iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gac-042015

Ensembl Protein ID

ENSGACP00000011507.1

UniProt Accession

G3P1N4; G3P1N4_GASAC

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Gene Name

esr1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000008711.1	ENSGACT00000011530.1	ENSGACP00000011507.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	64.46	1.00e-125	448.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Gasterosteus aculeatus

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MLLRQSPTQS RPVLRTRISP ALSELETRSP QRPSPPPRAH FSEMYPEESR GSGGVATVDF 60
LEGTYDYAAP TPAPTPLYSH STPGYYSAPL DSHRPPSDGS LQSLGSGPTS PIVFVPSSPR 120

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Nucleotide Sequence
(Fasta)

GTGAACCGGG AGGTTATTTG GGAATCCCCG TTTCTCTGTC CATCTTTCTC GTCCTTATCC 60
CACCAGCATG GGAGGAGCCT TCTCGCATGT CTTTTTGTTT TTTTCTGCTG CTCGGTGGGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005634--C:nucleus
GO:0030284--F:estrogen receptor activity
GO:0043565--F:sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	64.32	5.00e-128	451.00
IUUC-Apl-003688	Anas platyrhynchos	51.57	4.00e-126	445.00
IUUC-Aca-005222	Anolis carolinensis	53.79	8.00e-134	470.00
IUUC-Ame-010731	Astyanax mexicanus	64.86	3.00e-168	585.00
IUUC-Bta-013112	Bos taurus	62.76	3.00e-130	459.00
IUUC-Cja-019408	Callithrix jacchus	64.81	2.00e-129	455.00
IUUC-Cfa-020694	Canis familiaris	64.14	9.00e-129	454.00
IUUC-Cpo-021426	Cavia porcellus	61.40	6.00e-125	441.00
IUUC-Csa-023736	Chlorocebus sabaeus	59.64	5.00e-131	461.00
IUUC-Dre-027698	Danio rerio	61.17	2.00e-169	589.00
IUUC-Dno-029477	Dasypus novemcinctus	63.68	2.00e-127	449.00
IUUC-Dor-030572	Dipodomys ordii	58.97	1.00e-125	442.00
IUUC-Ete-032849	Echinops telfairi	50.14	7.00e-84	304.00
IUUC-Eca-033605	Equus caballus	60.91	9.00e-130	457.00
IUUC-Eeu-034683	Erinaceus europaeus	56.84	4.00e-53	202.00
IUUC-Fca-035928	Felis catus	63.32	5.00e-127	447.00
IUUC-Fal-036754	Ficedula albicollis	54.23	4.00e-138	484.00
IUUC-Gmo-038872	Gadus morhua	76.82	2.00e-167	581.00
IUUC-Gga-040988	Gallus gallus	52.71	9.00e-136	477.00
IUUC-Ggo-044749	Gorilla gorilla	64.92	9.00e-130	457.00
IUUC-Hsa-046944	Homo sapiens	62.57	2.00e-130	459.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	62.41	3.00e-128	452.00
IUUC-Loc-052414	Lepisosteus oculatus	64.56	0.00e+00	649.00
IUUC-Mcc-054781	Macaca mulatta	64.92	9.00e-130	457.00
IUUC-Meu-056232	Macropus eugenii	61.40	3.00e-127	449.00
IUUC-Mga-059319	Meleagris gallopavo	53.18	1.00e-135	476.00
IUUC-Mmr-061636	Microcebus murinus	57.59	2.00e-54	206.00
IUUC-Mdo-062661	Monodelphis domestica	64.39	4.00e-130	458.00
IUUC-Mmu-063330	Mus musculus	59.82	6.00e-130	457.00
IUUC-Mpu-065757	Mustela putorius furo	64.66	1.00e-130	460.00
IUUC-Mlu-067712	Myotis lucifugus	62.63	2.00e-128	452.00
IUUC-Nle-069283	Nomascus leucogenys	63.38	1.00e-129	457.00
IUUC-Opr-070391	Ochotona princeps	61.39	2.00e-133	469.00
IUUC-Ont-071369	Oreochromis niloticus	76.29	0.00e+00	745.00
IUUC-Oan-073734	Ornithorhynchus anatinus	46.69	1.00e-60	226.00
IUUC-Ocu-074292	Oryctolagus cuniculus	62.56	3.00e-128	452.00
IUUC-Ola-087052	Oryzias latipes	80.42	0.00e+00	762.00
IUUC-Oga-088586	Otolemur garnettii	59.09	6.00e-127	447.00
IUUC-Oar-090156	Ovis aries	60.41	5.00e-133	467.00
IUUC-Ptr-091321	Pan troglodytes	64.92	8.00e-130	457.00
IUUC-Pan-092851	Papio anubis	64.92	9.00e-130	457.00
IUUC-Psi-093434	Pelodiscus sinensis	55.07	2.00e-140	492.00
IUUC-Pfo-097379	Poecilia formosa	75.12	0.00e+00	769.00
IUUC-Pab-097735	Pongo abelii	64.92	9.00e-130	457.00
IUUC-Pva-102125	Pteropus vampyrus	53.60	9.00e-128	450.00
IUUC-Rno-106121	Rattus norvegicus	59.59	2.00e-130	459.00
IUUC-Sha-107547	Sarcophilus harrisii	59.28	5.00e-130	457.00
IUUC-Sar-113650	Sorex araneus	45.26	1.00e-68	253.00
IUUC-Tgu-117175	Taeniopygia guttata	54.04	2.00e-138	486.00
IUUC-Tru-117545	Takifugu rubripes	78.57	0.00e+00	765.00
IUUC-Tsy-119586	Tarsius syrichta	56.02	2.00e-109	389.00
IUUC-Tni-120121	Tetraodon nigroviridis	74.35	0.00e+00	746.00
IUUC-Tbe-127548	Tupaia belangeri	56.08	7.00e-102	364.00
IUUC-Ttr-128374	Tursiops truncatus	61.20	4.00e-116	411.00
IUUC-Vpa-130464	Vicugna pacos	51.23	1.00e-80	293.00
IUUC-Xtr-132171	Xenopus tropicalis	51.90	7.00e-128	451.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence