iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062446

UUCD1 version

UUC-MoD-00558

Ensembl Protein ID

ENSMODP00000021739.2

UniProt Accession

F7AJC4; F7AJC4_MONDO

Protein Name

Uncharacterized protein

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000017417.2	ENSMODT00000022117.2	ENSMODP00000021739.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.40e-39	135.0	94	263
UBD/ZnF/ZnF_A20	9.90e-23	79.9	764	795

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepeakg 77
           ++lkt+gDGnCL++A+sq+++gv+d+d+ l++al+++L+e+  +++    q es + +ef+e++        ++e++++ k+++p++  
   Q: 94   VALKTNGDGNCLMHATSQYMWGVQDTDLvLRKALYSTLKETDIRNFkfrwQLESLKSQEFVETGlrydtrnwNEEWDNLIKMASPDTSV 182
           789*******************************************99*9************************************542 PP
   S: 78   ..........eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
                     eeihi +L++iL+rpiiv+++++++s          kvggi+lpl++p+++ +k+pivL+Y+s H+ +Lv+
   Q: 183  vrgglqynslEEIHILVLSNILRRPIIVISDKMVRSlesgsnfaplKVGGIYLPLHWPAQEcYKYPIVLGYDSQHFAPLVT 263
           3558999999*********************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 3    skllCkk.gCgfYGnpetngyCSkCyreelrr 33
           +k++C++ +C+++Gn+++ngyC++Cy++++ +
   Q: 764  PKQRCRApACDHFGNAKCNGYCNECYQFKQLY 795
           69***************************977 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MAEQQILPQA LYLSNMRKAV KIRERTPEDI VKPTNGIIYH FKTMHRCTVE MFRTCQFCPQ 60
FREFILLALI DRSIQTSLES QRKLNWCREV RKLVALKTNG DGNCLMHATS QYMWGVQDTD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGAGGAATT TCTCATCCTC CGCGGCGCCT GCGCTAGCTG CAGCGGTTCT TACTCCGGCC 60
CTCTGGACAC CGACTGAGAG CCCCCTGGTG GCCACCAGCC CACTACCTAG CTTGCTCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0006955--P:immune response
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	80.43	0.00e+00	1302.00
IUUC-Apl-003501	Anas platyrhynchos	66.62	0.00e+00	1059.00
IUUC-Aca-004245	Anolis carolinensis	65.47	0.00e+00	1080.00
IUUC-Ame-011789	Astyanax mexicanus	46.11	0.00e+00	694.00
IUUC-Bta-012664	Bos taurus	77.79	0.00e+00	1216.00
IUUC-Cja-019895	Callithrix jacchus	80.55	0.00e+00	1294.00
IUUC-Cfa-020754	Canis familiaris	80.68	0.00e+00	1308.00
IUUC-Cpo-021780	Cavia porcellus	77.60	0.00e+00	1249.00
IUUC-Csa-023568	Chlorocebus sabaeus	81.18	0.00e+00	1313.00
IUUC-Cho-024300	Choloepus hoffmanni	84.30	1.00e-174	606.00
IUUC-Dre-028577	Danio rerio	48.88	0.00e+00	686.00
IUUC-Dno-029382	Dasypus novemcinctus	76.11	0.00e+00	1212.00
IUUC-Dor-030874	Dipodomys ordii	76.16	0.00e+00	1209.00
IUUC-Ete-032721	Echinops telfairi	84.93	0.00e+00	733.00
IUUC-Eca-033596	Equus caballus	78.17	0.00e+00	1248.00
IUUC-Eeu-035159	Erinaceus europaeus	76.50	0.00e+00	966.00
IUUC-Fca-035847	Felis catus	80.93	0.00e+00	1309.00
IUUC-Fal-036681	Ficedula albicollis	66.96	0.00e+00	1094.00
IUUC-Gmo-038521	Gadus morhua	58.62	8.00e-145	507.00
IUUC-Gga-040975	Gallus gallus	66.13	0.00e+00	1087.00
IUUC-Gac-042216	Gasterosteus aculeatus	61.89	9.00e-155	540.00
IUUC-Ggo-045258	Gorilla gorilla	80.93	0.00e+00	1310.00
IUUC-Hsa-046071	Homo sapiens	81.05	0.00e+00	1313.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	79.92	0.00e+00	1286.00
IUUC-Lch-050326	Latimeria chalumnae	58.20	0.00e+00	925.00
IUUC-Loc-051945	Lepisosteus oculatus	45.48	0.00e+00	627.00
IUUC-Laf-053722	Loxodonta africana	78.92	0.00e+00	1260.00
IUUC-Mcc-055503	Macaca mulatta	81.05	0.00e+00	1312.00
IUUC-Meu-056481	Macropus eugenii	84.37	0.00e+00	1351.00
IUUC-Mga-059690	Meleagris gallopavo	63.05	0.00e+00	978.00
IUUC-Mmr-061233	Microcebus murinus	79.35	0.00e+00	1260.00
IUUC-Mmu-063436	Mus musculus	78.80	0.00e+00	1236.00
IUUC-Mpu-066808	Mustela putorius furo	80.93	0.00e+00	1315.00
IUUC-Mlu-067339	Myotis lucifugus	79.82	0.00e+00	1259.00
IUUC-Nle-069888	Nomascus leucogenys	81.05	0.00e+00	1315.00
IUUC-Opr-070303	Ochotona princeps	78.50	0.00e+00	1253.00
IUUC-Ont-072283	Oreochromis niloticus	59.47	2.00e-148	519.00
IUUC-Oan-072925	Ornithorhynchus anatinus	77.32	0.00e+00	1271.00
IUUC-Ocu-073889	Oryctolagus cuniculus	79.20	0.00e+00	1254.00
IUUC-Ola-087417	Oryzias latipes	60.44	4.00e-150	525.00
IUUC-Oga-088708	Otolemur garnettii	77.42	0.00e+00	1201.00
IUUC-Oar-089271	Ovis aries	77.92	0.00e+00	1226.00
IUUC-Ptr-091296	Pan troglodytes	81.05	0.00e+00	1311.00
IUUC-Pan-092474	Papio anubis	81.05	0.00e+00	1311.00
IUUC-Psi-093447	Pelodiscus sinensis	68.74	0.00e+00	1096.00
IUUC-Pfo-096511	Poecilia formosa	44.64	0.00e+00	657.00
IUUC-Pab-098700	Pongo abelii	81.18	0.00e+00	1313.00
IUUC-Pca-100246	Procavia capensis	67.75	0.00e+00	1040.00
IUUC-Pva-102606	Pteropus vampyrus	72.41	8.00e-163	567.00
IUUC-Pte-104328	Pyrenophora teres	33.33	1.70e+00	26.90
IUUC-Rno-105818	Rattus norvegicus	78.20	0.00e+00	1252.00
IUUC-Sha-106559	Sarcophilus harrisii	89.95	0.00e+00	1481.00
IUUC-Sar-113454	Sorex araneus	88.45	1.00e-175	610.00
IUUC-Ssc-116064	Sus scrofa	79.55	0.00e+00	1259.00
IUUC-Tgu-117212	Taeniopygia guttata	66.62	0.00e+00	1076.00
IUUC-Tru-118230	Takifugu rubripes	60.92	3.00e-153	535.00
IUUC-Tsy-119066	Tarsius syrichta	77.64	0.00e+00	1253.00
IUUC-Tni-119825	Tetraodon nigroviridis	47.49	0.00e+00	674.00
IUUC-Tur-126383	Triticum urartu	50.00	2.90e-02	30.00
IUUC-Tbe-127601	Tupaia belangeri	89.97	6.00e-179	620.00
IUUC-Ttr-128930	Tursiops truncatus	78.34	0.00e+00	1242.00
IUUC-Vpa-130450	Vicugna pacos	86.82	0.00e+00	723.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence