iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012517

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-like modifier-activating enzyme 5; UFM1-activating enzyme; Ubiquitin-activating enzyme E1 domain-containing protein 1

Genbank Nucleotide ID

BC151254

Gene Name

UBA5; UBE1DC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000004495.4	ENSBTAT00000005894.4	ENSBTAP00000005894.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	95.89	0.00e+00	649.00	IUUC-Hsa-046777

Active Site

Position(s)	Description	Evidence
250	Glycyl thioester intermediate	{ECO:0000250\|UniProtKB:Q9GZZ9}

Organism

Bos taurus

Functional Description
(View)

E1-like enzyme which activates UFM1 and SUMO2.

Protein Sequence
(Fasta)

MAESVERLQQ RVEELERELA QERSRRALGS GDGGGGRARI EKMSSEVVDS NPYSRLMALK 60
RMGIVSDYEK IRTFTVAIVG VGGVGSVTAE MLTRCGIGKL LLFDYDKVEL ANMNRLFFQP 120

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Nucleotide Sequence
(Fasta)

GGGAGACCCG CAGGAGCGGC GGAGACGTGT CGGGCAGGGG CGCGCTGGGA GCGCTTCCCC 60
AGGTTTGTGG GCTGGGAAAG CCGCAGCAAG GTGACTCGCC ACATATCCCT CTCGGGGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR029752--D-isomer_DH_CS1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0071566--F:UFM1 activating enzyme activity
GO:1990592--P:protein K69-linked ufmylation
GO:0071569--P:protein ufmylation
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0034976--P:response to endoplasmic reticulum stress

KEGG

bta:509292

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001324	Ailuropoda melanoleuca	93.80	0.00e+00	656.00
IUUC-Atr-002660	Amborella trichopoda	58.67	7.00e-116	410.00
IUUC-Apl-003722	Anas platyrhynchos	88.03	1.00e-168	585.00
IUUC-Aca-004584	Anolis carolinensis	86.32	2.00e-169	588.00
IUUC-Aly-005881	Arabidopsis lyrata	58.47	2.00e-117	416.00
IUUC-Ath-007286	Arabidopsis thaliana	61.33	3.00e-121	428.00
IUUC-Ame-011679	Astyanax mexicanus	81.37	7.00e-146	509.00
IUUC-Bdi-014894	Brachypodium distachyon	60.98	2.00e-115	408.00
IUUC-Bol-016054	Brassica oleracea	63.66	1.00e-120	426.00
IUUC-Bra-016708	Brassica rapa	62.75	8.00e-124	436.00
IUUC-Cel-018424	Caenorhabditis elegans	70.99	1.00e-124	439.00
IUUC-Cja-019825	Callithrix jacchus	96.68	5.00e-144	503.00
IUUC-Cfa-021160	Canis familiaris	94.55	0.00e+00	689.00
IUUC-Cpo-022255	Cavia porcellus	89.15	0.00e+00	671.00
IUUC-Csa-023827	Chlorocebus sabaeus	95.05	0.00e+00	714.00
IUUC-Cho-025078	Choloepus hoffmanni	88.86	0.00e+00	634.00
IUUC-Cin-025217	Ciona intestinalis	69.06	1.00e-154	538.00
IUUC-Dre-027578	Danio rerio	79.89	2.00e-174	604.00
IUUC-Dno-029330	Dasypus novemcinctus	90.45	0.00e+00	675.00
IUUC-Dor-030425	Dipodomys ordii	59.71	1.00e-107	382.00
IUUC-Dme-031645	Drosophila melanogaster	62.35	1.00e-137	483.00
IUUC-Ete-032912	Echinops telfairi	90.23	2.00e-58	219.00
IUUC-Eca-033247	Equus caballus	94.52	0.00e+00	660.00
IUUC-Eeu-034472	Erinaceus europaeus	93.71	0.00e+00	627.00
IUUC-Fca-035684	Felis catus	94.57	0.00e+00	657.00
IUUC-Fal-037654	Ficedula albicollis	85.05	5.00e-172	597.00
IUUC-Gmo-039449	Gadus morhua	67.49	8.00e-128	449.00
IUUC-Gga-041051	Gallus gallus	86.85	2.00e-176	611.00
IUUC-Gac-042325	Gasterosteus aculeatus	75.68	1.00e-176	612.00
IUUC-Gma-043136	Glycine max	57.32	5.00e-124	437.00
IUUC-Ggo-044414	Gorilla gorilla	94.55	0.00e+00	694.00
IUUC-Hsa-046777	Homo sapiens	94.55	0.00e+00	701.00
IUUC-Hvu-047549	Hordeum vulgare	60.50	7.00e-98	350.00
IUUC-Itr-048175	Ictidomys tridecemlineatus	94.29	0.00e+00	657.00
IUUC-Lch-050142	Latimeria chalumnae	79.51	1.00e-179	622.00
IUUC-Lpe-050769	Leersia perrieri	67.02	1.00e-103	369.00
IUUC-Loc-052405	Lepisosteus oculatus	82.63	2.00e-168	585.00
IUUC-Laf-054152	Loxodonta africana	94.06	0.00e+00	684.00
IUUC-Mcc-055618	Macaca mulatta	95.98	0.00e+00	629.00
IUUC-Meu-056486	Macropus eugenii	91.15	1.00e-170	592.00
IUUC-Mtr-057871	Medicago truncatula	59.89	2.00e-122	432.00
IUUC-Mga-059284	Meleagris gallopavo	86.85	9.00e-176	609.00
IUUC-Mmr-061242	Microcebus murinus	93.65	0.00e+00	687.00
IUUC-Mdo-063034	Monodelphis domestica	90.49	0.00e+00	635.00
IUUC-Mmu-064322	Mus musculus	88.08	0.00e+00	631.00
IUUC-Mac-065128	Musa acuminata	67.98	6.00e-69	259.00
IUUC-Mpu-066438	Mustela putorius furo	94.25	0.00e+00	651.00
IUUC-Mlu-067578	Myotis lucifugus	95.34	0.00e+00	657.00
IUUC-Nle-069542	Nomascus leucogenys	95.92	0.00e+00	666.00
IUUC-Opr-070710	Ochotona princeps	88.12	0.00e+00	647.00
IUUC-Ont-072067	Oreochromis niloticus	85.71	8.00e-172	596.00
IUUC-Oan-073593	Ornithorhynchus anatinus	87.50	5.00e-176	610.00
IUUC-Ocu-073964	Oryctolagus cuniculus	91.09	0.00e+00	676.00
IUUC-Oba-075476	Oryza barthii	59.09	8.00e-118	416.00
IUUC-Obr-076517	Oryza brachyantha	61.28	2.00e-116	412.00
IUUC-Ogu-078664	Oryza glumaepatula	59.36	4.00e-118	417.00
IUUC-Olo-081012	Oryza longistaminata	59.09	1.00e-117	416.00
IUUC-Ome-081129	Oryza meridionalis	60.56	2.00e-117	415.00
IUUC-Oni-082265	Oryza nivara	59.35	4.00e-116	410.00
IUUC-Opu-084121	Oryza punctata	57.22	5.00e-117	414.00
IUUC-Oru-084451	Oryza rufipogon	58.44	4.00e-101	362.00
IUUC-Osa-086132	Oryza sativa	59.09	8.00e-118	416.00
IUUC-Ola-086842	Oryzias latipes	79.95	2.00e-165	575.00
IUUC-Oga-088160	Otolemur garnettii	93.75	0.00e+00	639.00
IUUC-Oar-089362	Ovis aries	98.63	0.00e+00	706.00
IUUC-Ptr-091256	Pan troglodytes	95.05	0.00e+00	706.00
IUUC-Pan-092913	Papio anubis	95.12	0.00e+00	672.00
IUUC-Psi-093740	Pelodiscus sinensis	88.03	4.00e-163	566.00
IUUC-Pma-094485	Petromyzon marinus	83.41	4.00e-107	380.00
IUUC-Ppa-095673	Physcomitrella patens	62.29	1.00e-114	406.00
IUUC-Pfo-096196	Poecilia formosa	82.38	8.00e-169	586.00
IUUC-Pab-098449	Pongo abelii	94.31	0.00e+00	704.00
IUUC-Pop-099049	Populus trichocarpa	61.21	4.00e-118	417.00
IUUC-Pca-100917	Procavia capensis	93.72	1.00e-124	439.00
IUUC-Ppe-101797	Prunus persica	56.73	3.00e-122	431.00
IUUC-Pva-102852	Pteropus vampyrus	94.84	0.00e+00	666.00
IUUC-Rno-105213	Rattus norvegicus	88.08	0.00e+00	633.00
IUUC-Sha-107569	Sarcophilus harrisii	85.33	0.00e+00	651.00
IUUC-Smo-109146	Selaginella moellendorffii	62.64	5.00e-116	411.00
IUUC-Sit-109794	Setaria italica	59.15	1.00e-117	416.00
IUUC-Sly-111622	Solanum lycopersicum	60.27	4.00e-119	421.00
IUUC-Stu-112522	Solanum tuberosum	61.81	4.00e-119	421.00
IUUC-Sar-113045	Sorex araneus	80.74	1.00e-171	595.00
IUUC-Sbi-113861	Sorghum bicolor	58.99	9.00e-118	416.00
IUUC-Ssc-115290	Sus scrofa	96.72	4.00e-164	570.00
IUUC-Tgu-117125	Taeniopygia guttata	85.25	1.00e-173	602.00
IUUC-Tru-118041	Takifugu rubripes	82.34	3.00e-175	607.00
IUUC-Tsy-119300	Tarsius syrichta	85.43	1.00e-153	535.00
IUUC-Tni-120310	Tetraodon nigroviridis	82.34	9.00e-165	572.00
IUUC-Tca-121405	Theobroma cacao	56.70	1.00e-120	426.00
IUUC-Tae-123656	Triticum aestivum	62.32	2.00e-116	412.00
IUUC-Tur-125985	Triticum urartu	62.03	1.00e-116	412.00
IUUC-Tbe-127478	Tupaia belangeri	76.24	3.00e-158	551.00
IUUC-Ttr-128169	Tursiops truncatus	77.23	2.00e-151	528.00
IUUC-Vpa-130508	Vicugna pacos	87.71	1.00e-160	558.00
IUUC-Vvi-131252	Vitis vinifera	59.75	2.00e-121	428.00
IUUC-Xtr-132776	Xenopus tropicalis	83.20	2.00e-171	595.00
IUUC-Xma-133110	Xiphophorus maculatus	82.38	4.00e-171	593.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence