iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020207

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AAEX03018288

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000010573.3	ENSCAFT00000016817.3	ENSCAFP00000015562.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.40e-101	339.3	1	321

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
164	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 1    MTGNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 78
           788999************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + +++++    +++af
   Q: 79   FAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDAKTSAK----EEDAF 163
           ****************************************************************************9887....79*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +        
   Q: 164  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeeepmd 249
           **************************9.78999*********..******************************976666577888888 PP
   S: 260  .keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
             +  ++l++i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+    + +++
   Q: 250  tDQGNNMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 321
           7444589*********************************************************993...33344 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MTGNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP 60
GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCCGCTGC GGCATCGCAT CCCCTTACGC TTGTCGACCA TCCCCGCGGA CTGCAGGGCA 60
GGCCTTTCTC CCCTGGTCAT TCCCTCCAGG ATAAATTCGC CTCCGGTCTG CCCACAAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	47.29	1.00e-84	306.00
IUUC-Aml-001866	Ailuropoda melanoleuca	100.00	0.00e+00	653.00
IUUC-Atr-002966	Amborella trichopoda	46.55	2.00e-79	289.00
IUUC-Apl-003306	Anas platyrhynchos	86.03	3.00e-177	613.00
IUUC-Aca-004763	Anolis carolinensis	95.50	6.00e-180	622.00
IUUC-Aly-005581	Arabidopsis lyrata	48.33	1.00e-79	289.00
IUUC-Ath-007283	Arabidopsis thaliana	48.63	1.00e-82	299.00
IUUC-Ago-007999	Ashbya gossypii	33.33	1.00e-33	136.00
IUUC-Acl-008231	Aspergillus clavatus	43.15	2.00e-52	199.00
IUUC-Afl-008557	Aspergillus flavus	37.58	1.00e-54	206.00
IUUC-Afu-008988	Aspergillus fumigatus	45.00	2.00e-54	205.00
IUUC-Ani-009420	Aspergillus nidulans	37.81	1.00e-52	199.00
IUUC-Ang-009859	Aspergillus niger	40.82	4.00e-49	188.00
IUUC-Aor-010145	Aspergillus oryzae	37.58	1.00e-54	206.00
IUUC-Ate-010347	Aspergillus terreus	41.73	4.00e-53	201.00
IUUC-Ame-010791	Astyanax mexicanus	90.27	0.00e+00	630.00
IUUC-Bgr-012298	Blumeria graminis	37.50	4.00e-49	188.00
IUUC-Bta-013251	Bos taurus	99.04	0.00e+00	644.00
IUUC-Bci-013786	Botrytis cinerea	37.76	1.00e-57	216.00
IUUC-Bdi-014132	Brachypodium distachyon	49.07	8.00e-82	296.00
IUUC-Bol-015611	Brassica oleracea	49.70	1.00e-84	306.00
IUUC-Bra-017769	Brassica rapa	49.70	2.00e-84	305.00
IUUC-Cel-018604	Caenorhabditis elegans	47.13	1.00e-81	296.00
IUUC-Cja-019768	Callithrix jacchus	90.62	0.00e+00	629.00
IUUC-Cpo-021925	Cavia porcellus	95.85	8.00e-180	622.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.21	6.00e-74	270.00
IUUC-Csa-023958	Chlorocebus sabaeus	99.04	0.00e+00	642.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	1.00e-42	166.00
IUUC-Cin-025771	Ciona intestinalis	54.18	1.00e-99	356.00
IUUC-Csv-026149	Ciona savignyi	57.68	1.00e-102	365.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.50	2.00e-51	196.00
IUUC-Cne-026955	Cryptococcus neoformans	37.87	6.00e-55	207.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.06	2.00e-48	186.00
IUUC-Dre-027409	Danio rerio	89.36	5.00e-179	619.00
IUUC-Dno-028921	Dasypus novemcinctus	99.36	0.00e+00	649.00
IUUC-Dse-031170	Dothistroma septosporum	39.24	1.00e-58	219.00
IUUC-Dme-031677	Drosophila melanogaster	59.46	9.00e-115	406.00
IUUC-Ete-032707	Echinops telfairi	68.97	1.00e-119	422.00
IUUC-Eca-033776	Equus caballus	99.65	3.00e-172	597.00
IUUC-Eeu-035305	Erinaceus europaeus	79.26	1.00e-83	303.00
IUUC-Fca-035846	Felis catus	92.06	0.00e+00	636.00
IUUC-Fal-037597	Ficedula albicollis	95.83	2.00e-159	554.00
IUUC-Fox-037670	Fusarium oxysporum	42.86	2.00e-55	209.00
IUUC-Fso-038243	Fusarium solani	42.81	8.00e-55	207.00
IUUC-Gmo-038499	Gadus morhua	84.03	2.00e-161	561.00
IUUC-Ggr-039975	Gaeumannomyces graminis	41.06	7.00e-48	184.00
IUUC-Gga-040904	Gallus gallus	94.80	0.00e+00	647.00
IUUC-Gac-042058	Gasterosteus aculeatus	88.82	8.00e-171	592.00
IUUC-Gma-043030	Glycine max	48.96	2.00e-85	308.00
IUUC-Ggo-044699	Gorilla gorilla	93.49	4.00e-171	593.00
IUUC-Hsa-046227	Homo sapiens	99.36	0.00e+00	650.00
IUUC-Hvu-047359	Hordeum vulgare	46.69	5.00e-83	301.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	90.41	0.00e+00	632.00
IUUC-Lch-049829	Latimeria chalumnae	92.65	1.00e-175	608.00
IUUC-Lpe-050899	Leersia perrieri	48.58	2.00e-78	285.00
IUUC-Loc-052264	Lepisosteus oculatus	90.76	1.00e-173	602.00
IUUC-Lma-053110	Leptosphaeria maculans	38.41	3.00e-48	185.00
IUUC-Laf-053639	Loxodonta africana	100.00	0.00e+00	653.00
IUUC-Mcc-055506	Macaca mulatta	99.04	0.00e+00	642.00
IUUC-Mor-057001	Magnaporthe oryzae	45.38	5.00e-55	207.00
IUUC-Mpo-057608	Magnaporthe poae	40.64	1.00e-32	132.00
IUUC-Mtr-057731	Medicago truncatula	49.55	3.00e-85	308.00
IUUC-Mla-059016	Melampsora laricipopulina	43.28	2.00e-43	168.00
IUUC-Mga-060178	Meleagris gallopavo	95.39	7.00e-174	602.00
IUUC-Mvi-060353	Microbotryum violaceum	38.21	5.00e-54	204.00
IUUC-Mmr-060738	Microcebus murinus	99.36	0.00e+00	650.00
IUUC-Mdo-062266	Monodelphis domestica	98.04	1.00e-120	424.00
IUUC-Mmu-063619	Mus musculus	96.49	0.00e+00	635.00
IUUC-Mac-065301	Musa acuminata	50.79	5.00e-88	317.00
IUUC-Mpu-066058	Mustela putorius furo	99.68	0.00e+00	651.00
IUUC-Mlu-067292	Myotis lucifugus	97.76	0.00e+00	635.00
IUUC-Nfi-068275	Neosartorya fischeri	37.50	4.00e-55	208.00
IUUC-Ncr-068713	Neurospora crassa	38.68	5.00e-58	218.00
IUUC-Nle-069013	Nomascus leucogenys	98.72	0.00e+00	640.00
IUUC-Opr-070628	Ochotona princeps	87.06	1.00e-171	595.00
IUUC-Ont-072688	Oreochromis niloticus	89.52	2.00e-171	594.00
IUUC-Oan-073004	Ornithorhynchus anatinus	96.75	2.00e-142	498.00
IUUC-Ocu-074303	Oryctolagus cuniculus	99.68	0.00e+00	653.00
IUUC-Oba-075002	Oryza barthii	48.49	7.00e-82	297.00
IUUC-Obr-076392	Oryza brachyantha	48.90	1.00e-79	290.00
IUUC-Ogl-077271	Oryza glaberrima	48.49	7.00e-82	297.00
IUUC-Ogu-078493	Oryza glumaepatula	48.49	2.00e-82	299.00
IUUC-Oin-080084	Oryza indica	48.49	2.00e-82	299.00
IUUC-Olo-080803	Oryza longistaminata	48.19	3.00e-82	298.00
IUUC-Ome-081146	Oryza meridionalis	47.59	4.00e-81	294.00
IUUC-Oni-082146	Oryza nivara	48.49	2.00e-82	299.00
IUUC-Opu-083633	Oryza punctata	49.21	1.00e-78	286.00
IUUC-Oru-084789	Oryza rufipogon	48.49	2.00e-82	299.00
IUUC-Osa-086196	Oryza sativa	48.49	2.00e-82	299.00
IUUC-Ola-087126	Oryzias latipes	89.46	5.00e-168	583.00
IUUC-Olu-087665	Ostreococcus lucimarinus	41.67	4.00e-69	254.00
IUUC-Oga-089140	Otolemur garnettii	90.88	0.00e+00	632.00
IUUC-Oar-090296	Ovis aries	98.72	0.00e+00	644.00
IUUC-Ptr-090566	Pan troglodytes	99.36	0.00e+00	650.00
IUUC-Pan-092052	Papio anubis	99.04	0.00e+00	642.00
IUUC-Psi-093723	Pelodiscus sinensis	95.49	1.00e-165	575.00
IUUC-Pma-094568	Petromyzon marinus	61.11	1.00e-106	379.00
IUUC-Pno-095120	Phaeosphaeria nodorum	39.02	6.00e-50	191.00
IUUC-Ppa-095761	Physcomitrella patens	47.66	2.00e-84	305.00
IUUC-Pfo-096210	Poecilia formosa	89.46	4.00e-172	597.00
IUUC-Pab-098463	Pongo abelii	99.36	0.00e+00	649.00
IUUC-Pop-099109	Populus trichocarpa	48.37	7.00e-85	306.00
IUUC-Pca-100108	Procavia capensis	97.56	7.00e-143	499.00
IUUC-Ppe-101176	Prunus persica	51.20	3.00e-86	311.00
IUUC-Pva-102629	Pteropus vampyrus	96.18	3.00e-149	521.00
IUUC-Pgr-103419	Puccinia graminis	39.76	6.00e-57	214.00
IUUC-Pte-104207	Pyrenophora teres	44.38	8.00e-33	132.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	39.34	5.00e-57	214.00
IUUC-Rno-105579	Rattus norvegicus	86.69	1.00e-162	565.00
IUUC-Sha-106894	Sarcophilus harrisii	94.20	8.00e-156	542.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	38.87	4.00e-59	221.00
IUUC-Spo-108371	Schizosaccharomyces pombe	41.58	7.00e-59	220.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	38.41	1.00e-47	182.00
IUUC-Smo-109396	Selaginella moellendorffii	51.38	2.00e-88	318.00
IUUC-Sit-110630	Setaria italica	49.54	3.00e-86	311.00
IUUC-Sly-110972	Solanum lycopersicum	50.48	1.00e-80	293.00
IUUC-Stu-112185	Solanum tuberosum	50.90	6.00e-89	320.00
IUUC-Sar-113294	Sorex araneus	82.91	2.00e-165	575.00
IUUC-Sbi-113951	Sorghum bicolor	49.85	1.00e-86	313.00
IUUC-Ssc-115501	Sus scrofa	98.32	3.00e-175	607.00
IUUC-Tgu-117152	Taeniopygia guttata	95.49	2.00e-159	554.00
IUUC-Tru-118388	Takifugu rubripes	88.50	6.00e-171	592.00
IUUC-Tsy-119109	Tarsius syrichta	99.68	0.00e+00	651.00
IUUC-Tni-120048	Tetraodon nigroviridis	88.50	2.00e-171	594.00
IUUC-Tca-121750	Theobroma cacao	49.11	2.00e-88	319.00
IUUC-Tre-122130	Trichoderma reesei	39.33	2.00e-55	209.00
IUUC-Tvi-122284	Trichoderma virens	39.53	7.00e-53	200.00
IUUC-Tae-124082	Triticum aestivum	47.59	4.00e-83	301.00
IUUC-Tur-126366	Triticum urartu	43.25	2.00e-66	246.00
IUUC-Tme-127187	Tuber melanosporum	40.59	8.00e-58	217.00
IUUC-Tbe-127619	Tupaia belangeri	90.59	1.00e-145	508.00
IUUC-Ttr-128867	Tursiops truncatus	88.16	3.00e-124	437.00
IUUC-Vda-129912	Verticillium dahliae	37.37	1.00e-52	199.00
IUUC-Vpa-130552	Vicugna pacos	100.00	1.00e-126	445.00
IUUC-Vvi-130881	Vitis vinifera	50.74	2.00e-84	305.00
IUUC-Xtr-131934	Xenopus tropicalis	85.71	7.00e-174	602.00
IUUC-Xma-133312	Xiphophorus maculatus	89.46	5.00e-172	596.00
IUUC-Yli-134487	Yarrowia lipolytica	40.34	2.00e-48	186.00
IUUC-Zma-135462	Zea mays	43.69	2.00e-71	262.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence