iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046611

UUCD1 version

UUC-HoS-01183

Ensembl Protein ID

ENSP00000263228.3

UniProt Accession

Q712K3; D3DRL5; Q9NX64; UB2R2_HUMAN

Genbank Protein ID

CAC80336.1; BAA91156.1; CAG33514.1; CAI39656.1; EAW58479.1; EAW58480.1; AAH04862.1; AAH47584.1

Protein Name

Ubiquitin-conjugating enzyme E2 R2; E2 ubiquitin-conjugating enzyme R2; Ubiquitin carrier protein R2; Ubiquitin-conjugating enzyme E2-CDC34B; Ubiquitin-protein ligase R2

Genbank Nucleotide ID

AJ240087; AK000426; CR457233; AL139113; CH471071; CH471071; BC004862; BC047584

Gene Name

UBE2R2; CDC34B; UBC3B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000107341.4	ENST00000263228.3	ENSP00000263228.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	12037680

Classification

Family	E-value	Score	Start	End
E2/UBC	7.40e-49	166.7	13	153

Active Site

Position(s)	Description	Evidence
93	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk...... 87
           l+ elk+l+++p+eg+++++vdesdl++wev+i+Gp++t Yegg+Fk++i+fp dYP++PP+++fltk++hPn+yenG+vC+sil+      
   Q: 13   LMLELKSLQEEPVEGFRITLVDESDLYNWEVAIFGPPNTLYEGGYFKAHIKFPIDYPYSPPTFRFLTKMWHPNIYENGDVCISILHppvddp 104
           678**********************************************************************************9999999 PP
   S: 88   .....eeekWspalsvesvllsiqsllaepnpesplneeaaellkknre 131
                ++e+W+p+++v+++lls++sll+epn+ sp+n++a+ +++k+r 
   Q: 105  qsgelPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMFRKWRD 153
           99*9*************************************99998875 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin.

Protein Sequence
(Fasta)

MAQQQMTSSQ KALMLELKSL QEEPVEGFRI TLVDESDLYN WEVAIFGPPN TLYEGGYFKA 60
HIKFPIDYPY SPPTFRFLTK MWHPNIYENG DVCISILHPP VDDPQSGELP SERWNPTQNV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGTGTGTGA GGAGGACCCC GGGCGGGCCC ACGGGCCGTG TGGGGCCTGG TCTGGCCCGC 60
CGGGTGTGTG AAGACCGGGG CCCGGTGCTG CCCGGCCGGA GGGCGAGCGG AGGGGAGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0016567--P:protein ubiquitination

KEGG

hsa:54926

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003563	Anas platyrhynchos	97.96	3.00e-84	304.00
IUUC-Aca-004589	Anolis carolinensis	97.54	4.00e-118	417.00
IUUC-Ate-010563	Aspergillus terreus	45.16	3.00e-37	148.00
IUUC-Ame-011300	Astyanax mexicanus	94.97	3.00e-113	401.00
IUUC-Bta-012968	Bos taurus	100.00	2.00e-112	397.00
IUUC-Cel-018460	Caenorhabditis elegans	66.84	2.00e-74	271.00
IUUC-Cja-018764	Callithrix jacchus	100.00	2.00e-120	424.00
IUUC-Cfa-020955	Canis familiaris	100.00	2.00e-120	424.00
IUUC-Cpo-021451	Cavia porcellus	100.00	2.00e-120	424.00
IUUC-Csa-024239	Chlorocebus sabaeus	100.00	2.00e-120	424.00
IUUC-Cho-024999	Choloepus hoffmanni	81.67	4.00e-26	111.00
IUUC-Cin-025344	Ciona intestinalis	70.20	2.00e-85	308.00
IUUC-Csv-025954	Ciona savignyi	71.43	1.00e-86	312.00
IUUC-Dre-028153	Danio rerio	94.09	4.00e-114	404.00
IUUC-Dno-029368	Dasypus novemcinctus	100.00	2.00e-112	397.00
IUUC-Dor-030686	Dipodomys ordii	100.00	2.00e-120	424.00
IUUC-Dme-032106	Drosophila melanogaster	74.09	3.00e-88	318.00
IUUC-Ete-033001	Echinops telfairi	100.00	1.00e-64	238.00
IUUC-Eca-034221	Equus caballus	99.32	8.00e-85	305.00
IUUC-Fca-036381	Felis catus	98.65	2.00e-85	307.00
IUUC-Fal-037135	Ficedula albicollis	99.01	4.00e-114	404.00
IUUC-Gmo-039565	Gadus morhua	92.93	1.00e-110	392.00
IUUC-Gga-040182	Gallus gallus	99.01	4.00e-114	404.00
IUUC-Gac-041909	Gasterosteus aculeatus	92.42	1.00e-110	391.00
IUUC-Ggo-045150	Gorilla gorilla	99.51	2.00e-119	421.00
IUUC-Itr-047984	Ictidomys tridecemlineatus	92.61	9.00e-107	379.00
IUUC-Lch-050173	Latimeria chalumnae	99.01	3.00e-119	421.00
IUUC-Loc-051916	Lepisosteus oculatus	96.52	2.00e-113	401.00
IUUC-Laf-053860	Loxodonta africana	100.00	2.00e-120	424.00
IUUC-Mcc-054820	Macaca mulatta	100.00	2.00e-120	424.00
IUUC-Meu-056681	Macropus eugenii	94.09	2.00e-112	397.00
IUUC-Mmr-060666	Microcebus murinus	100.00	2.00e-120	424.00
IUUC-Mdo-062804	Monodelphis domestica	99.51	9.00e-120	422.00
IUUC-Mmu-063472	Mus musculus	100.00	2.00e-120	424.00
IUUC-Mlu-067397	Myotis lucifugus	95.43	1.00e-110	392.00
IUUC-Nle-070152	Nomascus leucogenys	99.08	4.00e-63	232.00
IUUC-Ont-071627	Oreochromis niloticus	92.50	1.00e-111	395.00
IUUC-Ocu-074229	Oryctolagus cuniculus	100.00	5.00e-113	400.00
IUUC-Ola-086587	Oryzias latipes	91.92	2.00e-110	391.00
IUUC-Oga-089161	Otolemur garnettii	100.00	2.00e-112	397.00
IUUC-Oar-089383	Ovis aries	100.00	2.00e-120	424.00
IUUC-Ptr-091096	Pan troglodytes	100.00	2.00e-120	424.00
IUUC-Pan-092560	Papio anubis	100.00	2.00e-112	397.00
IUUC-Psi-093263	Pelodiscus sinensis	98.63	5.00e-84	303.00
IUUC-Pma-094368	Petromyzon marinus	86.81	1.00e-74	271.00
IUUC-Pfo-096974	Poecilia formosa	92.42	9.00e-111	392.00
IUUC-Pab-098344	Pongo abelii	100.00	2.00e-120	424.00
IUUC-Rno-105821	Rattus norvegicus	100.00	2.00e-120	424.00
IUUC-Sha-107364	Sarcophilus harrisii	99.51	9.00e-120	422.00
IUUC-Sar-112992	Sorex araneus	96.02	5.00e-110	390.00
IUUC-Tgu-117074	Taeniopygia guttata	99.01	4.00e-114	404.00
IUUC-Tru-118641	Takifugu rubripes	91.37	4.00e-109	387.00
IUUC-Tsy-118797	Tarsius syrichta	97.10	1.00e-77	282.00
IUUC-Tni-119817	Tetraodon nigroviridis	91.41	9.00e-110	389.00
IUUC-Tbe-128014	Tupaia belangeri	100.00	2.00e-120	424.00
IUUC-Ttr-129037	Tursiops truncatus	99.46	1.00e-107	382.00
IUUC-Vpa-130680	Vicugna pacos	100.00	6.00e-84	302.00
IUUC-Xtr-131819	Xenopus tropicalis	100.00	2.00e-109	388.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence