iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106762

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01128447

Gene Name

CUL4A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000016779.1	ENSSHAT00000019925.1	ENSSHAP00000019768.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	4.80e-216	719.3	25	622

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkif 87
           kl+eav++i++++s+k+++eely+av+nlc++kv+  lYk+l++v+e+++ +q+ + +e s d+  +Lk++n++W+++++q+ ++r+if
   Q: 25   KLHEAVRAIQSSTSIKYNLEELYQAVENLCSYKVSPTLYKQLRQVCEDHVkAQILQFREYSLDSVlFLKKINKCWQDHCRQMIMIRSIF 113
           5899**********************************************99************************************* PP
   S: 88   ayldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfle 174
           ++ldrtyv +++++ ++++++l+l+r+++++d  +++++++ +l lie+eR+geavdr+ll+++ ++l++L     ++yk+sFE+kfle
   Q: 114  LFLDRTYVLQNSMLPSIWDMGLELFRNHVISDklVQSKTIDGILLLIERERNGEAVDRSLLRSLLSMLSDL-----QVYKDSFEQKFLE 197
           *******************************************************************9998.....9************ PP
   S: 175  atqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLl 262
           +t+ +y+ae ++++qe+ev eYl++v++rl+ee +r+ +yl++st+++L+++vek+l+ +hl+++l ++l++ll++++  dl++my+L+
   Q: 198  ETNCLYAAEGQRLMQEREVPEYLNHVNKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILqKGLDNLLDENRVPDLTQMYQLF 286
           ****************************************************************9989********************* PP
   S: 263  srvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.E 350
           srv+ g + ll++++++ik+ g+++++++ek+kd   +V++ll++k+k++++++ +F++++kF++ ++++fetf+nk+     +++p E
   Q: 287  SRVKGGQQILLQHWSEYIKTFGTTIVVNPEKDKD---MVQELLDFKDKVDHIIEVCFQKNEKFINLMKESFETFINKR-----PNKPaE 367
           **********************************...*****************************************.....66666* PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           l+A+++D++Lr+++k++t+eele++ldk++++f++i++kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+
   Q: 368  LIAKHVDSKLRAGNKEATDEELERILDKIMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFK 456
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkk 528
           d+++S+d+++qFk+ ++n+++  +++l+v++L++g+Wpt++ +e v+L++e+ k++e f++fYl khsgRkLqWq+tlg+a lkae+k+
   Q: 457  DMELSKDIMIQFKQYMQNQSDPGNIDLTVNILTMGYWPTYTPME-VHLTPEMVKLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKAEFKE 544
           ****************************************9999.******************************************** PP
   S: 529  gkyelqVstfQmavLLafnnsekvsveelkkatelp..eeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           gk+e+qVs fQ++vLL+fn+ +++s+ee+k+at+++  ++eLrrtlqsL+++k++vl k+p++k+++++d+f +N +f
   Q: 545  GKKEFQVSLFQTLVLLMFNEGDEFSFEEIKMATGVDteDSELRRTLQSLACGKARVLIKSPKGKDVDDGDKFFFNGDF 622
           *********************************98522679**********************************998 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

XKLVIKNFRD RPKLPDNYTQ DTWQKLHEAV RAIQSSTSIK YNLEELYQAV ENLCSYKVSP 60
TLYKQLRQVC EDHVKAQILQ FREYSLDSVL FLKKINKCWQ DHCRQMIMIR SIFLFLDRTY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNGAAATTAG TGATTAAAAA TTTCAGAGGT AGGTAAGTGT GTGCAAACGA GGTGAGGGCG 60
CGGAGGGAGG CGGGCGGGGA GGCATAGTCG GGACGGGTCG GGCCCTGTCG CGTCGGGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0030097--P:hemopoiesis
GO:0001701--P:in utero embryonic development
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:2000001--P:regulation of DNA damage checkpoint
GO:2000819--P:regulation of nucleotide-excision repair
GO:0051246--P:regulation of protein metabolic process
GO:0035019--P:somatic stem cell population maintenance

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001592	Ailuropoda melanoleuca	93.33	0.00e+00	1362.00
IUUC-Apl-003269	Anas platyrhynchos	95.79	0.00e+00	1374.00
IUUC-Bta-012355	Bos taurus	91.55	0.00e+00	1351.00
IUUC-Cja-019861	Callithrix jacchus	92.90	0.00e+00	1363.00
IUUC-Cfa-021009	Canis familiaris	95.54	0.00e+00	1397.00
IUUC-Cpo-021867	Cavia porcellus	93.19	0.00e+00	1369.00
IUUC-Csa-024139	Chlorocebus sabaeus	93.59	0.00e+00	1368.00
IUUC-Cho-024899	Choloepus hoffmanni	97.23	0.00e+00	1017.00
IUUC-Cme-027355	Cyanidioschyzon merolae	32.22	1.00e-111	397.00
IUUC-Dno-028879	Dasypus novemcinctus	90.07	0.00e+00	1305.00
IUUC-Dor-030698	Dipodomys ordii	93.33	0.00e+00	1352.00
IUUC-Ete-033101	Echinops telfairi	90.20	0.00e+00	1277.00
IUUC-Eca-033696	Equus caballus	93.93	0.00e+00	1376.00
IUUC-Fca-036333	Felis catus	94.25	0.00e+00	1367.00
IUUC-Fal-036995	Ficedula albicollis	95.42	0.00e+00	1385.00
IUUC-Gga-040358	Gallus gallus	95.05	0.00e+00	1390.00
IUUC-Hsa-045679	Homo sapiens	93.59	0.00e+00	1370.00
IUUC-Lch-050417	Latimeria chalumnae	93.06	0.00e+00	1352.00
IUUC-Loc-051804	Lepisosteus oculatus	87.78	0.00e+00	1277.00
IUUC-Laf-054100	Loxodonta africana	95.00	0.00e+00	1388.00
IUUC-Mcc-055168	Macaca mulatta	93.79	0.00e+00	1251.00
IUUC-Meu-056492	Macropus eugenii	88.48	2.00e-171	595.00
IUUC-Mga-059866	Meleagris gallopavo	95.52	0.00e+00	1371.00
IUUC-Mmr-061551	Microcebus murinus	93.32	0.00e+00	1360.00
IUUC-Mdo-062215	Monodelphis domestica	98.89	0.00e+00	1429.00
IUUC-Mmu-063402	Mus musculus	93.61	0.00e+00	1370.00
IUUC-Mpu-066383	Mustela putorius furo	94.13	0.00e+00	1365.00
IUUC-Mlu-067450	Myotis lucifugus	91.14	0.00e+00	1310.00
IUUC-Nle-069606	Nomascus leucogenys	93.45	0.00e+00	1368.00
IUUC-Opr-070671	Ochotona princeps	83.66	4.00e-116	411.00
IUUC-Oan-073299	Ornithorhynchus anatinus	93.73	0.00e+00	1364.00
IUUC-Ocu-074731	Oryctolagus cuniculus	94.31	0.00e+00	1382.00
IUUC-Oar-089346	Ovis aries	91.11	0.00e+00	1340.00
IUUC-Ptr-091177	Pan troglodytes	93.59	0.00e+00	1370.00
IUUC-Pan-092191	Papio anubis	92.93	0.00e+00	1358.00
IUUC-Pab-097622	Pongo abelii	93.18	0.00e+00	1365.00
IUUC-Pca-100391	Procavia capensis	84.98	0.00e+00	1002.00
IUUC-Rno-105829	Rattus norvegicus	93.61	0.00e+00	1369.00
IUUC-Ssc-116133	Sus scrofa	92.63	0.00e+00	1332.00
IUUC-Tgu-116961	Taeniopygia guttata	95.29	0.00e+00	1381.00
IUUC-Tvi-122568	Trichoderma virens	39.23	1.00e-125	444.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence