iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Beta-Prp	Beta-Prp	21070969

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-20	71.2	79	111
UBD/Beta-Prp	1.20e-48	164.2	70	309

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDl 30
           gHt+ v + +f   +d++++sGsdD +i +WD+
   Q: 79   GHTAQVLDTDFdpfNDHRIASGSDDSKIGIWDI 111
           8************999****************5 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfsp.sgdklvsGshdrtirvwdletgqclee...............tlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdl 166
           ++++v  ++gh+++vl+++f+p ++++++sGs+d+ i +wd+++++++++               +l+gh + v +v +hp + n+l+s+s D tv+lW++
   Q: 70   APDQVPLFRGHTAQVLDTDFDPfNDHRIASGSDDSKIGIWDIPENYKFHDhvdedgepidikpvkFLTGHARKVGHVLYHPVAeNVLASSSGDYTVKLWNV 170
           7889999***************999**************************************************************************** PP
   S: 167  ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgs....sDgsiriW...dlrsgdllkt 259
           +tgk + tl+  h d+v+s+sf+++g++l+++++d+++++w+++++++v +  +ht   ++  ++  n++rl++++    sD++i iW   ++++gdl + 
   Q: 171  ETGKDMITLK--HPDMVTSMSFSYDGNYLATVARDKKLRVWNIREEKIVSEGPAHTGAKNQRVVWlGNSDRLATTGfsklSDRQIGIWdafNIEKGDLGGF 269
           *********5..9***********************************************999999*********************************** PP
   S: 260  lqlhnssvisvavlsfgdnvlvlgse.dskvniwklkkne 298
           ++  +ss i + +++ g+++l+l+++ d+++++++++++e
   Q: 270  YTVDQSSGILMPFYDEGNKILYLVGKgDGNIRYYEFQNDE 309
           ***********************9999*********9987 PP

Organism

Saccharomyces cerevisiae

Protein Sequence
(Fasta)

MSGKFVRASK YRHVFGQAAK KELQYEKLKV TNNAWDSNLL KTNGKFIAVN WNASGGGAFA 60
VIPIEEVGKA PDQVPLFRGH TAQVLDTDFD PFNDHRIASG SDDSKIGIWD IPENYKFHDH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTGGAA AATTTGTTCG TGCTTCTAAA TATAGACACG TCTTTGGCCA AGCGGCCAAA 60
AAGGAACTGC AATATGAAAA ACTCAAAGTG ACCAACAACG CATGGGACTC CAACTTGCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR015505--Coronin
IPR015048--DUF1899
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0030479--C:actin cortical patch
GO:0005826--C:actomyosin contractile ring
GO:0051015--F:actin filament binding
GO:0008017--F:microtubule binding
GO:0030674--F:protein binding, bridging
GO:0051666--P:actin cortical patch localization
GO:0007015--P:actin filament organization
GO:0007017--P:microtubule-based process
GO:0034316--P:negative regulation of Arp2/3 complex-mediated actin nucleation
GO:2000601--P:positive regulation of Arp2/3 complex-mediated actin nucleation

KEGG

sce:YLR429W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001462	Ailuropoda melanoleuca	41.33	7.00e-94	335.00
IUUC-Apl-003861	Anas platyrhynchos	40.05	1.00e-90	324.00
IUUC-Aca-005215	Anolis carolinensis	39.61	1.00e-88	318.00
IUUC-Ago-007901	Ashbya gossypii	57.97	0.00e+00	759.00
IUUC-Acl-008280	Aspergillus clavatus	54.93	2.00e-140	490.00
IUUC-Afl-008393	Aspergillus flavus	56.16	1.00e-140	491.00
IUUC-Afu-008865	Aspergillus fumigatus	53.35	2.00e-137	480.00
IUUC-Ani-009155	Aspergillus nidulans	56.90	2.00e-143	500.00
IUUC-Ang-009523	Aspergillus niger	49.89	1.00e-132	464.00
IUUC-Aor-010049	Aspergillus oryzae	55.56	9.00e-136	475.00
IUUC-Ate-010368	Aspergillus terreus	52.96	7.00e-131	459.00
IUUC-Ame-011256	Astyanax mexicanus	40.83	5.00e-91	326.00
IUUC-Bgr-011990	Blumeria graminis	55.37	9.00e-143	498.00
IUUC-Bta-013225	Bos taurus	40.79	8.00e-92	328.00
IUUC-Bci-013935	Botrytis cinerea	58.78	2.00e-152	530.00
IUUC-Cel-018669	Caenorhabditis elegans	36.57	3.00e-69	254.00
IUUC-Cja-019934	Callithrix jacchus	38.95	9.00e-94	335.00
IUUC-Cfa-020414	Canis familiaris	41.33	3.00e-94	337.00
IUUC-Cpo-022256	Cavia porcellus	39.30	6.00e-94	335.00
IUUC-Csa-023319	Chlorocebus sabaeus	41.33	2.00e-93	333.00
IUUC-Cho-024687	Choloepus hoffmanni	41.28	1.00e-91	328.00
IUUC-Cin-025202	Ciona intestinalis	31.25	7.00e-53	200.00
IUUC-Csv-026184	Ciona savignyi	31.23	3.00e-54	203.00
IUUC-Cgl-026456	Colletotrichum gloeosporioides	53.86	2.00e-138	484.00
IUUC-Cne-026773	Cryptococcus neoformans	45.16	1.00e-107	381.00
IUUC-Dre-028541	Danio rerio	41.56	2.00e-92	330.00
IUUC-Dno-029363	Dasypus novemcinctus	40.87	1.00e-91	328.00
IUUC-Dor-030506	Dipodomys ordii	41.09	3.00e-94	337.00
IUUC-Dse-031378	Dothistroma septosporum	57.91	8.00e-143	498.00
IUUC-Dme-032091	Drosophila melanogaster	39.41	5.00e-82	296.00
IUUC-Ete-032839	Echinops telfairi	36.12	9.00e-75	271.00
IUUC-Eca-033550	Equus caballus	41.81	5.00e-95	339.00
IUUC-Eeu-034499	Erinaceus europaeus	40.17	9.00e-73	265.00
IUUC-Fca-035787	Felis catus	41.57	3.00e-95	340.00
IUUC-Fal-037065	Ficedula albicollis	40.54	7.00e-92	329.00
IUUC-Fox-037737	Fusarium oxysporum	56.34	1.00e-139	487.00
IUUC-Fso-038184	Fusarium solani	53.30	3.00e-140	489.00
IUUC-Gmo-038678	Gadus morhua	40.83	3.00e-89	320.00
IUUC-Ggr-039956	Gaeumannomyces graminis	56.72	2.00e-148	517.00
IUUC-Gga-040842	Gallus gallus	39.80	4.00e-91	326.00
IUUC-Gac-041543	Gasterosteus aculeatus	42.79	1.00e-89	321.00
IUUC-Ggo-044731	Gorilla gorilla	41.33	5.00e-94	336.00
IUUC-Hsa-046725	Homo sapiens	41.57	4.00e-94	336.00
IUUC-Itr-048296	Ictidomys tridecemlineatus	41.57	8.00e-94	335.00
IUUC-Kpa-049089	Komagataella pastoris	59.22	0.00e+00	639.00
IUUC-Lch-050582	Latimeria chalumnae	40.64	1.00e-90	325.00
IUUC-Loc-052911	Lepisosteus oculatus	40.83	8.00e-92	328.00
IUUC-Lma-053160	Leptosphaeria maculans	60.15	3.00e-153	533.00
IUUC-Laf-053427	Loxodonta africana	41.45	1.00e-93	334.00
IUUC-Mcc-055571	Macaca mulatta	41.57	2.00e-94	337.00
IUUC-Meu-056083	Macropus eugenii	40.38	2.00e-84	303.00
IUUC-Mor-056978	Magnaporthe oryzae	56.97	1.00e-148	518.00
IUUC-Mpo-057410	Magnaporthe poae	57.21	2.00e-143	500.00
IUUC-Mla-058883	Melampsora laricipopulina	50.61	2.00e-111	394.00
IUUC-Mga-059353	Meleagris gallopavo	40.82	2.00e-92	330.00
IUUC-Mvi-060569	Microbotryum violaceum	46.15	2.00e-108	384.00
IUUC-Mmr-060830	Microcebus murinus	41.33	2.00e-93	334.00
IUUC-Mdo-062469	Monodelphis domestica	41.11	8.00e-91	325.00
IUUC-Mmu-064073	Mus musculus	41.09	9.00e-93	332.00
IUUC-Mpu-066824	Mustela putorius furo	41.09	2.00e-93	334.00
IUUC-Mlu-066994	Myotis lucifugus	39.22	4.00e-93	332.00
IUUC-Nfi-068476	Neosartorya fischeri	55.17	2.00e-140	490.00
IUUC-Ncr-068781	Neurospora crassa	57.56	3.00e-150	523.00
IUUC-Nle-069218	Nomascus leucogenys	41.57	4.00e-94	336.00
IUUC-Opr-071137	Ochotona princeps	41.81	4.00e-94	336.00
IUUC-Ont-071983	Oreochromis niloticus	41.56	1.00e-92	331.00
IUUC-Oan-073547	Ornithorhynchus anatinus	41.28	1.00e-91	327.00
IUUC-Ocu-074167	Oryctolagus cuniculus	40.86	1.00e-92	331.00
IUUC-Ola-086713	Oryzias latipes	42.54	1.00e-95	341.00
IUUC-Oga-088077	Otolemur garnettii	39.08	2.00e-94	337.00
IUUC-Oar-089260	Ovis aries	41.18	5.00e-94	336.00
IUUC-Ptr-090488	Pan troglodytes	41.57	8.00e-94	335.00
IUUC-Pan-091682	Papio anubis	41.33	2.00e-93	333.00
IUUC-Psi-093011	Pelodiscus sinensis	41.28	1.00e-92	331.00
IUUC-Pma-094375	Petromyzon marinus	38.62	1.00e-54	204.00
IUUC-Pno-094994	Phaeosphaeria nodorum	60.39	5.00e-152	529.00
IUUC-Pfo-097309	Poecilia formosa	41.63	2.00e-92	330.00
IUUC-Pab-098296	Pongo abelii	41.04	3.00e-89	320.00
IUUC-Pca-100411	Procavia capensis	38.46	2.00e-74	271.00
IUUC-Pva-102483	Pteropus vampyrus	40.71	3.00e-93	333.00
IUUC-Pgr-103354	Puccinia graminis	49.63	8.00e-118	415.00
IUUC-Ptt-103735	Puccinia triticina	40.36	1.00e-90	325.00
IUUC-Pte-104194	Pyrenophora teres	57.61	9.00e-153	531.00
IUUC-Pyt-104437	Pyrenophora triticirepentis	58.33	2.00e-151	527.00
IUUC-Rno-104937	Rattus norvegicus	41.13	6.00e-92	328.00
IUUC-Sha-107210	Sarcophilus harrisii	38.06	1.00e-89	322.00
IUUC-Sja-107992	Schizosaccharomyces japonicus	55.06	1.00e-138	484.00
IUUC-Spo-108364	Schizosaccharomyces pombe	56.48	2.00e-150	523.00
IUUC-Sar-113292	Sorex araneus	40.68	4.00e-81	292.00
IUUC-Sre-114911	Sporisorium reilianum	48.37	4.00e-102	363.00
IUUC-Ssc-115348	Sus scrofa	40.29	3.00e-91	327.00
IUUC-Tgu-116597	Taeniopygia guttata	40.54	3.00e-91	327.00
IUUC-Tru-118425	Takifugu rubripes	40.27	2.00e-93	334.00
IUUC-Tsy-119223	Tarsius syrichta	35.14	6.00e-66	242.00
IUUC-Tni-120610	Tetraodon nigroviridis	42.30	7.00e-95	338.00
IUUC-Tre-122159	Trichoderma reesei	54.39	1.00e-141	494.00
IUUC-Tvi-122480	Trichoderma virens	54.88	1.00e-142	497.00
IUUC-Tme-126924	Tuber melanosporum	54.50	4.00e-140	489.00
IUUC-Tbe-127703	Tupaia belangeri	38.94	1.00e-66	244.00
IUUC-Ttr-128689	Tursiops truncatus	41.59	8.00e-92	328.00
IUUC-Uma-129489	Ustilago maydis	48.37	2.00e-109	387.00
IUUC-Vda-129792	Verticillium dahliae	54.88	6.00e-143	499.00
IUUC-Vpa-130339	Vicugna pacos	40.52	9.00e-76	275.00
IUUC-Xtr-132098	Xenopus tropicalis	40.00	2.00e-83	300.00
IUUC-Xma-133523	Xiphophorus maculatus	42.54	1.00e-95	341.00
IUUC-Yli-134440	Yarrowia lipolytica	56.98	1.00e-153	535.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence