iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066449

Ensembl Protein ID

ENSMPUP00000013914.1

UniProt Accession

M3YRF5; M3YRF5_MUSPF

Genbank Protein ID

ENSMPUP00000013914

Protein Name

E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8

Genbank Nucleotide ID

AEYP01006388

Gene Name

RNF8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000014020.1	ENSMPUT00000014135.1	ENSMPUP00000013914.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.00e-07	30.9	405	443

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C++ w       +++  CP+Cr
   Q: 405  CIICSEYFIE-AVTLNCAHSFCSYCINEW------MKRKVECPICR 443
           ********99.899***************......**********8 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MEEPGSLVMG DRAGGRSWCL RRVGMNAEWL LLEDGNEVTI GRGFGVTYQL VSKICPLMIS 60
RNHCVLKQNV EGQWTIMDNK SLNGVWLNRE RLEPLKVYSI HKGDHIQLGV PLENKENAEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGAGC CCGGCTCGTT GGTCATGGGA GACCGCGCCG GTGGCCGAAG CTGGTGCTTG 60
CGGCGGGTAG GGATGAACGC CGAATGGCTG CTGCTGGAGG ACGGAAACGA GGTGAGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00498--FHA
PF00097--zf-C3HC4

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002124	Ailuropoda melanoleuca	94.00	0.00e+00	756.00
IUUC-Apl-003664	Anas platyrhynchos	80.22	1.00e-40	158.00
IUUC-Aca-005036	Anolis carolinensis	58.33	2.00e-121	429.00
IUUC-Ame-011537	Astyanax mexicanus	42.17	9.00e-90	324.00
IUUC-Bta-013297	Bos taurus	89.32	0.00e+00	696.00
IUUC-Cja-019201	Callithrix jacchus	83.75	0.00e+00	674.00
IUUC-Cfa-021041	Canis familiaris	94.21	0.00e+00	793.00
IUUC-Csa-024133	Chlorocebus sabaeus	86.04	0.00e+00	731.00
IUUC-Cho-024624	Choloepus hoffmanni	82.59	2.00e-147	515.00
IUUC-Dre-027918	Danio rerio	41.95	1.00e-82	300.00
IUUC-Dno-029774	Dasypus novemcinctus	88.43	0.00e+00	738.00
IUUC-Dor-030190	Dipodomys ordii	75.00	1.00e-161	562.00
IUUC-Ete-032301	Echinops telfairi	69.42	3.00e-148	518.00
IUUC-Eca-033607	Equus caballus	90.85	0.00e+00	657.00
IUUC-Eeu-034888	Erinaceus europaeus	85.53	8.00e-132	463.00
IUUC-Fca-036075	Felis catus	92.36	0.00e+00	796.00
IUUC-Fal-037569	Ficedula albicollis	63.55	8.00e-121	427.00
IUUC-Gmo-038588	Gadus morhua	40.85	8.00e-76	277.00
IUUC-Gga-040777	Gallus gallus	60.47	2.00e-125	442.00
IUUC-Gac-042463	Gasterosteus aculeatus	42.70	1.00e-64	240.00
IUUC-Ggo-045269	Gorilla gorilla	86.86	0.00e+00	744.00
IUUC-Hsa-046249	Homo sapiens	86.45	0.00e+00	723.00
IUUC-Itr-048314	Ictidomys tridecemlineatus	87.68	0.00e+00	745.00
IUUC-Lch-049805	Latimeria chalumnae	51.69	3.00e-120	425.00
IUUC-Loc-052377	Lepisosteus oculatus	50.32	3.00e-98	352.00
IUUC-Mcc-055344	Macaca mulatta	86.04	0.00e+00	734.00
IUUC-Meu-055950	Macropus eugenii	65.17	3.00e-133	468.00
IUUC-Mla-059052	Melampsora laricipopulina	36.92	3.00e-10	58.50
IUUC-Mga-060049	Meleagris gallopavo	59.36	5.00e-121	427.00
IUUC-Mmr-061431	Microcebus murinus	88.61	0.00e+00	703.00
IUUC-Mdo-062016	Monodelphis domestica	70.65	4.00e-130	459.00
IUUC-Mmu-063235	Mus musculus	74.85	0.00e+00	655.00
IUUC-Mlu-067588	Myotis lucifugus	84.06	0.00e+00	679.00
IUUC-Nle-069192	Nomascus leucogenys	86.86	0.00e+00	741.00
IUUC-Opr-070300	Ochotona princeps	67.77	3.00e-156	544.00
IUUC-Ont-071998	Oreochromis niloticus	42.77	8.00e-68	251.00
IUUC-Oan-073610	Ornithorhynchus anatinus	66.96	6.00e-68	250.00
IUUC-Ocu-074603	Oryctolagus cuniculus	82.44	0.00e+00	676.00
IUUC-Ola-086681	Oryzias latipes	41.44	6.00e-76	278.00
IUUC-Oga-088183	Otolemur garnettii	89.09	0.00e+00	752.00
IUUC-Oar-090255	Ovis aries	89.71	0.00e+00	630.00
IUUC-Ptr-091029	Pan troglodytes	85.62	0.00e+00	675.00
IUUC-Pan-092241	Papio anubis	86.24	0.00e+00	739.00
IUUC-Psi-093506	Pelodiscus sinensis	63.39	1.00e-139	489.00
IUUC-Pma-094579	Petromyzon marinus	56.67	1.00e-26	114.00
IUUC-Pfo-097014	Poecilia formosa	41.75	1.00e-65	243.00
IUUC-Pab-098530	Pongo abelii	85.96	0.00e+00	686.00
IUUC-Pca-100939	Procavia capensis	67.56	3.00e-159	555.00
IUUC-Pva-103148	Pteropus vampyrus	83.88	0.00e+00	699.00
IUUC-Rno-105338	Rattus norvegicus	76.80	0.00e+00	687.00
IUUC-Sce-106282	Saccharomyces cerevisiae	35.96	2.00e-06	47.40
IUUC-Sha-107187	Sarcophilus harrisii	69.14	1.00e-108	386.00
IUUC-Sar-113356	Sorex araneus	69.98	6.00e-138	483.00
IUUC-Ssc-116290	Sus scrofa	90.25	0.00e+00	803.00
IUUC-Tru-117910	Takifugu rubripes	41.19	9.00e-65	241.00
IUUC-Tsy-119329	Tarsius syrichta	82.10	9.00e-175	606.00
IUUC-Tni-120521	Tetraodon nigroviridis	39.87	2.00e-65	243.00
IUUC-Tme-126989	Tuber melanosporum	32.76	7.00e-07	48.90
IUUC-Ttr-128997	Tursiops truncatus	84.12	0.00e+00	682.00
IUUC-Vpa-130154	Vicugna pacos	86.93	0.00e+00	751.00
IUUC-Xtr-132805	Xenopus tropicalis	51.24	1.00e-109	390.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence