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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063482
Ensembl Protein ID ENSMUSP00000073402.5
UniProt Accession Q9Z1B8; O54808; PHF1_MOUSE
Genbank Protein ID BAA25074.1; AAD00518.1
Protein Name PHD finger protein 1; Polycomb-like protein 1; T-complex testis-expressed 3
Genbank Nucleotide ID AB011550; U81490
Gene Name Phf1; Plc1; Tctex-3; Tctex3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024193.7 ENSMUST00000073724.5 ENSMUSP00000073402.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
iRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.20e-09 39.3 89 140
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedek.slveCekCrewfHpaClklsveeelpnsek.wiCpkCr 52
            C vC++++      lv CekCr+++H++C+ + +  + +++ + w C++C 
   Q: 89   LCCVCRSETVVPGnRLVSCEKCRHAYHQDCHVPRAPAPGEGEGAsWVCRQCV 140
           588***999876459*******************55555555558******7 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18086877). According to other reports, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
 Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18086877). According to other reports, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
Protein Sequence
(Fasta)
MAQLPRLSRL GAPSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV 60
CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV 120
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Protein Fasta Sequence


>IUUC-Mmu-063482|E3,PHD|Mus musculus
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Nucleotide Sequence
(Fasta)
AGAAGGTTAT TTCCTGCTGA CCCAGAGCAA GCCTCCCATC CGAAAAAGGG GCTGCAGGGA 60
TTTCCTCGAC CTCCGCGACC GGCCGCGCCC CCAACAGCGC AGCGCCCTCC GGGCCCGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063482|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR025894--Mtf2_C_dom
IPR031202--PHF1
IPR002999--Tudor
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF14061--Mtf2_C
PF00628--PHD
SMART

SM00249--PHD
SM00333--TUDOR
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035098--C:ESC/E(Z) complex
GO:0005815--C:microtubule organizing center
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0003682--F:chromatin binding
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016569--P:covalent chromatin modification
GO:0061086--P:negative regulation of histone H3-K27 methylation
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:21652
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001720 Ailuropoda melanoleuca 93.12 0.00e+00 909.00
IUUC-Ame-011369 Astyanax mexicanus 48.90 9.00e-127 447.00
IUUC-Bta-012536 Bos taurus 90.30 0.00e+00 875.00
IUUC-Cja-019049 Callithrix jacchus 90.30 0.00e+00 886.00
IUUC-Cfa-021211 Canis familiaris 92.59 0.00e+00 902.00
IUUC-Cpo-021980 Cavia porcellus 91.04 0.00e+00 892.00
IUUC-Csa-023154 Chlorocebus sabaeus 90.12 0.00e+00 908.00
IUUC-Dre-028597 Danio rerio 50.93 3.00e-139 488.00
IUUC-Dor-030431 Dipodomys ordii 91.55 0.00e+00 860.00
IUUC-Ete-032589 Echinops telfairi 87.78 0.00e+00 894.00
IUUC-Eca-034315 Equus caballus 92.95 0.00e+00 931.00
IUUC-Gmo-039382 Gadus morhua 64.69 2.00e-119 422.00
IUUC-Gac-041748 Gasterosteus aculeatus 65.52 8.00e-122 429.00
IUUC-Ggo-044966 Gorilla gorilla 90.48 0.00e+00 885.00
IUUC-Hsa-045967 Homo sapiens 90.48 0.00e+00 854.00
IUUC-Itr-048249 Ictidomys tridecemlineatus 94.47 0.00e+00 916.00
IUUC-Lch-050336 Latimeria chalumnae 52.97 1.00e-150 526.00
IUUC-Laf-053729 Loxodonta africana 88.99 0.00e+00 852.00
IUUC-Mcc-055486 Macaca mulatta 90.12 0.00e+00 908.00
IUUC-Meu-055933 Macropus eugenii 81.75 0.00e+00 764.00
IUUC-Mmr-061114 Microcebus murinus 91.90 0.00e+00 915.00
IUUC-Mdo-062033 Monodelphis domestica 80.59 0.00e+00 786.00
IUUC-Mpu-065725 Mustela putorius furo 92.42 0.00e+00 917.00
IUUC-Mlu-067243 Myotis lucifugus 90.65 0.00e+00 894.00
IUUC-Nle-069759 Nomascus leucogenys 90.48 0.00e+00 885.00
IUUC-Ont-071655 Oreochromis niloticus 54.06 9.00e-125 440.00
IUUC-Ocu-073930 Oryctolagus cuniculus 92.77 0.00e+00 890.00
IUUC-Oga-088161 Otolemur garnettii 90.12 0.00e+00 890.00
IUUC-Oar-089582 Ovis aries 89.96 0.00e+00 868.00
IUUC-Ptr-090810 Pan troglodytes 90.30 0.00e+00 905.00
IUUC-Pan-091980 Papio anubis 90.12 0.00e+00 908.00
IUUC-Pfo-097260 Poecilia formosa 60.92 9.00e-123 432.00
IUUC-Pab-098556 Pongo abelii 90.30 0.00e+00 882.00
IUUC-Pca-100360 Procavia capensis 93.32 0.00e+00 801.00
IUUC-Pva-102900 Pteropus vampyrus 90.64 0.00e+00 882.00
IUUC-Rno-105536 Rattus norvegicus 96.79 0.00e+00 959.00
IUUC-Sha-107357 Sarcophilus harrisii 83.68 0.00e+00 835.00
IUUC-Ssc-116070 Sus scrofa 89.77 0.00e+00 852.00
IUUC-Tsy-119247 Tarsius syrichta 97.78 0.00e+00 629.00
IUUC-Tbe-127780 Tupaia belangeri 86.60 0.00e+00 825.00
Created Date 25-Jun-2017

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