iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065786

Ensembl Protein ID

ENSMPUP00000018036.1

UniProt Accession

M3Z374; M3Z374_MUSPF

Genbank Protein ID

ENSMPUP00000018036

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01004878

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000018147.1	ENSMPUT00000018299.1	ENSMPUP00000018036.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.00e-122	407.5	1267	1599

Active Site

Position(s)	Description	Evidence
1567	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1267 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1352
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1353 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1435
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1436 MVKWRVERGVVQQTEALVRGFCEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1522
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1523 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1599
           ************************999***********************************************985 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MLLHLCSVKN LYQNRFLGLA AMASPSRTSQ NRRRCKEPLR HSYNPGQFHS MAIRNGPHGT 60
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIDEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAACCCTGT TTGAAAGCTG GTCTTGCCCA ACAATAGATT GGGGGGGGGT AGTATTTTCA 60
CCCTTTGCAT TTGTAATTAC AATGTTTGTT TTGTGTTTTT GCGGTGCAGA CACAGGATGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	91.36	0.00e+00	2266.00
IUUC-Apl-003299	Anas platyrhynchos	79.21	0.00e+00	2407.00
IUUC-Aca-005024	Anolis carolinensis	78.86	0.00e+00	2382.00
IUUC-Bta-012604	Bos taurus	89.66	0.00e+00	2652.00
IUUC-Cja-019880	Callithrix jacchus	84.28	0.00e+00	2211.00
IUUC-Cfa-021216	Canis familiaris	93.29	0.00e+00	1824.00
IUUC-Cpo-021466	Cavia porcellus	96.77	0.00e+00	1714.00
IUUC-Csa-023080	Chlorocebus sabaeus	90.80	0.00e+00	2667.00
IUUC-Cho-024740	Choloepus hoffmanni	92.59	0.00e+00	1133.00
IUUC-Dre-028750	Danio rerio	72.86	0.00e+00	1545.00
IUUC-Dno-030019	Dasypus novemcinctus	89.25	0.00e+00	2605.00
IUUC-Dor-031030	Dipodomys ordii	73.48	0.00e+00	1131.00
IUUC-Ete-032352	Echinops telfairi	94.00	0.00e+00	1255.00
IUUC-Eca-033948	Equus caballus	89.79	0.00e+00	2567.00
IUUC-Eeu-034474	Erinaceus europaeus	70.35	0.00e+00	831.00
IUUC-Fca-036148	Felis catus	94.70	0.00e+00	2723.00
IUUC-Fal-036957	Ficedula albicollis	81.03	0.00e+00	2413.00
IUUC-Gmo-038714	Gadus morhua	68.88	0.00e+00	1018.00
IUUC-Gga-041194	Gallus gallus	80.12	0.00e+00	2397.00
IUUC-Gac-041366	Gasterosteus aculeatus	77.91	0.00e+00	1365.00
IUUC-Ggo-045442	Gorilla gorilla	81.19	0.00e+00	1632.00
IUUC-Hsa-045730	Homo sapiens	90.86	0.00e+00	2667.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	90.50	0.00e+00	2669.00
IUUC-Lch-050185	Latimeria chalumnae	72.43	0.00e+00	1389.00
IUUC-Loc-052744	Lepisosteus oculatus	75.24	0.00e+00	2222.00
IUUC-Laf-054368	Loxodonta africana	98.45	0.00e+00	1500.00
IUUC-Mcc-055487	Macaca mulatta	90.68	0.00e+00	2669.00
IUUC-Meu-056751	Macropus eugenii	91.34	0.00e+00	726.00
IUUC-Mga-059545	Meleagris gallopavo	80.46	0.00e+00	2396.00
IUUC-Mmr-061078	Microcebus murinus	89.44	0.00e+00	2508.00
IUUC-Mdo-062176	Monodelphis domestica	84.63	0.00e+00	1704.00
IUUC-Mmu-063513	Mus musculus	86.24	0.00e+00	2507.00
IUUC-Mlu-067780	Myotis lucifugus	84.85	0.00e+00	2397.00
IUUC-Nle-069213	Nomascus leucogenys	94.44	0.00e+00	1914.00
IUUC-Opr-070208	Ochotona princeps	97.06	0.00e+00	1491.00
IUUC-Ont-072132	Oreochromis niloticus	81.27	0.00e+00	1357.00
IUUC-Oan-072807	Ornithorhynchus anatinus	88.00	0.00e+00	1788.00
IUUC-Ocu-074745	Oryctolagus cuniculus	89.02	0.00e+00	2528.00
IUUC-Ola-086981	Oryzias latipes	74.24	0.00e+00	1487.00
IUUC-Oga-087965	Otolemur garnettii	87.86	0.00e+00	2474.00
IUUC-Oar-089749	Ovis aries	90.65	0.00e+00	1886.00
IUUC-Ptr-091243	Pan troglodytes	90.80	0.00e+00	2666.00
IUUC-Pan-092201	Papio anubis	90.02	0.00e+00	2644.00
IUUC-Psi-093511	Pelodiscus sinensis	82.77	0.00e+00	1717.00
IUUC-Pfo-097001	Poecilia formosa	71.06	0.00e+00	1439.00
IUUC-Pab-098728	Pongo abelii	88.64	0.00e+00	2555.00
IUUC-Pca-100129	Procavia capensis	82.46	0.00e+00	1254.00
IUUC-Pva-102250	Pteropus vampyrus	81.18	0.00e+00	2163.00
IUUC-Rno-105031	Rattus norvegicus	86.40	0.00e+00	2519.00
IUUC-Tgu-117515	Taeniopygia guttata	80.96	0.00e+00	2403.00
IUUC-Tru-117914	Takifugu rubripes	75.36	0.00e+00	1370.00
IUUC-Tsy-119379	Tarsius syrichta	78.98	0.00e+00	783.00
IUUC-Tni-120178	Tetraodon nigroviridis	76.64	0.00e+00	1385.00
IUUC-Tbe-127762	Tupaia belangeri	83.72	0.00e+00	1952.00
IUUC-Ttr-128806	Tursiops truncatus	94.14	0.00e+00	1753.00
IUUC-Xtr-132903	Xenopus tropicalis	82.63	0.00e+00	1709.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence