iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tae-125686

Ensembl Protein ID

TRIAE_CS42_3DS_TGACv1_271994_AA0912640.4

UniProt Accession

A0A1D5WSE4; A0A1D5WSE4_WHEAT

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIAE_CS42_3DS_TGACv1_271994_AA0912640	TRIAE_CS42_3DS_TGACv1_271994_AA0912640.1	TRIAE_CS42_3DS_TGACv1_271994_AA0912640.1
TRIAE_CS42_3DS_TGACv1_271994_AA0912640	TRIAE_CS42_3DS_TGACv1_271994_AA0912640.2	TRIAE_CS42_3DS_TGACv1_271994_AA0912640.2
TRIAE_CS42_3DS_TGACv1_271994_AA0912640	TRIAE_CS42_3DS_TGACv1_271994_AA0912640.4	TRIAE_CS42_3DS_TGACv1_271994_AA0912640.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.10e-54	186.4	345	827
UBD/Alpha-Helix/UBA	3.30e-10	42.4	704	743

Active Site

Position(s)	Description	Evidence
354	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
790	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw....... 61
           tGl NlgN+CYm Sv+Q++++++++ + ++e +  +++ + ++ +p+ +l ++++kl + ++       
   Q: 345  TGLVNLGNSCYMASVMQVMFSTHPFISRYFEkQSLKAVFAISQADPTLDLNMQMTKLAHGMLsgkysap 413
           7************************988877455566667778999***************76666666 PP
   S: 62   .kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde 129
            ++ ++ + pr++++++++ ++efs+++qqDa Ef ++l+d++e++                       
   Q: 414  sQEGQEGIRPRMFKSVIAASHPEFSSMRQQDALEFYHHLIDKVEQAN---------------------- 460
           677788*************************************9988...................... PP
   S: 130  aeekkkkknkslisdlFqgqlksqikclecdnvs.sreepfldlslpvpgkeetkke............ 185
               + +++ +   + F++ ++++++c++ + ++ +  ++fl+ls+p+++ ++++++            
   Q: 461  ----PGNHELN-PCTGFKFIIEERVQCPSGKVSYnQHCDNFLTLSIPLHEATNKEQLeafhekkaamdl 524
           ....3444444.4568************999888788899*********999776669*********** PP
   S: 186  ...............slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsf 239
                           l+ cL+sf+  ee+ +   +y++  ++k++a k+++lk++P++L+l++ +f +
   Q: 525  dgkevskeeivrprvPLEACLASFSGGEEVPE---FYSTALNSKTTAIKTTGLKTFPDYLVLQMRKF-V 589
           ******************************96...********************************.6 PP
   S: 240  seeqksrekinkkvefpleLdlspfcts......................................... 267
             e+++++k++ ++++p+ +d+s++ ++                                         
   Q: 590  MGEGWVPKKLDVYIDVPDIIDISHMRSNgvqpgeellpegascgnkaeparpvadedivsqlanigfny 658
           6889*******************9998889999999998888888888888888888888888888888 PP
   S: 268  ..................................................................... 267
                                                                                
   Q: 659  facqkaaintsnagleeamnwllshtqdpdinepisqdpmpaedtideaslqtlvsfgfpedvsrmalk 727
           888777777777777777777777777777766666666666666666666666666665555555555 PP
   S: 268  .........peekqke...............................kkkYeLiavvvHsG.slssGHY 295
                    +     e                               + +Y+L+a v+H+G s+++GHY
   Q: 728  asggnieraT-----EwvfshpeasssvsadsstnnvkdddshisdgSGRYKLMAFVSHMGtSTHCGHY 791
           5555555550.....05555555555556666666777788888999********************** PP
   S: 296  vayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           va++ + +g+W  f+D+kV ++   +  +   + +Y++f++r
   Q: 792  VAHILK-DGRWTIFNDNKVAAS--VDLPK---DMGYLYFFQR 827
           ******.9***********999..68888...999*999997 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +de  l+ lv+ GF+++  + aL a+++n+e+A+e+++++
   Q: 704  IDEASLQTLVSFGFPEDVSRMALKASGGNIERATEWVFSH 743
           58899*********************************97 PP

Organism

Triticum aestivum

Protein Sequence
(Fasta)

MFQALWAFLQ GLIRFLWSYV RDATRLRRRP PRPAAMDLLR ANLHKVRIPE PTNRIHKDEC 60
CVSFDTPRSE GGLYVDMNSF LGFGREHVAW NFEKSENPVY LHIVQRRKPE PDETDRPLKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGGAACGG AGGGAGAGGC GATCGAGGTC GAGGGGGTAC CTGACGAGGG GGAATTCTGC 60
GTGCGTGCGT GCGTGCGTGT CAAGAGCGAC GTCTCCGTTG GGATAGTGGC CGTGAGCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0732--Signal
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	95.28	0.00e+00	1473.00
IUUC-Aml-002104	Ailuropoda melanoleuca	47.08	0.00e+00	736.00
IUUC-Apl-003774	Anas platyrhynchos	47.51	0.00e+00	718.00
IUUC-Aca-005368	Anolis carolinensis	48.98	0.00e+00	768.00
IUUC-Ame-011470	Astyanax mexicanus	41.45	0.00e+00	657.00
IUUC-Bta-013179	Bos taurus	47.54	0.00e+00	739.00
IUUC-Cja-019063	Callithrix jacchus	46.61	0.00e+00	729.00
IUUC-Cfa-020976	Canis familiaris	48.50	0.00e+00	753.00
IUUC-Cpo-022265	Cavia porcellus	48.38	0.00e+00	753.00
IUUC-Csa-024078	Chlorocebus sabaeus	41.99	0.00e+00	663.00
IUUC-Cho-024702	Choloepus hoffmanni	41.22	2.00e-112	400.00
IUUC-Cin-025411	Ciona intestinalis	43.40	3.00e-179	622.00
IUUC-Csv-026347	Ciona savignyi	42.21	7.00e-174	604.00
IUUC-Dre-027651	Danio rerio	42.94	0.00e+00	699.00
IUUC-Dno-029034	Dasypus novemcinctus	47.44	0.00e+00	742.00
IUUC-Ete-032865	Echinops telfairi	43.26	0.00e+00	648.00
IUUC-Eca-034059	Equus caballus	47.20	0.00e+00	738.00
IUUC-Eeu-035304	Erinaceus europaeus	44.50	0.00e+00	661.00
IUUC-Fca-035515	Felis catus	47.42	0.00e+00	744.00
IUUC-Gmo-039071	Gadus morhua	44.21	0.00e+00	640.00
IUUC-Gac-042528	Gasterosteus aculeatus	42.62	0.00e+00	650.00
IUUC-Ggo-044602	Gorilla gorilla	47.31	0.00e+00	741.00
IUUC-Hsa-045959	Homo sapiens	47.31	0.00e+00	741.00
IUUC-Hvu-047563	Hordeum vulgare	97.31	0.00e+00	1237.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	46.96	0.00e+00	746.00
IUUC-Lch-049648	Latimeria chalumnae	47.07	0.00e+00	740.00
IUUC-Loc-052072	Lepisosteus oculatus	42.82	0.00e+00	663.00
IUUC-Laf-054327	Loxodonta africana	47.19	0.00e+00	742.00
IUUC-Mvi-060476	Microbotryum violaceum	31.82	7.00e-98	352.00
IUUC-Mdo-062183	Monodelphis domestica	46.87	0.00e+00	738.00
IUUC-Mmu-063592	Mus musculus	47.42	0.00e+00	743.00
IUUC-Mac-065634	Musa acuminata	65.93	0.00e+00	1129.00
IUUC-Mpu-066082	Mustela putorius furo	48.26	0.00e+00	744.00
IUUC-Mlu-067345	Myotis lucifugus	46.61	0.00e+00	734.00
IUUC-Ncr-068960	Neurospora crassa	31.67	1.00e-97	352.00
IUUC-Nle-070173	Nomascus leucogenys	48.74	0.00e+00	749.00
IUUC-Opr-070556	Ochotona princeps	46.84	0.00e+00	748.00
IUUC-Ont-071502	Oreochromis niloticus	45.58	0.00e+00	659.00
IUUC-Ocu-074861	Oryctolagus cuniculus	48.01	0.00e+00	757.00
IUUC-Ola-086951	Oryzias latipes	42.67	0.00e+00	637.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.48	3.00e-168	585.00
IUUC-Oga-088625	Otolemur garnettii	46.54	0.00e+00	737.00
IUUC-Psi-093957	Pelodiscus sinensis	46.85	0.00e+00	759.00
IUUC-Pab-098068	Pongo abelii	43.27	2.00e-178	620.00
IUUC-Pca-100738	Procavia capensis	44.48	1.00e-139	491.00
IUUC-Pva-102154	Pteropus vampyrus	46.72	0.00e+00	731.00
IUUC-Rno-105801	Rattus norvegicus	47.54	0.00e+00	745.00
IUUC-Sha-107635	Sarcophilus harrisii	48.44	0.00e+00	747.00
IUUC-Ssc-115686	Sus scrofa	46.37	0.00e+00	739.00
IUUC-Tbe-127261	Tupaia belangeri	40.26	2.00e-116	414.00
IUUC-Vda-129688	Verticillium dahliae	33.33	1.00e-105	378.00
IUUC-Vpa-130170	Vicugna pacos	36.32	5.00e-144	505.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence