iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067339

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02007424

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000011543.2	ENSMLUT00000011542.2	ENSMLUP00000010517.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.70e-38	131.5	93	263
UBD/ZnF/ZnF_A20	2.10e-24	85.2	750	782

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepeakg 77
           ++lkt+gDGnCL++A+sq+++gv+d+d+ l++ l+++L+e+ ++++    q es + +ef+e++         de++++ k++++++ g
   Q: 93   VALKTNGDGNCLMHAASQYMWGVQDTDLvLRKLLFSTLKETDTRNFkfrwQLESLKSQEFVETGlrydtrnwTDEWDNLIKMASTDTPG 181
           789***********************************************************************************555 PP
   S: 78   ..........eeihifaLaqiLsrpiivvdvdsles...........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
                     ee+hif+L++iL+rpiiv+++d++ +           kvggi+lpl++p+++ +++pivL+Y+s H+ +Lv+
   Q: 182  arsglpynslEEVHIFVLCNILRRPIIVIAADKMLRslesgsnfaplKVGGIYLPLHWPAQEcYRYPIVLGYDSQHFVPLVT 263
           5667*************************98877666*******************************************97 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrr 33
           p+k++C++ +C+++Gn ++ngyC++C+++++++
   Q: 750  PPKQRCRApACDHFGNTKCNGYCNECFQFKQMY 782
           9*******************************9 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MAEQLLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHL KSMHRYTLEM FRTCQFCPQF 60
REIIHKALID RTIQASLESQ KKLNWCREVR KLVALKTNGD GNCLMHAASQ YMWGVQDTDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGAAC AACTCCTTCC TCAGGCTTTG TATTTGAGCA ATATGCGGAA AGCTGTGAAG 60
ATCAGAGAGA GAACTCCAGA AGATATATTT AAACCTACCA ATGGAATCAT TCATCATTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	91.27	0.00e+00	1479.00
IUUC-Apl-003501	Anas platyrhynchos	66.37	0.00e+00	1054.00
IUUC-Aca-004245	Anolis carolinensis	63.74	0.00e+00	1042.00
IUUC-Ame-011789	Astyanax mexicanus	46.64	0.00e+00	702.00
IUUC-Bta-012664	Bos taurus	86.33	0.00e+00	1379.00
IUUC-Cja-019895	Callithrix jacchus	89.75	0.00e+00	1458.00
IUUC-Cfa-020754	Canis familiaris	91.39	0.00e+00	1487.00
IUUC-Cpo-021780	Cavia porcellus	87.96	0.00e+00	1439.00
IUUC-Csa-023568	Chlorocebus sabaeus	90.25	0.00e+00	1481.00
IUUC-Cho-024300	Choloepus hoffmanni	88.08	0.00e+00	635.00
IUUC-Dre-028577	Danio rerio	48.94	0.00e+00	692.00
IUUC-Dno-029382	Dasypus novemcinctus	82.41	0.00e+00	1332.00
IUUC-Dor-030874	Dipodomys ordii	86.08	0.00e+00	1382.00
IUUC-Ete-032721	Echinops telfairi	90.43	0.00e+00	787.00
IUUC-Eca-033596	Equus caballus	87.45	0.00e+00	1420.00
IUUC-Eeu-035159	Erinaceus europaeus	87.58	0.00e+00	1115.00
IUUC-Fca-035847	Felis catus	91.52	0.00e+00	1484.00
IUUC-Fal-036681	Ficedula albicollis	64.68	0.00e+00	1054.00
IUUC-Gmo-038521	Gadus morhua	59.07	3.00e-146	512.00
IUUC-Gga-040975	Gallus gallus	64.48	0.00e+00	1065.00
IUUC-Gac-042216	Gasterosteus aculeatus	60.63	3.00e-152	532.00
IUUC-Ggo-045258	Gorilla gorilla	90.00	0.00e+00	1472.00
IUUC-Hsa-046071	Homo sapiens	89.87	0.00e+00	1472.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	91.39	0.00e+00	1471.00
IUUC-Lch-050326	Latimeria chalumnae	58.08	0.00e+00	917.00
IUUC-Loc-051945	Lepisosteus oculatus	45.51	1.00e-178	620.00
IUUC-Laf-053722	Loxodonta africana	87.22	0.00e+00	1412.00
IUUC-Mcc-055503	Macaca mulatta	90.00	0.00e+00	1476.00
IUUC-Meu-056481	Macropus eugenii	75.58	0.00e+00	1177.00
IUUC-Mga-059690	Meleagris gallopavo	63.62	0.00e+00	1000.00
IUUC-Mmr-061233	Microcebus murinus	89.02	0.00e+00	1425.00
IUUC-Mdo-062446	Monodelphis domestica	79.92	0.00e+00	1285.00
IUUC-Mmu-063436	Mus musculus	86.51	0.00e+00	1384.00
IUUC-Mpu-066808	Mustela putorius furo	91.65	0.00e+00	1484.00
IUUC-Nle-069888	Nomascus leucogenys	90.00	0.00e+00	1475.00
IUUC-Opr-070303	Ochotona princeps	87.39	0.00e+00	1412.00
IUUC-Ont-072283	Oreochromis niloticus	57.92	1.00e-147	517.00
IUUC-Oan-072925	Ornithorhynchus anatinus	76.82	0.00e+00	1238.00
IUUC-Ocu-073889	Oryctolagus cuniculus	88.82	0.00e+00	1410.00
IUUC-Oni-082742	Oryza nivara	27.27	5.50e+00	27.70
IUUC-Ola-087417	Oryzias latipes	58.77	2.00e-151	530.00
IUUC-Oga-088708	Otolemur garnettii	87.28	0.00e+00	1362.00
IUUC-Oar-089271	Ovis aries	86.84	0.00e+00	1393.00
IUUC-Ptr-091296	Pan troglodytes	89.87	0.00e+00	1470.00
IUUC-Pan-092474	Papio anubis	90.13	0.00e+00	1479.00
IUUC-Psi-093447	Pelodiscus sinensis	69.41	0.00e+00	1115.00
IUUC-Pfo-096511	Poecilia formosa	58.39	3.00e-149	522.00
IUUC-Pab-098700	Pongo abelii	90.00	0.00e+00	1472.00
IUUC-Pca-100246	Procavia capensis	74.56	0.00e+00	1164.00
IUUC-Pva-102606	Pteropus vampyrus	78.23	3.00e-178	618.00
IUUC-Rno-105818	Rattus norvegicus	86.77	0.00e+00	1405.00
IUUC-Sha-106559	Sarcophilus harrisii	79.72	0.00e+00	1280.00
IUUC-Sit-110516	Setaria italica	40.48	6.60e-02	33.50
IUUC-Sar-113454	Sorex araneus	93.31	0.00e+00	642.00
IUUC-Ssc-116064	Sus scrofa	88.61	0.00e+00	1412.00
IUUC-Tgu-117212	Taeniopygia guttata	65.02	0.00e+00	1048.00
IUUC-Tru-118230	Takifugu rubripes	59.90	3.00e-151	529.00
IUUC-Tsy-119066	Tarsius syrichta	86.58	0.00e+00	1405.00
IUUC-Tni-119825	Tetraodon nigroviridis	46.86	0.00e+00	682.00
IUUC-Tbe-127601	Tupaia belangeri	94.53	0.00e+00	656.00
IUUC-Ttr-128930	Tursiops truncatus	87.22	0.00e+00	1400.00
IUUC-Vpa-130450	Vicugna pacos	94.03	0.00e+00	787.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence