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Tag Content
UUCD2 ID IUUC-Dre-027985
UUCD1 version UUC-DaR-00824
Ensembl Protein ID ENSDARP00000123888.1
UniProt Accession Q6EWH2; F8W4M2; Q58HR4; Q6DI27; Q9I8J8; FYNA_DANRE
Genbank Protein ID AAX47959.1; CAF06179.1; AAH75763.1; AAF81748.1
Protein Name Tyrosine-protein kinase fyna; Proto-oncogene c-Fyna
Genbank Nucleotide ID AY948197; AJ620748; CU306817; AF269145
Gene Name fyna; fyn
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000011370.11 ENSDART00000150232.2 ENSDARP00000123888.1
ENSDARG00000011370.11 ENSDART00000023320.6 ENSDARP00000003208.6
ENSDARG00000011370.11 ENSDART00000046414.5 ENSDARP00000046413.4
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 6.50e-15 55.8 87 142
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L+++kG++ +++  ++++++W+++ + ++g  G +P+n+v+ ++
   Q: 87   FVALYDYEARSEDDLSFRKGEKFQIL--NSTEGDWWEARSLTTGGTGYIPSNYVAPVD 142
           789***********************..8999**********************9987 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in cntn1-mediated signaling (By similarity). Required for convergent extension cell movements during gastrulation, acting with yes via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling.
 Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in cntn1-mediated signaling (By similarity). Required for convergent extension cell movements during gastrulation, acting with yes via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling.
Protein Sequence
(Fasta)
MGCVQCKDKE ATKLTDERET SVSQHAGYRY GSDPTPQHYP SFGVTAIPNY NNFHAPVSQG 60
VTVFGGVNSS SHSGTLRSRG GTGVTLFVAL YDYEARSEDD LSFRKGEKFQ ILNSTEGDWW 120
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Protein Fasta Sequence


>IUUC-Dre-027985|UBD,SH3|Danio rerio
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Nucleotide Sequence
(Fasta)
ATCTGTTACA CTCGGCGACA GGAGCAGCCT GAACCGTCAG GGCCAATGTT GTTATTTTCA 60
TAATTCACCG AGATTTTATT AATAGAAGAA GCCGTCTGCA AATGACCTAT TTTCGATTCT 120
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Nucleotide Fasta Sequence


>IUUC-Dre-027985|UBD,SH3|Danio rerio
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0464--Manganese
KW-0479--Metal-binding
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004672--F:protein kinase activity
GO:0005102--F:receptor binding
GO:0034334--P:adherens junction maintenance
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0007417--P:central nervous system development
GO:0060027--P:convergent extension involved in gastrulation
GO:0001702--P:gastrulation with mouth forming second
GO:0045087--P:innate immune response
GO:0042552--P:myelination
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0046777--P:protein autophosphorylation
GO:0042981--P:regulation of apoptotic process
GO:0042127--P:regulation of cell proliferation
GO:0051480--P:regulation of cytosolic calcium ion concentration
GO:0045859--P:regulation of protein kinase activity
GO:0042110--P:T cell activation
GO:0050852--P:T cell receptor signaling pathway
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG dre:373872
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002009 Ailuropoda melanoleuca 92.36 0.00e+00 1025.00
IUUC-Apl-003716 Anas platyrhynchos 87.20 0.00e+00 953.00
IUUC-Aca-005065 Anolis carolinensis 92.36 0.00e+00 1022.00
IUUC-Aly-005712 Arabidopsis lyrata 31.91 2.00e-19 91.70
IUUC-Ame-011533 Astyanax mexicanus 98.46 0.00e+00 937.00
IUUC-Bta-012645 Bos taurus 92.18 0.00e+00 1023.00
IUUC-Cja-019027 Callithrix jacchus 92.36 0.00e+00 1025.00
IUUC-Cfa-021163 Canis familiaris 92.36 0.00e+00 1025.00
IUUC-Cpo-022315 Cavia porcellus 92.36 0.00e+00 1025.00
IUUC-Csa-023721 Chlorocebus sabaeus 92.36 0.00e+00 1026.00
IUUC-Cho-025014 Choloepus hoffmanni 92.36 0.00e+00 1025.00
IUUC-Dno-030043 Dasypus novemcinctus 77.87 0.00e+00 907.00
IUUC-Dor-031035 Dipodomys ordii 91.06 0.00e+00 1005.00
IUUC-Eca-033928 Equus caballus 83.19 0.00e+00 775.00
IUUC-Eeu-034582 Erinaceus europaeus 90.49 0.00e+00 637.00
IUUC-Fca-035582 Felis catus 92.36 0.00e+00 1025.00
IUUC-Fal-037320 Ficedula albicollis 87.52 0.00e+00 957.00
IUUC-Gmo-038992 Gadus morhua 94.25 0.00e+00 1061.00
IUUC-Gga-041262 Gallus gallus 87.52 0.00e+00 957.00
IUUC-Gac-042461 Gasterosteus aculeatus 94.04 0.00e+00 1067.00
IUUC-Ggo-044469 Gorilla gorilla 91.45 0.00e+00 1021.00
IUUC-Hsa-045723 Homo sapiens 92.36 0.00e+00 1026.00
IUUC-Itr-048519 Ictidomys tridecemlineatus 92.36 0.00e+00 1025.00
IUUC-Lch-049825 Latimeria chalumnae 91.25 0.00e+00 1001.00
IUUC-Loc-052531 Lepisosteus oculatus 93.11 0.00e+00 1060.00
IUUC-Laf-053659 Loxodonta africana 92.36 0.00e+00 1024.00
IUUC-Mcc-055039 Macaca mulatta 86.72 0.00e+00 954.00
IUUC-Mga-060067 Meleagris gallopavo 92.75 0.00e+00 1025.00
IUUC-Mmr-061194 Microcebus murinus 92.36 0.00e+00 1025.00
IUUC-Mdo-062628 Monodelphis domestica 92.18 0.00e+00 1023.00
IUUC-Mmu-063896 Mus musculus 92.36 0.00e+00 1025.00
IUUC-Mpu-066333 Mustela putorius furo 92.36 0.00e+00 1027.00
IUUC-Mlu-067315 Myotis lucifugus 92.36 0.00e+00 1025.00
IUUC-Nle-068978 Nomascus leucogenys 87.15 0.00e+00 955.00
IUUC-Ont-072516 Oreochromis niloticus 95.72 0.00e+00 1086.00
IUUC-Ocu-074284 Oryctolagus cuniculus 92.36 0.00e+00 1026.00
IUUC-Ola-087431 Oryzias latipes 94.41 0.00e+00 1072.00
IUUC-Oga-088789 Otolemur garnettii 86.96 0.00e+00 952.00
IUUC-Oar-089408 Ovis aries 92.18 0.00e+00 1023.00
IUUC-Ptr-091068 Pan troglodytes 92.36 0.00e+00 1026.00
IUUC-Pan-092217 Papio anubis 92.36 0.00e+00 1026.00
IUUC-Psi-093602 Pelodiscus sinensis 92.55 0.00e+00 1027.00
IUUC-Pfo-097084 Poecilia formosa 94.60 0.00e+00 1075.00
IUUC-Pab-097673 Pongo abelii 91.99 0.00e+00 1022.00
IUUC-Pca-100245 Procavia capensis 91.56 0.00e+00 921.00
IUUC-Pva-102645 Pteropus vampyrus 91.23 0.00e+00 995.00
IUUC-Rno-105372 Rattus norvegicus 92.18 0.00e+00 1023.00
IUUC-Sha-107637 Sarcophilus harrisii 91.99 0.00e+00 1012.00
IUUC-Sar-113016 Sorex araneus 81.56 0.00e+00 881.00
IUUC-Ssc-116389 Sus scrofa 91.99 0.00e+00 1018.00
IUUC-Tgu-117206 Taeniopygia guttata 87.52 0.00e+00 957.00
IUUC-Tru-118241 Takifugu rubripes 94.82 0.00e+00 1078.00
IUUC-Tni-120031 Tetraodon nigroviridis 95.16 0.00e+00 1076.00
IUUC-Tbe-127707 Tupaia belangeri 90.85 0.00e+00 920.00
IUUC-Ttr-129145 Tursiops truncatus 92.36 0.00e+00 1025.00
IUUC-Vpa-130815 Vicugna pacos 89.70 0.00e+00 970.00
IUUC-Xtr-132293 Xenopus tropicalis 86.78 0.00e+00 954.00
Created Date 25-Jun-2017

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