iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012604

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02011189

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000021216.5	ENSBTAT00000028268.5	ENSBTAP00000028268.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-121	405.6	1264	1596

Active Site

Position(s)	Description	Evidence
1564	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+++fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1264 ELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1349
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1350 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1432
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v +r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid+ d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1433 MVRWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLADWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1519
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1520 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1596
           ************************999***********************************************985 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

PLLTVCLPPQ NLYQNRFLGL AAMASPSRNS QNRRRCKEPL RHSYNPGQYH SVAIRTGPHG 60
AVTIPRSTSD TDLVTSDSRS TLMVSSSYYS IGHSQDLVIH WDIKEEVDAG DWIGMYLIDE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCTGCTGA CTGTCTGTTT GCCCCCACAG AATCTGTACC AGAACAGGTT CTTAGGCCTG 60
GCCGCCATGG CATCTCCATC TAGAAACTCC CAGAATCGAC GCCGGTGCAA GGAGCCGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	86.83	0.00e+00	2183.00
IUUC-Apl-003299	Anas platyrhynchos	79.42	0.00e+00	2420.00
IUUC-Aca-005024	Anolis carolinensis	79.32	0.00e+00	2372.00
IUUC-Cja-019880	Callithrix jacchus	85.56	0.00e+00	2232.00
IUUC-Cfa-021216	Canis familiaris	89.32	0.00e+00	1796.00
IUUC-Cpo-021466	Cavia porcellus	96.32	0.00e+00	1707.00
IUUC-Csa-023080	Chlorocebus sabaeus	90.75	0.00e+00	2683.00
IUUC-Cho-024740	Choloepus hoffmanni	80.33	0.00e+00	1150.00
IUUC-Dre-028750	Danio rerio	81.39	0.00e+00	1496.00
IUUC-Dno-030019	Dasypus novemcinctus	87.52	0.00e+00	2645.00
IUUC-Dor-031030	Dipodomys ordii	73.08	0.00e+00	1125.00
IUUC-Ete-032352	Echinops telfairi	93.27	0.00e+00	1253.00
IUUC-Eca-033948	Equus caballus	90.05	0.00e+00	2575.00
IUUC-Eeu-034474	Erinaceus europaeus	80.59	0.00e+00	839.00
IUUC-Fca-036148	Felis catus	91.90	0.00e+00	2635.00
IUUC-Fal-036957	Ficedula albicollis	80.72	0.00e+00	2397.00
IUUC-Gmo-038714	Gadus morhua	69.30	0.00e+00	1020.00
IUUC-Gga-041194	Gallus gallus	80.01	0.00e+00	2389.00
IUUC-Gac-041366	Gasterosteus aculeatus	77.84	0.00e+00	1368.00
IUUC-Ggo-045442	Gorilla gorilla	76.01	0.00e+00	1964.00
IUUC-Hsa-045730	Homo sapiens	90.81	0.00e+00	2681.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	90.66	0.00e+00	2682.00
IUUC-Lch-050185	Latimeria chalumnae	73.14	0.00e+00	1382.00
IUUC-Loc-052744	Lepisosteus oculatus	74.56	0.00e+00	2204.00
IUUC-Laf-054368	Loxodonta africana	97.94	0.00e+00	1494.00
IUUC-Mcc-055487	Macaca mulatta	90.81	0.00e+00	2677.00
IUUC-Meu-056751	Macropus eugenii	91.34	0.00e+00	726.00
IUUC-Mga-059545	Meleagris gallopavo	80.77	0.00e+00	2385.00
IUUC-Mmr-061078	Microcebus murinus	89.16	0.00e+00	2499.00
IUUC-Mdo-062176	Monodelphis domestica	84.76	0.00e+00	1691.00
IUUC-Mmu-063513	Mus musculus	85.65	0.00e+00	2499.00
IUUC-Mpu-065786	Mustela putorius furo	91.09	0.00e+00	2642.00
IUUC-Mlu-067780	Myotis lucifugus	84.82	0.00e+00	2384.00
IUUC-Nle-069213	Nomascus leucogenys	90.06	0.00e+00	2621.00
IUUC-Opr-070208	Ochotona princeps	96.54	0.00e+00	1482.00
IUUC-Ont-072132	Oreochromis niloticus	77.72	0.00e+00	1364.00
IUUC-Oan-072807	Ornithorhynchus anatinus	84.76	0.00e+00	1779.00
IUUC-Ocu-074745	Oryctolagus cuniculus	86.29	0.00e+00	2543.00
IUUC-Ola-086981	Oryzias latipes	72.19	0.00e+00	1464.00
IUUC-Oga-087965	Otolemur garnettii	94.04	0.00e+00	1843.00
IUUC-Oar-089749	Ovis aries	98.06	0.00e+00	2795.00
IUUC-Ptr-091243	Pan troglodytes	90.62	0.00e+00	2674.00
IUUC-Pan-092201	Papio anubis	90.09	0.00e+00	2666.00
IUUC-Psi-093511	Pelodiscus sinensis	79.20	0.00e+00	2370.00
IUUC-Pfo-097001	Poecilia formosa	78.13	0.00e+00	1381.00
IUUC-Pab-098728	Pongo abelii	88.03	0.00e+00	2562.00
IUUC-Pca-100129	Procavia capensis	81.66	0.00e+00	1258.00
IUUC-Pva-102250	Pteropus vampyrus	80.14	0.00e+00	2185.00
IUUC-Rno-105031	Rattus norvegicus	86.62	0.00e+00	2519.00
IUUC-Tgu-117515	Taeniopygia guttata	79.42	0.00e+00	2400.00
IUUC-Tru-117914	Takifugu rubripes	77.07	0.00e+00	1375.00
IUUC-Tsy-119379	Tarsius syrichta	78.79	0.00e+00	787.00
IUUC-Tni-120178	Tetraodon nigroviridis	77.44	0.00e+00	1395.00
IUUC-Tbe-127762	Tupaia belangeri	82.76	0.00e+00	1952.00
IUUC-Ttr-128806	Tursiops truncatus	93.92	0.00e+00	1745.00
IUUC-Xtr-132903	Xenopus tropicalis	73.17	0.00e+00	1860.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence