  +++pC+H fha Cl kw       + +++CP C
   Q: 507  CAICYHEFTTSARITPCNHYFHALCLRKW------LYIQDTCPMC 545
           ********999******************......********** PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MPPLSSSWLE EVDPETGGST CIFVSSIVLI LSQRSLFKFY MYSSAFLLAA TSVLVNYYAA 60
LHIDFYGAYN TSAFGIELLP RKGPSLWMAL IVLQLTFGIG YITLLQIHSI YSQLIILDLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGCCCC TGTCATCTAG TTGGCTAGAA GAGGTGGATC CTGAGACGGG AGGATCTACT 60
TGTGAGTGAC CCTGAAAGCG TCAGCTCAGG CCAGGTTTCA CCCCTCTTGT CTCCTGGTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13705--TRC8_N
PF13639--zf-RING_2

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0036503--P:ERAD pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0017148--P:negative regulation of translation
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0070613--P:regulation of protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002401	Ailuropoda melanoleuca	97.68	0.00e+00	1108.00
IUUC-Apl-004214	Anas platyrhynchos	85.69	0.00e+00	965.00
IUUC-Aca-005326	Anolis carolinensis	82.44	0.00e+00	944.00
IUUC-Ame-011687	Astyanax mexicanus	76.54	0.00e+00	840.00
IUUC-Bta-013394	Bos taurus	99.34	0.00e+00	1157.00
IUUC-Bci-013813	Botrytis cinerea	41.38	7.00e-08	51.60
IUUC-Cja-019499	Callithrix jacchus	96.85	0.00e+00	1153.00
IUUC-Cfa-020357	Canis familiaris	97.35	0.00e+00	1110.00
IUUC-Cpo-021924	Cavia porcellus	95.21	0.00e+00	1150.00
IUUC-Csa-023513	Chlorocebus sabaeus	97.02	0.00e+00	1132.00
IUUC-Cho-024285	Choloepus hoffmanni	90.23	0.00e+00	983.00
IUUC-Cin-025223	Ciona intestinalis	53.93	2.00e-74	271.00
IUUC-Csv-026018	Ciona savignyi	47.92	3.00e-64	238.00
IUUC-Dre-028660	Danio rerio	70.17	0.00e+00	771.00
IUUC-Dno-029463	Dasypus novemcinctus	97.54	1.00e-135	476.00
IUUC-Dor-030728	Dipodomys ordii	95.25	0.00e+00	1123.00
IUUC-Dse-031284	Dothistroma septosporum	43.40	8.00e-09	54.30
IUUC-Dme-032186	Drosophila melanogaster	45.08	1.00e-98	353.00
IUUC-Ete-032368	Echinops telfairi	88.76	0.00e+00	1088.00
IUUC-Eca-034325	Equus caballus	97.18	0.00e+00	1111.00
IUUC-Fca-035537	Felis catus	97.48	0.00e+00	1093.00
IUUC-Fal-037459	Ficedula albicollis	85.66	0.00e+00	944.00
IUUC-Gmo-039442	Gadus morhua	79.03	2.00e-98	353.00
IUUC-Ggr-039921	Gaeumannomyces graminis	31.91	2.00e-08	54.30
IUUC-Gga-041071	Gallus gallus	83.51	0.00e+00	962.00
IUUC-Gac-042483	Gasterosteus aculeatus	70.07	0.00e+00	868.00
IUUC-Ggo-044672	Gorilla gorilla	96.69	0.00e+00	1130.00
IUUC-Hsa-045836	Homo sapiens	96.03	0.00e+00	1095.00
IUUC-Itr-048588	Ictidomys tridecemlineatus	96.04	0.00e+00	1152.00
IUUC-Lch-050073	Latimeria chalumnae	74.56	0.00e+00	943.00
IUUC-Loc-052908	Lepisosteus oculatus	73.04	0.00e+00	905.00
IUUC-Lma-053202	Leptosphaeria maculans	42.59	3.00e-08	52.40
IUUC-Laf-053519	Loxodonta africana	94.54	0.00e+00	1147.00
IUUC-Mcc-054674	Macaca mulatta	97.10	6.00e-71	259.00
IUUC-Mor-057262	Magnaporthe oryzae	32.93	3.00e-08	54.30
IUUC-Mga-059922	Meleagris gallopavo	85.35	0.00e+00	954.00
IUUC-Mmr-061452	Microcebus murinus	96.19	0.00e+00	1123.00
IUUC-Mdo-062412	Monodelphis domestica	90.83	0.00e+00	1082.00
IUUC-Mmu-063147	Mus musculus	93.74	0.00e+00	1125.00
IUUC-Mpu-065929	Mustela putorius furo	97.52	0.00e+00	1112.00
IUUC-Mlu-067899	Myotis lucifugus	92.89	0.00e+00	1083.00
IUUC-Nle-070083	Nomascus leucogenys	96.69	0.00e+00	1128.00
IUUC-Opr-070461	Ochotona princeps	92.75	0.00e+00	1116.00
IUUC-Ont-072256	Oreochromis niloticus	72.76	0.00e+00	870.00
IUUC-Oan-073150	Ornithorhynchus anatinus	85.48	0.00e+00	934.00
IUUC-Ocu-073748	Oryctolagus cuniculus	93.74	0.00e+00	1087.00
IUUC-Oga-088565	Otolemur garnettii	97.19	0.00e+00	1139.00
IUUC-Ptr-091422	Pan troglodytes	96.52	0.00e+00	1129.00
IUUC-Pan-092331	Papio anubis	97.02	0.00e+00	1133.00
IUUC-Psi-092933	Pelodiscus sinensis	85.19	0.00e+00	915.00
IUUC-Pfo-097466	Poecilia formosa	65.58	0.00e+00	875.00
IUUC-Pab-098702	Pongo abelii	96.52	0.00e+00	1128.00
IUUC-Pca-100125	Procavia capensis	91.36	0.00e+00	1082.00
IUUC-Pva-102628	Pteropus vampyrus	97.34	0.00e+00	1111.00
IUUC-Rno-104886	Rattus norvegicus	93.74	0.00e+00	1124.00
IUUC-Sha-106702	Sarcophilus harrisii	90.97	0.00e+00	1085.00
IUUC-Ssc-115482	Sus scrofa	97.64	0.00e+00	1138.00
IUUC-Tgu-116829	Taeniopygia guttata	86.14	0.00e+00	964.00
IUUC-Tru-118557	Takifugu rubripes	67.51	0.00e+00	853.00
IUUC-Tsy-119399	Tarsius syrichta	91.24	0.00e+00	672.00
IUUC-Tni-120006	Tetraodon nigroviridis	62.68	0.00e+00	719.00
IUUC-Tbe-127664	Tupaia belangeri	95.68	0.00e+00	1112.00
IUUC-Ttr-129144	Tursiops truncatus	97.85	0.00e+00	1172.00
IUUC-Vpa-130226	Vicugna pacos	98.18	0.00e+00	1149.00
IUUC-Vvi-131278	Vitis vinifera	41.07	2.00e-10	58.90
IUUC-Xtr-132461	Xenopus tropicalis	73.15	0.00e+00	902.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence