iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062376

Ensembl Protein ID

ENSMODP00000011041.3

UniProt Accession

F7CU18; F7CU18_MONDO

Protein Name

Eukaryotic translation initiation factor 3 subunit F; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47

Gene Name

EIF3F; EIF3S5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000008867.3	ENSMODT00000011258.3	ENSMODP00000011041.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/JAMM	94.40	1.00e-149	526.00	IUUC-Hsa-046860

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Monodelphis domestica

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Protein Sequence
(Fasta)

MAAAMAASGS SPTSTPAPTP TPVSAPDPVQ ASAPAPAPTP PQAQGQAPAS APPPAAPTPA 60
PAPAPLGPGL PGPFPGGRVV RLHPVILASI VDSYERRNEG AGRVIGTLLG TIDKHSVEVT 120

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Nucleotide Sequence
(Fasta)

TCCATCAGTT GTTTGGCCAA TGCTAGGACC TACAGCTGAT GCCTGAAGCC ATTTTAAGAA 60
CTTGAAACTG GACTCCTTAC CCTTACCATT TACCCCAACT CTTCTTTGCA GATCTTCATC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome

Interpro

IPR027531--eIF3f
IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0016020--C:membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003743--F:translation initiation factor activity
GO:0031369--F:translation initiation factor binding
GO:0001731--P:formation of translation preinitiation complex
GO:0075522--P:IRES-dependent viral translational initiation
GO:0016579--P:protein deubiquitination
GO:0006446--P:regulation of translational initiation
GO:0006413--P:translational initiation

KEGG

mdo:100030376

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001150	Aegilops tauschii	36.49	9.00e-47	180.00
IUUC-Aml-001527	Ailuropoda melanoleuca	94.40	7.00e-151	526.00
IUUC-Atr-002686	Amborella trichopoda	40.68	1.00e-49	189.00
IUUC-Apl-003977	Anas platyrhynchos	92.86	2.00e-124	437.00
IUUC-Aca-004335	Anolis carolinensis	90.67	3.00e-147	514.00
IUUC-Aly-005945	Arabidopsis lyrata	38.40	3.00e-50	191.00
IUUC-Ath-007045	Arabidopsis thaliana	38.40	4.00e-49	187.00
IUUC-Acl-008365	Aspergillus clavatus	34.55	7.00e-42	164.00
IUUC-Afl-008742	Aspergillus flavus	35.27	5.00e-41	161.00
IUUC-Afu-009030	Aspergillus fumigatus	34.18	1.00e-41	163.00
IUUC-Ani-009212	Aspergillus nidulans	35.27	8.00e-42	164.00
IUUC-Ang-009712	Aspergillus niger	34.18	2.00e-40	159.00
IUUC-Aor-009885	Aspergillus oryzae	35.27	1.00e-42	166.00
IUUC-Ate-010315	Aspergillus terreus	35.27	3.00e-40	159.00
IUUC-Ame-010801	Astyanax mexicanus	54.48	2.00e-67	248.00
IUUC-Bgr-011982	Blumeria graminis	35.38	3.00e-41	162.00
IUUC-Bta-012804	Bos taurus	94.78	2.00e-150	525.00
IUUC-Bci-013891	Botrytis cinerea	34.66	1.00e-35	144.00
IUUC-Bdi-014328	Brachypodium distachyon	39.25	4.00e-49	187.00
IUUC-Bol-015446	Brassica oleracea	38.78	5.00e-51	194.00
IUUC-Bra-016862	Brassica rapa	39.16	1.00e-51	196.00
IUUC-Cel-018171	Caenorhabditis elegans	34.84	1.00e-45	176.00
IUUC-Cja-019335	Callithrix jacchus	94.40	3.00e-150	524.00
IUUC-Cfa-020138	Canis familiaris	94.03	4.00e-150	523.00
IUUC-Cpo-022109	Cavia porcellus	83.27	1.00e-129	455.00
IUUC-Cre-022664	Chlamydomonas reinhardtii	39.18	8.00e-59	220.00
IUUC-Csa-023994	Chlorocebus sabaeus	94.40	3.00e-150	524.00
IUUC-Cho-024351	Choloepus hoffmanni	72.39	9.00e-105	373.00
IUUC-Cin-025801	Ciona intestinalis	54.85	1.00e-86	313.00
IUUC-Csv-025805	Ciona savignyi	54.10	1.00e-84	305.00
IUUC-Cgl-026643	Colletotrichum gloeosporioides	31.77	1.00e-36	146.00
IUUC-Cne-026868	Cryptococcus neoformans	29.15	6.00e-29	120.00
IUUC-Cme-027328	Cyanidioschyzon merolae	26.13	5.00e-23	101.00
IUUC-Dre-028085	Danio rerio	80.15	3.00e-128	451.00
IUUC-Dno-030099	Dasypus novemcinctus	94.03	4.00e-150	524.00
IUUC-Dor-030324	Dipodomys ordii	85.82	3.00e-132	464.00
IUUC-Dse-031314	Dothistroma septosporum	36.00	6.00e-45	174.00
IUUC-Dme-031926	Drosophila melanogaster	48.15	6.00e-76	276.00
IUUC-Ete-032569	Echinops telfairi	87.31	9.00e-137	479.00
IUUC-Eca-033502	Equus caballus	89.18	5.00e-138	483.00
IUUC-Eeu-034883	Erinaceus europaeus	78.38	1.00e-77	281.00
IUUC-Fca-035873	Felis catus	94.40	1.00e-150	525.00
IUUC-Fal-036921	Ficedula albicollis	92.91	6.00e-150	523.00
IUUC-Fox-037765	Fusarium oxysporum	32.61	4.00e-31	128.00
IUUC-Fso-038240	Fusarium solani	33.33	8.00e-34	137.00
IUUC-Gmo-038864	Gadus morhua	79.70	1.00e-129	455.00
IUUC-Ggr-039862	Gaeumannomyces graminis	29.96	3.00e-30	125.00
IUUC-Gga-040952	Gallus gallus	92.91	1.00e-149	521.00
IUUC-Gac-041677	Gasterosteus aculeatus	79.78	2.00e-129	454.00
IUUC-Gma-043061	Glycine max	39.54	5.00e-48	184.00
IUUC-Ggo-045591	Gorilla gorilla	94.40	1.00e-150	525.00
IUUC-Hsa-046860	Homo sapiens	94.40	3.00e-150	524.00
IUUC-Hvu-047410	Hordeum vulgare	30.41	1.00e-20	92.00
IUUC-Itr-048211	Ictidomys tridecemlineatus	94.03	4.00e-150	523.00
IUUC-Lch-049410	Latimeria chalumnae	73.53	3.00e-87	314.00
IUUC-Lpe-051102	Leersia perrieri	38.82	6.00e-47	181.00
IUUC-Loc-052016	Lepisosteus oculatus	73.41	3.00e-114	404.00
IUUC-Lma-053157	Leptosphaeria maculans	34.67	2.00e-43	169.00
IUUC-Laf-054568	Loxodonta africana	94.03	9.00e-150	522.00
IUUC-Mcc-054613	Macaca mulatta	94.40	1.00e-150	525.00
IUUC-Meu-056832	Macropus eugenii	77.14	6.00e-87	313.00
IUUC-Mor-057104	Magnaporthe oryzae	30.96	5.00e-31	128.00
IUUC-Mtr-058445	Medicago truncatula	39.16	2.00e-56	212.00
IUUC-Mla-059038	Melampsora laricipopulina	30.77	4.00e-32	131.00
IUUC-Mga-059548	Meleagris gallopavo	93.22	8.00e-132	462.00
IUUC-Mvi-060520	Microbotryum violaceum	27.85	4.00e-21	95.50
IUUC-Mmu-063254	Mus musculus	93.66	5.00e-149	520.00
IUUC-Mac-065635	Musa acuminata	40.00	2.00e-52	199.00
IUUC-Mpu-066314	Mustela putorius furo	94.40	2.00e-150	525.00
IUUC-Mlu-067512	Myotis lucifugus	94.03	1.00e-149	522.00
IUUC-Nfi-068262	Neosartorya fischeri	34.18	1.00e-41	163.00
IUUC-Ncr-068872	Neurospora crassa	31.77	1.00e-33	136.00
IUUC-Nle-070118	Nomascus leucogenys	94.40	1.00e-150	525.00
IUUC-Opr-071228	Ochotona princeps	94.47	2.00e-132	464.00
IUUC-Ont-072600	Oreochromis niloticus	81.65	1.00e-132	465.00
IUUC-Oan-073584	Ornithorhynchus anatinus	96.19	6.00e-134	469.00
IUUC-Ocu-074542	Oryctolagus cuniculus	94.78	2.00e-151	528.00
IUUC-Oba-075923	Oryza barthii	39.16	5.00e-50	191.00
IUUC-Obr-076313	Oryza brachyantha	39.61	2.00e-49	189.00
IUUC-Ogl-076932	Oryza glaberrima	39.16	5.00e-50	191.00
IUUC-Ogu-078152	Oryza glumaepatula	39.16	5.00e-50	191.00
IUUC-Oin-079528	Oryza indica	39.16	5.00e-50	191.00
IUUC-Olo-080401	Oryza longistaminata	39.16	5.00e-50	191.00
IUUC-Ome-081553	Oryza meridionalis	39.54	2.00e-50	192.00
IUUC-Oni-082090	Oryza nivara	39.16	5.00e-50	191.00
IUUC-Opu-083583	Oryza punctata	39.61	4.00e-49	187.00
IUUC-Oru-084492	Oryza rufipogon	39.16	5.00e-50	191.00
IUUC-Osa-085383	Oryza sativa	39.16	5.00e-50	191.00
IUUC-Ola-086835	Oryzias latipes	79.78	9.00e-130	456.00
IUUC-Olu-087716	Ostreococcus lucimarinus	28.20	6.00e-27	114.00
IUUC-Oga-088886	Otolemur garnettii	94.40	8.00e-151	526.00
IUUC-Oar-090079	Ovis aries	94.78	1.00e-150	525.00
IUUC-Ptr-091457	Pan troglodytes	94.40	3.00e-150	524.00
IUUC-Pan-092317	Papio anubis	93.51	7.00e-100	355.00
IUUC-Psi-093129	Pelodiscus sinensis	86.49	3.00e-132	464.00
IUUC-Pma-094488	Petromyzon marinus	76.40	4.00e-124	437.00
IUUC-Pno-095049	Phaeosphaeria nodorum	34.67	1.00e-43	170.00
IUUC-Ppa-095341	Physcomitrella patens	40.00	3.00e-61	228.00
IUUC-Pfo-096286	Poecilia formosa	79.78	8.00e-130	456.00
IUUC-Pab-097765	Pongo abelii	94.40	3.00e-150	524.00
IUUC-Pop-099131	Populus trichocarpa	39.16	5.00e-53	201.00
IUUC-Pca-100524	Procavia capensis	79.49	6.00e-103	366.00
IUUC-Ppe-101934	Prunus persica	40.30	8.00e-58	216.00
IUUC-Pva-102577	Pteropus vampyrus	93.66	8.00e-150	523.00
IUUC-Pgr-103521	Puccinia graminis	29.28	7.00e-30	124.00
IUUC-Pte-104304	Pyrenophora teres	35.40	4.00e-44	171.00
IUUC-Pyt-104563	Pyrenophora triticirepentis	35.40	2.00e-44	172.00
IUUC-Rno-105717	Rattus norvegicus	94.03	7.00e-150	523.00
IUUC-Sha-107190	Sarcophilus harrisii	99.62	6.00e-155	540.00
IUUC-Sja-107918	Schizosaccharomyces japonicus	35.02	6.00e-44	171.00
IUUC-Spo-108355	Schizosaccharomyces pombe	35.13	4.00e-46	178.00
IUUC-Smo-109374	Selaginella moellendorffii	43.40	7.00e-67	246.00
IUUC-Sit-110119	Setaria italica	38.78	2.00e-49	188.00
IUUC-Sly-111570	Solanum lycopersicum	36.91	8.00e-46	177.00
IUUC-Stu-112308	Solanum tuberosum	38.82	3.00e-52	198.00
IUUC-Sar-113515	Sorex araneus	90.43	6.00e-48	183.00
IUUC-Sbi-114605	Sorghum bicolor	38.40	6.00e-49	188.00
IUUC-Sre-114906	Sporisorium reilianum	39.42	1.00e-52	199.00
IUUC-Tgu-117087	Taeniopygia guttata	91.95	2.00e-129	454.00
IUUC-Tru-117700	Takifugu rubripes	79.03	4.00e-129	453.00
IUUC-Tni-120470	Tetraodon nigroviridis	80.90	1.00e-130	458.00
IUUC-Tca-121109	Theobroma cacao	38.78	6.00e-47	180.00
IUUC-Tre-122095	Trichoderma reesei	33.33	4.00e-33	135.00
IUUC-Tvi-122580	Trichoderma virens	32.97	2.00e-32	133.00
IUUC-Tae-125129	Triticum aestivum	39.25	2.00e-51	195.00
IUUC-Tur-126658	Triticum urartu	35.69	2.00e-43	169.00
IUUC-Tme-127043	Tuber melanosporum	37.83	4.00e-48	184.00
IUUC-Tbe-127927	Tupaia belangeri	94.40	1.00e-150	525.00
IUUC-Ttr-129231	Tursiops truncatus	94.78	5.00e-151	526.00
IUUC-Uma-129578	Ustilago maydis	39.05	2.00e-51	196.00
IUUC-Vda-129730	Verticillium dahliae	32.49	9.00e-39	154.00
IUUC-Vpa-130677	Vicugna pacos	60.58	2.00e-38	152.00
IUUC-Vvi-130968	Vitis vinifera	41.44	4.00e-54	204.00
IUUC-Xtr-132203	Xenopus tropicalis	85.02	2.00e-136	478.00
IUUC-Xma-133972	Xiphophorus maculatus	79.40	2.00e-129	454.00
IUUC-Yli-134553	Yarrowia lipolytica	36.33	9.00e-41	160.00
IUUC-Zma-134941	Zea mays	39.25	3.00e-45	175.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence