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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046254
Ensembl Protein ID ENSP00000372035.4
UniProt Accession Q9NRM7; B1AM47; Q9P2X1; LATS2_HUMAN
Genbank Protein ID AAF80561.1; BAG36905.1; CAH71526.1; CAH71526.1; CAI15861.1; CAI15861.1; EAX08286.1; BAA92381.1
Protein Name Serine/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm; Warts-like kinase
Genbank Nucleotide ID AF207547; AK314235; AL161613; AL356285; AL356285; AL161613; CH471075; AB028019
Gene Name LATS2; KPM
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000150457.8 ENST00000382592.4 ENSP00000372035.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 21233212; 25026211; 26598551
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 5.10e-05 24.9 100 137
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLl 39
           + ++l++lv+ G+d+e a +aL ++ + ++eaA+ey+ 
   Q: 100  NRQMLQELVNAGCDQEMAGRALKQTgSRSIEAALEYIS 137
           669*********************************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
 Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
Protein Sequence
(Fasta)
MRPKTFPATT YSGNSRQRLQ EIREGLKQPS KSSVQGLPAG PNSDTSLDAK VLGSKDATRQ 60
QQQMRATPKF GPYQKALREI RYSLLPFANE SGTSAAAEVN RQMLQELVNA GCDQEMAGRA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046254|UBD,UBA|Homo sapiens
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Nucleotide Sequence
(Fasta)
TTGGGTCTGC GCTTTGGAAC CGCGGCGTGA GCGCCCCGGG AAGATGGAGC AGTCGCCGTC 60
CACGCCACCG CCGCCGCCCG GGGCTCCCCC GTCCCTGCGG GGCCAGCAGC AGCTCCAGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046254|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0043--Tumor suppressor
Interpro

IPR000961--AGC-kinase_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS51285--AGC_KINASE_CTER
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA
Pfam

PF00069--Pkinase
SMART

SM00133--S_TK_X
SM00220--S_TKc
Gene Ontology

GO:0005829--C:cytosol
GO:0005815--C:microtubule organizing center
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0051301--P:cell division
GO:0034613--P:cellular protein localization
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035329--P:hippo signaling
GO:0009755--P:hormone-mediated signaling pathway
GO:0001827--P:inner cell mass cell fate commitment
GO:0001828--P:inner cell mass cellular morphogenesis
GO:0035556--P:intracellular signal transduction
GO:0030216--P:keratinocyte differentiation
GO:0007067--P:mitotic nuclear division
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0018105--P:peptidyl-serine phosphorylation
GO:0043065--P:positive regulation of apoptotic process
GO:0006468--P:protein phosphorylation
GO:0046620--P:regulation of organ growth
KEGG hsa:26524
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001960 Ailuropoda melanoleuca 85.56 0.00e+00 1894.00
IUUC-Apl-003521 Anas platyrhynchos 73.63 0.00e+00 1282.00
IUUC-Aca-004995 Anolis carolinensis 73.78 0.00e+00 1566.00
IUUC-Ame-011481 Astyanax mexicanus 61.59 0.00e+00 1235.00
IUUC-Bta-012618 Bos taurus 85.36 0.00e+00 997.00
IUUC-Cja-019430 Callithrix jacchus 94.32 0.00e+00 1995.00
IUUC-Cfa-020687 Canis familiaris 85.41 0.00e+00 1841.00
IUUC-Cpo-021985 Cavia porcellus 86.80 0.00e+00 1084.00
IUUC-Csa-023534 Chlorocebus sabaeus 98.96 0.00e+00 1024.00
IUUC-Cho-024363 Choloepus hoffmanni 79.02 0.00e+00 731.00
IUUC-Dre-027538 Danio rerio 60.95 0.00e+00 1247.00
IUUC-Dno-029126 Dasypus novemcinctus 82.71 0.00e+00 1861.00
IUUC-Dor-030172 Dipodomys ordii 86.68 0.00e+00 1632.00
IUUC-Eca-033868 Equus caballus 84.66 0.00e+00 1831.00
IUUC-Eeu-034881 Erinaceus europaeus 69.62 0.00e+00 1361.00
IUUC-Fca-036203 Felis catus 81.41 0.00e+00 1703.00
IUUC-Fal-036668 Ficedula albicollis 74.96 0.00e+00 1669.00
IUUC-Gmo-039195 Gadus morhua 85.05 0.00e+00 780.00
IUUC-Gac-041789 Gasterosteus aculeatus 84.66 0.00e+00 875.00
IUUC-Ggo-044904 Gorilla gorilla 94.12 0.00e+00 1951.00
IUUC-Itr-047948 Ictidomys tridecemlineatus 88.31 0.00e+00 1670.00
IUUC-Lch-050079 Latimeria chalumnae 66.26 0.00e+00 1452.00
IUUC-Loc-052265 Lepisosteus oculatus 83.50 0.00e+00 869.00
IUUC-Laf-053806 Loxodonta africana 84.05 0.00e+00 1849.00
IUUC-Mcc-055253 Macaca mulatta 96.24 0.00e+00 1958.00
IUUC-Meu-056509 Macropus eugenii 83.52 0.00e+00 812.00
IUUC-Mga-059600 Meleagris gallopavo 74.43 0.00e+00 1669.00
IUUC-Mmr-061586 Microcebus murinus 89.44 0.00e+00 1803.00
IUUC-Mdo-062126 Monodelphis domestica 75.20 0.00e+00 1634.00
IUUC-Mmu-063164 Mus musculus 81.70 0.00e+00 1655.00
IUUC-Mpu-065992 Mustela putorius furo 84.93 0.00e+00 1876.00
IUUC-Mlu-067728 Myotis lucifugus 77.97 0.00e+00 1605.00
IUUC-Nle-069546 Nomascus leucogenys 98.07 0.00e+00 1962.00
IUUC-Opr-070872 Ochotona princeps 84.63 0.00e+00 1761.00
IUUC-Ont-072296 Oreochromis niloticus 86.53 0.00e+00 911.00
IUUC-Ocu-074068 Oryctolagus cuniculus 84.77 0.00e+00 1767.00
IUUC-Ola-086756 Oryzias latipes 86.12 0.00e+00 908.00
IUUC-Oga-089066 Otolemur garnettii 89.56 0.00e+00 1931.00
IUUC-Oar-090416 Ovis aries 85.02 0.00e+00 993.00
IUUC-Ptr-091247 Pan troglodytes 99.45 0.00e+00 2010.00
IUUC-Pan-092438 Papio anubis 96.24 0.00e+00 1957.00
IUUC-Psi-093920 Pelodiscus sinensis 73.77 0.00e+00 1643.00
IUUC-Pfo-096334 Poecilia formosa 85.05 0.00e+00 890.00
IUUC-Pab-098452 Pongo abelii 97.09 0.00e+00 1998.00
IUUC-Pca-101081 Procavia capensis 79.40 0.00e+00 1741.00
IUUC-Pva-103036 Pteropus vampyrus 82.33 0.00e+00 766.00
IUUC-Rno-105102 Rattus norvegicus 82.34 0.00e+00 1659.00
IUUC-Sha-106917 Sarcophilus harrisii 74.85 0.00e+00 1640.00
IUUC-Sar-113711 Sorex araneus 79.28 0.00e+00 1520.00
IUUC-Tgu-116553 Taeniopygia guttata 77.68 0.00e+00 1696.00
IUUC-Tru-118069 Takifugu rubripes 85.31 0.00e+00 899.00
IUUC-Tni-120617 Tetraodon nigroviridis 81.92 0.00e+00 887.00
IUUC-Ttr-129256 Tursiops truncatus 86.86 0.00e+00 1014.00
IUUC-Xtr-132593 Xenopus tropicalis 71.09 0.00e+00 1529.00
Created Date 25-Jun-2017

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