iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	93.38	0.00e+00	1699.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
796	N/A	{ECO:0000250}

Organism

Rattus norvegicus

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.

Protein Sequence
(Fasta)

MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVATALPL QVAPAAVPMD LRLDHQFSLP 60
LEPALREQQL QQELLALKQK QQIQRQILIA EFQRQHEQLS RQHEAQLHEH IKQQQEMLAM 120

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Nucleotide Sequence
(Fasta)

GGAGCGCCTG ACGGGCGTAG GGCGCGGCCT ATCCCCGCGC GGCTCTGCGC TCGAGGGGGA 60
GCAGCATCAT GGTTCAACGT GGGTCAATTT TTTGTGAATG AGGAGGGGAG GTTGTGGGGC 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0031672--C:A band
GO:0042641--C:actomyosin
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0030017--C:sarcomere
GO:0017053--C:transcriptional repressor complex
GO:0030018--C:Z disc
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0008270--F:zinc ion binding
GO:0071260--P:cellular response to mechanical stimulus
GO:0071374--P:cellular response to parathyroid hormone stimulus
GO:0071356--P:cellular response to tumor necrosis factor
GO:0006338--P:chromatin remodeling
GO:0016575--P:histone deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0010592--P:positive regulation of lamellipodium assembly
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0033235--P:positive regulation of protein sumoylation
GO:1903428--P:positive regulation of reactive oxygen species biosynthetic process
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0014911--P:positive regulation of smooth muscle cell migration
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0042493--P:response to drug
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

KEGG

rno:363287

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	91.71	0.00e+00	1689.00
IUUC-Apl-003250	Anas platyrhynchos	87.36	0.00e+00	1563.00
IUUC-Aca-004668	Anolis carolinensis	82.75	0.00e+00	1590.00
IUUC-Bta-013215	Bos taurus	92.03	0.00e+00	1678.00
IUUC-Cja-019816	Callithrix jacchus	93.16	0.00e+00	1732.00
IUUC-Cfa-020861	Canis familiaris	92.50	0.00e+00	1666.00
IUUC-Cpo-021562	Cavia porcellus	92.87	0.00e+00	1720.00
IUUC-Csa-023612	Chlorocebus sabaeus	92.92	0.00e+00	1715.00
IUUC-Csv-026359	Ciona savignyi	54.73	3.00e-94	338.00
IUUC-Dre-028284	Danio rerio	78.22	0.00e+00	1361.00
IUUC-Dno-029951	Dasypus novemcinctus	89.34	0.00e+00	1546.00
IUUC-Dor-030362	Dipodomys ordii	83.63	0.00e+00	1459.00
IUUC-Dme-031766	Drosophila melanogaster	59.57	3.00e-162	566.00
IUUC-Fca-036187	Felis catus	93.46	0.00e+00	1656.00
IUUC-Gmo-038473	Gadus morhua	76.71	0.00e+00	737.00
IUUC-Gga-040501	Gallus gallus	90.33	0.00e+00	1653.00
IUUC-Gac-042335	Gasterosteus aculeatus	69.62	0.00e+00	1246.00
IUUC-Ggo-045380	Gorilla gorilla	93.17	0.00e+00	1697.00
IUUC-Hsa-046925	Homo sapiens	93.55	0.00e+00	1736.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	93.65	0.00e+00	1660.00
IUUC-Lch-050325	Latimeria chalumnae	83.85	0.00e+00	1495.00
IUUC-Loc-052231	Lepisosteus oculatus	81.57	0.00e+00	1449.00
IUUC-Laf-054490	Loxodonta africana	86.18	0.00e+00	1609.00
IUUC-Mcc-055265	Macaca mulatta	93.04	0.00e+00	1730.00
IUUC-Meu-056676	Macropus eugenii	86.49	0.00e+00	729.00
IUUC-Mmr-061633	Microcebus murinus	84.72	0.00e+00	1498.00
IUUC-Mmu-063089	Mus musculus	98.41	0.00e+00	1798.00
IUUC-Mpu-065887	Mustela putorius furo	92.33	0.00e+00	1712.00
IUUC-Mlu-067470	Myotis lucifugus	92.77	0.00e+00	1673.00
IUUC-Nle-069099	Nomascus leucogenys	90.25	0.00e+00	1113.00
IUUC-Ont-071613	Oreochromis niloticus	71.94	0.00e+00	1265.00
IUUC-Oan-073275	Ornithorhynchus anatinus	90.13	0.00e+00	1630.00
IUUC-Ola-087031	Oryzias latipes	66.94	0.00e+00	1164.00
IUUC-Oga-088201	Otolemur garnettii	87.49	0.00e+00	1471.00
IUUC-Oar-089997	Ovis aries	83.95	0.00e+00	1371.00
IUUC-Ptr-091116	Pan troglodytes	93.45	0.00e+00	1738.00
IUUC-Pan-092132	Papio anubis	92.04	0.00e+00	1112.00
IUUC-Psi-093734	Pelodiscus sinensis	88.94	0.00e+00	1532.00
IUUC-Pma-094347	Petromyzon marinus	70.14	0.00e+00	715.00
IUUC-Pfo-096293	Poecilia formosa	69.35	0.00e+00	1189.00
IUUC-Pab-098491	Pongo abelii	90.46	0.00e+00	1638.00
IUUC-Pca-101004	Procavia capensis	82.79	0.00e+00	892.00
IUUC-Pva-102961	Pteropus vampyrus	69.94	0.00e+00	833.00
IUUC-Sha-107646	Sarcophilus harrisii	66.29	0.00e+00	954.00
IUUC-Ssc-115428	Sus scrofa	91.16	0.00e+00	1595.00
IUUC-Tgu-116776	Taeniopygia guttata	89.99	0.00e+00	1644.00
IUUC-Tru-118180	Takifugu rubripes	82.63	0.00e+00	822.00
IUUC-Tsy-119468	Tarsius syrichta	88.01	0.00e+00	740.00
IUUC-Tni-120196	Tetraodon nigroviridis	68.89	0.00e+00	1237.00
IUUC-Ttr-128360	Tursiops truncatus	82.16	0.00e+00	944.00
IUUC-Xtr-132956	Xenopus tropicalis	80.15	0.00e+00	1419.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence