iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Kpa-049156

Ensembl Protein ID

CAY70994

UniProt Accession

C4R608; C4R608_KOMPG

Genbank Protein ID

CAY70994.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

FN392321

Gene Name

PAS_chr3_0933

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PAS_chr3_0933	CAY70994	CAY70994

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-52	176.8	307	789
UBD/Alpha-Helix/UBA	6.20e-22	75.2	589	628

Active Site

Position(s)	Description	Evidence
316	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
744	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkk..............avsprellkalkkeaeefsgy 87
           tG+kNlgN+CY+ SvLQ+L+++++ +e++l+   ++++ +  ++p+++l  +l k+   l++++ +               ++p  +++ +++ ++efs++
   Q: 307  TGFKNLGNSCYLASVLQTLFSLRSYKEFFLN---RDFPIDRLTTPNTDLNIQLIKIADGLLSGRYSipdystteeikfqrGIKPFGFKNLIGQNHPEFSTM 404
           7******************************...77777777899999999999999999633333333333345666669******************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvp.........gk 179
           +qqDa Ef+ +++d+++e                               +++++ +  +++ l++++kc +c +v   +e  ++l lpv+         g+
   Q: 405  KQQDAYEFWLYIMDKIDELY----------------------------VSEENPPNSPLHFVLENKLKCSTCSSVRFIKEVTNSLALPVEdtvldidddGR 477
           ******************88............................67899*************************************77777766666 PP
   S: 180  eetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefp.......leLdlspfcts...... 267
           e  ++ ++++c++++++eee+e     +c+ c++++  +k+ +l+++P+vL++   R+  + ++++++k +  + f+       +++dls+  ++      
   Q: 478  ERYQPVTFESCFKNWAQEEEIE----HKCSFCQGEK-LVKSQSLQTFPDVLTVSTERI--KLKNWVPIKTDVPILFKraeektlERIDLSNLRSQgllege 571
           666666****************....59****9988.89999****************..6688************9998888556999988888999999 PP
   S: 268  ..................................................................................................... 267
                                                                                                                
   Q: 572  slmpedvsdseetgfepnpeaiqqleamgfpnnrclkalfntgnlsaedamnwlfshmedpdidspfelpkdsssskpaiepsqelvdnlvsmgftsklak 672
           99999999999999999999999999999988888888888888888888888888888888888888877777777777766666666666666666666 PP
   S: 268  ...............................peekqke..................kkkYeLiavvvHsG.slssGHYvayvknekgk...WllfdDskVt 315
                                          p     +                  + +Y+L+av++H+G +++sGHYv+++k++ ++   W+lf+D+kV 
   Q: 673  kalilnninieaavewlfsnpdddgeipdgpP-----KaksqeqqiselivkesikRPEYKLLAVICHKGiTVHSGHYVVFIKKKIDGqprWILFNDEKVV 768
           66666666666666666666666666666551.....04445567778888888889**************************95443488********** PP
   S: 316  evkeeevleetgstaYvlfYkr 337
             +e++++e++ s++Y++++ +
   Q: 769  LADEANIKEME-SNGYLYIFAK 789
           *********65.9***998865 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           + ++++ql++MGF+++++l+aL ++ n ++e A+++L+++
   Q: 589  NPEAIQQLEAMGFPNNRCLKALFNTgNLSAEDAMNWLFSH 628
           6899**********************************97 PP

Organism

Komagataella pastoris

Protein Sequence
(Fasta)

MACTHFNSAD NIKAPTKGTP VFKDDCMLCF DTAFEPKGLD ICLHCFQSFS RGDLNHTQLH 60
SALFDHTLYL NLKKVLKPKR ERKEGEESPE KIAKLEIKDQ SEEDLFNIQT ALFCSSCDDQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTTGCA CACACTTTAA TAGTGCTGAC AACATTAAAG CTCCGACAAA GGGCACTCCG 60
GTATTTAAAG ATGACTGCAT GCTGTGTTTT GATACAGCGT TCGAACCGAA AGGTCTCGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR033864--UBA2_scUBP14-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ppa:PAS_chr3_0933

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	30.14	3.00e-91	327.00
IUUC-Aml-002104	Ailuropoda melanoleuca	32.87	5.00e-112	396.00
IUUC-Atr-002580	Amborella trichopoda	29.35	5.00e-93	333.00
IUUC-Apl-003774	Anas platyrhynchos	33.69	8.00e-112	395.00
IUUC-Aca-005368	Anolis carolinensis	33.57	2.00e-116	411.00
IUUC-Aly-005727	Arabidopsis lyrata	32.09	7.00e-104	369.00
IUUC-Ath-006974	Arabidopsis thaliana	32.09	1.00e-103	369.00
IUUC-Ago-007890	Ashbya gossypii	36.03	6.00e-136	476.00
IUUC-Acl-008057	Aspergillus clavatus	39.64	1.00e-161	561.00
IUUC-Afl-008547	Aspergillus flavus	41.43	2.00e-148	517.00
IUUC-Afu-008805	Aspergillus fumigatus	37.47	6.00e-139	485.00
IUUC-Ani-009441	Aspergillus nidulans	39.46	9.00e-136	475.00
IUUC-Ang-009720	Aspergillus niger	39.16	6.00e-165	572.00
IUUC-Aor-010111	Aspergillus oryzae	40.12	7.00e-171	592.00
IUUC-Ate-010531	Aspergillus terreus	37.92	5.00e-143	499.00
IUUC-Ame-011470	Astyanax mexicanus	29.84	6.00e-99	353.00
IUUC-Bgr-012183	Blumeria graminis	38.44	1.00e-159	554.00
IUUC-Bta-013179	Bos taurus	33.18	3.00e-112	397.00
IUUC-Bci-013858	Botrytis cinerea	40.62	2.00e-175	607.00
IUUC-Bdi-014904	Brachypodium distachyon	31.64	1.00e-99	355.00
IUUC-Bol-015536	Brassica oleracea	31.76	4.00e-104	370.00
IUUC-Bra-017939	Brassica rapa	32.20	1.00e-106	378.00
IUUC-Cel-018625	Caenorhabditis elegans	29.90	9.00e-79	286.00
IUUC-Cja-019063	Callithrix jacchus	32.61	9.00e-111	392.00
IUUC-Cfa-020976	Canis familiaris	33.96	2.00e-115	407.00
IUUC-Cpo-022265	Cavia porcellus	33.89	7.00e-115	405.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	28.17	4.00e-52	197.00
IUUC-Csa-024177	Chlorocebus sabaeus	33.73	2.00e-102	365.00
IUUC-Cho-024702	Choloepus hoffmanni	31.34	3.00e-64	237.00
IUUC-Cin-025411	Ciona intestinalis	29.94	7.00e-88	316.00
IUUC-Csv-026347	Ciona savignyi	29.10	9.00e-90	322.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	40.64	2.00e-164	570.00
IUUC-Cne-026831	Cryptococcus neoformans	41.15	6.00e-153	532.00
IUUC-Cme-027335	Cyanidioschyzon merolae	30.86	2.00e-51	195.00
IUUC-Dre-027651	Danio rerio	30.33	5.00e-103	367.00
IUUC-Dno-029034	Dasypus novemcinctus	32.83	6.00e-114	402.00
IUUC-Dor-030479	Dipodomys ordii	34.24	3.00e-48	184.00
IUUC-Dse-031467	Dothistroma septosporum	39.00	9.00e-167	578.00
IUUC-Dme-032075	Drosophila melanogaster	31.65	4.00e-96	343.00
IUUC-Ete-032865	Echinops telfairi	30.01	5.00e-94	337.00
IUUC-Eca-034059	Equus caballus	32.83	6.00e-110	389.00
IUUC-Eeu-035304	Erinaceus europaeus	34.63	2.00e-100	357.00
IUUC-Fca-035515	Felis catus	32.95	2.00e-112	398.00
IUUC-Fal-037271	Ficedula albicollis	33.99	2.00e-108	384.00
IUUC-Fox-037745	Fusarium oxysporum	42.09	2.00e-176	610.00
IUUC-Fso-038158	Fusarium solani	42.34	1.00e-178	617.00
IUUC-Gmo-039071	Gadus morhua	31.01	2.00e-92	331.00
IUUC-Ggr-040098	Gaeumannomyces graminis	40.00	2.00e-160	556.00
IUUC-Gga-040635	Gallus gallus	33.45	2.00e-117	414.00
IUUC-Gac-042528	Gasterosteus aculeatus	31.37	1.00e-91	329.00
IUUC-Gma-043614	Glycine max	29.55	8.00e-100	355.00
IUUC-Ggo-044602	Gorilla gorilla	33.14	6.00e-113	399.00
IUUC-Hsa-045959	Homo sapiens	33.14	6.00e-113	399.00
IUUC-Hvu-047563	Hordeum vulgare	33.63	1.00e-93	334.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	32.91	4.00e-112	397.00
IUUC-Lch-049648	Latimeria chalumnae	32.79	5.00e-106	376.00
IUUC-Lpe-051523	Leersia perrieri	30.13	3.00e-95	340.00
IUUC-Loc-052072	Lepisosteus oculatus	29.66	5.00e-100	356.00
IUUC-Lma-053216	Leptosphaeria maculans	40.02	6.00e-158	550.00
IUUC-Laf-054327	Loxodonta africana	32.53	5.00e-113	400.00
IUUC-Mcc-055443	Macaca mulatta	33.03	2.00e-111	394.00
IUUC-Meu-056298	Macropus eugenii	31.14	8.00e-70	256.00
IUUC-Mor-057106	Magnaporthe oryzae	40.62	9.00e-178	614.00
IUUC-Mpo-057589	Magnaporthe poae	41.06	5.00e-164	569.00
IUUC-Mtr-058680	Medicago truncatula	31.20	3.00e-102	363.00
IUUC-Mla-058903	Melampsora laricipopulina	36.80	4.00e-144	503.00
IUUC-Mga-059669	Meleagris gallopavo	33.21	5.00e-110	389.00
IUUC-Mvi-060476	Microbotryum violaceum	37.30	1.00e-138	484.00
IUUC-Mmr-060575	Microcebus murinus	33.03	2.00e-111	394.00
IUUC-Mdo-062183	Monodelphis domestica	33.14	9.00e-114	402.00
IUUC-Mmu-063592	Mus musculus	33.14	4.00e-113	400.00
IUUC-Mac-065634	Musa acuminata	31.49	1.00e-52	199.00
IUUC-Mpu-066082	Mustela putorius furo	34.16	4.00e-114	403.00
IUUC-Mlu-067345	Myotis lucifugus	32.84	7.00e-112	396.00
IUUC-Nfi-068558	Neosartorya fischeri	39.66	5.00e-154	535.00
IUUC-Ncr-068960	Neurospora crassa	40.32	3.00e-161	560.00
IUUC-Nle-070173	Nomascus leucogenys	33.85	2.00e-115	408.00
IUUC-Opr-070556	Ochotona princeps	32.91	3.00e-112	397.00
IUUC-Ont-071502	Oreochromis niloticus	31.18	1.00e-90	325.00
IUUC-Oan-072959	Ornithorhynchus anatinus	36.48	4.00e-39	152.00
IUUC-Ocu-074861	Oryctolagus cuniculus	33.85	4.00e-115	407.00
IUUC-Oba-075109	Oryza barthii	31.01	1.00e-100	358.00
IUUC-Obr-076292	Oryza brachyantha	30.22	3.00e-93	334.00
IUUC-Ogl-077065	Oryza glaberrima	31.43	3.00e-105	374.00
IUUC-Ogu-078776	Oryza glumaepatula	31.14	8.00e-105	372.00
IUUC-Oin-080048	Oryza indica	32.19	7.00e-106	375.00
IUUC-Olo-080711	Oryza longistaminata	31.66	4.00e-93	333.00
IUUC-Ome-081506	Oryza meridionalis	32.41	7.00e-96	342.00
IUUC-Oni-082320	Oryza nivara	30.41	3.00e-97	347.00
IUUC-Opu-083801	Oryza punctata	29.94	9.00e-93	332.00
IUUC-Oru-085139	Oryza rufipogon	30.41	6.00e-98	349.00
IUUC-Osa-085713	Oryza sativa	31.55	7.00e-106	376.00
IUUC-Ola-086951	Oryzias latipes	30.29	5.00e-84	303.00
IUUC-Olu-087822	Ostreococcus lucimarinus	29.24	7.00e-86	309.00
IUUC-Oga-088625	Otolemur garnettii	32.60	6.00e-110	389.00
IUUC-Oar-089995	Ovis aries	33.18	1.00e-111	395.00
IUUC-Ptr-090640	Pan troglodytes	34.08	3.00e-117	414.00
IUUC-Pan-091974	Papio anubis	32.72	2.00e-111	394.00
IUUC-Psi-093957	Pelodiscus sinensis	33.06	1.00e-115	408.00
IUUC-Pma-094242	Petromyzon marinus	33.42	1.00e-51	194.00
IUUC-Pno-094835	Phaeosphaeria nodorum	39.33	2.00e-140	490.00
IUUC-Ppa-095901	Physcomitrella patens	31.87	2.00e-102	365.00
IUUC-Pfo-097148	Poecilia formosa	31.52	9.00e-93	332.00
IUUC-Pab-098068	Pongo abelii	31.48	2.00e-96	344.00
IUUC-Pop-098943	Populus trichocarpa	30.48	6.00e-99	352.00
IUUC-Pca-100738	Procavia capensis	34.24	5.00e-82	296.00
IUUC-Ppe-101315	Prunus persica	30.70	3.00e-95	340.00
IUUC-Pva-102154	Pteropus vampyrus	32.49	1.00e-108	385.00
IUUC-Pgr-103343	Puccinia graminis	35.67	2.00e-114	404.00
IUUC-Ptt-103928	Puccinia triticina	30.69	2.00e-109	387.00
IUUC-Pte-104306	Pyrenophora teres	40.54	4.00e-145	506.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	40.66	4.00e-152	529.00
IUUC-Rno-105801	Rattus norvegicus	33.03	2.00e-112	397.00
IUUC-Sce-106304	Saccharomyces cerevisiae	37.68	7.00e-129	452.00
IUUC-Sha-107635	Sarcophilus harrisii	33.45	2.00e-114	404.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	39.35	7.00e-150	522.00
IUUC-Spo-108144	Schizosaccharomyces pombe	37.55	2.00e-142	497.00
IUUC-Smo-108848	Selaginella moellendorffii	33.86	1.00e-106	378.00
IUUC-Sit-110728	Setaria italica	32.38	2.00e-105	374.00
IUUC-Sly-111523	Solanum lycopersicum	31.28	7.00e-106	376.00
IUUC-Sar-113733	Sorex araneus	31.80	1.00e-52	199.00
IUUC-Sbi-114419	Sorghum bicolor	32.13	4.00e-101	360.00
IUUC-Sre-115225	Sporisorium reilianum	37.02	9.00e-139	485.00
IUUC-Ssc-115686	Sus scrofa	33.26	5.00e-113	400.00
IUUC-Tgu-117346	Taeniopygia guttata	33.41	3.00e-112	397.00
IUUC-Tru-118350	Takifugu rubripes	29.67	2.00e-90	325.00
IUUC-Tsy-119278	Tarsius syrichta	29.27	2.00e-79	288.00
IUUC-Tni-120804	Tetraodon nigroviridis	29.38	1.00e-97	348.00
IUUC-Tca-121585	Theobroma cacao	30.85	5.00e-99	353.00
IUUC-Tre-122043	Trichoderma reesei	41.61	2.00e-166	577.00
IUUC-Tvi-122303	Trichoderma virens	41.29	5.00e-168	582.00
IUUC-Tae-123798	Triticum aestivum	31.43	3.00e-105	373.00
IUUC-Tur-126732	Triticum urartu	29.80	4.00e-93	333.00
IUUC-Tme-126909	Tuber melanosporum	40.37	9.00e-164	568.00
IUUC-Tbe-127261	Tupaia belangeri	30.92	7.00e-62	229.00
IUUC-Ttr-129119	Tursiops truncatus	31.99	8.00e-50	190.00
IUUC-Uma-129599	Ustilago maydis	36.73	7.00e-146	509.00
IUUC-Vda-129688	Verticillium dahliae	41.54	8.00e-174	601.00
IUUC-Vpa-130170	Vicugna pacos	32.01	2.00e-43	169.00
IUUC-Vvi-131116	Vitis vinifera	30.12	3.00e-95	340.00
IUUC-Xtr-131953	Xenopus tropicalis	32.53	9.00e-100	355.00
IUUC-Xma-134273	Xiphophorus maculatus	30.83	8.00e-105	372.00
IUUC-Yli-134510	Yarrowia lipolytica	39.80	3.00e-156	543.00
IUUC-Zma-135786	Zea mays	32.29	5.00e-96	343.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence